Mithila Kasbe
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View article: IMMU-85. Uncovering differences in local and systemic immunity in human primary and metastatic brain tumors
IMMU-85. Uncovering differences in local and systemic immunity in human primary and metastatic brain tumors Open
While therapies targeting T cell immune checkpoint receptors have demonstrated clinical efficacy for patients with brain metastases, adults with high-grade gliomas fail to benefit. We comprehensively profiled intratumoral and circulating T…
View article: <i>SFPQ-TFE3</i>gene fusion reciprocally regulates mTORC1 activity and induces lineage plasticity in a novel mouse model of renal tumorigenesis
<i>SFPQ-TFE3</i>gene fusion reciprocally regulates mTORC1 activity and induces lineage plasticity in a novel mouse model of renal tumorigenesis Open
Summary The MiT/TFE family gene fusion proteins, such as SFPQ-TFE3 , drive both epithelial (eg, translocation renal cell carcinoma, tRCC) and mesenchymal (eg, perivascular epithelioid cell tumor, PEComa) neoplasms with aggressive behavior.…