Mitja Kos
YOU?
Author Swipe
View article: Perspectives on the impact of regulatory measures on national COVID-19 vaccination programs: a qualitative study from six EU member states
Perspectives on the impact of regulatory measures on national COVID-19 vaccination programs: a qualitative study from six EU member states Open
EMA's regulatory actions were not the main source informing adaptations to national vaccination strategies. National decision-makers country reverted to their preferred sources. The use of varying sources explains some of the variations in…
View article: Characteristics and availability of medicine early access programs and donations in Slovenia
Characteristics and availability of medicine early access programs and donations in Slovenia Open
Background Early access programs (EAPs) and medicine donation programs (MDPs) enable patients to have access to new medicines prior to regulatory approval or national reimbursement, respectively. The objective of this study was to evaluate…
View article: Knowledge of Cardiopulmonary Resuscitation and Automated External Defibrillator Use in the General Population
Knowledge of Cardiopulmonary Resuscitation and Automated External Defibrillator Use in the General Population Open
Introduction. Sudden cardiac arrest represents a significant public health issue worldwide. Laypersons are often the first responders in emergencies. Timely recognition of the distressed individual and providing aid is crucial. Education o…
View article: Impact of Regulatory Risk Communication on Thrombosis With Thrombocytopenia Syndrome for COVID‐19 Adenovirus Vector Vaccines on European Healthcare Professionals
Impact of Regulatory Risk Communication on Thrombosis With Thrombocytopenia Syndrome for COVID‐19 Adenovirus Vector Vaccines on European Healthcare Professionals Open
Purpose The European Medicines Agency (EMA) issued regulatory actions and communications in 2021 on thrombosis with thrombocytopenia syndrome (TTS) associated with adenovirus vector vaccines Vaxzevria or Jcovden. This study aimed to evalua…
View article: Challenges in the Implementation of EU Risk Minimisation Measures for Medicinal Products in Clinical Practice Guidelines: Mixed Methods Multi-Case Study
Challenges in the Implementation of EU Risk Minimisation Measures for Medicinal Products in Clinical Practice Guidelines: Mixed Methods Multi-Case Study Open
The inclusion of RMM information in relevant CPGs is remarkably limited. It may be explained by characteristics of CPGs and of RMMs as well as lack of connection between national regulators and organisations and authors developing CPGs. Mo…
View article: Pharmacist-led hospital intervention reduces unintentional patient-generated medication discrepancies after hospital discharge
Pharmacist-led hospital intervention reduces unintentional patient-generated medication discrepancies after hospital discharge Open
Background Medication reconciliation can significantly reduce clinically important medication errors at hospital discharge, but its impact on post-discharge medication management has not been investigated. We aimed to investigate the incid…
View article: Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Development and Pilot of a Metadata List and Catalogue in Europe
Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Development and Pilot of a Metadata List and Catalogue in Europe Open
Purpose Metadata for data dIscoverability aNd study rEplicability in obseRVAtional studies (MINERVA), a European Medicines Agency–funded project (EUPAS39322), defined a set of metadata to describe real‐world data sources (RWDSs) and pilote…
View article: Sodelovanje in vztrajanje bolnikov z multiplo sklerozo pri zdravljenju z zdravili
Sodelovanje in vztrajanje bolnikov z multiplo sklerozo pri zdravljenju z zdravili Open
Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system that presents the second highest cause of disability among young adults in their thirties. Medication treatments are based on paren…
View article: Deprescribing: An umbrella review
Deprescribing: An umbrella review Open
This umbrella review examined systematic reviews of deprescribing studies by characteristics of intervention, population, medicine, and setting. Clinical and humanistic outcomes, barriers and facilitators, and tools for deprescribing are p…
View article: Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy
Sedative load and anticholinergic burden among older adults in Slovenia over a decade: Potential for optimization of pharmacotherapy Open
This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization…
View article: Effectiveness of pharmacist-led medication reconciliation on medication errors at hospital discharge and healthcare utilization in the next 30 days: a pragmatic clinical trial
Effectiveness of pharmacist-led medication reconciliation on medication errors at hospital discharge and healthcare utilization in the next 30 days: a pragmatic clinical trial Open
Transitions of care often lead to medication errors and unnecessary healthcare utilization. Medication reconciliation has been repeatedly shown to reduce this risk. However, the great majority of evidence is limited to the provision of med…
View article: Psychometric evaluation of the 5-item Medication Adherence Report Scale questionnaire in persons with multiple sclerosis
Psychometric evaluation of the 5-item Medication Adherence Report Scale questionnaire in persons with multiple sclerosis Open
The 5-item Medication Adherence Report Scale (MARS-5) is a reliable and valid questionnaire for evaluating adherence in patients with asthma, hypertension, and diabetes. Validity has not been determined in multiple sclerosis (MS). We aimed…
View article: Public's perspective on COVID-19 adenovirus vector vaccines after thrombosis with thrombocytopenia syndrome (TTS) reports and associated regulatory actions – A cross-sectional study in six EU member states
Public's perspective on COVID-19 adenovirus vector vaccines after thrombosis with thrombocytopenia syndrome (TTS) reports and associated regulatory actions – A cross-sectional study in six EU member states Open
Knowledge about TTS seemed to have influenced the public's opinion in Europe resulting in less willingness to be vaccinated with Vaxzevria® and Jcovden®. Willingness for vaccination against COVID-19 with other vaccines and widespread use o…
View article: Medication persistence among multiple sclerosis patients in Slovenia treated with dimethyl fumarate: a retrospective observational cohort study
Medication persistence among multiple sclerosis patients in Slovenia treated with dimethyl fumarate: a retrospective observational cohort study Open
Background Multiple sclerosis is a chronic, demyelinating inflammatory disease of the central nervous system. Medication persistence is an interval between initiation and last dose of a medication, followed by discontinuation of the applie…
View article: Cardiovascular morbidity and mortality in patients with type 2 diabetes using novel antidiabetic medicines as add-on therapy: an observational real-world study
Cardiovascular morbidity and mortality in patients with type 2 diabetes using novel antidiabetic medicines as add-on therapy: an observational real-world study Open
Objective To evaluate the effect of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA), compared with dipeptidyl peptidase-4 inhibitors (DPP-4i) as add-on therapy on cardiovascular (…
View article: Initiation of insulin therapy in patients with type 2 diabetes: An observational study
Initiation of insulin therapy in patients with type 2 diabetes: An observational study Open
The aim of the study was to assess the initiation of insulin therapy in patients with type 2 diabetes using health claims data on prescription medicines. The study evaluated time to insulin initiation and prescribing patterns of other anti…
View article: Prevalence and incidence of frailty among community-dwelling older adults in Slovenia
Prevalence and incidence of frailty among community-dwelling older adults in Slovenia Open
Introduction Frailty is recognized as one of the most important global health challenges as the population is aging. The aim of this study was to evaluate prevalence and incidence of frailty, and associated factors, among the population of…
View article: The association between medication or alcohol use and the incidence of frailty: a retrospective cohort study
The association between medication or alcohol use and the incidence of frailty: a retrospective cohort study Open
Background Understanding potentially modifiable factors that influence the risk of frailty is a key concern for the management of this urgent contemporary public health challenge. This study evaluates the association between the use of var…
View article: Regulatory and clinical perspective on patient access to antidiabetic medicines in Slovenia
Regulatory and clinical perspective on patient access to antidiabetic medicines in Slovenia Open
Introduction/Objective. Three novel classes of antidiabetic medicines have been introduced into the market in the last decade, namely dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, and sodium-glucose co-trans…
View article: Cerebral Thrombolysis in Rural Residents Aged ≥ 80
Cerebral Thrombolysis in Rural Residents Aged ≥ 80 Open
Piotr Sobolewski,1,2 Waldemar Brola,1,3 Jacek Wilczyński,1 Wiktor Szczuchniak,2 Tomasz Wójcik,1 Aleksandra Wach-Klink,2 Marek Kos,2,4 Grzegorz Kozera5 1Collegium Medicum, Jan Kochanowski University, Kielce, Poland; 2Department of Neurology…
View article: Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study
Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study Open
Anticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide data…
View article: Influence of generic reference pricing on medicine cost in Slovenia: a retrospective study
Influence of generic reference pricing on medicine cost in Slovenia: a retrospective study Open
AIM: To assess the impact of the generic reference pricing (GRP) system on the prices and cost of medicines in Slovenia approximately 8 years after its introduction in 2003 and before the implementation of the therapeutic reference pricing…
View article: Patient Access to Medicines for Rare Diseases in European Countries
Patient Access to Medicines for Rare Diseases in European Countries Open
Patient access to medicines for rare diseases varies largely across Europe. Patients in Germany, Scandinavian countries, Switzerland, France, and the United Kingdom can access larger numbers of medicines in shorter time.