Mitsuhiro Arisawa
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View article: Effects of Oxygen Atom Position in Linear Side Chains of Ansellone Analogues on HIV Latency-Reversing Activity
Effects of Oxygen Atom Position in Linear Side Chains of Ansellone Analogues on HIV Latency-Reversing Activity Open
Antiretroviral therapy can manage HIV infections, but a cure remains elusive owing to viral latency. The "shock and kill" strategy uses latency-reversing agents (LRAs) to reactivate viral production toward eliminating latent HIV. However, …
View article: Development of Suzuki–Miyaura Coupling between 4-Pyridine Boronate Derivatives and Aryl Halide to Suppress Phenylated Impurities Derived from Phosphorus Ligands
Development of Suzuki–Miyaura Coupling between 4-Pyridine Boronate Derivatives and Aryl Halide to Suppress Phenylated Impurities Derived from Phosphorus Ligands Open
A method has been developed to suppress the formation of impurities derived from the aryl group on the phosphorus atom of the ligand used in the Suzuki-Miyaura coupling of 4-pyridineboronic acid derivatives. 4-Arylpyridine, a key substruct…
View article: Grignard Method for Preparing Thioesters from Esters and Its Application to One-Pot Synthesis of Ketones and Aldehydes
Grignard Method for Preparing Thioesters from Esters and Its Application to One-Pot Synthesis of Ketones and Aldehydes Open
A new protocol for preparing thioesters from the corresponding methyl esters was developed using i PrMgCl and odorless 1-dodecanthiol, n C12H25SH, under mild reaction conditions, du…
View article: Remodelling molecular frameworks <i>via</i> atom-level surgery: recent advances in skeletal editing of (hetero)cycles
Remodelling molecular frameworks <i>via</i> atom-level surgery: recent advances in skeletal editing of (hetero)cycles Open
Skeletal editing enables atom-level modifications to molecular skeletons. This review highlights advances in single-atom insertions, deletions, and transmutations in (hetero)cyclic systems, offering a comprehensive view on cutting-edge str…
View article: Impact of helical elongation of symmetric oxa[<i>n</i>]helicenes on their structural, photophysical, and chiroptical characteristics
Impact of helical elongation of symmetric oxa[<i>n</i>]helicenes on their structural, photophysical, and chiroptical characteristics Open
The adjustment of the main helical scaffold in helicenes is a fundamental strategy for modulating their optical features, thereby enhancing their potential for diverse applications. This work explores the influence of helical elongation (n…
View article: Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii
Chemical Constituents and Anticancer Activities of Marine-Derived Fungus Trichoderma lixii Open
The fungal genus Trichoderma is a rich source of structurally diverse secondary metabolites with remarkable pharmaceutical properties. The chemical constituents and anticancer activities of the marine-derived fungus Trichoderma lixii have …
View article: Data-driven Electrochemical One-pot Synthesis of Double Hetero[7]dehydrohelicene
Data-driven Electrochemical One-pot Synthesis of Double Hetero[7]dehydrohelicene Open
The pursuit of chiral nanographenes with robust chiral stability and good chiroptical responses is of great interest for material-based applications. However, the most reported preparation processes involve intricate synthetic pathways and…
View article: CCDC 2209715: Experimental Crystal Structure Determination
CCDC 2209715: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2209714: Experimental Crystal Structure Determination
CCDC 2209714: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2243829: Experimental Crystal Structure Determination
CCDC 2243829: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2240761: Experimental Crystal Structure Determination
CCDC 2240761: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2240763: Experimental Crystal Structure Determination
CCDC 2240763: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2240762: Experimental Crystal Structure Determination
CCDC 2240762: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays
A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays Open
View article: CCDC 2247662: Experimental Crystal Structure Determination
CCDC 2247662: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2247661: Experimental Crystal Structure Determination
CCDC 2247661: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Supplementary table 1 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary table 1 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
A list of primers used for PCR and gRNA
View article: Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
This file includes extended experimental procedures including 1. Cell culture and transfection, 2. Genome editing using CRISPR/Cas9 system, 3. Western blotting, 4. Production of Spliceostatin A, 5. PAR-CLIP,6. Bioinformatics and supplement…
View article: Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
Androgen receptor splice variant-7 (AR-V7) is a constitutively active AR variant implicated in castration-resistant prostate cancers. Here, we show that the RNA splicing factor SF3B2, identified by in silico and CRISPR/Cas9 analyses…
View article: Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
This file includes extended experimental procedures including 1. Cell culture and transfection, 2. Genome editing using CRISPR/Cas9 system, 3. Western blotting, 4. Production of Spliceostatin A, 5. PAR-CLIP,6. Bioinformatics and supplement…
View article: Supplementary table 2 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary table 2 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
A list of antibodies used in the study
View article: Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
This text file includes SF3B2 binding sites.
View article: Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
This text file includes SF3B2 binding sites.
View article: Supplementary table 1 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary table 1 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
A list of primers used for PCR and gRNA
View article: Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
Supplementary Figures 1-8. (1) Figure S1 shows Identification of SF3B2 as a splicing modulating factor associated with AR-V7 expression. (2) Figure S2 shows FACS analysis of gRNA against each candidate gene-transfected AR-V7-GFP cell popul…
View article: Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
Supplementary Figures 1-8. (1) Figure S1 shows Identification of SF3B2 as a splicing modulating factor associated with AR-V7 expression. (2) Figure S2 shows FACS analysis of gRNA against each candidate gene-transfected AR-V7-GFP cell popul…
View article: Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Data from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
Androgen receptor splice variant-7 (AR-V7) is a constitutively active AR variant implicated in castration-resistant prostate cancers. Here, we show that the RNA splicing factor SF3B2, identified by in silico and CRISPR/Cas9 analyses…
View article: Supplementary table 2 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression
Supplementary table 2 from SF3B2-Mediated RNA Splicing Drives Human Prostate Cancer Progression Open
A list of antibodies used in the study
View article: Palladium-Catalyzed Intramolecular Migratory Cycloisomerization of 3-Phenoxy Acrylic Acid Ester <i>via</i> C–O Bond Cleavage and C–O/C–C Bonds Formation for 2,3-Disubstituted Benzofurans Synthesis
Palladium-Catalyzed Intramolecular Migratory Cycloisomerization of 3-Phenoxy Acrylic Acid Ester <i>via</i> C–O Bond Cleavage and C–O/C–C Bonds Formation for 2,3-Disubstituted Benzofurans Synthesis Open
Migratory cycloisomerization using transition metal catalyst is useful for synthesizing substituted heterocyclic compounds. We achieved palladium-catalyzed migratory cycloisomerization of 3-o-alkynylphenoxy acrylic acid ester derivatives t…
View article: CCDC 2206548: Experimental Crystal Structure Determination
CCDC 2206548: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …