Mitsuhiro Isaka
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View article: Novel CYP2A7/CYP2A6 germline hybrids associated with mutation burden in lung cancer revealed by whole-genome long-read sequencing
Novel CYP2A7/CYP2A6 germline hybrids associated with mutation burden in lung cancer revealed by whole-genome long-read sequencing Open
Nicotine is metabolized to cotinine by CYP2A6. CYP2A6 genotypes are associated with variations in enzymatic activity and increase the risk of developing tobacco-related diseases, including lung cancer. The high sequence similarity between …
View article: 167eP Artificial intelligence powered evaluation of pathological response to preoperative therapy of non-small cell lung cancer
167eP Artificial intelligence powered evaluation of pathological response to preoperative therapy of non-small cell lung cancer Open
View article: Localization of epidermal growth factor receptor-mutations using PNA:DNA probes in clinical specimens from patients with non-small cell lung cancer
Localization of epidermal growth factor receptor-mutations using PNA:DNA probes in clinical specimens from patients with non-small cell lung cancer Open
View article: Development of prediction model for zone-specific lymph node metastasis in clinical stage I–II non-small cell lung cancer: a supplementary analysis of Japan Clinical Oncology Group study 1413
Development of prediction model for zone-specific lymph node metastasis in clinical stage I–II non-small cell lung cancer: a supplementary analysis of Japan Clinical Oncology Group study 1413 Open
View article: Surgical resection following chemoradiotherapy for thoracic SMARCA4-deficient undifferentiated tumor: a report of two cases
Surgical resection following chemoradiotherapy for thoracic SMARCA4-deficient undifferentiated tumor: a report of two cases Open
View article: Risk Factors for Locoregional Relapse After Segmentectomy: Supplementary Analysis of the JCOG0802/WJOG4607L Trial
Risk Factors for Locoregional Relapse After Segmentectomy: Supplementary Analysis of the JCOG0802/WJOG4607L Trial Open
Thin-section computed tomography findings and margin distance are important factors to avoid LR in segmentectomy.
View article: Prognostic Impact of Postoperative Recurrence in Patients With Epidermal Growth Factor Receptor–Positive Non‐Small Cell Lung Cancer
Prognostic Impact of Postoperative Recurrence in Patients With Epidermal Growth Factor Receptor–Positive Non‐Small Cell Lung Cancer Open
Background Mutations in the epidermal growth factor receptor ( EGFR ) gene are the most common targetable gene alterations in non‐small cell lung cancer (NSCLC). In Japan, approximately 40% of patients who undergo surgical resection for no…
View article: Brain Metastasis of Non-small Cell Lung Cancer After Disease-Free Survival of 5 years: Case Series and Comprehensive Literature Review
Brain Metastasis of Non-small Cell Lung Cancer After Disease-Free Survival of 5 years: Case Series and Comprehensive Literature Review Open
LRBM is rare in patients with NSCLC. In our institution, many of these patients harbored driver gene mutations, and achieved long-term survival with aggressive local therapy. Multicenter analysis is mandatory.
View article: Distribution of Osteoprotegerin and Vascular Endothelial Growth Factor in the Synovium, Cranial Cruciate Ligament, and Meniscus of Canine Knees with Osteoarthritis Secondary to Cranial Cruciate Ligament Rupture
Distribution of Osteoprotegerin and Vascular Endothelial Growth Factor in the Synovium, Cranial Cruciate Ligament, and Meniscus of Canine Knees with Osteoarthritis Secondary to Cranial Cruciate Ligament Rupture Open
View article: Relationships between Myxomatous Mitral Valve Disease and Bone Biomarkers in Dogs
Relationships between Myxomatous Mitral Valve Disease and Bone Biomarkers in Dogs Open
View article: Prognostic impact of postoperative recurrence in patients with epidermal growth factor receptor-positive non-small cell lung cancer.
Prognostic impact of postoperative recurrence in patients with epidermal growth factor receptor-positive non-small cell lung cancer. Open
Background : There are no reports conducted with a long follow-up period on a large number of EGFR+ non small cell lung carcinoma (NSCLC) patients withpostoperative recurrence (PR). Methods : We conducted a retrospective review of the data…
View article: EP07.01-32 Long Term Outcomes beyond Five Years after Pulmonary Resection for Non Small Cell Lung Cancer
EP07.01-32 Long Term Outcomes beyond Five Years after Pulmonary Resection for Non Small Cell Lung Cancer Open
View article: P1.25-14 Delayed Recovery Time of Percutaneous Oxygen Saturation After Stair-climbing as a Predictor of Postoperative Complications
P1.25-14 Delayed Recovery Time of Percutaneous Oxygen Saturation After Stair-climbing as a Predictor of Postoperative Complications Open
View article: EP07.01-19 Factors Affecting Postoperative Nausea and Vomiting in Surgical Patients with Non-Small Cell Lung Cancer
EP07.01-19 Factors Affecting Postoperative Nausea and Vomiting in Surgical Patients with Non-Small Cell Lung Cancer Open
View article: Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer
Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer Open
Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors…
View article: Diagnostic sensitivity of solid volume measurement for pathological invasion in non-solid lung adenocarcinoma
Diagnostic sensitivity of solid volume measurement for pathological invasion in non-solid lung adenocarcinoma Open
TS >20 mm and SS >5 mm were well-correlated with IAD. SV measurement may complement the current computed tomographic diagnosis of IAD based on the SS (2.1-3.0 cm).
View article: Displaced bronchus and anomalous pulmonary vein passing dorsal to the pulmonary artery in a patient who underwent right upper lobectomy for lung cancer with lymph node metastases: a case report
Displaced bronchus and anomalous pulmonary vein passing dorsal to the pulmonary artery in a patient who underwent right upper lobectomy for lung cancer with lymph node metastases: a case report Open
View article: Pyruvate kinase deficiency mutant gene carriage in stray cats and rescued cats from animal hoarding in Hokkaido, Japan
Pyruvate kinase deficiency mutant gene carriage in stray cats and rescued cats from animal hoarding in Hokkaido, Japan Open
The mutant allele frequency of the Pyruvate kinase (PK) gene has been investigated mostly in pure breed cats. We investigated the PK mutant gene in stray and animal hoarding mongrel cats in Hokkaido, Japan. We also investigated the kinship…
View article: Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes
Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes Open
View article: Quantitative severity of emphysema is related to the prognostic outcome of early-stage lung cancer
Quantitative severity of emphysema is related to the prognostic outcome of early-stage lung cancer Open
OBJECTIVES Although pulmonary emphysema is a component of chronic obstructive pulmonary disease, the prognostic significance of the quantitative severity of emphysema in patients with primary lung cancer is unclear. This study aimed to ide…
View article: Perioperative changes in cardiac biomarkers in juvenile cats during neutering
Perioperative changes in cardiac biomarkers in juvenile cats during neutering Open
Perioperative myocardial injury (PMI) is commonly caused by myocardial ischemia that develops during or after non-cardiac surgery. It occurs in 17.9% of human patients after non-cardiac surgery due to elevated high-sensitive perioperation …
View article: Artificial Intelligence–Powered Prediction of <i>ALK</i> Gene Rearrangement in Patients With Non–Small-Cell Lung Cancer
Artificial Intelligence–Powered Prediction of <i>ALK</i> Gene Rearrangement in Patients With Non–Small-Cell Lung Cancer Open
PURPOSE Several studies reported the possibility of predicting genetic abnormalities in non–small-cell lung cancer by deep learning (DL). However, there are no data of predicting ALK gene rearrangement ( ALKr) using DL. We evaluated the AL…
View article: Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug- metabolizing enzyme genes
Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug- metabolizing enzyme genes Open
The differences in genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma are unclear. Hence, we developed a customized, targeted gene sequencing panel for efficient and sensitive identification of germline variants, inc…
View article: Comparison of Intestinal Microbiota Between Healthy and MMVD Chihuahuas Using 16S rRNA Gene Amplicon Sequencing
Comparison of Intestinal Microbiota Between Healthy and MMVD Chihuahuas Using 16S rRNA Gene Amplicon Sequencing Open
Myxomatous mitral valve disease (MMVD) is the most common cause of congestive heart failure in dogs, and although complications of MMVD to the lungs and kidneys have been identified, complications to the gut are less well understood. The i…
View article: Chylothorax after pulmonary resection and lymph node dissection for primary lung cancer; retrospective observational study
Chylothorax after pulmonary resection and lymph node dissection for primary lung cancer; retrospective observational study Open
Background Pulmonary resection with mediastinal lymph node dissection for treating primary lung cancer could sometimes causes chylothorax as a postoperative complication. This study examined the validity of treatments for chylothorax in ou…
View article: Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs
Serum Concentrations of Osteoprotegerin, Brain-Derived Nerve Factor, Angiotensin II, and Endothelin-1 in aging dogs Open
Background: Gerontology is a major research topic in veterinary medicine; however, there are few reports on changes in biomarker levels in aged dogs. Aim: The purpose of this preliminary study was to evaluate the differences in serum bioma…
View article: Positive Outcomes after Surgical Correction of Grade IV Medial Patellar Luxation in Small Breed Dogs.
Positive Outcomes after Surgical Correction of Grade IV Medial Patellar Luxation in Small Breed Dogs. Open
Objective: Medial patellar luxation (MPL) is a common orthopedic condition in dogs. After surgical correction, the recurrent rates appear to be higher and outcomes worse in grade IV than in lower grade MPL. To describe the outcomes of surg…
View article: Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas
Intestinal Complication With Myxomatous Mitral Valve Diseases in Chihuahuas Open
The effects of cardiac disease on the intestine have been reported in humans but not in dogs. We investigated the effects of myxomatous mitral valve disease (MMVD), which is capable of causing congestion and tissue hypoperfusion, on the in…
View article: Biomarkers of Ageing in Dogs
Biomarkers of Ageing in Dogs Open
Gerontology is a major research topic in veterinary medicine. Although several reports have shown that aging in companion dogs is similar to human aging, there are few reports on changes in biomarker levels in aged dogs. The purpose of thi…
View article: Genomic profiling of multiple tissues in two patients with multiple endocrine neoplasia type 1
Genomic profiling of multiple tissues in two patients with multiple endocrine neoplasia type 1 Open
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant tumor syndrome. This hereditary cancer is caused by germline variants in MEN1. Two patients with MEN1 were identified via whole exome sequencing and gene expression profil…