Mitsuhiro Shimura
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View article: Impact of tube feeding after pancreaticoduodenectomy on nutritional intake and status: a retrospective cohort study in Japan
Impact of tube feeding after pancreaticoduodenectomy on nutritional intake and status: a retrospective cohort study in Japan Open
Purpose: Pancreaticoduodenectomy (PD) is one of the most invasive procedures in gastrointestinal surgery. However, the clinical significance of postoperative tube feeding remains unclear. This study investigated the impact of enteral nutri…
View article: Frey procedure for chronic pancreatitis improves bile duct stricture
Frey procedure for chronic pancreatitis improves bile duct stricture Open
Purposes Chronic pancreatitis (CP), a progressive inflammatory disorder characterized by pancreatic fibrosis and degeneration, often leads to common bile duct (CBD) strictures. However, the optimal management of CBD strictures remains cont…
View article: Molecular insights into HER2/ERBB2 amplification and carcinogenesis in gallbladder cancer associated with pancreaticobiliary maljunction
Molecular insights into HER2/ERBB2 amplification and carcinogenesis in gallbladder cancer associated with pancreaticobiliary maljunction Open
Background Pancreaticobiliary maljunction (PBM) contributes to epithelial hyperplasia and, ultimately, the development of gallbladder cancer (GBC). Despite its clinical significance, the molecular and cellular mechanisms driving carcinogen…
View article: Characteristics of late recurrences after hepatectomy for perihilar cholangiocarcinoma: A single-center cohort study
Characteristics of late recurrences after hepatectomy for perihilar cholangiocarcinoma: A single-center cohort study Open
Background: Surgical resection is the only curative treatment for perihilar cholangiocarcinoma (pCCA); however, the majority of patients experience postoperative recurrence. While recurrence typically occurs within five years after surgery…
View article: Safe Laparoscopic Pancreatectomy in a Patient with Rare Superior Mesenteric Artery-Derived Gastroduodenal Artery: A Case Report and Technical Considerations
Safe Laparoscopic Pancreatectomy in a Patient with Rare Superior Mesenteric Artery-Derived Gastroduodenal Artery: A Case Report and Technical Considerations Open
Laparoscopic pancreatectomy can be safely performed in patients with SMA-derived GDA anomalies, when supported by detailed preoperative imaging and precise intraoperative techniques. These findings highlight the necessity of routine preope…
View article: A Case of Rendezvous Dilation under Laparotomy for Pancreaticojejunostomy Stricture after Pancreaticoduodenectomy
A Case of Rendezvous Dilation under Laparotomy for Pancreaticojejunostomy Stricture after Pancreaticoduodenectomy Open
Symptomatic anastomotic stenosis necessitates treatment, with an endoscopic approach generally preferred as the first-line option. When endoscopic visualization of the anastomosis proves challenging, an ultrasound endoscope can be utilized…
View article: Updated risk prediction model for pancreaticoduodenectomy using data from the National Clinical Database in Japan
Updated risk prediction model for pancreaticoduodenectomy using data from the National Clinical Database in Japan Open
Aim Risk prediction models for mortality, severe postoperative complications, and postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy were established using data from the National Clinical Database more than a d…
View article: IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growth
IQGAP3 signalling mediates intratumoral functional heterogeneity to enhance malignant growth Open
Background The elevation of IQGAP3 expression in diverse cancers indicates a key role for IQGAP3 in carcinogenesis. Although IQGAP3 was established as a proliferating stomach stem cell factor and a regulator of the RAS-ERK pathway, how it …
View article: A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach Open
RUNX3R122C missense mutation is associated with the continuous cycling of isthmus stem/progenitor cells, maturation arrest, and development of a precancerous state. This work highlights the importance of RUNX3 in the prevention of metaplas…
View article: A Case of Multiple Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Multimodal Therapy
A Case of Multiple Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Multimodal Therapy Open
症例は62歳の女性で，糖尿病教育入院中の腹部超音波検査で，肝S4に24 mmと22 mm大の低エコー腫瘤を認めた．同病変は造影CTの動脈相で淡く造影され，平衡相では周囲の肝実質よりやや低吸収域を呈した．経動脈的門脈造影下CT，MRIでは肝S1にも8 mm大の病変を認めた．多発肝細胞癌と診断し，肝切除の方針とした．術中に肝S1病変は同定できず，肝内側区域切除術を施行した．病理結果からmucosa-associated lymphoid tissue（以下，MALTと略記）リン…
View article: Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma
Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma is one of the most aggressive types of cancer. Certain proteins in the tumor microenvironment have attracted considerable attention owing to their association with tumor invasion and metastasis. Here, we us…
View article: Cardiac Tamponade Caused by Pericardial Metastasis of Rectal Cancer
Cardiac Tamponade Caused by Pericardial Metastasis of Rectal Cancer Open
症例は65歳の女性で，2013年12月，直腸癌に対し腹腔鏡下高位前方切除術を施行し，pStage IIIbのため術後補助化学療法を行った．2015年9月，肺転移に対し胸腔鏡下肺部分切除術を施行した．2016年9月に縦隔リンパ節転移を認め，化学療法を開始した．2018年11月に呼吸苦，労作時息切れを認め，心タンポナーデの診断で心囊ドレナージを施行した．心囊液の細胞診で腺癌を認め，直腸癌の心膜転移と診断した．退院後に化学療法を再開したが，2019年3月に食思不振，心囊液貯留を認…
View article: A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis
A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis Open
The aim of this study was to identify novel liver metastasis-correlated proteins of PanNEN by proteomics to compare pancreatic tumor (PT) with paired metastatic liver tumor (LT). Of 118 surgical cases with PanNEN, 7 cases with formalin-fix…
View article: Metachronous multicentric pancreatic cancer with multiple intraductal papillary mucinous neoplasms (IPMN)
Metachronous multicentric pancreatic cancer with multiple intraductal papillary mucinous neoplasms (IPMN) Open
症例は58歳女性.父が膵癌の家族歴がある.2008年11月に背部痛で発症し,当院で精査を施行.膵鉤部と体尾部に複数の分枝型膵管内乳頭粘液性腫瘍(IPMN)に併存する膵体部の通常型膵癌に対し,2009年4月に膵体尾部切除術を施行した.組織学的には分枝型IPMNに併存した高分化型管状腺癌(tub1)であり,膵癌取扱い規約では,T3N0M0,Stage III,R0であった.膵断端近傍にPanIN1A-1B相当の所見を認めた.術後37ヶ月からCA19-9の上昇を認め,精査で異時性…