Mitsuo Osuga
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View article: Circulating Tumour <scp>DNA</scp> in Patients With <scp><i>EGFR</i></scp>‐Mutated Non‐Small‐Cell Lung Cancer and Early Disease Progression After First‐Line Osimertinib Treatment: The <scp>ELUCIDATOR</scp> Multicentre Prospective Observational Study
Circulating Tumour <span>DNA</span> in Patients With <span><i>EGFR</i></span>‐Mutated Non‐Small‐Cell Lung Cancer and Early Disease Progression After First‐Line Osimertinib Treatment: The <span>ELUCIDATOR</span> Multicentre Prospective Observational Study Open
Background Osimertinib is the standard therapy for patients with chemotherapy‐naive advanced non‐small‐cell lung cancer (NSCLC) harbouring sensitising epidermal growth factor receptor ( EGFR ) mutations. However, some patients treated with…
View article: Baseline genetic abnormalities and effectiveness of osimertinib treatment in patients with chemotherapy-naïve EGFR-mutated NSCLC based on performance status
Baseline genetic abnormalities and effectiveness of osimertinib treatment in patients with chemotherapy-naïve EGFR-mutated NSCLC based on performance status Open
There was no between-group difference in PFS, although OS was significantly inferior in the poor PS group. Additionally, there was a significant increase in APC-positive cases and a trend toward more CTNNB1-positive cases in the poor PS gr…
View article: Mechanisms of Resistance and Correlation between Pre-Treatment Co-Alterations and Prognosis to Osimertinib in Chemo-Naïve Advanced Non-Small Cell Lung Cancer
Mechanisms of Resistance and Correlation between Pre-Treatment Co-Alterations and Prognosis to Osimertinib in Chemo-Naïve Advanced Non-Small Cell Lung Cancer Open
View article: Detection of the <i>JAK2</i> V617F Mutation in Urinary Cell-free DNA in Patients with Myeloproliferative Neoplasms
Detection of the <i>JAK2</i> V617F Mutation in Urinary Cell-free DNA in Patients with Myeloproliferative Neoplasms Open
Objective Testing for the Janus activating kinase 2 (JAK2) V617F mutation is important for diagnosing and treating myeloproliferative neoplasms (MPNs). Recently, urine cell-free DNA (ucfDNA) was reported to be useful for detecting tumor-sp…