Mitsuru Esaki
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View article: Clinical feasibility of gastric endoscopic submucosal dissection in patients on glucocorticoids or immunomodulators: Propensity-score-matched study
Clinical feasibility of gastric endoscopic submucosal dissection in patients on glucocorticoids or immunomodulators: Propensity-score-matched study Open
Evidence on gastric endoscopic submucosal dissection (ESD) under glucocorticoids or immunomodulators (GC/IM) is limited. We evaluated whether GC/IM use affects gastric ESD outcomes. We retrospectively analyzed 411 consecutive ESDs (April 2…
View article: Personalized education approach based on cognitive psychology for endoscopic diagnosis: A multicenter randomized trial
Personalized education approach based on cognitive psychology for endoscopic diagnosis: A multicenter randomized trial Open
The learning curve for endoscopic diagnosis varies, and an optimal educational strategy is not available. Working memory (WM) refers to an individual’s ability to store and process information quickly and simultaneously. This study aimed t…
View article: A prospective, randomized, double-blind, placebo-controlled trial of the Kampo formula daiobotanpito combined with antibiotic therapy for acute diverticulitis
A prospective, randomized, double-blind, placebo-controlled trial of the Kampo formula daiobotanpito combined with antibiotic therapy for acute diverticulitis Open
Daiobotanpito (DBT) is a Kampo formula traditionally used to treat abscesses in intestinal disorders. This double-blind, multicenter, randomized controlled trial was conducted at participating hospitals in Japan. Patients with CT-proven mo…
View article: From bench to bedside: the role of gastrointestinal stem cells in health and disease
From bench to bedside: the role of gastrointestinal stem cells in health and disease Open
View article: Clinical backgrounds and outcomes of patients with Barrett's esophageal adenocarcinoma treated via endoscopic submucosal dissection in Kyushu, Japan: A retrospective multicenter cohort study
Clinical backgrounds and outcomes of patients with Barrett's esophageal adenocarcinoma treated via endoscopic submucosal dissection in Kyushu, Japan: A retrospective multicenter cohort study Open
Objectives Most esophageal cancers in Japan are squamous cell carcinomas; however, there has been some concern regarding a recent increase in Barrett's esophageal adenocarcinoma (BEA). This study aimed to clarify the clinical characteristi…
View article: Spray and Forced Coagulation Mode Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multicenter Randomized Controlled Trial
Spray and Forced Coagulation Mode Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multicenter Randomized Controlled Trial Open
INTRODUCTION: Controlling intraoperative bleeding during endoscopic submucosal dissection (ESD) is essential to ensure the safety and reliability of the procedure. ESD in spray coagulation mode (SCM-ESD) is expected to ensure more effectiv…
View article: Usefulness and safety of remimazolam in upper gastrointestinal endoscopy: A comparative study between elderly and non‐elderly patients
Usefulness and safety of remimazolam in upper gastrointestinal endoscopy: A comparative study between elderly and non‐elderly patients Open
Objectives In gastroenterology, sedation demand is increasing, although elderly patients are more prone to experiencing adverse events. Remimazolam, a novel ultra‐short‐acting benzodiazepine, may reduce recovery time after endoscopic proce…
View article: The interplay of gut microbiota and intestinal motility in gastrointestinal function
The interplay of gut microbiota and intestinal motility in gastrointestinal function Open
The relationship between gut microbiota and intestinal motility is crucial for maintaining gastrointestinal health. Intestinal motility refers to the coordinated movements of the digestive tract, essential for effective digestion, nutrient…
View article: Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis
Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis Open
Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two g…
View article: Antral early gastric neoplasm with severe oral scarring successfully treated by endoscopic submucosal dissection using retroflex approach and a novel, thin therapeutic endoscope
Antral early gastric neoplasm with severe oral scarring successfully treated by endoscopic submucosal dissection using retroflex approach and a novel, thin therapeutic endoscope Open
Endoscopic submucosal dissection (ESD) for early gastric neoplasms (EGNs) may be associated with challenges. A recently developed endoscope (EG-840TP; Fujifilm Co., Tokyo, Japan), with a thinner outer diameter (7.9 mm) that is equipped wit…
View article: Randomized Controlled Trial of Remimazolam Compared with Placebo in Japanese Patients Undergoing Colonoscopy: A Phase III, Investigator-Initiated Trial
Randomized Controlled Trial of Remimazolam Compared with Placebo in Japanese Patients Undergoing Colonoscopy: A Phase III, Investigator-Initiated Trial Open
Introduction: We conducted an investigator-initiated clinical trial in which remimazolam was used to achieve sedation in patients undergoing colonoscopies. Methods: This multicenter, double-blind, placebo-controlled, phase III investigator…
View article: Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis
Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis Open
Objectives To compare the efficacy and safety of sedation with midazolam and remimazolam for colorectal endoscopy. Methods This single‐center, two‐arm, post‐hoc analysis of the REM‐IICTJP01 study investigated the efficacy and safety of rem…
View article: Enhanced visualization of vessels in submucosa by amber red color imaging in colonic endoscopic submucosal dissection
Enhanced visualization of vessels in submucosa by amber red color imaging in colonic endoscopic submucosal dissection Open
Intraoperative bleeding is a major complication of endoscopic submucosal dissection (ESD). Various devices and techniques have been developed to control intraoperative bleeding [1] [2] [3] [4]. Amber red color imaging is a recently develop…
View article: Effective hemostasis with a self-assembling peptide hemostatic gel to manage leaky hemorrhage at the ulcer closure site after gastric endoscopic submucosal dissection
Effective hemostasis with a self-assembling peptide hemostatic gel to manage leaky hemorrhage at the ulcer closure site after gastric endoscopic submucosal dissection Open
Intraoperative bleeding is a major complication of endoscopic submucosal dissection (ESD), presenting challenges in identifying the bleeding source and achieving effective hemostasis. Recently, a self-assembling peptide hemostatic gel (Pur…
View article: Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator‐initiated clinical trial
Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator‐initiated clinical trial Open
Objectives To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in a multicenter, randomized, double‐blind, investigator‐initiated phase III controlled trial. Methods We included 48 J…
View article: Development of postoperative bleeding management in gastric endoscopic submucosal dissection
Development of postoperative bleeding management in gastric endoscopic submucosal dissection Open
In this issue of Digestive Endoscopy, Tang et al. (2023)1 reported that an aspiration and coagulation (AC) technique to visualize residual vessels on postgastric endoscopic submucosal dissection (ESD) ulcers reduced postoperative bleeding …
View article: Hemostatic efficacy of a novel self‐assembling peptide gel for delayed bleeding following colorectal endoscopic submucosal dissection with complete endoscopic defect closure
Hemostatic efficacy of a novel self‐assembling peptide gel for delayed bleeding following colorectal endoscopic submucosal dissection with complete endoscopic defect closure Open
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View article: Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for multicenter randomized controlled trial (Spray-G trial)
Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for multicenter randomized controlled trial (Spray-G trial) Open
Background Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding is crucial for ensuring safe and reliable procedures. ESD using the spray coagulation mode (…
View article: Three-point traction method for endoscopic submucosal dissection using clip-with-thread and clip-with-silicon bands for large early gastric neoplasms
Three-point traction method for endoscopic submucosal dissection using clip-with-thread and clip-with-silicon bands for large early gastric neoplasms Open
Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGNs), and traction methods have been developed to make ESD safe and simple [1] [2] [3]. Applying appropriate traction provides better visibility…
View article: Double-scope technique to recover from hand-suturing trouble in the duodenum
Double-scope technique to recover from hand-suturing trouble in the duodenum Open
Duodenal adenomas are uncommon, with a prevalence of 0.3%–4.6% [1] [2]. Endoscopic resection (ER) is the standard treatment for a solitary adenoma. As ER for duodenal lesions is associated with a high risk of adverse events, such as bleedi…
View article: Two-point fixed pulley-traction method in endoscopic submucosal dissection for early gastric neoplasm
Two-point fixed pulley-traction method in endoscopic submucosal dissection for early gastric neoplasm Open
Endoscopic submucosal dissection (ESD) is a technically challenging procedure with substantial risk of intraoperative complications. Traction assistance is a promising strategy for simplifying ESD. Although multiple traction methods have b…
View article: Two-step traction-assisted endoscopic submucosal dissection for a gastric neoplasm using a clip with a traction band and thread
Two-step traction-assisted endoscopic submucosal dissection for a gastric neoplasm using a clip with a traction band and thread Open
The traction technique is a common assistance method for gastric endoscopic submucosal dissection (ESD) [1] [2] [3]. We previously developed intralesional traction-assisted ESD (ILT-ESD) [4] [5]. Although this provides a favorable clear vi…
View article: Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: A study protocol for multicenter randomized controlled trial (Spray-G trial)
Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: A study protocol for multicenter randomized controlled trial (Spray-G trial) Open
Background: Endoscopic submucosal dissection (ESD) is the standard treatment for early gastric neoplasms (EGN). Controlling intraoperative bleeding is crucial for ensuring safe and reliable procedures. ESD using the Spray Coagulation Mode …
View article: Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial
Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial Open
Background We have determined that the impaired accommodation of the lower esophageal sphincter (LES) underlies the pathogenesis of esophagogastric junction outflow obstruction (EGJOO). We have also found that acotiamide may treat EGJOO by…
View article: Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial
Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial Open
Background We have determined that the impaired accommodation of the lower esophageal sphincter (LES) underlies the pathogenesis of esophagogastric junction outflow obstruction (EGJOO). We have also found that acotiamide may treat EGJOO by…
View article: Underwater precutting endoscopic mucosal resection using a multifunctional snare for a large colonic laterally spreading tumor
Underwater precutting endoscopic mucosal resection using a multifunctional snare for a large colonic laterally spreading tumor Open
Underwater endoscopic mucosal resection (UEMR) is a recently developed procedure characterized by resection of the colon polyps immersed in water. Thanks to the "floating effect" on the mucosa and submucosa, UEMR allows snaring the lesion …
View article: Rare complications related to lumen-apposing metal stent placement, successfully treated by endoscopic hand-suturing device.
Rare complications related to lumen-apposing metal stent placement, successfully treated by endoscopic hand-suturing device. Open
A 56-year-old man with a walled-off necrosis (WON) underwent endoscopic necrosectomy using a lumen-apposing metal stent (LAMS) (Hot Axios; Boston Scientific, Boston, Massachusetts, USA) ([Fig. 1 a]), which improved the abdominal inflammati…
View article: Triangle‐traction‐assisted endoscopic submucosal dissection with multiple loop traction device for colorectal neoplasms
Triangle‐traction‐assisted endoscopic submucosal dissection with multiple loop traction device for colorectal neoplasms Open
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View article: Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands
Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands Open
Several traction techniques for endoscopic submucosal dissection (ESD) of gastric neoplasms have been reported to be useful [1] [2] [3] [4] [5]. We have previously reported an intralesional traction technique using a single traction band […
View article: Hybrid and Conventional Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multi-Center Randomized Controlled Trial
Hybrid and Conventional Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multi-Center Randomized Controlled Trial Open