Explanipedia

Cardiac Damage Stages and Clinical Outcomes in Patients With Severe Aortic Stenosis Open

Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai, Takeshi Kitai , et al. · 2025

Cardiac damage staging is a useful tool for prognostic stratification in patients with severe AS, independent of gradient patterns, symptoms, and initial treatment strategies.

Prognostic Value of the 6-Minute Walk Test in Patients With Severe Aortic Stenosis Open

Norio Kanamori, Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai , et al. · 2025

The 6MWD is a reliable prognostic marker for patients with severe AS, regardless of initial treatment strategy.

Safety of Calcium Channel Blockers in Patients With Severe Aortic Stenosis and Hypertension Open

Ko Yamamoto, Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai , et al. · 2024

Among patients with severe AS and hypertension, CCB was the most commonly prescribed antihypertensive agents, and antihypertensive therapy with CCB was associated with comparable clinical outcomes to antihypertensive therapy without CCB. S…

10-Year Trends of Antithrombotic Therapy Status and Clinical Outcomes in Patients With Atrial Fibrillation and Renal Dysfunction　― The Fushimi AF Registry ― Open

Nobutoyo Masunaga, Mitsuru Ishii, Keisuke Oka, Keita Okamoto, Yusuke Yoshida , et al. · 2024

Despite the increased use of DOAC in patients with AF since 2011, anticoagulation therapy for AF patients with severe renal dysfunction has largely remained unchanged, and a reduction in adverse events in those patients has not been observ…

Aspirin‐Free Strategy for Percutaneous Coronary Intervention in Patients With Oral Anticoagulation: Prespecified Subgroup Analysis From the STOPDAPT‐3 Trial Open

Masahiro Natsuaki, Hirotoshi Watanabe, Takeshi Morimoto, Ko Yamamoto, Yuki Obayashi , et al. · 2024

Background The effects of aspirin‐free strategy on bleeding and cardiovascular events in patients undergoing percutaneous coronary intervention with oral anticoagulation (OAC) have not been fully elucidated. Methods and Results We conducte…

Concomitant Mitral Regurgitation in Severe Aortic Stenosis　― Insights From the CURRENT AS Registry-2 ― Open

Yuki Obayashi, Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai , et al. · 2024

Moderate/severe MR was associated with a higher risk for death or HF hospitalization in the initial SAVR and conservative strategies, while the association was less pronounced in the initial TAVI strategy.

Sublingual administration of atropine eye drops for treating organophosphorus poisoning Open

Ichiro Hirayama, Yoshito Kamijo, Minaho Nonaka, Tetsuhiro Yano, Mitsuru Ishii , et al. · 2024

Key Clinical Message An 89‐year‐old patient with fenitrothion toxicity received sublingual atropine eye drops, reducing the intravenous atropine requirement. This alternative method enabled rapid rehabilitation, and he walked unaided, lead…

Guanfacine poisoning resulting in transient ST-segment elevation: a case report Open

Ichiro Hirayama, Yoshito Kamijo, Hiroko Abe, Minaho Nonaka, Tetsuhiro Yano , et al. · 2024

Background Guanfacine is an alpha-2 adrenergic agonist that decreases norepinephrine release and sympathetic outflow. With the increased use of guanfacine for attention-deficit hyperactivity disorder (ADHD), reports of guanfacine poisoning…

Association of left atrial enlargement with heart failure events in non-valvular atrial fibrillation patients with preserved left ventricular ejection fraction Open

Yasuhiro Hamatani, Moritake Iguchi, Keita Okamoto, Yumiko Nakanishi, Kimihito Minami , et al. · 2024

Aims Atrial fibrillation (AF) increases the risk of heart failure (HF); however, little is known regarding the risk stratification for incident HF in AF patients, especially with preserved left ventricular ejection fraction (LVEF). Methods…

Year-to-year change of antithrombotic strategy and clinical outcomes of atrial fibrillation patients with vascular disease in this decade: The Fushimi AF Registry Open

Nobutoyo Masunaga, Kenjiro Ishigami, Syuhei Ikeda, K Doi, Takashi Yoshizawa , et al. · 2023

Background Many atrial fibrillation (AF) patients have concomitant vascular diseases, and therefore, antithrombotic therapy is crucial for prevention of cardiovascular events in AF patients. In the last decade, antithrombotic therapy of AF…

The gender difference in risk factor and incidence rate of hospitalization for heart failure in Japanese atrial fibrillation patients: The Fushimi AF Registry Open

K Doi, Yumiko Nakanishi, Kimihito Minami, Kenjiro Ishigami, Syuhei Ikeda , et al. · 2023

Background Gender-specific medicine is of concern in cardiovascular medicine. However, the gender difference in risk factor and incidence rate of hospitalization for heart failure (HF) in Japanese atrial fibrillation (AF) patients is littl…

CORRIGENDUM: Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2 Open

Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai, Takeshi Kitai , et al. · 2023

Registry-2 InvestigatorsFigure.Study flowchart.AVR included both SAVR and TAVI.High-gradient AS was defined as Vmax >4.0 m/s or mean aortic PG >40 mmHg, whereas low-gradient AS was defined as Vmax ≤4.0 m/s and mean aortic PG ≤40 mmHg.AVA, …

In-hospital outcomes after SAVR or TAVI in patients with severe aortic stenosis Open

Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai, Takeshi Kitai , et al. · 2023

Rivaroxaban Monotherapy in Patients With Atrial Fibrillation and Coronary Stenting at Multiple Vessels or the Left Main Trunk: The AFIRE Trial Subanalysis Open

Mitsuru Ishii, Masaharu Akao, Satoshi Yasuda, Koichi Kaikita, Junya Ako , et al. · 2022

Clinical characteristics and outcomes of atrial fibrillation patients with peripheral artery disease: the Fushimi AF Registry Open

N Masunaga, Hisashi Ogawa, Syuhei Ikeda, K Doi, Takashi Yoshizawa , et al. · 2022

Background Atrial fibrillation (AF) represents the common arrhythmia and increases the risk of thromboembolism. Risk assessment for thromboembolism is important for the management of AF patients. Peripheral artery disease (PAD) is identifi…

Association of cardiothoracic ratio with heart failure hospitalization in patients with atrial fibrillation: the Fushimi AF Registry Open

Syuhei Ikeda, M Iguchi, Hisashi Ogawa, Kimihito Minami, Kenjiro Ishigami , et al. · 2022

Background Chest radiography is the most common diagnostic imaging test in clinical medicine, and the cardiothoracic ratio (CTR) is a readily available and non-invasive tool with which to assess the volume status and cardiomegaly. However,…

Association of beta blocker use with new-onset heart failure and mortality in atrial fibrillation without pre-existing heart failure: the Fushimi AF registry Open

M Iguchi, N Masunaga, Mitsuru Ishii, A Fujino, Kaori Ide , et al. · 2022

Background Heart failure (HF) is one of the major complications in atrial fibrillation (AF). We previously reported that not a few AF patients without pre-existing HF (defined as prior HF hospitalization, New York Heart Association functio…

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Taiki Sato, Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Hiroya Mizuno , et al. · 2022

Association of Concomitant Coronary Artery Disease With Cardiovascular Events in Patients With Atrial Fibrillation　― The Fushimi AF Registry ― Open

Nobutoyo Masunaga, Hisashi Ogawa, Kimihito Minami, Kenjiro Ishigami, Syuhei Ikeda , et al. · 2022

In Japanese AF patients, concomitant CAD was associated with higher prevalences of major co-morbidities and higher incidences of cardiovascular events; however, history of CAD was not associated with the incidence of stroke/SE.

Rationale, Design, and Baseline Characteristics of the CURRENT AS Registry-2 Open

Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai, Takeshi Kitai , et al. · 2022

The CURRENT AS Registry-2 might be large and meticulous enough to determine the appropriate timing of intervention for patients with severe AS in contemporary clinical practice.

10-Year Trends of Antithrombotic Therapy Status and Outcomes in Japanese Atrial Fibrillation Patients　― The Fushimi AF Registry ― Open

Masaharu Akao, Hisashi Ogawa, Nobutoyo Masunaga, Kimihito Minami, Kenjiro Ishigami , et al. · 2022

Over the past 10 years, there has been a major transition in antithrombotic therapy and a decline in the incidence of adverse events in AF patients.

A case of infective endocarditis mimicking antineutrophil cytoplasmic antibody-associated vasculitis Open

Kosuke Doi, Kimihito Minami, Kenjiro Ishigami, Syuhei Ikeda, Yasuhiro Hamatani , et al. · 2022

Isometric Handgrip Stress Test during Right Heart Catheterization in Patients with Mitral Regurgitation -A Case Series Study- Open

Yasuhiro Hamatani, Moritake Iguchi, Kimihito Minami, Kenjiro Ishigami, Syuhei Ikeda , et al. · 2021

Objective The severity of mitral regurgitation (MR) dynamically changes during a stress test. Isometric handgrip is a readily-available stress test in daily practice; however, little is known regarding the response to isometric handgrip in…

Clinical Characteristics and Outcomes of Very Elderly Patients With Atrial Fibrillation at High Bleeding Risk　― The Fushimi AF Registry ― Open

Yuya Ide, Hisashi Ogawa, Kenjiro Ishigami, Syuhei Ikeda, Kosuke Doi , et al. · 2021

Background: The ELDERCARE-AF trial demonstrated that low-dose edoxaban prevented stroke or systemic embolism (SE) in very elderly Japanese patients with non-valvular atrial fibrillation (NVAF) in whom standard oral anticoagul…

Association of left ventricular end-diastolic diameter with incidence of thromboembolism in patients with non-valvular atrial fibrillation: the Fushimi AF Registry Open

Yuji Tezuka, K Doi, Yasuhiro Hamatani, Yoshimori An, Mitsuru Ishii , et al. · 2021

Background Atrial fibrillation (AF) is a common arrhythmia and a risk factor for thromboembolism including ischemic stroke (IS) and systemic embolism (SE). Thrombus formation mainly occurs in the left atrium (LA), but we reported that rela…

The relationship between diastolic blood pressure and the risk of cardiovascular events in patients with atrial fibrillation whose systolic blood pressure was treated to less than 130 mmHg Open

Syuhei Ikeda, Moritake Iguchi, Hisashi Ogawa, Kenjiro Ishigami, K Doi , et al. · 2021

Background Hypertension is one of the major risk factors of cardiovascular events in patients with atrial fibrillation (AF). Low diastolic blood pressure (DBP) has been reported to be associated with the incidence of cardiovascular events,…

Association of the degree of thrombocytopenia with cause of death in patients with atrial fibrillation: the Fushimi AF Registry Open

Kenjiro Ishigami, Syuhei Ikeda, K Doi, Yasuhiro Hamatani, Kaori Ide , et al. · 2021

Background Thrombocytopenia is sometimes found in routine blood tests and is associated with an increased risk of mortality in general population. We have previously reported that atrial fibrillation (AF) patients with thrombocytopenia hav…

Concomitant Mitral Regurgitation in Severe Aortic Stenosis　― A Report From the CURRENT AS Registry ― Open

Ryosuke Murai, Yuichi Kawase, Tomohiko Taniguchi, Takeshi Morimoto, Kazushige Kadota , et al. · 2021

Concomitant moderate/severe MR was not independently associated with higher risk for the primary outcome measure regardless of the initial treatment strategy.

Risk Factors and Outcomes of Recurrent Drug‐Eluting Stent Thrombosis: Insights From the REAL‐ST Registry Open

Soichiro Enomoto, Shoichi Kuramitsu, Tomohiro Shinozaki, Masanobu Ohya, Hiromasa Otake , et al. · 2021

Background Stent thrombosis (ST) after drug‐eluting stent (DES) implantation remains a life‐threatening complication. Recurrent ST (RST) is not a rare phenomenon, potentially contributing to high mortality after the index ST events. Howeve…

Long-Term Impact of Diabetes Mellitus on Initially Conservatively Managed Patients With Severe Aortic Stenosis Open

Xiaoyang Song, Naritatsu Saito, Takeshi Morimoto, Tomohiko Taniguchi, Hiroki Shiomi , et al. · 2020

In initially conservatively managed patients with AS, DM was independently associated with higher risk for a composite of AV-related death or HF hospitalization; however, insulin use was not associated with poor outcomes.

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