Mitzi Boardman
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View article: Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma
Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) remains a morbid disease with poor prognosis and treatment that typically leaves patients with permanent damage to critical functions such as eating and talking. Currently only three targeted t…
View article: Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in<i>in vivo</i>
Destruction complex dynamics: Wnt/β-catenin signaling alters Axin-GSK3β interactions in<i>in vivo</i> Open
The central regulator of the Wnt/β-catenin pathway is the Axin/APC/GSK3β destruction complex (DC), which in unstimulated conditions targets cytoplasmic β-catenin for degradation. How Wnt activation inhibits the DC to permit β-catenin-depen…
View article: Stand and Move at Work.
Stand and Move at Work. Open
Cardiovascular disease and diabetes are epidemic in the United States, and efforts to shift this trend have been largely ineffective. The greatest challenge that health care practitioners face is inspiring the lifestyle changes necessary t…