Explanipedia

Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models Open

Kosuke Inoue, Hirotaka Ito, Miwako Iwai, Minoru Tanaka, Yoshiyuki Mori , et al. · 2023

A complete resection of tongue cancer is often difficult. We investigate the usefulness of administering G47Δ (teserpaturev), a triple-mutated oncolytic herpes simplex virus type 1, prior to resection. G47Δ exhibits good cytopathic effects…

Fusion peptide is superior to co-expressing subunits for arming oncolytic herpes virus with interleukin 12 Open

Hiroshi Fukuhara, Y. SATO, Jiangang Hou, Miwako Iwai, Tomoki Todo · 2023

Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors Open

Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Minoru Tanaka, Hideaki Ijichi , et al. · 2022

Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma Open

Shoh Yajima, Kotaro Sugawara, Miwako Iwai, Minoru Tanaka, Yasuyuki Seto , et al. · 2021

Oncolytic herpes virus G47Δ injected into tongue cancer swiftly traffics in lymphatics and suppresses metastasis Open

Toshihiro Uchihashi, Hirokazu Nakahara, Hiroshi Fukuhara, Miwako Iwai, Hirotaka Ito , et al. · 2021

Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation Open

Kotaro Sugawara, Miwako Iwai, Hirotaka Ito, Minoru Tanaka, Yasuyuki Seto , et al. · 2021

Evaluation of Chemotherapy Regimen Management Practice by Oncology-Specialized and Non-specialized Pharmacists Collaboration Open

Yoshitaka Saito, Kazuki Uchiyama, Tatsuhiko Sakamoto, Kosei Kubota, Hiromitsu Oki , et al. · 2021

Chemotherapy regimen management is one of the most important oncology pharmacy practices, because chemotherapy is conducted according to the registered regimens. In this study, we evaluated the pharmaceutical practice that assumes the init…

Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation Open

Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Kazuhiko Koike, Tomoki Todo · 2020

Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer Open

Kotaro Sugawara, Miwako Iwai, Shoh Yajima, Minoru Tanaka, Kazuyoshi Yanagihara , et al. · 2020

Lower-Extremity Torque Capacity and Physical Function in Mobility-Limited Older Adults Open

Gregory J. Grosicki, Davis A. Englund, Lori Lyn Price, Miwako Iwai, Makoto Kashiwa , et al. · 2019

SKELETAL MUSCLE FATIGABILITY PREDICTS PHYSICAL FUNCTION IN MOBILITY-LIMITED OLDER ADULTS Open

Gregory J. Grosicki, Davis A. Englund, Lori Lyn Price, Miwako Iwai, Makoto Kashiwa , et al. · 2018

We previously demonstrated that progressive resistance training (PRT) improves lower-extremity skeletal muscle fatigability in mobility-limited older adults. The objective of this study was to examine the relationship between lower-extremi…

412. The Efficacy and Bio-Distribution of Oncolytic HSV-1 (G47Δ) in Mouse Orthotopic Esophageal Cancer Models Open

Shoh Yajima, Yasushi Ino, Hiroshi Fukuhara, Miwako Iwai, Yasuyuki Seto , et al. · 2016

Esophageal squamous cell carcinoma (ESCC) is one of the most lethal among cancer, because it easily metastasizes to the mediastinal lymph nodes and invades adjacent organs. The majority of patients with ESCC are diagnosed at advanced stage…

664. Therapeutic Effect of Oncolytic Herpes Simplex Virus Type 1 (G47Δ) in Combination with Chemotherapy on Colorectal Cancer Open

Shinya Abe, Yasushi Ino, Hiroshi Fukuhara, Miwako Iwai, Toshiaki Watanabe , et al. · 2016

One of the reasons for the difficulty of curing unresectable advanced stage colorectal cancer is that cancer cells acquire resistance to anticancer drugs. Oncolytic virus therapy is a potent candidate for developing a new therapeutic appro…

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