Miyoko Higuchi
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View article: Ultrasound findings suggestive of microscopic extranodal extension in papillary thyroid carcinoma
Ultrasound findings suggestive of microscopic extranodal extension in papillary thyroid carcinoma Open
Purpose Extranodal extension (ENE) of metastatic carcinoma in patients with papillary thyroid carcinoma (PTC) has been associated with an increased risk of recurrent disease, persistent disease, and disease-specific mortality; however, ult…
View article: Proposal for including risk of malignancy and clinical management in the Japanese system for reporting thyroid cytopathology - A multi-institutional study
Proposal for including risk of malignancy and clinical management in the Japanese system for reporting thyroid cytopathology - A multi-institutional study Open
Objective: The Japanese System for Reporting Thyroid Cytopathology (JSRTC) does not include the risks of malignancies (ROMs) or recommended clinical management. This multi-institutional study aimed to determine the frequency, re-aspiration…
View article: Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia
Fine needle aspiration cytology diagnoses of follicular thyroid carcinoma: results from a multicenter study in Asia Open
Background: This study was designed to compare diagnostic categories of thyroid fine needle aspiration cytology (FNAC) and incidence of thyroid tumors in the multi-institutional Asian series with a special focus on diagnostic category IV (…
View article: Nodule-Specific NRF2-Targeted Upregulation in Patients With <i>KEAP1</i> Mutations and Familial Nontoxic Multinodular Goiter
Nodule-Specific NRF2-Targeted Upregulation in Patients With <i>KEAP1</i> Mutations and Familial Nontoxic Multinodular Goiter Open
Context Kelch-like ECH-associated protein 1 (KEAP1) is associated with nuclear factor erythroid-2–related factor 2 (NRF2) and promotes NRF2 degradation in normal conditions. Genetic abnormality in KEAP1 is a rare disease and presents with …
View article: Diagnostic significance of clay-like materials aspirated from thyroid nodules
Diagnostic significance of clay-like materials aspirated from thyroid nodules Open
Objective: The simplest way to determine the adequacy of aspirated materials is the on-site gross visual assessment of aspirated materials. However, few studies have examined the gross findings of thyroid aspirates. This study aimed to cla…
View article: Prevalence and diagnostic significance of non‐invasive follicular thyroid neoplasm with papillary‐like nuclear features in Japan—A multi‐institutional study
Prevalence and diagnostic significance of non‐invasive follicular thyroid neoplasm with papillary‐like nuclear features in Japan—A multi‐institutional study Open
This multi‐institutional study investigated non‐invasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) frequency and its diagnostic significance in Japan. We reviewed 4008 thyroid nodules resected in six institut…
View article: High‐grade medullary thyroid carcinoma with papillary‐like nuclear features: A report of five cases
High‐grade medullary thyroid carcinoma with papillary‐like nuclear features: A report of five cases Open
Background Medullary thyroid carcinoma (MTC) with papillary‐like nuclear features has not been previously described. Here, we aimed to describe the unique features of MTC and examine their prognostic value as markers of high‐grade MTC. Met…
View article: Clinical, cytological, and pathological characteristics of metastatic renal cell carcinoma to the thyroid: A study of 14 cases at a Japanese single institution
Clinical, cytological, and pathological characteristics of metastatic renal cell carcinoma to the thyroid: A study of 14 cases at a Japanese single institution Open
A preoperative diagnosis of metastatic renal cell carcinoma to the thyroid (MRCCT) is important for determining clinical management but is challenging even in cases with a clinical history of renal cell carcinoma (RCC). This study aimed to…
View article: Non-hyalinizing trabecular thyroid adenoma: A novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma
Non-hyalinizing trabecular thyroid adenoma: A novel thyroid tumor with diagnostic pitfalls of hyalinizing trabecular adenoma and medullary thyroid carcinoma Open
Background Only one thyroid follicular cell-derived tumor with a purely trabecular growth pattern has previously been described. This report aims to describe the histological, immunohistochemical, and molecular findings of our second case,…
View article: Differential diagnosis of follicular thyroid lesions and management of non-invasive follicular thyroid neoplasms with papillary-like nuclear features
Differential diagnosis of follicular thyroid lesions and management of non-invasive follicular thyroid neoplasms with papillary-like nuclear features Open
甲状腺細胞診にて濾胞状パターンがみられる疾患として腺腫様結節，濾胞性腫瘍，濾胞型乳頭癌などがあり，それらの鑑別に苦慮する場合が少なくない．さらに近年では，被膜で囲まれ，被膜浸潤のない濾胞型乳頭癌と診断されていた腫瘍が，新たな疾患概念として乳頭癌様核所見を伴う非浸潤性濾胞型腫瘍（non-invasive follicular thyroid neoplasm with papillary-like nuclear features：NIFTP）と名称を変えたことにより，ベセス…
View article: B-cell to T-cell ratio as a novel indicator in flow cytometry in the diagnosis of thyroid lymphoma
B-cell to T-cell ratio as a novel indicator in flow cytometry in the diagnosis of thyroid lymphoma Open
Preoperative flow cytometry is recommended to prove the monoclonality and confirm the diagnosis of thyroid lymphoma. However, lymphoma cases without light chain restriction may also have monoclonality. The aim of our study was to identify …
View article: Clinical significance and cytological detection of tracheal puncture following thyroid fine‐needle aspiration: A retrospective study
Clinical significance and cytological detection of tracheal puncture following thyroid fine‐needle aspiration: A retrospective study Open
Background There have been no detailed reports on tracheal puncture after thyroid fine‐needle aspiration (FNA). This study aimed to discuss the cytological differential diagnoses of tracheal puncture after thyroid FNA and clarify its clini…
View article: Histological alterations following fine‐needle aspiration for parathyroid adenoma: Incidence and diagnostic problems
Histological alterations following fine‐needle aspiration for parathyroid adenoma: Incidence and diagnostic problems Open
This study aimed to clarify the histological alterations following fine‐needle aspiration for parathyroid adenoma and discuss the occurrence of diagnostic problems. Among the 392 patients with parathyroid adenoma who underwent resection, f…
View article: 53BP1 expression as a biomarker to differentiate thyroid follicular tumors
53BP1 expression as a biomarker to differentiate thyroid follicular tumors Open
We have previously reported that the expression of p53-binding protein 1 (53BP1) in nuclear foci (NF), a marker reflecting DNA damage response (DDR), detected using immunofluorescence (IF) is useful to estimate the malignant potency of div…
View article: Preoperative Detection of the TERT Promoter Mutations in Papillary Thyroid Carcinomas
Preoperative Detection of the TERT Promoter Mutations in Papillary Thyroid Carcinomas Open
Telomerase reverse transcriptase promoter ( TERT -p) mutations are strongly associated with tumor aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). Since the TERT -p promoter mutations have been reported to be subc…
View article: Potential role of mobile rapid on-site evaluation<sup>®</sup> in thyroid fine-needle aspiration cytology to reduce delayed repeated aspiration
Potential role of mobile rapid on-site evaluation<sup>®</sup> in thyroid fine-needle aspiration cytology to reduce delayed repeated aspiration Open
Rapid on-site evaluation of fine-needle aspiration cytology is time-consuming and requires specialized cytopathology staff. Mobile Rose® is a newly developed device for rapid on-site evaluation of fine-needle aspiration cytology. This stud…
View article: Variants of Papillary Thyroid Carcinoma
Variants of Papillary Thyroid Carcinoma Open
乳頭癌には多くの細胞学的特徴があることから, その細胞診における診断精度は極めて高い. 一方, 乳頭癌には多くの亜型があり, それらを正確に推定することは容易ではない. 本総説では, 乳頭癌亜型の定義, 臨床的特徴, 細胞所見, 鑑別診断などを概説している. 細胞診で乳頭癌亜型を推測する意義は, ①予後不良あるいは侵襲性の高い乳頭癌亜型を推定することが治療や予後の指標となる, ②篩型乳頭癌を推定することは治療方針の決定に極めて重要である, ③亜型の細胞像に精通することにより…
View article: The Japanese reporting system for thyroid aspiration cytology 2019 (JRSTAC2019)
The Japanese reporting system for thyroid aspiration cytology 2019 (JRSTAC2019) Open
We introduce the Japanese reporting system for thyroid aspiration cytology 2019 (JRSTAC2019) proposed by the Japan Association of Endocrine Surgery and the Japanese Society of Thyroid Pathology. Pathological classification and recommended …
View article: Fine‐needle aspiration of parathyroid adenomas: Indications as a diagnostic approach
Fine‐needle aspiration of parathyroid adenomas: Indications as a diagnostic approach Open
Background We aimed to determine the indication of fine‐needle aspiration (FNA) for parathyroid adenoma (PA)‐suspected nodules and the cytological features of PA, and to discuss the ancillary techniques for diagnostic confirmation. Method …
View article: Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis
Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis Open
Background Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease. Methods We analyzed the clinicopathologi…
View article: Prevalence and diagnostic significance of noninvasive follicular thyroid neoplasm with papillary-like nuclear features among tumors previously diagnosed as follicular adenoma: a single-institutional study in Japan
Prevalence and diagnostic significance of noninvasive follicular thyroid neoplasm with papillary-like nuclear features among tumors previously diagnosed as follicular adenoma: a single-institutional study in Japan Open
The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary thyroid carcinoma (PTC) is significantly lower in Asian countries than Western countries; however, the difference remains un…
View article: Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma: a useful marker for capsular invasion
Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma: a useful marker for capsular invasion Open
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma (EFV-PTC) are indistinguishable preoperatively. CD26 expression in follicular…
View article: Risk of malignancy and clinical outcomes of cyst fluid only nodules in the thyroid based on ultrasound and aspiration cytology
Risk of malignancy and clinical outcomes of cyst fluid only nodules in the thyroid based on ultrasound and aspiration cytology Open
Background The number of extensive studies focusing on cyst fluid only (CFO) thyroid nodules is limited, and the risk of malignancy (ROM) in CFO nodules has not been well‐established. Thus, the purpose of this study was to investigate CFO …
View article: Needle Tract Implantation Following Fine‐Needle Aspiration of Thyroid Cancer
Needle Tract Implantation Following Fine‐Needle Aspiration of Thyroid Cancer Open
Background Needle tract implantation (NTI) can occur after thyroid fine‐needle aspiration cytology (FNAC). To date, no studies enrolling a large number of patients and studying the cumulative incidence (CI) of NTI have been published. This…
View article: Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features
Important cytological findings for distinction between follicular variant and conventional papillary thyroid carcinoma, including noninvasive follicular thyroid tumors with papillary-like nuclear features Open
We studied cytological specimens of conventional papillary thyroid carcinoma (PTC), follicular variant papillary thyroid carcinoma (FVPTC), and noninvasive follicular thyroid tumor with papillary-like nuclear features (NIFTP) (formerly non…
View article: Diagnostic clues indicating tall cell variants of papillary thyroid carcinoma in fine needle aspiration
Diagnostic clues indicating tall cell variants of papillary thyroid carcinoma in fine needle aspiration Open
Background The definition of tall cell variant of papillary thyroid carcinoma (TCV‐PTC) depends on the articles, and the defined cytological findings characteristic of TCV‐PTC have not yet been fully analyzed. This study aimed to establish…
View article: Optimal needle size for thyroid fine needle aspiration cytology
Optimal needle size for thyroid fine needle aspiration cytology Open
Concerning the needle size for thyroid fine needle aspiration cytology (FNAC), 25-27-gauge needles are generally used in Western countries. However, in Japan, the use of larger needles (21-22-gauge needles) is common. The aim of our study …
View article: Derivation of thyroid lymphoepithelial cysts from follicular cells
Derivation of thyroid lymphoepithelial cysts from follicular cells Open
The pathogenesis of thyroid lymphoepithelial cysts is controversial, and two hypotheses have been proposed, namely derivation from branchial-derived remnants or from squamous metaplasia of the follicular cells. The aim of this study was to…