Miyuki Uno
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View article: TFAM Loss Induces Oxidative Stress and Divergent Phenotypes in Glioblastoma Metabolic Subtypes
TFAM Loss Induces Oxidative Stress and Divergent Phenotypes in Glioblastoma Metabolic Subtypes Open
Mitochondrial transcription factor A (TFAM) is essential for mitochondrial DNA (mtDNA) maintenance and function, but its role in glioblastoma (GBM) remains largely unexplored. Analysis of patient astrocytomas and TCGA datasets has revealed…
View article: The impact of <i>APOE</i> ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effects
The impact of <i>APOE</i> ε4 on cognition in Brazilians with type 2 diabetes: exploring ethnicity effects Open
INTRODUCTION Type 2 diabetes (T2D) is associated with cognitive decline, but the role of APOE ε4 – a known Alzheimer's risk allele – in cognition among admixed populations with T2D remains unclear. METHODS We analyzed 883 Brazilian adults …
View article: Advancing HIV and Cancer Research: Implementing an AIDS and Cancer Specimen Resource in Latin America
Advancing HIV and Cancer Research: Implementing an AIDS and Cancer Specimen Resource in Latin America Open
The AIDS and Cancer Specimen Resource (ACSR) has developed a global biorepository network to support research on AIDS-defining and non-AIDS-defining cancers. This article details the establishment of a dedicated HIV-associated cancer biore…
View article: Association of Genetic Ancestry and Colorectal Cancer Risk in a Large Brazilian Cohort: Replication of Single-Nucleotide Polymorphisms Identified by Genome-Wide Association Studies
Association of Genetic Ancestry and Colorectal Cancer Risk in a Large Brazilian Cohort: Replication of Single-Nucleotide Polymorphisms Identified by Genome-Wide Association Studies Open
PURPOSE Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) linked to colorectal cancer (CRC) risk in European and Asian populations, but studies in admixed populations, like Brazilians, remain sc…
View article: Sequential Applications of Adipose Tissue–derived Stem Cells Enhance Healing in Complex Wounds: Experimental Model
Sequential Applications of Adipose Tissue–derived Stem Cells Enhance Healing in Complex Wounds: Experimental Model Open
Background: Complex wounds represent a challenge to global health, incurring significant healthcare costs and compromising patients’ quality of life. Recently, research has investigated the potential of adipose tissue–derived stem cells (A…
View article: Detection of mutated KRAS, TP53, CDK2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing
Detection of mutated KRAS, TP53, CDK2A, and SMAD4 in tumor cell-free DNA of Brazilian pancreatic adenocarcinoma patients using next-generation sequencing Open
Pancreatic adenocarcinoma (PDAC) is one of the most lethal cancer types worldwide, with early diagnosis being challenging due to nonspecific symptoms that are often noticed only when the tumor reaches a large size. Liquid biopsy has emerge…
View article: Frog skin as an alternative temporary dressing for diabetic foot ulcers treatment: animal model
Frog skin as an alternative temporary dressing for diabetic foot ulcers treatment: animal model Open
Purpose: Diabetic foot ulcers (DFUs) are chronic lesions, and despite extensive research, no standardized treatment exists yet. This study aimed to evaluate the effect of frog skin application as a temporary dressing on the DFUs of diabeti…
View article: Clinical, ethnic and genetic risk factors associated with postoperative nausea and vomiting in patients undergoing cancer surgery: a case-control study
Clinical, ethnic and genetic risk factors associated with postoperative nausea and vomiting in patients undergoing cancer surgery: a case-control study Open
A previous history of PONV or motion sickness was identified as being the strongest predictor of PONV in our analysis. Genetic association, ancestry and external validation analyses suggest that genetic factors for PONV may significantly d…
View article: Effect of ASC Injection in the Inflammatory Reaction in Silicone Implant Capsule: Animal Model
Effect of ASC Injection in the Inflammatory Reaction in Silicone Implant Capsule: Animal Model Open
Background: Capsular contracture is a common complication affecting about 80% of patients who receive radiotherapy after breast reconstruction with silicone prostheses. This study examines the use of adipocyte stem cells (ASCs) to treat ca…
View article: A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma
A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma Open
Pleiotropic variants (i.e. genetic polymorphisms influencing more than one phenotype) are often associated with cancer risk. A scan of pleiotropic variants was successfully conducted 10 years ago in relation to pancreatic ductal adenocarci…
View article: deltaXpress (ΔXpress): a tool for mapping differentially correlated genes using single-cell qPCR data
deltaXpress (ΔXpress): a tool for mapping differentially correlated genes using single-cell qPCR data Open
Background High-throughput experiments provide deep insight into the molecular biology of different species, but more tools need to be developed to handle this type of data. At the transcriptomics level, quantitative Polymerase Chain React…
View article: Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer
Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer Open
In the oncological area, pancreatic cancer is one of the most lethal diseases, with 5-year survival rising just 10% in high-development countries. This disease is genetically characterized by KRAS as a driven mutation followed by SMAD4, CD…
View article: Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer
Circulating Cell-Free Nucleic Acids as Biomarkers for Diagnosis and Prognosis of Pancreatic Cancer Open
A lack of reliable early diagnostic tools represents a major challenge in the management of pancreatic cancer (PCa), as the disease is often only identified after it reaches an advanced stage. This highlights the urgent need to identify bi…
View article: Expression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma
Expression data of FOS and JUN genes and FTIR spectra provide diagnosis of thyroid carcinoma Open
We explore the feasibility of using FOS and JUN gene expression and ATR-FTIR for diagnosis of thyroid cancer. For the study, 38 samples (6 non-neoplastic (NN), 10 papillary thyroid carcinoma (PTC), 7 follicular thyroid carcinoma (FTC), and…
View article: Raw data of the study
Raw data of the study Open
Raw data of TaqMan Low-Density Array (TLDA) and Sanger sequencing plus clinical information of participants.
View article: miRNA and mRNA Expression Profiles Associated with Lymph Node Metastasis and Prognosis in Penile Carcinoma
miRNA and mRNA Expression Profiles Associated with Lymph Node Metastasis and Prognosis in Penile Carcinoma Open
Penile cancer (PeC) is a rare disease, and no prognostic biomarkers have been adopted in clinical practice yet. The objective of the present study was to identify differentially expressed miRNAs (DEmiRs) and genes (DEGs) as potential bioma…
View article: Plasma Exosome-Derived microRNAs as Potential Diagnostic and Prognostic Biomarkers in Brazilian Pancreatic Cancer Patients
Plasma Exosome-Derived microRNAs as Potential Diagnostic and Prognostic Biomarkers in Brazilian Pancreatic Cancer Patients Open
Pancreatic cancer represents one of the leading causes of oncological death worldwide. A combination of pancreatic cancer aggressiveness and late diagnosis are key factors leading to a low survival rate and treatment inefficiency, and earl…
View article: Disruption of miRNA-mRNA Networks Defines Novel Molecular Signatures for Penile Carcinogenesis
Disruption of miRNA-mRNA Networks Defines Novel Molecular Signatures for Penile Carcinogenesis Open
Penile cancer (PeC) carcinogenesis is not fully understood, and no biomarkers are reported in clinical practice. We aimed to investigate molecular signatures based on miRNA and mRNA and perform an integrative analysis to identify molecular…
View article: Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness Open
Background Glioblastoma is the most frequent and high-grade adult malignant central nervous system tumor. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy.…
View article: Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer
Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer Open
Cervical cancer, which main etiologic factor is Human Papillomavirus (HPV) infection, continues to be a burden for public health systems in developing countries. Our laboratory has been working with the hypothesis that signals generated in…
View article: Peptidomics-Driven Strategy Reveals Peptides and Predicted Proteases Associated With Oral Cancer Prognosis
Peptidomics-Driven Strategy Reveals Peptides and Predicted Proteases Associated With Oral Cancer Prognosis Open
Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging because changes can occur simultaneously…
View article: Susceptibility Loci for Pancreatic Cancer in the Brazilian Population
Susceptibility Loci for Pancreatic Cancer in the Brazilian Population Open
Background: Pancreatic adenocarcinoma (PA) is a very aggressive cancer and has one of the poorest prognoses. Usually the diagnosis is late and resistant to conventional treatment. Environmental and genetic factors contribute to the etiolog…
View article: Let-7 miRNA’s Expression Profile and Its Potential Prognostic Role in Uterine Leiomyosarcoma
Let-7 miRNA’s Expression Profile and Its Potential Prognostic Role in Uterine Leiomyosarcoma Open
The lethal-7 (let-7) family is an important microRNA (miRNA) group that usually exerts functions as a tumor suppressor. We aimed to evaluate the expression profile of let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i and t…
View article: MP49-20 CORRELATION BETWEEN MICRORNAS AND MRNA EXPRESSION PROFILES WITH THE PROGNOSIS OF CLINICALLY LOCALIZED PENILE CANCER
MP49-20 CORRELATION BETWEEN MICRORNAS AND MRNA EXPRESSION PROFILES WITH THE PROGNOSIS OF CLINICALLY LOCALIZED PENILE CANCER Open
You have accessJournal of UrologyPenile & Testicular Cancer: Penile & Testicular Cancer I (MP49)1 Apr 2019MP49-20 CORRELATION BETWEEN MICRORNAS AND MRNA EXPRESSION PROFILES WITH THE PROGNOSIS OF CLINICALLY LOCALIZED PENILE CANCER Claudio M…