Mizuha Hashiguchi
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View article: Acquired <scp>MTAP</scp> Loss Following Entrectinib Resistance in <scp>ROS1</scp> ‐Rearranged <scp>NSCLC</scp> With <scp>CD74</scp> Exon 3– <scp>ROS1</scp> Exon 34 Fusion
Acquired <span>MTAP</span> Loss Following Entrectinib Resistance in <span>ROS1</span> ‐Rearranged <span>NSCLC</span> With <span>CD74</span> Exon 3– <span>ROS1</span> Exon 34 Fusion Open
This case highlights acquired MTAP loss during disease progression in ROS1-rearranged NSCLC. Despite persistent CD74-ROS1 fusion and absence of known resistance mutations, the patient developed CNS progression after entrectinib, underscori…
View article: Anxiety, depression, and fear after coronavirus disease 2019 infection and their association with long coronavirus disease symptoms
Anxiety, depression, and fear after coronavirus disease 2019 infection and their association with long coronavirus disease symptoms Open
Introduction The coronavirus disease 2019 (COVID-19) pandemic has had widespread physical and psychological repercussions. Additionally, long COVID symptoms such as fatigue, dyspnea, and cognitive impairment have been well-documented; howe…
View article: Idiopathic Interstitial Lung Disease with Positive Anti-Zo and Anti-Ro52/SSA1 Antibodies
Idiopathic Interstitial Lung Disease with Positive Anti-Zo and Anti-Ro52/SSA1 Antibodies Open
A 70-year-old male presented with infiltration, ground-glass opacities, and bronchiectasis on chest radiography, which indicated interstitial pneumonia. Clinical findings (thickening of the skin on the fingers, slight nail fold petechiae, …
View article: The first Japanese case of autosomal dominant cutis laxa with a frameshift mutation in exon 30 of the elastin gene complicated by small airway disease with 8 years of follow-up
The first Japanese case of autosomal dominant cutis laxa with a frameshift mutation in exon 30 of the elastin gene complicated by small airway disease with 8 years of follow-up Open
This case highlighted an instance of autosomal dominant cutis laxa arising from a frameshift variant in exon 30 of ELN, accompanied by small airway disease. Comprehensive investigation, utilizing quantitative CT analysis, revealed a longit…
View article: The first Japanese case of small airway disease in a patient with autosomal dominant cutis laxa harboring frameshift variant in exon 30 of the elastin gene
The first Japanese case of small airway disease in a patient with autosomal dominant cutis laxa harboring frameshift variant in exon 30 of the elastin gene Open
Background: Cutis laxa constitutes a diverse group of connective tissue diseases, both inherited and acquired, characterized by loose skin and varying systemic involvement, including pulmonary lesions. While cutis laxa has been linked to c…
View article: Cluster analysis of long COVID in Japan and association of its trajectory of symptoms and quality of life
Cluster analysis of long COVID in Japan and association of its trajectory of symptoms and quality of life Open
Background Multiple prolonged symptoms observed in patients who recovered from COVID-19 are defined as long COVID. Although diverse phenotypic combinations are possible, they remain unclear. This study aimed to perform a cluster analysis o…
View article: Interaction of BMI and respiratory status in obstructive sleep apnea, a cross-sectional COPD study
Interaction of BMI and respiratory status in obstructive sleep apnea, a cross-sectional COPD study Open
This cross-sectional study of 136 patients with chronic obstructive pulmonary disease (COPD) investigated the mechanism underlying overlap syndrome, defined as coexisting COPD and obstructive sleep apnea (OSA). OSA was defined as a respira…
View article: Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force
Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force Open
Background To determine the effectiveness of baricitinib in patients with coronavirus disease 2019 (COVID-19), investigate whether baricitinib prevents the need for invasive mechanical ventilation and identify patient subgroups that would …
View article: Comprehensive Analysis of Long COVID in a Japanese Nationwide Prospective Cohort Study
Comprehensive Analysis of Long COVID in a Japanese Nationwide Prospective Cohort Study Open
View article: Successful Tepotinib Challenge After Capmatinib-Induced Interstitial Lung Disease in a Patient With Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation: Case Report
Successful Tepotinib Challenge After Capmatinib-Induced Interstitial Lung Disease in a Patient With Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation: Case Report Open
MET tyrosine kinase inhibitors, capmatinib and tepotinib, have been recently introduced for the treatment of advanced NSCLC with MET exon 14 skipping mutations. Although interstitial lung disease (ILD) induced by these drugs is repo…
View article: Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease
Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease Open
Background: The vertical P-wave axis on electrocardiography (ECG) is a useful criterion for screening patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the clinical characteristics of…
View article: Standard therapy‑resistant small cell lung cancer showing dynamic transition of neuroendocrine fate during the cancer trajectory: A case report
Standard therapy‑resistant small cell lung cancer showing dynamic transition of neuroendocrine fate during the cancer trajectory: A case report Open
While small cell lung cancer (SCLC) has been treated as a single disease historically, recent studies have suggested that SCLC can be classified into molecular subtypes based on the expression of lineage transcription factors such as achae…
View article: A case of lung adenocarcinoma with a novel <scp><i>CD74</i>‐<i>ROS1</i></scp> fusion variant identified by comprehensive genomic profiling that responded to crizotinib and entrectinib
A case of lung adenocarcinoma with a novel <span><i>CD74</i>‐<i>ROS1</i></span> fusion variant identified by comprehensive genomic profiling that responded to crizotinib and entrectinib Open
ROS1 rearrangements are found in 1–2% of patients with non‐small‐cell lung cancer. The detection of the rearrangements is crucial since clinically effective molecular targeted drugs are available for them. We present a case of lung adenoca…
View article: Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study
Trends of concerns from diagnosis in patients with advanced lung cancer and their family caregivers: A 2-year longitudinal study Open
Background: Both advanced cancer patients and their family caregivers experience distress and have a range of concerns after cancer diagnosis. However, longitudinal studies on this topic have been lacking. Aim: To investigate concerns in b…
View article: Supplementary Material for: Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease
Supplementary Material for: Clinical Utility of the Electrocardiographic P-Wave Axis in Patients with Chronic Obstructive Pulmonary Disease Open
Background: The vertical P-wave axis on electrocardiography (ECG) is a useful criterion for screening patients with chronic obstructive pulmonary disease (COPD). This study aimed to investigate the clinical characteristics of…
View article: <p>Characteristics of Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension Assessed by Echocardiography in a Three-Year Observational Cohort Study</p>
Characteristics of Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension Assessed by Echocardiography in a Three-Year Observational Cohort Study Open
In this study, we identified the clinical characteristics of COPD patients with PH detected by echocardiography. The presence of PH assessed by echocardiography was related to future COPD exacerbations and closely related to radiographical…