Mizuho Nagao
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View article: Diagnostic potential of allergen-specific lymphocyte stimulation test in hen’s egg yolk–induced, food protein–induced enterocolitis syndrome
Diagnostic potential of allergen-specific lymphocyte stimulation test in hen’s egg yolk–induced, food protein–induced enterocolitis syndrome Open
View article: Distinct regional allergen sensitization patterns in pediatric populations: A comparative latent class analysis of multiple antigen simultaneous test-derived sensitization profiles in Japan and Taiwan
Distinct regional allergen sensitization patterns in pediatric populations: A comparative latent class analysis of multiple antigen simultaneous test-derived sensitization profiles in Japan and Taiwan Open
Background: Allergen sensitization patterns vary across regions; however, few studies have directly compared pediatric sensitization profiles between Japan and Taiwan. Objective: This study aimed to compare allergen sensitization patterns …
View article: Long-term efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: Results from a phase 3 open-label extension study
Long-term efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: Results from a phase 3 open-label extension study Open
This analysis supports the long-term efficacy and safety of dupilumab in Japanese patients aged ≥6 months to <18 years with moderate-to-severe atopic dermatitis.
View article: The burden of illness in Prader-Willi syndrome: a systematic literature review
The burden of illness in Prader-Willi syndrome: a systematic literature review Open
View article: Predictors of Long-Term Desensitization in Children Treated with Oral Immunotherapy for Food Allergy: A Real-World Cohort Study
Predictors of Long-Term Desensitization in Children Treated with Oral Immunotherapy for Food Allergy: A Real-World Cohort Study Open
Background: The degree of desensitization achieved through oral immunotherapy (OIT) varies widely. This study aimed to identify factors predictive of full desensitization—defined as daily, symptom-free consumption of allergenic foods—in ch…
View article: Early-onset wheeze trajectories in infants: the Phenotyping of Wheezing Infants (P-WIN) study
Early-onset wheeze trajectories in infants: the Phenotyping of Wheezing Infants (P-WIN) study Open
View article: Predictors of Long-Term Desensitization in Children Treated with Oral Immunotherapy for Food Allergy: A Real-World Cohort Study
Predictors of Long-Term Desensitization in Children Treated with Oral Immunotherapy for Food Allergy: A Real-World Cohort Study Open
Background: The degree of desensitization achieved through oral immunotherapy (OIT) varies widely. This study aimed to identify factors predictive of full desensitization—defined as daily, symptom-free consumption of allergenic foods—in ch…
View article: Low‐dose oral cow's milk challenge outcome for patients on complete avoidance: A multicenter study in Japan
Low‐dose oral cow's milk challenge outcome for patients on complete avoidance: A multicenter study in Japan Open
Background Few studies have reported significant risk factors for allergic symptoms during low‐dose (1–3 mL) cow's milk (CM) oral food challenges (OFCs). We investigated patients from multiple centers in Japan to identify high‐risk, low‐do…
View article: Emulsion containing a chitosan derivative in children with mild atopic dermatitis: A randomized controlled trial
Emulsion containing a chitosan derivative in children with mild atopic dermatitis: A randomized controlled trial Open
Background Recently, partially myristoylated carboxymethyl chitosan (PMCMC) was developed in Japan. To compare the efficacy and safety of PMCMC‐containing emulsion and petrolatum, we conducted a randomized controlled trial. Methods Eligibl…
View article: Non-protein allergen (pectin or erythritol)
Non-protein allergen (pectin or erythritol) Open
View article: Usefulness of gibberellin‐regulated protein specific <scp>IgE</scp> measurement in patients with systemic symptoms of apple allergy with exercise
Usefulness of gibberellin‐regulated protein specific <span>IgE</span> measurement in patients with systemic symptoms of apple allergy with exercise Open
Patients with peach allergy who experience severe symptoms, including anaphylaxis, reportedly have a higher positivity for peach gibberellin‐regulated protein (GRP)‐specific immunoglobulin (Ig) E than those with only oral symptoms. However…
View article: Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2024
Executive summary: Japanese guidelines for atopic dermatitis (ADGL) 2024 Open
This is an abridged edition of English version of the Clinical Practice Guidelines for the Management of Atopic Dermatitis 2024. Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion. A cru…
View article: Cross-sectional Survey of Allergic Diseases in Staff and Their Families at Designated Allergic Disease Medical Hospitals in Japan: Calculation of Age-adjusted Prevalence
Cross-sectional Survey of Allergic Diseases in Staff and Their Families at Designated Allergic Disease Medical Hospitals in Japan: Calculation of Age-adjusted Prevalence Open
This survey is the first in Japan to calculate the age-adjusted prevalence of allergic diseases. Moreover, pollinosis is the most common allergic disease in Japan.
View article: Peach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients
Peach component-specific IgE measurement helps to differentiate between local and systemic reactions in peach-allergic Japanese patients Open
Sensitization to Pru p 1 was associated with LRs, while sensitization to Pru p 7 was associated with SRs; approximately one-third of patients in the SR group tested negative for the titer of peach crude sIgE ab, many of whom tested positiv…
View article: Chapter 5: Long-Term Management
Chapter 5: Long-Term Management Open
小児気管支喘息における長期管理は,薬物療法以外にも増悪因子への対応や患者教育等も重要であることから,JPGL2020の「長期管理に関する薬物療法」から,「長期管理」へとタイトルを変更した.改訂点として,治療と管理の両方の視点で目標を設定し診療を最適化すること,従来の評価・調節・治療の長期サイクルに「決定」を加え患者と保護者の主体的な診療参加・医療者との意思決定を促したこと,病診連携を明記し適正で効率的な診療を行い,難治性喘息の診療における位置づけを明確化したことがあげられる…
View article: Anti-TSLP Drug
Anti-TSLP Drug Open
Thymic stromal lymphopoietin(TSLP)は,上皮細胞由来のサイトカインであり,自然免疫および獲得免疫の経路を介して2型炎症の誘導に重要な役割を果たす.テゼペルマブは,TSLPがTSLP受容体に結合するのを阻害するヒトIgG2モノクローナル抗体であり,喘息の新しい生物学的製剤である.テゼペルマブの喘息における有効性と作用機序を評価するために,PATHWAY,NAVIGATOR,NOZOMI,UPSTREAM,CASCADE,SOURCE,DESTI…
View article: Efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: A randomized, double-blind, placebo-controlled phase 3 study
Efficacy and safety of dupilumab with concomitant topical corticosteroids in Japanese pediatric patients with moderate-to-severe atopic dermatitis: A randomized, double-blind, placebo-controlled phase 3 study Open
Dupilumab showed consistent efficacy and was well tolerated in Japanese patients aged ≥6 months to <18 years with moderate-to-severe atopic dermatitis previously insufficiently controlled with existing therapies.
View article: Practical guide for the diagnosis and management of primary ciliary dyskinesia
Practical guide for the diagnosis and management of primary ciliary dyskinesia Open
This practical guide provides clinicians with useful information for the diagnosis and management of PCD in Japan.
View article: Comparison of face-to-face and online learning effectiveness in pediatric allergic disease education with active learning
Comparison of face-to-face and online learning effectiveness in pediatric allergic disease education with active learning Open
目的:アクティブラーニングを用いた小児アレルギー教育セミナーにおいてオンライン式が対面式と同様の学習到達度,行動変容を促すのか明らかにする.
View article: A case of a one-year-old girl with cashew nut allergy diagnosed as pectin allergy based on anaphylaxis after ingestion of fruit gummies
A case of a one-year-old girl with cashew nut allergy diagnosed as pectin allergy based on anaphylaxis after ingestion of fruit gummies Open
【緒言】ペクチンはよく用いられる食品添加物である.カシューナッツ(CN)とペクチンの交差感作が報告されているが,あまり認識されていない.
View article: Randomized Trial of Preventing Complete Avoidance in Challenge-proven Egg-allergic Infants
Randomized Trial of Preventing Complete Avoidance in Challenge-proven Egg-allergic Infants Open
View article: Prediction of clinical outcome of egg allergy by measuring avidity of ovomucoid-specific IgE
Prediction of clinical outcome of egg allergy by measuring avidity of ovomucoid-specific IgE Open
View article: Linear growth in prepubertal children with asthma in a real-world setting
Linear growth in prepubertal children with asthma in a real-world setting Open
View article: Avidity of specific IgE antibody may predict the development of hen's egg allergy in infants
Avidity of specific IgE antibody may predict the development of hen's egg allergy in infants Open
View article: Dual assessment of total binding and antigen avidity of specific IgE antibody better predicts outcomes of oral food challenge in children
Dual assessment of total binding and antigen avidity of specific IgE antibody better predicts outcomes of oral food challenge in children Open
View article: Two Pediatric Cases of Primary Ciliary Dyskinesia Caused by Loss‐of‐Function Variants in Oral‐Facial‐Digital Syndrome Gene, <i>OFD1</i>
Two Pediatric Cases of Primary Ciliary Dyskinesia Caused by Loss‐of‐Function Variants in Oral‐Facial‐Digital Syndrome Gene, <i>OFD1</i> Open
Primary ciliary dyskinesia (PCD) is a hereditary disease caused by genes related to motile cilia. We report two male pediatric cases of PCD caused by hemizygous pathogenic variants in the OFD1 centriole and centriolar satellite protein ( O…
View article: Perspectives and gaps in the management of food allergy and anaphylaxis in the Asia-Pacific Region
Perspectives and gaps in the management of food allergy and anaphylaxis in the Asia-Pacific Region Open
Our study offers a cross-sectional evaluation of the management practices for FA in each Asia Pacific Association of Allergy Asthma and Clinical Immunology member country or territory. Urgent actions are required to enhance allergy service…
View article: Development and validation of a new asthma questionnaire to help achieve a high level of control in school-age children and adolescents
Development and validation of a new asthma questionnaire to help achieve a high level of control in school-age children and adolescents Open
The Best ACT-S is a valid questionnaire for children/adolescents aiming for best asthma control.
View article: Gut microbiota and fecal metabolites in sustained unresponsiveness by oral immunotherapy in school-age children with cow's milk allergy
Gut microbiota and fecal metabolites in sustained unresponsiveness by oral immunotherapy in school-age children with cow's milk allergy Open
In this study, we identified the clinical and gut environmental factors associated with SU acquisition in CM-OIT.
View article: Analysis of clinical features of Japanese patients with primary ciliary dyskinesia
Analysis of clinical features of Japanese patients with primary ciliary dyskinesia Open
あった(表１ : Table 1) ．PICADAR スコアの平均は７． ３(３-１ ４)点であった(図３ : Fig. 3) ．鼓膜所見は約５ ０％が陥 凹を示し，滲出性中耳炎が示唆された(図４ : Fig. 4) ．Lund-Mackay スコアは平均１ ２． ８(７-１ ７)点であり，画像所 見は必ずしも高度病変ではなかった(図５ ; Fig. 5) ．内臓逆位のある患者とない患者の間で，Lund-Mackay スコアに 有意差は認めなかった(それぞれ１ ２． ７と１…