Masahiro Ono
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View article: 248 Exploitation of endogenous TCR signaling using an oncolytic virus for modulation of CAR T phenotype and function against solid tumors
248 Exploitation of endogenous TCR signaling using an oncolytic virus for modulation of CAR T phenotype and function against solid tumors Open
View article: Potential of 211At-Labeled Amyloid-β Binding Agent for Targeted Alpha Therapy in Alzheimer’s Disease
Potential of 211At-Labeled Amyloid-β Binding Agent for Targeted Alpha Therapy in Alzheimer’s Disease Open
View article: Early Postpartum Screening: Predictive Value of Edinburgh Postnatal Depression Scale (EPDS) Scores on Day 3 for Depression at One Month
Early Postpartum Screening: Predictive Value of Edinburgh Postnatal Depression Scale (EPDS) Scores on Day 3 for Depression at One Month Open
View article: Novel bivalent albumin binder for enhanced tumor retention of fibroblast activation protein-targeted radioligand
Novel bivalent albumin binder for enhanced tumor retention of fibroblast activation protein-targeted radioligand Open
Fibroblast activation protein (FAP) is a promising target for cancer diagnosis and therapy. FAPI-46-based radioligands have shown promising diagnostic results, but their insufficient tumor retention needs to be improved for effective thera…
View article: Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements
Comparison of carbonic anhydrase-IX-targeted trifunctional radioligands between linear- and branched-chain arrangements Open
Background Carbonic anhydrase-IX (CA-IX) is overexpressed in tumors due to hypoxic conditions and considered an attractive biomarker for tumor-targeting radioligands. The introduction of an albumin binder (ALB) to radioligands can delay th…
View article: GatingTree: Pathfinding Analysis of Group-Specific Effects in Cytometry Data
GatingTree: Pathfinding Analysis of Group-Specific Effects in Cytometry Data Open
Advancements in cytometry technologies have led to a remarkable increase in the number of markers that can be analyzed simultaneously, presenting significant challenges in data analysis. Traditional approaches, such as dimensional reductio…
View article: New objective simple evaluation methods of amyloid PET/CT using whole-brain histogram and Top20%-Map
New objective simple evaluation methods of amyloid PET/CT using whole-brain histogram and Top20%-Map Open
Objective This study aims to assess the utility of newly developed objective methods for the evaluation of intracranial abnormal amyloid deposition using PET/CT histogram without use of cortical ROI analyses. Methods Twenty-five healthy vo…
View article: Novel technetium-99m-labeled bivalent PSMA-targeting probe based on hydroxamamide chelate for diagnosis of prostate cancer
Novel technetium-99m-labeled bivalent PSMA-targeting probe based on hydroxamamide chelate for diagnosis of prostate cancer Open
Objective: Prostate-specific membrane antigen (PSMA) is a well-known biomarker of prostate cancer. Previously, our group reported that the succinimidyl-cystatin-urea-glutamate (SCUE) moiety has a high affinity for PSMA. In this study, we d…
View article: New objective simple evaluation methods of amyloid PET/CT using whole brain histogram and Top20%-Map
New objective simple evaluation methods of amyloid PET/CT using whole brain histogram and Top20%-Map Open
Objective This study aims to assess the utility of newly developed objective methods for the evaluation of intracranial abnormal amyloid deposition using PET/CT histogram without use of cortical ROI analyses. Methods Twenty-five healthy vo…
View article: Development of Novel Bimodal Agents Based on Near-Infrared BODIPY-Conjugated Hoechst Derivatives for Combined Use in Auger Electron and Photodynamic Cancer Therapy
Development of Novel Bimodal Agents Based on Near-Infrared BODIPY-Conjugated Hoechst Derivatives for Combined Use in Auger Electron and Photodynamic Cancer Therapy Open
Auger electron therapy and photodynamic therapy (PDT) have attracted attention as powerful anticancer modalities. Herein, we report the development of novel bimodal agents for Auger electron therapy and PDT, and their application to combin…
View article: Optical Power Delivery with Suppressed Fiber Fuse in Standard Single Mode Fiber at a Wavelength of 1064 nm
Optical Power Delivery with Suppressed Fiber Fuse in Standard Single Mode Fiber at a Wavelength of 1064 nm Open
We confirm the suppression of both fiber-fuse propagation and initiation in standard single mode fibers (SMFs) by using optical pulses with a pulse period of 7.5 μs, for an average input power of 2.0 W and wavelength of 1064 nm. Using the …
View article: Radiotheranostics Based on Chemical Control of Radioactivity Pharmacokinetics
Radiotheranostics Based on Chemical Control of Radioactivity Pharmacokinetics Open
Recently, radiotheranostics, which systematically combines diagnosis by nuclear medicine imaging and treatment by internal radiotherapy, constitutes a new modality in cancer treatment, with some clinical reports showing marked effects on c…
View article: Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain
Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain Open
View article: Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain
Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain Open
It is generally accepted that the orexin 2 receptor (OX2R) plays a critical role in the arousal-promoting function, and in vivo imaging of OX2R is expected to contribute to elucidation of orexin systems and the develo…
View article: Structure–Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes
Structure–Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes Open
Synucleinopathies are characterized by the deposition of α-synuclein (α-syn) aggregates before the onset of clinical symptoms. Therefore, in vivo imaging of α-syn may contribute to early diagnosis of these diseases and has attracted…
View article: Application of the Chelator-Based Clickable Radiotheranostic Platform to Moderate-Molecular-Weight Ligands
Application of the Chelator-Based Clickable Radiotheranostic Platform to Moderate-Molecular-Weight Ligands Open
We have reported that the chelator-based clickable radiotheranostic platform, ADIBO-DOTADG-ALB (ADA), has favorable properties as a radiotheranostic platform for low-molecular-weight ligands. In this study, we evaluated the applicability o…
View article: Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes
Development of a hydroxamamide-based bifunctional chelating agent to prepare technetium-99m-labeled bivalent ligand probes Open
Hydroxamamide (Ham) is a thiol-free chelating agent that forms technetium-99m ( 99m Tc)-complexes with a metal-to-ligand ratio of 1:2 under moderate reaction conditions. Therefore, Ham-based chelating agents will produce 99m Tc-labeled com…
View article: First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas
First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas Open
Pancreatic β-cell mass (BCM) has a central importance in the pathophysiology of diabetes mellitus. Recently, pancreatic β-cell-specific imaging, especially positron emission tomography (PET) with exendin-based probes, has emerged for non-i…
View article: Characterization and Optimization of Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives as Tau-SPECT Probes
Characterization and Optimization of Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives as Tau-SPECT Probes Open
The accumulation of hyperphosphorylated tau protein in the brain is regarded as one of the hallmarks of Alzheimer's disease (AD). In vivo imaging of tau aggregates is helpful for diagnosis and monitoring of the progression of AD. In this s…
View article: Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors
Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors Open
View article: Structure–Activity and Brain Kinetics Relationships of <sup>18</sup>F-Labeled Benzimidazopyridine Derivatives as Tau PET Tracers
Structure–Activity and Brain Kinetics Relationships of <sup>18</sup>F-Labeled Benzimidazopyridine Derivatives as Tau PET Tracers Open
Noninvasive imaging of tau aggregates with a positron emission tomography (PET) tracer is useful for the diagnosis and staging of Alzheimer's disease (AD). Recently, we found that benzimidazopyridine (BIP) is an attractive scaffold for dev…
View article: PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide
PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide Open
Carbonic anhydrase-IX (CA-IX) is attracting much attention as a target molecule for cancer treatment since high expression of CA-IX can lead to a poor prognosis of patients. We previously reported low-molecular-weight 111 In/ 90 Y complexe…
View article: Development of Gold Nanorods Conjugated with Radiolabeled Anti-human Epidermal Growth Factor Receptor 2 (HER2) Monoclonal Antibody as Single-Photon Emission Computed Tomography/Photoacoustic Dual-Imaging Probes Targeting HER2-Positive Tumors
Development of Gold Nanorods Conjugated with Radiolabeled Anti-human Epidermal Growth Factor Receptor 2 (HER2) Monoclonal Antibody as Single-Photon Emission Computed Tomography/Photoacoustic Dual-Imaging Probes Targeting HER2-Positive Tumors Open
Surgery remains one of the main treatments of cancer and both precise pre- and intraoperative diagnoses are crucial in order to guide the operation. We consider that using an identical probe for both pre- and intra-operative diagnoses woul…
View article: <p>Spatial Patterns of Amyloid Deposition in Patients with Chronic Focal or Diffuse Traumatic Brain Injury Using <sup>18</sup>F-FPYBF-2 PET</p>
Spatial Patterns of Amyloid Deposition in Patients with Chronic Focal or Diffuse Traumatic Brain Injury Using <sup>18</sup>F-FPYBF-2 PET Open
Varying spatial patterns of amyloid deposition suggest amyloid pathology diversity depending on the injury type in chronic-TBI patients.
View article: Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain
Feasibility studies of radioiodinated pyridyl benzofuran derivatives as potential SPECT imaging agents for prion deposits in the brain Open
View article: Activatable Fluorescence Imaging of Macrophages in Cerebral Aneurysms Using Iron Oxide Nanoparticles Conjugated With Indocyanine Green
Activatable Fluorescence Imaging of Macrophages in Cerebral Aneurysms Using Iron Oxide Nanoparticles Conjugated With Indocyanine Green Open
NIRF imaging using an activatable IONP-ICG probe is feasible for detecting the macrophage-rich regions in CAs and the cerebral artery wall, which is considered an early lesion in the process of CA formation.
View article: Structure–Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes
Structure–Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes Open
Tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of Alzheimer's disease (AD). In this study, we designed and synthesized six radioiodina…
View article: Stabilization Mechanism for a Nonfibrillar Amyloid β Oligomer Based on Formation of a Hydrophobic Core Determined by Dissipative Particle Dynamics
Stabilization Mechanism for a Nonfibrillar Amyloid β Oligomer Based on Formation of a Hydrophobic Core Determined by Dissipative Particle Dynamics Open
Neurotoxicity caused by nonfibrillar amyloid β (Aβ) oligomers in the brain is suggested to be associated with the onset of Alzheimer's disease (AD). Elucidating the structural features of Aβ oligomers is critical for promoting drug discove…
View article: Dataset of "Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats."
Dataset of "Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats." Open
We fed ExHC rats, SD rats and Congenic (ExHC.BN-Dihc2BN) rats on three diets (high sucrose diet, high starch diet, high fructose diet) for 2 weeks. We measured the parameters related to glucose and lipid metabolism in t…
View article: Dataset of "Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats."
Dataset of "Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats." Open
We fed ExHC rats, SD rats and Congenic (ExHC.BN-Dihc2BN) rats on three diets (high sucrose diet, high starch diet, high fructose diet) for 2 weeks. We measured the parameters related to glucose and lipid metabolism in t…