Mohammed K. Ali
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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy Open
Interleukin-12 (IL-12) is a proinflammatory T cell- and natural killer (NK) cell-activating cytokine with potent preclinical anti-tumor efficacy, but clinical toxicity has limited its use as an immunotherapy. In a mouse tumor model, wild-t…
View article: Household Aggregation of Hypertension in India: A Cross‐Sectional Study of Nationally Representative Data From 450 000 Households
Household Aggregation of Hypertension in India: A Cross‐Sectional Study of Nationally Representative Data From 450 000 Households Open
Background Over 315 million adults live with hypertension in India, of whom only 37% are diagnosed. In addition to community‐based screening, targeting high‐risk households may identify undiagnosed individuals. We estimated the magnitude o…
Sociodemographic determinants, clinical characteristics, and survival outcomes of solid tumor patients at Tikur Anbessa Specialized Hospital, Ethiopia: a five-year retrospective cohort study Open
Background Cancer survival in sub-Saharan Africa is poorly characterized, and Ethiopia lacks large-scale outcome data. Tikur Anbessa Specialized Hospital (TASH), the country’s only comprehensive cancer center, receives the majority of refe…
Altered lipid and neurotransmitter metabolism as potential mechanisms of weight gain in women with HIV initiating INSTIs in a pilot study Open
Objective: This pilot study used metabolomics to provide insight into metabolic alterations of INSTI-associated weight gain among women with HIV (WWH). Methods: The study included 33 virally suppressed WWH who switched to or added an INSTI…
Cardiometabolic Benefits and Risks of Sodium-Glucose Co-Transporter-2 (SGLT-2) Inhibitor and Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Combination Therapy in Type 2 Diabetes: A Systematic Review Open
Type 2 diabetes (T2DM) management increasingly focuses on cardiometabolic protection. Sodium-glucose co-transporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have complementary mechanisms, making thei…
View article: Prescribing Trends of Glucagon-Like Peptide 1 Receptor Agonists for Type 2 Diabetes or Obesity
Prescribing Trends of Glucagon-Like Peptide 1 Receptor Agonists for Type 2 Diabetes or Obesity Open
This cross-sectional study examines the US prescribing trends of glucagon-like peptide 1 (GLP-1) receptor agonists among individuals with type 2 diabetes and/or obesity.
View article: Does health insurance coverage improve cardiometabolic risk factor levels? Quasi-experimental evidence from India
Does health insurance coverage improve cardiometabolic risk factor levels? Quasi-experimental evidence from India Open
Health insurance coverage was associated with better cardiometabolic risk profiles and health status, largely mediated by increased healthcare utilization. Expanding insurance coverage to include outpatient chronic care services should be …
Perceptions of and barriers to health information exchange use among emergency medicine and inpatient internal medicine clinicians in the Atlanta, Georgia metropolitan region Open
Background Health information exchanges (HIE), tools that electronically share clinical data across healthcare organizations, provide the opportunity to improve patient care. While widely available, HIE is utilized in only 2%-10% of patien…
View article: Efficacy and safety of ascending doses of orodispersible ivermectin co-administered with albendazole for Trichuris trichiura infections in preschool-aged children in Tanzania: a single-blind, randomised, controlled, dose-ranging, phase 2 trial
Efficacy and safety of ascending doses of orodispersible ivermectin co-administered with albendazole for Trichuris trichiura infections in preschool-aged children in Tanzania: a single-blind, randomised, controlled, dose-ranging, phase 2 trial Open
Swiss National Science Foundation.
View article: Cardiovascular-kidney-metabolic syndrome: A new frontier or simple rebranding?
Cardiovascular-kidney-metabolic syndrome: A new frontier or simple rebranding? Open
Cardiovascular-kidney-metabolic (CKM) syndrome is an emerging framework proposed by the American Heart Association for management of patients with cardio-metabolic multimorbidity. This novel framework offers several improvements over exist…
View article: Social Partner Effects on Type 2 Diabetes Prevention and Management and “Spillover” Health Effects: Better Together Pilot (Preprint)
Social Partner Effects on Type 2 Diabetes Prevention and Management and “Spillover” Health Effects: Better Together Pilot (Preprint) Open
BACKGROUND South Asian (SA) Americans are at high risk of prediabetes (pre-DM) and diabetes (T2DM). SA populations are typically close-knit communities, with support networks that could be leveraged in lifestyle interventions. OBJECTIVE Th…
County Prevalence and Control of High Blood Pressure from Health Kiosks, 2017-2024 Open
Background As the leading modifiable risk factor for death in the United States, hypertension requires timely and locally detailed surveillance. Current estimates of the high blood pressure (BP) care continuum are lagged national averages …
View article: The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial
The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial Open
Background Collaborative care models (CoCM) improve both depression and cardiometabolic outcomes, but the mechanisms driving these effects remain unclear. Objective To determine whether changes in depressive symptoms, positive health behav…
View article: Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older
Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older Open
US National Institute on Aging; Ministry of Health and Family Welfare, Government of India.
Blood Pressure Measurements From Self-Service Health Kiosks in US Retail Stores, 2017-2024 Open
Importance Hypertension is the leading risk factor for mortality in the US. Current national estimates of the prevalence of high blood pressure (BP) are derived from lagged averages based on complex, multistage, probability sampling design…
Culture-Negative Lemierre’s Syndrome: A Case Report of Septic Thrombophlebitis With Multi-organ Involvement Open
Lemierre's syndrome is a rare and potentially life-threatening condition characterized by septic thrombophlebitis of the internal jugular vein, typically following an oropharyngeal infection. We report a case of a young, previously healthy…
View article: Efficacy and safety of moxidectin–albendazole combination therapy for Trichuris trichiura infections in school-aged children: a double-blind, randomised, controlled, superiority trial
Efficacy and safety of moxidectin–albendazole combination therapy for Trichuris trichiura infections in school-aged children: a double-blind, randomised, controlled, superiority trial Open
Swiss National Science Foundation (reference 320030_175585).
Classification of Radish, Radish Leaf and Potato Leaf Disease Using Deep Learning Algorithm: Study and Accuracy Measurement Open
Radish and potato are important root vegetables that are extensively grown for their nutritional and economic importance. However, foliar diseases drastically impair productivity and quality. Early detection of these diseases is crucial fo…
Perceptions of body size and non-communicable disease risk among people with HIV in Nairobi, Kenya: an explanatory mixed-methods study Open
Introduction Burden of non-communicable diseases (NCDs) continues to rise in low- and middle-income countries like Kenya. People with HIV (PWH) may be at greater risk for obesity and NCDs. National health policies recommend integrated appr…
Trends in cardiometabolic multimorbidity in non-elderly adult Medicaid enrollees, 2018–2022 Open
Importance Medicaid, as the largest U.S. insurer, can reduce cardiometabolic multimorbidity. Objective Assess patterns and trends in cardiometabolic multimorbidity among Medicaid-enrolled adults. Design Analysis of 2018–2022 National Healt…
View article: Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians
Subtypes of Type 2 Diabetes and Prediabetes: Mortality and Excess Life Lost in South Asians Open
Background Current definitions of type 2 diabetes (T2D) and prediabetes do not capture their pathophysiological heterogeneity. We investigated data-driven subtypes of T2D and prediabetes and evaluated their associations with mortality. Met…
View article: Does home-based screening improve hypertension diagnosis, treatment and control? A regression discontinuity analysis in urban India
Does home-based screening improve hypertension diagnosis, treatment and control? A regression discontinuity analysis in urban India Open
As part of India’s efforts to expand primary healthcare services, several state governments are implementing or considering home-based hypertension screening programmes to improve population-wide diagnosis and blood pressure (BP) control r…
View article: REPRIEVE final results: What does it mean for guidelines in low‐ and middle‐income countries?
REPRIEVE final results: What does it mean for guidelines in low‐ and middle‐income countries? Open
Introduction The REPRIEVE study demonstrated significant reductions in major adverse cardiovascular events (MACE) with pitavastatin among people living with HIV (PWH) with low to moderate cardiovascular risk. Most MACE events occurred in h…
Recognizing Type 5 Diabetes: A Distinct and Urgent Clinical Challenge Open
The recent recognition of a fifth type of diabetes (Type 5 diabetes) by the International Diabetes Federation represents a meaningful step forward in identifying a new and historically undefined type of diabetes largely consisting of malnu…