Manpreet K. Singh
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View article: Methodological challenges in outcomes research for early-trials for implementation of new therapies in neuropediatric rare diseases
Methodological challenges in outcomes research for early-trials for implementation of new therapies in neuropediatric rare diseases Open
During 2023, the leads of the ECNP TWG focused on Clinical Outcomes in Early-Trials in Neurosciences scheduled two brainstorming sessions to allow a deep discussion about challenges facing neurosciences drug development in neuropediatric r…
View article: Differences in Cannabis and Cannabidiol Attitudes, Perceptions, and Behaviors Between US Adolescents Receiving Mood Disorder Treatment and Their Parents Across Legal Contexts
Differences in Cannabis and Cannabidiol Attitudes, Perceptions, and Behaviors Between US Adolescents Receiving Mood Disorder Treatment and Their Parents Across Legal Contexts Open
Dramatic shifts in state-level cannabis laws (CLs) and federal hemp regulations have resulted in increased availability and use of cannabis and cannabidiol (CBD) products throughout the US, with unknown implications for the youth. Youth wi…
View article: Clinical outcomes of youth at familial risk for bipolar disorder: A 2-year longitudinal, observational study
Clinical outcomes of youth at familial risk for bipolar disorder: A 2-year longitudinal, observational study Open
ClinicalTrials.gov Identifier: NCT03017781.
View article: Ketamine for suicidal ideations in severe depression
Ketamine for suicidal ideations in severe depression Open
This case report describes the management of a 38-year-old female with recurrent depressive disorder, who presented with severe depressive symptoms and active suicidal ideations. She reported persistent low mood, loss of interest in pleasu…
View article: Aberrant White Matter Microstructure in Youth at High Risk for Bipolar Disorder
Aberrant White Matter Microstructure in Youth at High Risk for Bipolar Disorder Open
Compared with the HC group, youths at risk for BD had altered integrity in the white matter of the callosum forceps minor, anterior thalamic radiation, and corticospinal tracts. Damage to these tracts may be a structural basis for impaired…
View article: Disrupted structural connectivity-gray matter covariance coupling and associated cytoarchitectural and transcriptomic profiles in attention-deficit/hyperactivity disorder
Disrupted structural connectivity-gray matter covariance coupling and associated cytoarchitectural and transcriptomic profiles in attention-deficit/hyperactivity disorder Open
Our findings provide novel insights into atypical couplings between brain gray and white matter structural connectomes in ADHD, their histological and transcriptional correlates, and prospects of using these data to expand clinical phenoty…
View article: Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review
Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review Open
The COVID-19 pandemic has posed an unprecedented threat to global health. However, neural substrates underlying mental health vulnerabilities brought by the pandemic remain elusive. We conducted a systematic review relating structural and …
View article: Mapping ADHD Heterogeneity and Biotypes through Topological Deviations in Morphometric Similarity Networks
Mapping ADHD Heterogeneity and Biotypes through Topological Deviations in Morphometric Similarity Networks Open
Attention-deficit/hyperactivity disorder (ADHD) is characterized by considerable clinical heterogeneity. This study investigates whether normative modelling of topological properties derived from brain morphometry similarity networks can p…
View article: A novel framework to predict ADHD symptoms using irritability in adolescents and young adults with and without ADHD
A novel framework to predict ADHD symptoms using irritability in adolescents and young adults with and without ADHD Open
Background Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents characterized by persistent patterns of hyperactivity, impulsivity, and inattentiveness. ADHD persists for many …
View article: A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder
A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder Open
Background Studies across multiple addictions have suggested that repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (L-DLPFC) reduces cue-induced-craving (CIC), however there are no stud…
View article: Current progress in targeted pharmacotherapy to treat symptoms of major depressive disorder: moving from broad-spectrum treatments to precision psychiatry
Current progress in targeted pharmacotherapy to treat symptoms of major depressive disorder: moving from broad-spectrum treatments to precision psychiatry Open
Major depressive disorder (MDD) is a disabling condition affecting children, adolescents, and adults worldwide. A high proportion of patients do not respond to one or more pharmacological treatments and are said to have treatment-resistant…
View article: Editors’ Best of 2024
Editors’ Best of 2024 Open
In our second year as JAACAP Open, which is now available on PubMed Central, we are proud to support the dissemination of among the highest quality research being conducted in our field. Choosing the "best" among stars is always a tall ord…
View article: Consensus review and considerations on TMS to treat depression: A comprehensive update endorsed by the National Network of Depression Centers, the Clinical TMS Society, and the International Federation of Clinical Neurophysiology
Consensus review and considerations on TMS to treat depression: A comprehensive update endorsed by the National Network of Depression Centers, the Clinical TMS Society, and the International Federation of Clinical Neurophysiology Open
This article updates the prior 2018 consensus statement by the National Network of Depression Centers (NNDC) on the use of transcranial magnetic stimulation (TMS) in the treatment of depression, incorporating recent research and clinical d…
View article: A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use
A Systematic Review: Investigating Biomarkers of Anhedonia and Amotivation in Depression and Cannabis Use Open
One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. One or more of the authors of this paper self-identifies as a member of one or more h…
View article: Augmenting mindfulness training through neurofeedback: a pilot study of the pre-post changes on resting-state functional connectivity in typically developing adolescents
Augmenting mindfulness training through neurofeedback: a pilot study of the pre-post changes on resting-state functional connectivity in typically developing adolescents Open
Background Mindfulness training has been shown to promote positive mental health outcomes and related changes in neural networks such as the default mode network, which has a central node in the posterior cingulate cortex (PCC). Previous w…
View article: Ethical Virtues of Sikhi
Ethical Virtues of Sikhi Open
Human life on this planet is full of misery, depression, sorrow, and sufferings. The whole surroundings of the world seem a tensed and unhappy place. In so-called modernized western society, human beings are living in stress and miseries. …
View article: Future Directions: The Phenomenology of Irritable Mood and Outbursts: Hang Together or Hang Separately <sup>1</sup>
Future Directions: The Phenomenology of Irritable Mood and Outbursts: Hang Together or Hang Separately <sup>1</sup> Open
Recognition of the importance of irritable mood and outbursts has been increasing over the past several decades. This "Future Directions" aims to develop a set of recommendations for future research emphasizing that irritable mood and outb…
View article: Ensuring Stakeholder Feedback in the Design and Conduct of Clinical Trials for Rare Diseases: ISCTM Position Paper of the Orphan Disease Working Group.
Ensuring Stakeholder Feedback in the Design and Conduct of Clinical Trials for Rare Diseases: ISCTM Position Paper of the Orphan Disease Working Group. Open
The 1983 Orphan Drug Act in the United States (US) changed the landscape for development of therapeutics for rare or orphan diseases, which collectively affect approximately 300 million people worldwide, half of whom are children. The act …
View article: Editors’ Best of 2023
Editors’ Best of 2023 Open
In our inaugural year as JAACAP Open, we are proud to support the dissemination of some of the highest quality research being conducted in our field. Choosing the "best" among stars is a tall order and most certainly misses the many ways a…