Seung‐Mo Hong
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View article: High-speed holotomography of live cells and tissues using multi-pattern sparse axial scanning
High-speed holotomography of live cells and tissues using multi-pattern sparse axial scanning Open
Holotomography has enabled label-free 3D imaging of biological samples but is often limited by slow image acquisition speed. To address this limitation, we propose a fast-scanning scheme, in which multiple patterns are used sparsely along …
View article: The Brescia International Multidisciplinary Consensus Guidelines on the Optimal Pathology Assessment and Multidisciplinary Pathways of Non‐Pancreatic Neoplasms in and Around the Ampulla of Vater (PERIPAN)
The Brescia International Multidisciplinary Consensus Guidelines on the Optimal Pathology Assessment and Multidisciplinary Pathways of Non‐Pancreatic Neoplasms in and Around the Ampulla of Vater (PERIPAN) Open
Importance The lack of multidisciplinary workflow guidelines and clear definitions and classifications for neoplasms in and around the ampulla of Vater results in inconsistencies affecting patient care and research. Objective The PERIPAN i…
View article: Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues
Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues Open
Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but often profile small regions, requiring evaluation of many samples to compensate for limited assessment.…
View article: Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers
Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers Open
Although synchronous cancers shared a mutated gene, the mutation subtypes differed. SCRCs exhibited 5.1% MSI status discordance rate and a high discordance rate in somatic mutational variants. As intertumoral heterogeneity may affect the t…
View article: Self-Supervised Prompt Optimization
Self-Supervised Prompt Optimization Open
Well-designed prompts are crucial for enhancing Large language models' (LLMs) reasoning capabilities while aligning their outputs with task requirements across diverse domains. However, manually designed prompts require expertise and itera…
View article: Tissue inhibitor of metalloproteinase 1 as a biomarker of venous invasion in pancreatic ductal adenocarcinoma
Tissue inhibitor of metalloproteinase 1 as a biomarker of venous invasion in pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with a poor prognosis. While venous invasion is believed to contribute to liver metastasis and an unfavorable prognosis, the precise mechanisms involved remain unclear. Here, we co…
View article: FACT: Examining the Effectiveness of Iterative Context Rewriting for Multi-fact Retrieval
FACT: Examining the Effectiveness of Iterative Context Rewriting for Multi-fact Retrieval Open
View article: Synthesis and Characterization of UV-Curable Resin with High Refractive Index for a Luminance-Enhancing Prism Film
Synthesis and Characterization of UV-Curable Resin with High Refractive Index for a Luminance-Enhancing Prism Film Open
A novel monomer, 9-bis[4-(2-hydroxyethoxy)phenyl]fluorene di(mercaptopropionate), with a highly refractive index, purity, and excellent UV-curable properties, is synthesized through an optimized Fischer esterification process, reacting 9,9…
View article: Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models
Fluorescence-guided tumor visualization of colorectal cancer using tumor-initiating probe yellow in preclinical models Open
Fluorescence-guided surgery has emerged as an innovative technique with promising applications in the treatment of various tumors, including colon cancer. Tumor-initiating probe yellow (TiY) has been discovered for identifying tumorigenic …
View article: Prognostic value of tumor-infiltrating lymphocytes in distal extrahepatic bile duct carcinoma
Prognostic value of tumor-infiltrating lymphocytes in distal extrahepatic bile duct carcinoma Open
sTILs were superior to iTILs in predicting survival, and it was shown to be a strong prognosticator for DBDC patients regardless of the stage. The utility of sTILs may extend beyond prognostication to aid in predicting therapeutic response…
View article: FACT: Examining the Effectiveness of Iterative Context Rewriting for Multi-fact Retrieval
FACT: Examining the Effectiveness of Iterative Context Rewriting for Multi-fact Retrieval Open
Large Language Models (LLMs) are proficient at retrieving single facts from extended contexts, yet they struggle with tasks requiring the simultaneous retrieval of multiple facts, especially during generation. This paper identifies a novel…
View article: Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers
Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers Open
Molecular characteristics of synchronous colorectal cancers (SCRCs) remain incompletely elucidated, despite their importance in targeted therapy selection. This retrospective study (2012–2014) compared the molecular characteristics and som…
View article: TIPRL Regulates Stemness and Survival in Lung Cancer Stem Cells through CaMKK2‐CaMK4‐CREB Feedback Loop Activation
TIPRL Regulates Stemness and Survival in Lung Cancer Stem Cells through CaMKK2‐CaMK4‐CREB Feedback Loop Activation Open
Frequent recurrence and metastasis caused by cancer stem cells (CSCs) are major challenges in lung cancer treatment. Therefore, identifying and characterizing specific CSC targets are crucial for the success of prospective targeted therapi…
View article: Liquid-based cytology features of pancreatic acinar cell carcinoma: comparison with other non-ductal neoplasms of the pancreas
Liquid-based cytology features of pancreatic acinar cell carcinoma: comparison with other non-ductal neoplasms of the pancreas Open
Background: Acinar cell carcinoma (ACC) is a rare malignant epithelial neoplasm, which shares many cytomorphological features with other non-ductal pancreatic neoplasms such as pancreatic neuroendocrine neoplasm (PanNEN) and solid-pseudopa…
View article: Artificial Intelligence-based Segmentation of Residual Pancreatic Cancer in Resection Specimens Following Neoadjuvant Treatment (ISGPP-2)
Artificial Intelligence-based Segmentation of Residual Pancreatic Cancer in Resection Specimens Following Neoadjuvant Treatment (ISGPP-2) Open
Neoadjuvant therapy (NAT) has become routine in patients with borderline resectable pancreatic cancer. Pathologists examine pancreatic cancer resection specimens to evaluate the effect of NAT. However, an automated scoring system to object…
View article: Comprehensive Characterization of Intraductal Oncocytic Papillary Neoplasm of the Pancreas: A Systematic and Critical Review
Comprehensive Characterization of Intraductal Oncocytic Papillary Neoplasm of the Pancreas: A Systematic and Critical Review Open
Intraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a recently recognized pancreatic tumor. Here, we aimed to determine its most essential features with the systematic review tool. PubMed, Scopus, and Embase were searched fo…
View article: Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study
Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study Open
Background/Purpose Extranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear.…
View article: Practice guidelines for managing extrahepatic biliary tract cancers
Practice guidelines for managing extrahepatic biliary tract cancers Open
The extrahepatic guideline committee believed that this guideline could be helpful in the treatment of patients.
View article: Fourier space aberration correction for high resolution refractive index imaging using incoherent light
Fourier space aberration correction for high resolution refractive index imaging using incoherent light Open
An aberration correction method is introduced for 3D phase deconvolution microscopy. Our technique capitalizes on multiple illumination patterns to iteratively extract Fourier space aberrations, utilizing the overlapping information inhere…
View article: Malignant potential of neuroendocrine microtumor of the pancreas harboring high-grade transformation: lesson learned from a patient with von Hippel-Lindau syndrome
Malignant potential of neuroendocrine microtumor of the pancreas harboring high-grade transformation: lesson learned from a patient with von Hippel-Lindau syndrome Open
Pancreatic neuroendocrine microtumor (PNEMT) is a neuroendocrine tumor (NET) < 0.5 cm in diameter, and it is considered benign. We report a PNEMT with high-grade transformation (HGT). A man in his 60s with von Hippel-Lindau syndrome underw…
View article: Author response: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Author response: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Open
View article: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Open
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throug…
View article: Reviewer #1 (Public Review): Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Reviewer #1 (Public Review): Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Open
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throug…
View article: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Open
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throug…
View article: Author Response: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Author Response: Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Open
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throug…
View article: Reviewer #2 (Public Review): Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology
Reviewer #2 (Public Review): Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology Open
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throug…
View article: Prognostic value of CT-based radiomics in grade 1–2 pancreatic neuroendocrine tumors
Prognostic value of CT-based radiomics in grade 1–2 pancreatic neuroendocrine tumors Open
View article: Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors
Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors Open
Somatostatin analogues have recently been used as therapeutic targets for metastatic or surgically unresectable gastroenteropancreatic (GEP) neuroendocrine tumors (NETs), and associated somatostatin receptor (SSTR) expression has been well…
View article: Uncovering the clinicopathological features of early recurrence after surgical resection of pancreatic cancer
Uncovering the clinicopathological features of early recurrence after surgical resection of pancreatic cancer Open
To identify risk factors and biomarker for early recurrence in patients diagnosed with pancreatic cancer who undergo curative resection. Early recurrence after curative resection of pancreatic cancer is an obstacle to long-term survival. W…
View article: Synthesis of 9,9-Bis[4-(2-Hydroxyethoxy)Phenyl]Fluorene Di(Mercaptopropionate) for High-Luminance and Refractive Prism Sheets
Synthesis of 9,9-Bis[4-(2-Hydroxyethoxy)Phenyl]Fluorene Di(Mercaptopropionate) for High-Luminance and Refractive Prism Sheets Open