Jin‐Man Kim
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View article: Collision Tumor of Angioimmunoblastic T-Cell Lymphoma and Kaposi Sarcoma in an HIV-Negative Elderly Woman: The First Reported Case in Asia
Collision Tumor of Angioimmunoblastic T-Cell Lymphoma and Kaposi Sarcoma in an HIV-Negative Elderly Woman: The First Reported Case in Asia Open
Background/Objectives: Angioimmunoblastic T-cell lymphoma (AITL) is a rare peripheral T-cell lymphoma of follicular helper T-cell (TFH) origin, often associated with immune dysregulation and EBV-positive B-cell proliferation. Kaposi sarcom…
View article: Exercise-stimulated primary cilia on preosteoclasts promote periosteal-bone formation
Exercise-stimulated primary cilia on preosteoclasts promote periosteal-bone formation Open
Exercise profoundly impacts cortical bones that are refractory to current drugs. However, the mechanisms underlying these changes remain unclear. Here we show that mechanosensitive primary cilia on myeloid-lineage preosteoclasts play a cri…
View article: Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of <i>Bacteroides vulgatus</i>
Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of <i>Bacteroides vulgatus</i> Open
Radiation-induced gastrointestinal (GI) toxicity can be a major cause of morbidity in patients undergoing abdominal radiotherapy. There is an unmet need for treatments to ameliorate GI toxicity. Estrogen-related receptor alpha (ESRRA), a p…
View article: ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections
ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections Open
Infections caused by nontuberculous mycobacteria, such as Mycobacterium avium and Mycobacteroides abscessus, are becoming increasingly prevalent, and rising antibiotic resistance poses a significant clinical challenge. However, the mechani…
View article: JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production
JAK3-deficient mini-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production Open
These results suggest that JAK3 KO mini-pigs can be used as an effective model for the development of therapies for SCID patients, as well as for regenerative medicine applications such as the development of patient-specific artificial org…
View article: VGF and the VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through the C3a receptor
VGF and the VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through the C3a receptor Open
New therapeutic targets, especially those that stimulate bone formation in cortical bone, are needed to overcome the limitations of current antiosteoporotic drugs. We previously demonstrated that factors secreted from megakaryocytes (MKs) …
View article: GMP manufacturing of umbilical cord blood mesenchymal stem cell-released exosomes and verification of wound healing efficacy
GMP manufacturing of umbilical cord blood mesenchymal stem cell-released exosomes and verification of wound healing efficacy Open
Rationale: Drug development research using exosomes is being actively conducted worldwide. However, clear management standards and verification systems for the use of exosomes as drugs are still being developed. In this study, the e…
View article: GDF15 promotes gallbladder cancer progression by activating the NF-&#x3BA;B mediated Vascular Endothelial Growth Factor A (VEGFA) expression
GDF15 promotes gallbladder cancer progression by activating the NF-κB mediated Vascular Endothelial Growth Factor A (VEGFA) expression Open
Growth differentiation factor 15 (GDF15) has been found to be elevated in several different types of cancer, thus demonstrating its potential for use as a biomarker. Although its physiological and pathophysiological roles in cancer are inc…
View article: Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway
Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway Open
Background Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. Osteoclastogenesis, the formation of osteoclas…
View article: Optimization of the Frying Process for Maximizing Crispiness of Scallop (Patinopecten yessoensis) Adductor Muscle Snacks Using Vacuum Low-Temperature Frying
Optimization of the Frying Process for Maximizing Crispiness of Scallop (Patinopecten yessoensis) Adductor Muscle Snacks Using Vacuum Low-Temperature Frying Open
Scallops, an economically important seafood, are popular as fried snacks. Vacuum low-temperature frying creates crispy, healthier foods that meet consumer demand for nutritious snacks with excellent texture. However, research on vacuum fry…
View article: Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer
Taurine Synthesis by 2-Aminoethanethiol Dioxygenase as a Vulnerable Metabolic Alteration in Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) exhibits an altered metabolic profile compared to normal pancreatic tissue. However, studies on actual pancreatic tissues are limited. Untargeted metabolomics analysis was conducted on 54 pairs of tu…
View article: Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever
Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever Open
African swine fever (ASF), a contagious and lethal haemorrhagic disease of domestic pigs and wild boars, poses a significant threat to the global pig industry. Although experimental vaccine candidates derived from naturally attenuated, gen…
View article: The autophagy-targeting compound V46 enhances antimicrobial responses to Mycobacteroides abscessus by activating transcription factor EB
The autophagy-targeting compound V46 enhances antimicrobial responses to Mycobacteroides abscessus by activating transcription factor EB Open
Mycobacteroides abscessus (Mabc) is a rapidly growing nontuberculous mycobacterium that poses a considerable challenge as a multidrug-resistant pathogen causing chronic human infection. Effective therapeutics that enhance protective immune…
View article: Extracellular C1qbp inhibits myogenesis by suppressing NFATc1
Extracellular C1qbp inhibits myogenesis by suppressing NFATc1 Open
Aging and lack of exercise are the most important etiological factors for muscle loss. We hypothesized that new factors that contribute to muscle loss could be identified from ones commonly altered in expression in aged and exercise-limite…
View article: VGF and VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through C3a receptor
VGF and VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through C3a receptor Open
New therapeutic targets, especially those that stimulate bone formation in cortical bone, are needed to overcome the limitations of current anti-osteoporotic drugs. We previously demonstrated that factors secreted from megakaryocytes (MK) …
View article: Mitigation of Soil Erosion and Enhancement of Slope Stability through the Utilization of Lignin Biopolymer
Mitigation of Soil Erosion and Enhancement of Slope Stability through the Utilization of Lignin Biopolymer Open
Human activities have had a profound impact on the environment, particularly in relation to surface erosion and landslides. These processes, which are natural phenomena, have been exacerbated by human actions, leading to detrimental conseq…
View article: Age‐related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high‐risk cases
Age‐related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high‐risk cases Open
As people age, the risk and progression of colorectal cancer (CRC), along with cholesterol levels, tend to increase. Nevertheless, epidemiological studies on serum lipids and CRC have produced conflicting results. We previously demonstrate…
View article: CM1, a Chrysin Derivative, Protects from Endotoxin-Induced Lethal Shock by Regulating the Excessive Activation of Inflammatory Responses
CM1, a Chrysin Derivative, Protects from Endotoxin-Induced Lethal Shock by Regulating the Excessive Activation of Inflammatory Responses Open
Sepsis, a leading cause of death worldwide, is a harmful inflammatory condition that is primarily caused by an endotoxin released by Gram-negative bacteria. Effective targeted therapeutic strategies for sepsis are lacking. In this study, u…
View article: Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses
Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses Open
View article: CM1, a Chrysin Derivative, Protects Endotoxin-Induced Lethal Shock by Regulating the Excessive Activation of Inflammatory Responses
CM1, a Chrysin Derivative, Protects Endotoxin-Induced Lethal Shock by Regulating the Excessive Activation of Inflammatory Responses Open
Human sepsis is one of the leading cause of death worldwide and is known to be a harmful damaging host inflammatory condition, primarily caused by endotoxin released by gram-negative bacteria. Despite antibiotics administration being widel…
View article: Multimodality Imaging Features of Various Splenic Lesions: Clinical and Histopathologic Correlation
Multimodality Imaging Features of Various Splenic Lesions: Clinical and Histopathologic Correlation Open
The spleen is occasionally referred to as the 'forgotten organ' because splenic lesions are less common and encountered rarely compared to pathologies of other abdominal solid organs. Therefore, although well-demonstrated using various abd…
View article: Possibility and Application of Sustainability Monitoring Method for Cement Structures Using the Electrical Conductivity of Copper Functionalized Graphene Oxide
Possibility and Application of Sustainability Monitoring Method for Cement Structures Using the Electrical Conductivity of Copper Functionalized Graphene Oxide Open
View article: Occlusive membranes for guided regeneration of inflamed tissue defects
Occlusive membranes for guided regeneration of inflamed tissue defects Open
View article: Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome
Diagnosis of Crohn’s disease and ulcerative colitis using the microbiome Open
Background Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disease resulting from dysregulation of the mucosal immune response and gut microbiota. Crohn's disease (CD) and ulcerative colitis (UC) are difficult to …
View article: Self-Supervised Multi-Modality Learning for Multi-Label Skin Lesion Classification
Self-Supervised Multi-Modality Learning for Multi-Label Skin Lesion Classification Open
The clinical diagnosis of skin lesion involves the analysis of dermoscopic and clinical modalities. Dermoscopic images provide a detailed view of the surface structures whereas clinical images offer a complementary macroscopic information.…
View article: Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism
Correction: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism Open
View article: Assessing Health and Economic Benefits of Omega-3 Fatty Acid Supplementation on Cardiovascular Disease in the Republic of Korea
Assessing Health and Economic Benefits of Omega-3 Fatty Acid Supplementation on Cardiovascular Disease in the Republic of Korea Open
Background: Cardiovascular disease (CVD) is the primary cause of mortality worldwide and imposes a significant social burden on many countries. Methods: This study assessed the health and economic benefits of omega-3 associated with CVD. T…
View article: A study on the correlation of GDF15 with cancer cell invasion and poor prognosis in gallbladder cancer.
A study on the correlation of GDF15 with cancer cell invasion and poor prognosis in gallbladder cancer. Open
167 Background: Growth differentiation factor 15 (GDF15) is a member of the TGF-β superfamily and has been found to be expressed in various human cancers. This study investigated the role of GDF15 in gallbladder cancer and its underlying m…
View article: Protective effect of niclosamide on calcification of aortic valve interstitial cells and its underlying molecular mechanism
Protective effect of niclosamide on calcification of aortic valve interstitial cells and its underlying molecular mechanism Open
View article: Effect of a multichannel oral irrigator on periodontal health and the oral microbiome
Effect of a multichannel oral irrigator on periodontal health and the oral microbiome Open