Moamen Bydoun
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View article: 1336 DPX-based immune education recruits and activates unique subsets of antigen presenting cells to drive immunogenicity of peptide antigens
1336 DPX-based immune education recruits and activates unique subsets of antigen presenting cells to drive immunogenicity of peptide antigens Open
Background For peptide-based cancer vaccines, successful eradication of tumors relies on the effective and persistent delivery of antigenic peptides to antigen presenting cells (APCs) to prime potent antigen-specific, cytotoxic T cells. Pe…
View article: Haploinsufficient tumor suppressor PRP4K is negatively regulated during epithelial‐to‐mesenchymal transition
Haploinsufficient tumor suppressor PRP4K is negatively regulated during epithelial‐to‐mesenchymal transition Open
The pre‐mRNA processing factor 4 kinase (PRP4K, also known as PRPF4B) is an essential gene. However, reduced PRP4K expression is associated with aggressive breast and ovarian cancer phenotypes including taxane therapy resistance, increased…
View article: Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells
Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells Open
The efficacy of oncolytic viruses (OVs), such as reovirus, is dictated by host immune responses, including those mediated by the pro- versus anti-inflammatory macrophages. As such, a detailed understanding of the interaction between reovir…
View article: S100A10, a novel biomarker in pancreatic ductal adenocarcinoma
S100A10, a novel biomarker in pancreatic ductal adenocarcinoma Open
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for …
View article: Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10
Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10 Open
The link between oncogenic RAS expression and the acquisition of the invasive phenotype has been attributed to alterations in cellular activities that control degradation of the extracellular matrix. Oncogenic RAS-mediated upregulation of …