Moana Witte
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View article: <scp>HBV</scp> Dominance Is Associated With a Distinct Inflammatory Milieu in <scp>HBV</scp> / <scp>HCV</scp> Coinfection
<span>HBV</span> Dominance Is Associated With a Distinct Inflammatory Milieu in <span>HBV</span> / <span>HCV</span> Coinfection Open
Hepatitis B (HBV) and C (HCV) virus coinfection is linked to a higher risk of cirrhosis and hepatocellular carcinoma (HCC) compared to monoinfection. Despite this, data are limited, and further investigation is needed to understand the und…
View article: Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy
Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy Open
Background/Aims: Hepatitis C virus (HCV) infection remains a global health challenge, leading to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Despite the high efficacy of direct-acting antiviral therapy in achievin…
View article: Unifying DNA methylation-based in silico cell-type deconvolution with <i>deconvMe</i>
Unifying DNA methylation-based in silico cell-type deconvolution with <i>deconvMe</i> Open
Summary Cell-type deconvolution is widely applied to gene expression and DNA methylation data, but access to methods for the latter remains limited. We introduce deconvMe , a new R package that simplifies access to DNA methylation-based de…
View article: Unifying DNA methylation-based <i>in silico</i> cell-type deconvolution with <i>deconvMe</i>
Unifying DNA methylation-based <i>in silico</i> cell-type deconvolution with <i>deconvMe</i> Open
Summary Cell-type deconvolution is widely applied to gene expression and DNA methylation data, but access to methods for the latter remains limited. We introduce deconvMe, a new R package that simplifies access to DNA methylation-based dec…
View article: The impact of cirrhosis on the inflammatory milieu before and long-term after hepatitis C virus elimination by direct-acting antiviral therapy
The impact of cirrhosis on the inflammatory milieu before and long-term after hepatitis C virus elimination by direct-acting antiviral therapy Open
Background and Aims Chronic hepatitis C virus (HCV) infection can lead to cirrhosis, development of hepatocellular carcinoma (HCC) and several extrahepatic manifestations. A sustained virological response (SVR) is achieved with direct-acti…
View article: Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct‐acting antivirals
Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct‐acting antivirals Open
Chronic hepatitis C virus (HCV) infections compromise natural killer (NK)‐cell immunity. Direct‐acting antivirals (DAA) effectively eliminate HCV, but the long‐term effects on NK cells in cured patients are debated. We conducted a proteomi…