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View article: The Role of Short-Chain Fatty Acids (SCFAs) in Colic and Anti-Inflammatory Pathways in Horses
The Role of Short-Chain Fatty Acids (SCFAs) in Colic and Anti-Inflammatory Pathways in Horses Open
Equine colic remains a prevalent and potentially life-threatening condition with multifactorial origins, including dietary imbalances, stress, and microbial dysbiosis. Central to equine gut health is the production of short-chain fatty aci…
View article: Oral Cannabidiol for Acute Post-Extraction Pain: A Randomized Pilot Study
Oral Cannabidiol for Acute Post-Extraction Pain: A Randomized Pilot Study Open
Introduction/Objective: Dental extractions are among the most common oral surgical procedures worldwide, with postoperative pain representing a significant clinical concern. Cannabidiol (CBD), a non-intoxicating phytocannabinoid with analg…
View article: Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism
Exploring the Role of Oral Microbiota in the Pathophysiology and Treatment of Bruxism Open
Bruxism is an involuntary condition involving grinding and clenching of the teeth, occurring during both wakefulness and sleep. This behavior can lead to various detrimental effects on oral health, including significant tooth wear and dama…
View article: The Impact of Absenteeism on Academic Performance Among First‐Year Dental Students
The Impact of Absenteeism on Academic Performance Among First‐Year Dental Students Open
Background According to the U.S. Department of Education, chronic absenteeism is a significant concern in health professions education which is characterized by missing 10% or more of school days that affect over 7 million students. This p…
View article: Editorial: Animal models of hypertension
Editorial: Animal models of hypertension Open
View article: Exploring the relationship between periodontal diseases and osteoporosis: Potential role of butyrate
Exploring the relationship between periodontal diseases and osteoporosis: Potential role of butyrate Open
Osteoporosis, a condition marked by the loss of bone density and mass, affects individuals of all ages. However, it becomes more prevalent and severe with aging, increasing the risk of fractures and other health complications. Recent resea…
View article: Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review
Akkermansia muciniphila as a Potential Guardian against Oral Health Diseases: A Narrative Review Open
The oral microbiome is a diverse ecosystem containing a community of symbiotic, commensal, and pathogenic microorganisms. One key microorganism linked to periodontal disease (PD) is Porphyromonas gingivalis (P. gingivalis), a Gram-negative…
View article: The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr−/− Mice with Obesity
The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr−/− Mice with Obesity Open
Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is…
View article: Targeting mitochondrial stress with Szeto‐Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress
Targeting mitochondrial stress with Szeto‐Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress Open
Background and Purpose Mitochondrial dysfunction and inflammation contribute to a myriad of cardiovascular diseases. Deleterious crosstalk of mitochondria and persistent endoplasmic reticulum (ER) stress triggers oxidative stress, which is…
View article: Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and Fibronectin in Collecting Duct Cells
Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and Fibronectin in Collecting Duct Cells Open
Chronic diabetes mellitus (DM) can lead to kidney damage associated with increased reactive oxygen species (ROS), proteinuria, and tubular damage. Altered protein expression levels of transforming growth factor-beta 1 (TGF-β1), fibronectin…
View article: Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2
Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2 Open
Objectives: Short-chain fatty acids (SCFAs), the main metabolites released from the gut microbiota, are altered during hypertension and obesity. SCFAs play a beneficial role in the cardiovascular system. However, the effect of SCFAs on cer…
View article: Correction: Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway
Correction: Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway Open
View article: Inhibition of endoplasmic reticulum stress and mitochondrial oxidative stress limits the development of abdominal aortic aneurysm and cardiac hypertrophy
Inhibition of endoplasmic reticulum stress and mitochondrial oxidative stress limits the development of abdominal aortic aneurysm and cardiac hypertrophy Open
Background and purpose: Persistent endoplasmic reticulum (ER) stress and its deleterious crosstalk with mitochondria trigger oxidative stress, mitochondrial dysfunction and inflammation contributing to the pathophysiology of a myriad of ca…
View article: The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity
The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity Open
Objective In this study, the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity was investigated. Methods Eight‐week‐old C57BL/6 mice were fed with high‐fat diet for 12 wee…
View article: Gut Microbiota Regulates the Sympathetic Nerve Activity and Peripheral Serotonin Through Hypothalamic MicroRNA-204 in Order to Increase the Browning of White Adipose Tissue in Obesity
Gut Microbiota Regulates the Sympathetic Nerve Activity and Peripheral Serotonin Through Hypothalamic MicroRNA-204 in Order to Increase the Browning of White Adipose Tissue in Obesity Open
View article: Hypothalamic miR-204 Induces Alteration of Heart Electrophysiology and Neurogenic Hypertension by Regulating the Sympathetic Nerve Activity: Potential Role of Microbiota
Hypothalamic miR-204 Induces Alteration of Heart Electrophysiology and Neurogenic Hypertension by Regulating the Sympathetic Nerve Activity: Potential Role of Microbiota Open
There is abundant evidence demonstrating the association between gut dysbiosis and neurogenic diseases such as hypertension. A common characteristic of resistant hypertension is the chronic elevation in sympathetic nervous system (SNS) act…
View article: Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy.
Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy. Open
Anticancer drugs play an important role in reducing mortality rates and increasing life expectancy in cancer patients. Treatments include monotherapy and/or a combination of radiation therapy, chemotherapy, hormone therapy, or immunotherap…
View article: α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions
α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions Open
Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na + handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds reni…
View article: Augmented transcripts of kidney injury markers and renin angiotensin system in urine samples of overweight young adults
Augmented transcripts of kidney injury markers and renin angiotensin system in urine samples of overweight young adults Open
View article: MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy Open
View article: Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice
Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice Open
An impaired decline in blood pressure at rest is typical in people with diabetes, reflects endothelial dysfunction, and increases the risk of end-organ damage. Here we report that microRNA-204 (miR-204) promotes endothelial dysfunction and…
View article: SUMO2 regulates vascular endothelial function and oxidative stress in mice
SUMO2 regulates vascular endothelial function and oxidative stress in mice Open
SUMOylation is a posttranslational modification of lysine residues. Modification of proteins by small ubiquitin-like modifiers (SUMO)1, -2, and -3 can achieve varied, and often unique, physiological and pathological effects. We looked for …
View article: (Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells
(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells Open
The binding of prorenin to the (pro)renin receptor (PRR) triggers the activation of MAPK/ERK1/2 pathway, induction of cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), and the induction of transforming …
View article: Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm
Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm Open
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical management of AAA is limited to surgical repair, while an effective pharmacotherapy is still awaited.…
View article: Targeting Autophagy in Obesity‐Associated Heart Disease
Targeting Autophagy in Obesity‐Associated Heart Disease Open
Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechani…
View article: MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure
MiR-204 regulates type 1 IP3R to control vascular smooth muscle cell contractility and blood pressure Open
View article: Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway
Metformin prevents vascular damage in hypertension through the AMPK/ER stress pathway Open
View article: MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1
MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1 Open
Endoplasmic reticulum (ER) stress has been implicated in vascular endothelial dysfunction of obesity, diabetes, and hypertension. MicroRNAs play an important role in regulating ER stress. Here we show that microRNA-204 (miR-204) promotes v…
View article: Correction: Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress
Correction: Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress Open
View article: Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel Open