Moein Piroozkhah
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View article: Bioinformatics analysis reveals shared molecular pathways for relationship between ulcerative colitis and primary sclerosing cholangitis
Bioinformatics analysis reveals shared molecular pathways for relationship between ulcerative colitis and primary sclerosing cholangitis Open
View article: FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression
FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression Open
FadA appears to potentiate CRC progression by inducing the upregulation of LINC00460, consequently leading to the hyperexpression of ANXA2 through the ceRNA network.
View article: Toward Precision Medicine in Celiac Disease: Emerging Roles of Multiomics and Artificial Intelligence
Toward Precision Medicine in Celiac Disease: Emerging Roles of Multiomics and Artificial Intelligence Open
This paper focuses on celiac disease (CD), an autoimmune disorder characterized by small intestinal enteropathy and gastrointestinal symptoms. The prevalence of CD is rising, and there is a need for prompt and accurate diagnosis. The paper…
View article: Comprehensive Multi‐Omics Analysis Reveals <scp>NPC2</scp> and <scp>ITGAV</scp> Genes as Potential Prognostic Biomarkers in Gastrointestinal Cancers
Comprehensive Multi‐Omics Analysis Reveals <span>NPC2</span> and <span>ITGAV</span> Genes as Potential Prognostic Biomarkers in Gastrointestinal Cancers Open
Background Gastrointestinal cancers (GICs) continue to dominate in terms of both incidence and mortality worldwide. Due to the absence of efficient and accurate prognostic biomarkers, the prognosis and treatment outcomes of many GICs are p…
View article: Comprehensive analysis identifies endocrine fibroblast growth factors as promising prognostic markers for colorectal carcinoma
Comprehensive analysis identifies endocrine fibroblast growth factors as promising prognostic markers for colorectal carcinoma Open
Endocrine fibroblast growth factors (eFGFs) play essential roles in cellular signaling processes, including development and differentiation, and are implicated in various cancers. However, their precise involvement in colon neoplasia and c…
View article: Bioinformatics Analysis Reveals shared molecular pathways for Relationship between Ulcerative Colitis and Primary Sclerosing Cholangitis
Bioinformatics Analysis Reveals shared molecular pathways for Relationship between Ulcerative Colitis and Primary Sclerosing Cholangitis Open
Background Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, including ulcerative colitis (UC) and Crohn’s disease, affecting the gastrointestinal tract and is associated with high morbidity and mortality. Accu…
View article: IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p
IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p Open
Despite advances in treatment strategies, colorectal cancer (CRC) continues to cause significant morbidity and mortality, with mounting evidence a close link between immune system dysfunctions issued. Interleukin-2 receptor gamma (IL-2RG) …
View article: Decoding common genetic alterations between Barrett's esophagus and esophageal adenocarcinoma: A bioinformatics analysis
Decoding common genetic alterations between Barrett's esophagus and esophageal adenocarcinoma: A bioinformatics analysis Open
The present study provides novel potential candidate genes that may be involved in the molecular association between Esophageal adenocarcinoma and Barrett's Esophagus, resulting in developing the diagnostic tools and therapeutic targets to…
View article: The molecular mechanism of actions and clinical utilities of tumor infiltrating lymphocytes in gastrointestinal cancers: a comprehensive review and future prospects toward personalized medicine
The molecular mechanism of actions and clinical utilities of tumor infiltrating lymphocytes in gastrointestinal cancers: a comprehensive review and future prospects toward personalized medicine Open
Gastrointestinal (GI) cancers remain a significant global health burden, accounting for a substantial number of cases and deaths. Regrettably, the inadequacy of dependable biomarkers hinders the precise forecasting of patient prognosis and…
View article: Expression Analysis of Long Noncoding RNA-MALAT1 and Interleukin-6 in Inflammatory Bowel Disease Patients
Expression Analysis of Long Noncoding RNA-MALAT1 and Interleukin-6 in Inflammatory Bowel Disease Patients Open
Inflammatory bowel disease (IBD) manifests as chronic inflammation within the gastrointestinal tract. The study focuses on a long noncoding RNA (lncRNA) known as Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). MALAT1's mis…
View article: Guanylate cyclase-C Signaling Axis as a theragnostic target in colorectal cancer: a systematic review of literature
Guanylate cyclase-C Signaling Axis as a theragnostic target in colorectal cancer: a systematic review of literature Open
Introduction Colorectal cancer (CRC) is a devastating disease that affects millions of people worldwide. Recent research has highlighted the crucial role of the guanylate cyclase-C (GC-C) signaling axis in CRC, from the early stages of tum…
View article: Editorial: Computational methods for multi-omics data analysis in cancer precision medicine
Editorial: Computational methods for multi-omics data analysis in cancer precision medicine Open
EDITORIAL article Front. Genet., 05 July 2023Sec. Cancer Genetics and Oncogenomics Volume 14 - 2023 | https://doi.org/10.3389/fgene.2023.1226975
View article: Mixed data analysis detected Endocrine Fibroblast Growth Factors (FGF19, FGF21, and FGF23) as Prognostic and Diagnostic Markers of Colorectal Neoplasia and Carcinoma
Mixed data analysis detected Endocrine Fibroblast Growth Factors (FGF19, FGF21, and FGF23) as Prognostic and Diagnostic Markers of Colorectal Neoplasia and Carcinoma Open
Background Endocrine fibroblast growth factors (e FGFs ) play important roles in various cellular signaling processes such as development and differentiation. These genes were also found to be significantly related to several cancer. Howev…
View article: Comprehensive Multi-Omics Analysis Reveals NPC2 and ITGAV Genes as Potential Prognostic Biomarkers in Gastrointestinal Cancers
Comprehensive Multi-Omics Analysis Reveals NPC2 and ITGAV Genes as Potential Prognostic Biomarkers in Gastrointestinal Cancers Open
Background Gastrointestinal cancers (GICs) continue to dominate in terms of both incidence and mortality worldwide. Due to the absence of efficient and accurate prognostic biomarkers, the prognosis and treatment outcomes of many GICs are p…
View article: A systematic review and meta-analysis for the association of the insulin-like growth factor1 pathway genetic polymorphisms with colorectal cancer susceptibility
A systematic review and meta-analysis for the association of the insulin-like growth factor1 pathway genetic polymorphisms with colorectal cancer susceptibility Open
Background The receptors, ligands, and associated proteins of the insulin-like growth factor (IGF) family are involved in cancer development. The IGF1 receptor and its accompanying signaling cascade are a crucial growth-regulatory mechanis…
View article: Multi-omics data integration in upper gastrointestinal cancers research: A review of concepts, approaches, and application
Multi-omics data integration in upper gastrointestinal cancers research: A review of concepts, approaches, and application Open
Upper gastrointestinal (GI) cancers, including esophageal, gastric, liver, and pancreatic cancers, are a major medical and economic burden worldwide. Despite significant advances in radiotherapy, chemotherapy, and targeted treatments for u…