Moen Sen
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View article: Automated analysis of flow cytometry data with minimal training files: Research evaluation of an elastic image registration algorithm for <scp>TBNK</scp>, stem cell enumeration, and lymphoid screening tube assays
Automated analysis of flow cytometry data with minimal training files: Research evaluation of an elastic image registration algorithm for <span>TBNK</span>, stem cell enumeration, and lymphoid screening tube assays Open
Automated analysis of flow cytometry data can improve objectivity and reduce analysis time but has generally required work by software and algorithm experts. Here, we investigated the performance of BD ElastiGate™ Software (hereafter Elast…
View article: Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra‐cellular matrix marker expression
Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra‐cellular matrix marker expression Open
Dear Editor, Malignant pleural effusions (MPE) in advanced non-small-cell lung cancer (NSCLC) offer a rich source of tumour-derived material for liquid biopsy.1 However, molecular monitoring of NSCLC is largely dependent on tumour biopsies…
View article: Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics
Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics Open
Detection of disease-associated, cell-free nucleic acids in body fluids enables early diagnostics, genotyping and personalized therapy, but is challenged by the low concentrations of clinically significant nucleic acids and their sequence …
View article: Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue
Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue Open
[This corrects the article DOI: 10.18632/oncotarget.26911.].
View article: Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue
Flow based single cell analysis of the immune landscape distinguishes Barrett’s esophagus from adjacent normal tissue Open
Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not we…
View article: Highly specific enrichment of rare nucleic acids using<i>Thermus thermophilus</i>Argonaute
Highly specific enrichment of rare nucleic acids using<i>Thermus thermophilus</i>Argonaute Open
Characterization of disease-associated, cell-free nucleic acids (liquid biopsy) provides a powerful, minimally-invasive means for early detection, genotyping, and personalized therapy; but is challenged by alleles of interest differing by …
View article: An integrated enrichment system to facilitate isolation and molecular characterization of single cancer cells from whole blood
An integrated enrichment system to facilitate isolation and molecular characterization of single cancer cells from whole blood Open
Circulating tumor cells (CTCs) carry valuable biological information. While enumeration of CTCs in peripheral blood is an FDA‐approved prognostic indicator of survival in metastatic prostate and other cancers, analysis of CTC phenotypic an…
View article: An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters
An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters Open
Comprehensive molecular analysis of rare circulating tumor cells (CTCs) and cell clusters is often hampered by low throughput and purity, as well as cell loss. To address this, we developed a fully integrated platform for flow cytometry-ba…
View article: p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function
p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function Open
The p16/RB1 tumor suppressor pathway is inactivated in the vast majority, if not all, human cancers. The current paradigm is that p16 and RB1 function in a linear pathway to suppress tumorigenesis; however p16 is preferentially lost in hum…