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View article: Donor Characteristics Associated With Graft Loss and Delayed Graft Function in Very-Aged Kidney Donors: An Observational Multicentric Study
Donor Characteristics Associated With Graft Loss and Delayed Graft Function in Very-Aged Kidney Donors: An Observational Multicentric Study Open
This study explores the impact of using kidneys from very-aged donors to address the organ shortage, focusing on risk factors for graft loss and delayed graft function (DGF), independent of recipient factors. Data were sourced from the Fre…
View article: #2586 Urinary and blood mRNA biomarkers for detecting kidney allograft rejection (The KTD-Innov study: NCT03582436)
#2586 Urinary and blood mRNA biomarkers for detecting kidney allograft rejection (The KTD-Innov study: NCT03582436) Open
Background and Aims Blood and urinary mRNA biomarkers are non-invasive tools with potential for detecting kidney allograft rejection. However, their ability to provide added diagnostic value beyond current standard-of-care (SOC) patient mo…
View article: Shiga Toxin–Producing Escherichia coli–Associated Hemolytic Uremic Syndrome in Adult Kidney Transplant Recipients
Shiga Toxin–Producing Escherichia coli–Associated Hemolytic Uremic Syndrome in Adult Kidney Transplant Recipients Open
View article: Association between mycophenolic acid treatment and infection with specific strains of Pneumocystis jirovecii in solid organ transplant recipients in France and Switzerland: a multicentre, retrospective, cross-sectional study
Association between mycophenolic acid treatment and infection with specific strains of Pneumocystis jirovecii in solid organ transplant recipients in France and Switzerland: a multicentre, retrospective, cross-sectional study Open
View article: Identification of Donor–recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study
Identification of Donor–recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study Open
Background. Kidney marginality criteria consider the impact of donor characteristics on graft failure risk. To evaluate graft quality according to both the donor and recipient, we identified recipient characteristics that may modify the pr…
View article: Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation
Maximum cold ischemia duration for a kidney allograft: a prediction model for allograft failure at the time of organ allocation Open
View article: Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: A multicenter international study
Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: A multicenter international study Open
View article: Diagnostic Value of Biological Parameters in Biopsy-Confirmed Thrombotic Microangiopathy–MATRIX Consortium Group
Diagnostic Value of Biological Parameters in Biopsy-Confirmed Thrombotic Microangiopathy–MATRIX Consortium Group Open
View article: WCN25-1242 UPDATE TO THE LONG-TERM SAFETY AND EFFICACY OF IPTACOPAN IN C3G: 33-MONTH EXTENSION STUDY DATA FROM PATIENTS ENROLLED IN A PHASE 2 STUDY
WCN25-1242 UPDATE TO THE LONG-TERM SAFETY AND EFFICACY OF IPTACOPAN IN C3G: 33-MONTH EXTENSION STUDY DATA FROM PATIENTS ENROLLED IN A PHASE 2 STUDY Open
View article: Real-Life Data of 2-Year Lumasiran Use in the DAILY-LUMA Cohort
Real-Life Data of 2-Year Lumasiran Use in the DAILY-LUMA Cohort Open
View article: Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy
Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy Open
These data provide a clinical rationale for further evaluation of long-term treatment of C3G with iptacopan.
View article: Transplant patient classification based on everolimus blood concentrations: Is there a risk of “misclassifications” using immunoassays?
Transplant patient classification based on everolimus blood concentrations: Is there a risk of “misclassifications” using immunoassays? Open
View article: Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies
Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies Open
Recently, interest in transcriptomic assessment of kidney biopsies has been growing. This study investigates the use of NGS to identify gene expression changes and analyse the pathways involved in rejection. An Illumina bulk RNA sequencing…
View article: The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Open
View article: #2581 Cryptococcosis in kidney transplant recipients: a nationwide multicenter retrospective cohort study—CRITERE study
#2581 Cryptococcosis in kidney transplant recipients: a nationwide multicenter retrospective cohort study—CRITERE study Open
Background and Aims Cryptococcosis stands as the third most common invasive fungal infection in solid organ transplant recipients. Clinical management and prognosis of the disease remains largely unexplored in the context of kidney transpl…
View article: #2672 Cryoglobulin-Induced membranoproliferative glomerulonephritis in a HEV-infected kidney transplant recipient: outcomes post ribavirin failure
#2672 Cryoglobulin-Induced membranoproliferative glomerulonephritis in a HEV-infected kidney transplant recipient: outcomes post ribavirin failure Open
Background and Aims Hepatitis E is a zoonosis caused by hepatitis E virus (HEV), which was first discovered 40 years ago. It is the most prevalent hepatitis virus worldwide. Most hepatitis E cases are self-limiting acute hepatitis, but the…
View article: #277 Update to the long-term safety and efficacy of iptacopan in C3G: 33-month extension study data from patients enrolled in a phase 2 study
#277 Update to the long-term safety and efficacy of iptacopan in C3G: 33-month extension study data from patients enrolled in a phase 2 study Open
Background and Aims Complement 3 glomerulopathy (C3G), due to dysregulation of the alternative complement pathway (AP), is an ultra-rare primary glomerulonephritis. Iptacopan (LNP023) is an oral, proximal complement inhibitor that specific…
View article: Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection
Design, cohort profile and comparison of the KTD-Innov study: a prospective multidimensional biomarker validation study in kidney allograft rejection Open
There is an unmet need for robust and clinically validated biomarkers of kidney allograft rejection. Here we present the KTD-Innov study (ClinicalTrials.gov, NCT03582436), an unselected deeply phenotyped cohort of kidney transplant recipie…
View article: Prevalence of anti-neutrophil cytoplasmic antibody-associated vasculitis in the south of France, using the capture-recapture method
Prevalence of anti-neutrophil cytoplasmic antibody-associated vasculitis in the south of France, using the capture-recapture method Open
Objectives This study aimed to estimate the prevalence of ANCA-associated vasculitis (AAV). That is, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), in Southe…
View article: Kidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort
Kidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort Open
AA amyloidosis is a severe and rare disease. Kidney involvement is frequent and leads to end-stage kidney disease. Because of the involvement of other organs, these patients are often frail, which has raised concerns about their suitabilit…
View article: Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy
Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy Open
Iptacopan resulted in statistically significant and clinically important reductions in UPCR and normalization of serum C3 levels in the native cohort and reduced C3 deposit scores in the recurrent KT cohort with favorable safety and tolera…
View article: Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN Open
Background C3 glomerulopathy and idiopathic immunoglobulin-mediated membranoproliferative GN (Ig-MPGN) are rare complement-mediated kidney diseases. Inherited forms of C3 glomerulopathy/Ig-MPGN are rarely described. Methods Three hundred n…
View article: #6894 KIDNEY TRANSPLANTATION IN PATIENTS WITH AA AMYLOIDOSIS: A FRENCH MULTI-CENTER MATCHED COHORT STUDY IN THE ERA OF BIOTHERAPIES
#6894 KIDNEY TRANSPLANTATION IN PATIENTS WITH AA AMYLOIDOSIS: A FRENCH MULTI-CENTER MATCHED COHORT STUDY IN THE ERA OF BIOTHERAPIES Open
Background and Aims Outcomes of kidney transplantation for patients with renal AA amyloidosis are uncertain, with reports of poor survival and high allograft recurrence. However, recent advances in biotherapies, especially anti-IL-1 treatm…
View article: Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study
Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study Open
Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with the three current main equations for measuring GFR in kidney transplant recipients. Design Develop…
View article: Atypical Hemolytic Uremic Syndrome in a Patient with Acute Promyelocytic Leukemia: A Case Report
Atypical Hemolytic Uremic Syndrome in a Patient with Acute Promyelocytic Leukemia: A Case Report Open
Introduction: Acute Promyelocytic Leukemia (APL) is highly associated with hemostasis alterations. The atypical hemolytic uremic syndrome (aHUS) is a rare type of Thrombotic Microangiopathy (TMA) due to an overactivation of the alternative…
View article: C5b-9 Glomerular Deposits Are Associated With Poor Renal Survival in Membranous Nephropathy
C5b-9 Glomerular Deposits Are Associated With Poor Renal Survival in Membranous Nephropathy Open
INTRODUCTION: Membranous nephropathy (MN) is the first cause of nephrotic syndrome in patients without diabetes. Its prognosis is variable, and treatment remains controversial because of potential toxicity. Currently, there is no reliable …
View article: Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure
Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure Open
View article: Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients
Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients Open
Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive d…
View article: A comprehensive assessment of long-term SARS-CoV-2–specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients
A comprehensive assessment of long-term SARS-CoV-2–specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients Open
View article: Skeletal Muscle Phenotype in Patients Undergoing Long-Term Hemodialysis Awaiting Kidney Transplantation
Skeletal Muscle Phenotype in Patients Undergoing Long-Term Hemodialysis Awaiting Kidney Transplantation Open
Background and objectives Age and comorbidity-related sarcopenia represent a main cause of muscle dysfunction in patients on long-term hemodialysis. However, recent findings suggest muscle abnormalities that are not associated with sarcope…