Mohammad Javan
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View article: Mesenchymal stem cells-derived exosomes and Kaempferol improve myelin repair via attenuating inflammation and oxidative stress in a cuprizone-induced demyelination model
Mesenchymal stem cells-derived exosomes and Kaempferol improve myelin repair via attenuating inflammation and oxidative stress in a cuprizone-induced demyelination model Open
View article: Co-administration of Naringin and NLRP3 Inhibitor Improves Myelin Repair and Mitigates Oxidative Stress in Cuprizone-Induced Demyelination Model
Co-administration of Naringin and NLRP3 Inhibitor Improves Myelin Repair and Mitigates Oxidative Stress in Cuprizone-Induced Demyelination Model Open
Background: Naringin and MCC950 as an inflammasome inhibitor have exhibited numerous pharmacological activities, including antioxidant and anti-inflammatory effects. The present study has examined the combined impacts of naringin and MCC95…
View article: Olfactory bulb stimulation mitigates Alzheimer's‐like disease progression
Olfactory bulb stimulation mitigates Alzheimer's‐like disease progression Open
Background Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer's disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD‐related chang…
View article: Acetyl-L-carnitine Improves Depressive-like Behaviors Through Nitric Oxide Modulation in the Cuprizone Intoxication Mouse Model of Multiple Sclerosis
Acetyl-L-carnitine Improves Depressive-like Behaviors Through Nitric Oxide Modulation in the Cuprizone Intoxication Mouse Model of Multiple Sclerosis Open
Background: Demyelination and inflammation are the most common pathobiological manifestations contributing to depression in multiple sclerosis (MS). Objectives: The current study aimed to evaluate the effects of acetyl-L-carnitine (ALC) in…
View article: Long‐term demyelination and aging‐associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis
Long‐term demyelination and aging‐associated changes in mice corpus callosum; evidence for the role of accelerated aging in remyelination failure in a mouse model of multiple sclerosis Open
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder affecting the central nervous system. Evidence suggests that age‐related neurodegeneration contributes to disability progression during the chronic stages of MS. …
View article: Olfactory bulb stimulation mitigates Alzheimer’s-like disease progression
Olfactory bulb stimulation mitigates Alzheimer’s-like disease progression Open
Background Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer’s disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD-related chang…
View article: Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease
Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease Open
Metformin decreased inflammatory cells and reactive astrocytes as well as the dying neurons in the hippocampus region and the cortex in SAD, and improved the cognitive performance.
View article: Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior
Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior Open
View article: The properties of long-term potentiation at SC-CA1/ TA-CA1 hippocampal synaptic pathways depends upon their input pathway activation patterns
The properties of long-term potentiation at SC-CA1/ TA-CA1 hippocampal synaptic pathways depends upon their input pathway activation patterns Open
View article: Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus
Electrical impulses evoked activity patterns in ventral tegmental area and locus coeruleus modulate endogenous and learning-dependent disparity of cell proliferation along the mouse dentate gyrus Open
This study aimed to examine the effects of the ventral tegmental area (VTA) and the locus coeruleus (LC) patterned electrical stimulation on hippocampal-dependent learning and hippocampal neurogenesis in adult mouse. For this, mice were gi…
View article: Deferiprone Promoted Remyelination and Functional Recovery through Enhancement of Oligodendrogenesis in Experimental Demyelination Animal Model
Deferiprone Promoted Remyelination and Functional Recovery through Enhancement of Oligodendrogenesis in Experimental Demyelination Animal Model Open
Remyelination refers to myelin regeneration, which reestablishes metabolic supports to axons. However, remyelination often fails in multiple sclerosis (MS), leading to chronic demyelination and axonal degeneration. Therefore, pharmacologic…
View article: The electrophysiological signature of dorsal hippocampus-basolateral amygdala circuit in anxiety-like behavior in the intrahippocampal kainic acid mice model of temporal lobe epilepsy: With emphasis on the impact of glycolysis inhibition
The electrophysiological signature of dorsal hippocampus-basolateral amygdala circuit in anxiety-like behavior in the intrahippocampal kainic acid mice model of temporal lobe epilepsy: With emphasis on the impact of glycolysis inhibition Open
Pharmacoresistant temporal lobe epilepsy affects millions of people around the world with uncontrolled seizures and comorbidities, like anxiety, being the most problematic aspects calling for novel therapeutic procedures. The intrahippocam…
View article: Targeted drug delivery into glial scar using CAQK peptide in a mouse model of multiple sclerosis
Targeted drug delivery into glial scar using CAQK peptide in a mouse model of multiple sclerosis Open
In multiple sclerosis, lesions are formed in various areas of the CNS, which are characterized by reactive gliosis, immune cell infiltration, extracellular matrix changes and demyelination. CAQK peptide (peptide sequence: cysteine–alanine–…
View article: Ferroptosis inhibition by deferiprone, attenuates myelin damage and promotes neuroprotection in demyelinated optic nerve
Ferroptosis inhibition by deferiprone, attenuates myelin damage and promotes neuroprotection in demyelinated optic nerve Open
Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal demyelination in the brain and spinal cord. Studies showed that iron released during the course of myelin breakdown exacerbates tissue damage, which is in agre…
View article: Cis-p-tau plays crucial role in lysolecithin-induced demyelination and subsequent axonopathy in mouse optic chiasm
Cis-p-tau plays crucial role in lysolecithin-induced demyelination and subsequent axonopathy in mouse optic chiasm Open
Multiple sclerosis (MS) is an autoimmune demyelinating disease that leads to axon degeneration as the major cause of everlasting neurological disability. The cis-phosphorylated tau (cis-p-tau) is an isoform of tau phosphorylated on threoni…
View article: Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model
Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer’s disease model Open
View article: Mouse Degenerating Optic Axons Survived by Human Embryonic Stem Cell-Derived Neural Progenitor Cells.
Mouse Degenerating Optic Axons Survived by Human Embryonic Stem Cell-Derived Neural Progenitor Cells. Open
Our study indicated that intravenous injection of NPCs could protect RGCs probably mediated by trophic factors. Due to this ability and good manufacturing practices (GMP) grade production feasibility, NPCs may be used for optic nerve prote…
View article: Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod
Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod Open
Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully utilized in the management of multiple sclerosis. The active metabolite, fingolimod-phosphate, acts on sphingosine-1-phosphate receptors (S1PRs) to bri…
View article: Multicasting in NOMA-Based UAV Networks: Path Design and Throughput Maximization
Multicasting in NOMA-Based UAV Networks: Path Design and Throughput Maximization Open
In this paper, we propose a new resource allocation framework for unmanned aerial vehicle (UAV) assisted multicast wireless networks in which the network users according to their request are divided into several multicast groups. We adopt …
View article: Enhancement of pharmaceuticals treatment on activated sludge process by magnetic activated carbon pretreatment system
Enhancement of pharmaceuticals treatment on activated sludge process by magnetic activated carbon pretreatment system Open
In this study, the effect of antibiotic wastewater containing 20 common pharmaceuticals (14 antibiotics and 6 non-steroidal anti-inflammatory drugs (NSAIDs)) individually as well as their combination was investigated on activatedsludge in …
View article: The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies
The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies Open
Despite the significant differences in pathological background of neurodegenerative diseases, epileptic seizures are a comorbidity in many disorders such as Huntington disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS). Re…
View article: Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits
Unconditioned and learned morphine tolerance influence hippocampal-dependent short-term memory and the subjacent expression of GABA-A receptor alpha subunits Open
Background ɣ-aminobutyric acid ( GABA ) facilitator valproic acid may be able to curb memory disruption induced by morphine exposure. Objective The effects of the GABA facilitator valproic acid on the behavioral tolerance induced by morphi…
View article: Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment
Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment Open
Alzheimer’s disease (AD) is one of the most devastating brain disorders. Currently, there are no effective treatments to stop the disease progression and it is becoming a major public health concern. Several risk factors are involved in th…
View article: Hotair and Malat1 Long Noncoding RNAs regulate Bdnf Expression and Oligodendrocyte Precursor Cells Differentiation
Hotair and Malat1 Long Noncoding RNAs regulate Bdnf Expression and Oligodendrocyte Precursor Cells Differentiation Open
BDNF has remarkable protective roles in the central nervous system to ensure neurons and glial cells survival and proper functions. The regulatory processes behind the BDNF expression have not been revealed completely. Here, it was explore…
View article: Fingolimod Regulates BDNF-AS and HOTAIR Expression in Multiple Sclerosis Patients
Fingolimod Regulates BDNF-AS and HOTAIR Expression in Multiple Sclerosis Patients Open
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is expressed by neurons and glial cells in the central nervous system (CNS). In the CNS, BDNF is responsible for neuroprotection and neurogenesis. Recent studie…
View article: Metformin Protects Myelin from Degeneration in A Mouse Model of Iysophosphatidylcholine-Induced Demyelination in The Optic Chiasm.
Metformin Protects Myelin from Degeneration in A Mouse Model of Iysophosphatidylcholine-Induced Demyelination in The Optic Chiasm. Open
Our findings suggest metformin for combination therapy for patients suffering from the myelin degenerative diseases, especially multiple sclerosis; however, additional mechanistic studies are required.
View article: Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats
Deep brain stimulation effects on learning, memory and glutamate and GABAA receptor subunit gene expression in kindled rats Open
Epileptic seizures are accompanied by learning and memory impairments. In this study, the effect of low frequency stimulation (LFS) on spatial learning and memory was assessed in kindled animals and followed for one month. Fully kindled ra…
View article: Inhibition of Rho-kinase improves response to deep inspiration in ovalbumin-sensitized guinea pigs.
Inhibition of Rho-kinase improves response to deep inspiration in ovalbumin-sensitized guinea pigs. Open
We propose that alteration of Rho-kinase signaling pathway may be one of the mechanisms underlying the impairment of DI-induced bronchodilation in OVA-sensitized guinea pigs.
View article: A Unified Framework for Joint Energy and AoI Optimization via Deep\n Reinforcement Learning for NOMA MEC-based Networks
A Unified Framework for Joint Energy and AoI Optimization via Deep\n Reinforcement Learning for NOMA MEC-based Networks Open
In this paper, we design a novel scheduling and resource allocation algorithm\nfor a smart mobile edge computing (MEC) assisted radio access network.\nDifferent from previous energy efficiency (EE) based or the average age of\ninformation …
View article: The Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways
The Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways Open
Background Generation of oligodendrocytes is a sophisticated multistep process, the mechanistic underpinnings of which are not fully understood and demand further investigation. To systematically profile proteome dynamics during human embr…