Mohamed A. Dkhil
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View article: Antibacterial activity of Krameria lappacea root extract against gram-positive and gram-negative bacteria and its cytotoxicity on lung and breast cancer cell lines
Antibacterial activity of Krameria lappacea root extract against gram-positive and gram-negative bacteria and its cytotoxicity on lung and breast cancer cell lines Open
Introduction The rise of antibiotic-resistant microbes has diminished antibiotic effectiveness, leading to the exploration of alternatives. Krameria lappacea has been used traditionally for various ailments. This study evaluates the in vit…
View article: Multi-target approach of Egyptian leek extract in ameliorating depressive-like behavior in rats exposed to chronic unpredictable mild stress
Multi-target approach of Egyptian leek extract in ameliorating depressive-like behavior in rats exposed to chronic unpredictable mild stress Open
Introduction Depression is a widespread and debilitating disorder with a complex etiology involving oxidative stress, neuroinflammation, and apoptosis. Given the limitations of current treatments, there is an urgent need for alternative th…
View article: Krameria lappacea roots extract to rescue coccidiosis-mediated inflammation in the jejunum of C57BL/6 mice
Krameria lappacea roots extract to rescue coccidiosis-mediated inflammation in the jejunum of C57BL/6 mice Open
Introduction Coccidiosis is a protozoan disease caused by Eimeria species, which multiply in the intestinal tract and lead to severe inflammatory responses. While coccidiostats are available for control, resistance to these treatments has …
View article: Biosynthesized Zinc Oxide Nanoparticles Regulating Immune Response and Liver Enzymes in Reducing Inflammation from Cryptosporidiosis-induced Infection
Biosynthesized Zinc Oxide Nanoparticles Regulating Immune Response and Liver Enzymes in Reducing Inflammation from Cryptosporidiosis-induced Infection Open
Background: Cryptosporidium, a global intestinal protozoan parasite, induces mild to severe diarrhea in several vertebrate hosts, potentially resulting in life-threatening sickness. This study aimed to assess the efficacy of biosynthesized…
View article: Effectiveness of Biosynthesized Zinc Oxide Nanoparticles Derived From <i>Coriandrum sativum</i>: A Novel Nanomedicine Strategy Against Coccidiosis
Effectiveness of Biosynthesized Zinc Oxide Nanoparticles Derived From <i>Coriandrum sativum</i>: A Novel Nanomedicine Strategy Against Coccidiosis Open
Nanomedicine has emerged as a promising solution for treating various diseases. This study inspected the in vivo anticoccidial efficacy of biosynthesized zinc oxide nanoparticles (Bio‐ZnNPs) from Coriandrum sativum leaves in mice infected …
View article: Unexpected Efficacy of Albumin-Bound Glycerol Monolaurate Against Multidrug-Resistant Bacterial Isolates: A Time-Kill Assay Study
Unexpected Efficacy of Albumin-Bound Glycerol Monolaurate Against Multidrug-Resistant Bacterial Isolates: A Time-Kill Assay Study Open
Current findings suggest that HSA-bound GML could be developed as a novel broad-spectrum antimicrobial agent targeting multidrug-resistant pathogens. Future research should focus on formulation optimization, in vivo efficacy studies, and p…
View article: Utilizing coriander as a natural remedy for combating <i>Eimeria papillata</i> infection and oxidative stress in mice
Utilizing coriander as a natural remedy for combating <i>Eimeria papillata</i> infection and oxidative stress in mice Open
Coccidiosis, an intestinal disease caused by Eimeria spp., poses significant economic challenges globally, primarily due to the development of drug resistance from the prolonged use of anticoccidial medications. The recent use of botanical…
View article: Biochemical insights into the anthelmintic and anti-inflammatory potential of sea cucumber extract: <i>In vitro</i> and <i>in silico</i> approaches
Biochemical insights into the anthelmintic and anti-inflammatory potential of sea cucumber extract: <i>In vitro</i> and <i>in silico</i> approaches Open
Helminthiasis is a global parasitic disease, and current anthelmintics like albendazole are costly, toxic, and increasingly ineffective due to resistance. Marine organisms, such as Holothuria polii , rich in bioactive compounds, are emergi…
View article: Juglone’s apoptotic impact against eimeriosis-induced infection: a bioinformatics, <i>in-silico</i> , and <i>in vivo</i> approach
Juglone’s apoptotic impact against eimeriosis-induced infection: a bioinformatics, <i>in-silico</i> , and <i>in vivo</i> approach Open
Coccidiosis, induced by Eimeria spp., substantially affects gastrointestinal health and results in economic detriments. This research examined juglone (5-hydroxy-1,4-naphthoquinone), a phenolic chemical, as a prospective in-silico and in v…
View article: Assessment of sperm DNA integrity and ICSI outcome after sperm cryopreservation
Assessment of sperm DNA integrity and ICSI outcome after sperm cryopreservation Open
The association between suboptimal sperm parameters and DNA damage in mature spermatozoa indicates that some individuals may have intrinsic issues with spermatogenesis. The objective of this study is to evaluate the impact of cryopreservat…
View article: Cellulose Nanocrystals as a Drug Delivery System to Improve the Efficiency of Nitazoxanide against Cryptosporidium parvum Infected Mice
Cellulose Nanocrystals as a Drug Delivery System to Improve the Efficiency of Nitazoxanide against Cryptosporidium parvum Infected Mice Open
Background: Cryptosporidiosis poses several health risks, particularly due to its potential severity and the populations it can affect. Comprehending these hazards is crucial for efficient prevention and treatment. This study was to invest…
View article: Cassia alata Extract Exerts Antioxidant Power to Mitigate Eimeria papillata-Induced Liver Damage in Mice
Cassia alata Extract Exerts Antioxidant Power to Mitigate Eimeria papillata-Induced Liver Damage in Mice Open
Background: This study was intended to investigate the prospective role of Cassia alata extract as an anticoccidial, anti-inflammatory and hepatoprotective agent against Eimeria papillata parasitic infection. Therefore, this study was inte…
View article: Holothuria polii Extract as a Potential Anticoccidial Agent: Evidence of Its MUC2 Regulatory Impact in Murine Jejunum
Holothuria polii Extract as a Potential Anticoccidial Agent: Evidence of Its MUC2 Regulatory Impact in Murine Jejunum Open
Eimeria is a parasite that causes coccidiosis in a variety of animals, leading to nutritional imbalances, issues with food digestion and absorption, low weight, and intestinal inflammation of varying degrees in its hosts. Anticoccidial med…
View article: Fighting eimeriosis by using the anti-eimerial and anti-apoptotic properties of rhatany root extract
Fighting eimeriosis by using the anti-eimerial and anti-apoptotic properties of rhatany root extract Open
Background Over the last decade, extensive use of coccidiostats to treat and control Eimeria infection has developed drug resistance, prompting the search for new alternative therapies. Rhatany is proven to have various pharmacological pro…
View article: Ameliorative effect of aqueous avocado seed extract against chromium‐induced oxidative stress and cellular damage in rabbit kidney
Ameliorative effect of aqueous avocado seed extract against chromium‐induced oxidative stress and cellular damage in rabbit kidney Open
The accumulation of chromium in renal tissues promotes the generation of reactive oxygen species (ROS), leading to oxidative stress, genomic and cellular harm, and ultimately necrotic and apoptotic cell death induced by free radicals. Henc…
View article: Krameria lappacea root extract’s anticoccidial properties and coordinated control of CD4 T cells for IL-10 production and antioxidant monitoring
Krameria lappacea root extract’s anticoccidial properties and coordinated control of CD4 T cells for IL-10 production and antioxidant monitoring Open
Introduction Recently, the use of botanicals as an alternative to coccidiostats has been an appealing approach for controlling coccidiosis. Therefore, this study was conducted to evaluate the potential role of aqueous methanolic extract (2…
View article: Comparative Study on the Kidneys of Ptychadena mascarenensis and Chalcides ocellatus ocellatus in Relation to Their Environment
Comparative Study on the Kidneys of Ptychadena mascarenensis and Chalcides ocellatus ocellatus in Relation to Their Environment Open
Background: The kidneys manage body fluids and electrolytes in addition to performing osmoregulation and metabolic waste disposal. The goal of the present study was to investigate the structural characteristics of the kidneys of two tetrap…
View article: Therapeutic Strategies against Trypanosomiasis
Therapeutic Strategies against Trypanosomiasis Open
Trypanosoma evansi, an extracellular protozoan parasite, causes camel trypanosomiasis, also known as “surra”. The parasite, which can be found in camels, dromedaries, horses, and other Equidae family members, can cause 3% mortality and up …
View article: Zeolite abrogates cadmium-induced testicular damage in rats: implication of NF-κB/ TNF-α/IL-1β Pathway
Zeolite abrogates cadmium-induced testicular damage in rats: implication of NF-κB/ TNF-α/IL-1β Pathway Open
Cadmium (Cd) is an environmental pollutant affecting various tissues and organs, including the testis. Many studies demonstrated that Cd toxicity causes testicular impairment through oxidative stress and inflammatory action. Therefore, thi…
View article: Title: The ameliorative role of Camellia sinensis extract against spleenʼs extra-medullary hematopoiesis in acute myeloproliferative disorder model in rats: Histopathological study
Title: The ameliorative role of Camellia sinensis extract against spleenʼs extra-medullary hematopoiesis in acute myeloproliferative disorder model in rats: Histopathological study Open
Leukemia represents a kind of malignancy that affects the bone marrow and blood, resulting in un-controlled proliferation of abnormal leucocytes. Cyclophosphamide (CP) chemotherapy has a number of side effects, including liver toxicity and…
View article: Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection
Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection Open
View article: Nephroprotective Efficacy of <i>Echinops spinosus</i> against a Glycerol-Induced Acute Kidney Injury Model
Nephroprotective Efficacy of <i>Echinops spinosus</i> against a Glycerol-Induced Acute Kidney Injury Model Open
Nephroprotection or renal rescue is to revive and restore kidney function after damage, with no need for further dialysis. During acute kidney injury (AKI), sudden and recent reductions in kidney functions occur. Causes are multiple, and p…
View article: Hemoglobin E Prevalence among People Residing in Malaria Areas
Hemoglobin E Prevalence among People Residing in Malaria Areas Open
Background: Malaria can infect erythrocytes and hence cause different pathogenesis episodes leading to death mostly in pregnant women and children under the age of 5 years. The selective pressure of these parasites leads to the production …
View article: Morphological and molecular phylogenetic analyses of the apicomplexan parasites, Eimeria media and Eimeria stiedai, infecting the domestic rabbits, Oryctolagus cuniculus
Morphological and molecular phylogenetic analyses of the apicomplexan parasites, Eimeria media and Eimeria stiedai, infecting the domestic rabbits, Oryctolagus cuniculus Open
The eimerian infection is one of the most serious infections that can decrease rabbit productivity since it can lead to serious diseases. There is little information about Eimeria media and Eimeria stiedai infections in Saudi Arabia, and m…
View article: Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats
Histological and ultrastructural studies on the effect of Cassia alata methanolic leaf extracts against chemically induced lung adenocarcinoma in rats Open
The present work aims to evaluate anticancer performance of Cassia alata methanolic leaf extracts (CMLE) in ethyl carbamate-stimulated lung adenocarcinoma (LAD) in differentiation to the function of Cisplatin (CIPL). Rats were divided into…
View article: Blood Biomarkers of Neonatal Sepsis with Special Emphasis on the Monocyte Distribution Width Value as an Early Sepsis Index
Blood Biomarkers of Neonatal Sepsis with Special Emphasis on the Monocyte Distribution Width Value as an Early Sepsis Index Open
Background and Objectives: Early detection of neonatal sepsis is critical because it is potentially fatal. Therefore, sepsis biomarkers of sufficient sensitivity and specificity are needed. This study aimed to evaluate the utility of perip…
View article: Biosynthesized Nanosilver from Ginger Extract Exhibits Antioxidant and Hepatic Responses during <i>Eimeria papillata</i> Infection
Biosynthesized Nanosilver from Ginger Extract Exhibits Antioxidant and Hepatic Responses during <i>Eimeria papillata</i> Infection Open
Although several anticoccidial medications have long been used to prevent coccidiosis, their adverse effects necessitate the use of alternative control methods. In this study, Eimeria papillate was used to infect the mouse jejunum, …
View article: Assessment of Circulating lncRNA H19 in Ankylosing Spondylitis Patients and Its Correlation with Disease Activity
Assessment of Circulating lncRNA H19 in Ankylosing Spondylitis Patients and Its Correlation with Disease Activity Open
Ankylosing spondylitis (AS) is a chronic inflammatory disease that results in severe pain and stiffness in the joints. The causes and pathophysiology of AS are still largely unknown. The lncRNA H19 plays key roles in the pathogenesis of AS…
View article: Lung response to propolis treatment during experimentally induced lung adenocarcinoma
Lung response to propolis treatment during experimentally induced lung adenocarcinoma Open
Propolis is a natural agent produced by honeybees from several botanical sources. The purpose of our study is to evaluate the antitumor effect of propolis extract (PE) against urethane-induced lung cancer compared to Cisplatin (CIS) in rat…
View article: Role of Punica granatum-derived nanosilver in helminth protection
Role of Punica granatum-derived nanosilver in helminth protection Open
Pomegranate is a long-known edible fruit with medicinal properties. Helminth infections are among the most common human illnesses worldwide, due to a lack of suitable sanitary systems and safe drinking water sources. Although these illness…