Mohamed A. El‐Tayeb
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View article: Exploration of African natural products as VP35 inhibitors to combat Marburg virus infection: Molecular docking, molecular dynamics, and quantum mechanical computations
Exploration of African natural products as VP35 inhibitors to combat Marburg virus infection: Molecular docking, molecular dynamics, and quantum mechanical computations Open
Marburg virus (MBV) is a highly lethal filovirus responsible for hemorrhagic fever with case fatality rates of up to 88%. MBV was first recognized in 1967 during simultaneous outbreaks in Marburg and Frankfurt, Germany, and Belgrade, then …
View article: Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study
Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study Open
Ebola virus (EBOV), one of the deadliest diseases, is responsible for infecting individuals with hemorrhagic fever syndrome, which remains an ongoing worldwide health concern. The extremely deadly nature and virulence of EBOV illness illum…
View article: Targeting Metastasis: Exploring the Impact of Microbial Infections on Cancer Progression Through Innovative Biological Models
Targeting Metastasis: Exploring the Impact of Microbial Infections on Cancer Progression Through Innovative Biological Models Open
Infectious diseases, particularly viral infections, pose a significant threat to human health by contributing to cancer progression and metastasis. This review presents a novel perspective on how advanced biological models such as organoid…
View article: Microbial transformation of sewage sludge to biolipid-based fuel using potential oleaginous bacteria Streptomyces sp.
Microbial transformation of sewage sludge to biolipid-based fuel using potential oleaginous bacteria Streptomyces sp. Open
Introduction The high proportion of sludge generation worldwide has sparked interest in utilizing it for alternative purposes. Among different potential applications, using sludge as a substrate for oleaginous bacteria is a relatively nove…
View article: Novel Erodium glaucophyllum (L.) Aiton growing in arid environment: Phytochemical characterization, antimicrobial, antioxidant, and anticancer potential
Novel Erodium glaucophyllum (L.) Aiton growing in arid environment: Phytochemical characterization, antimicrobial, antioxidant, and anticancer potential Open
Background: The misuse of antimicrobial agents resulted in a global serious health concern, namely antimicrobial resistance. Also, traditional bioactive compounds are associated with undesirable adverse effects. This study aimed to first a…
View article: Prevalence of Drug-Resistant Nosocomial Pathogenic Bacterial Strains Isolated from Mobile Phones: A Cross-Sectional Study Between Microbiology Students and Other Disciplines
Prevalence of Drug-Resistant Nosocomial Pathogenic Bacterial Strains Isolated from Mobile Phones: A Cross-Sectional Study Between Microbiology Students and Other Disciplines Open
The widespread use of mobile phones in daily human transactions, especially those related to the medical field, leads to the spread of microbes among different communities. The microbiology student’s mobile phones could harbour various dru…
View article: Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies
Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies Open
Sesamol (SEL) is 3,4-methylenedioxyphenol isolated from sesame seeds. This study aimed to evaluate the antiemetic activity of SEL, supported by in vivo and in silico studies. Further, molecular docking was carried out to understand the mol…
View article: Molecular characterization of putative antibiotic resistance determinant and virulence factors genes of Acinetobacter baumannii strains isolated from intensive care unit patients in Riyadh, Saudi Arabia
Molecular characterization of putative antibiotic resistance determinant and virulence factors genes of Acinetobacter baumannii strains isolated from intensive care unit patients in Riyadh, Saudi Arabia Open
The study showed a strong relationship between virulence factors, especially biofilm formation, and antibiotic resistance.
View article: Exploring the multifaceted bioactivities of silver nanoparticles synthesized from red algae Hypnea pannosa: Antimicrobial, antibiofilm, and insecticidal potentials
Exploring the multifaceted bioactivities of silver nanoparticles synthesized from red algae Hypnea pannosa: Antimicrobial, antibiofilm, and insecticidal potentials Open
Background: The emergence of microbial resistance to conventional antibiotics and the environmental impact of chemical pesticides necessitates the search for alternative and sustainable solutions. This study explores the utilization of the…
View article: Exploring the Adsorption Features of Furan and 1,<i>n</i>‐Dioxane as Environmental Toxins on Two‐Dimensional RuC Nanosheet: A DFT Study
Exploring the Adsorption Features of Furan and 1,<i>n</i>‐Dioxane as Environmental Toxins on Two‐Dimensional RuC Nanosheet: A DFT Study Open
The potential of the two‐dimensional ruthenium carbide (RuC) nanosheet to detect highly toxic environmental compounds – namely, Furan (Fur) and 1, n ‐Dioxane (1, n ‐Diox) – was investigated utilizing the density functional theory (DFT) app…
View article: Protective Effects of Olive Leaf Extract as a Natural Growth Promoter and Immune Modulator in Broilers Challenged with Velogenic Newcastle Disease Virus
Protective Effects of Olive Leaf Extract as a Natural Growth Promoter and Immune Modulator in Broilers Challenged with Velogenic Newcastle Disease Virus Open
Newcastle disease (ND) is a serious menace to poultry production and requires stringent measures to enhance growth and improve resistance against viral challenges in infected flocks. In the present study, the immunostimulatory and growth-p…
View article: Benzothiazinone analogs as Anti-Mycobacterium tuberculosis DprE1 irreversible inhibitors: Covalent docking, validation, and molecular dynamics simulations
Benzothiazinone analogs as Anti-Mycobacterium tuberculosis DprE1 irreversible inhibitors: Covalent docking, validation, and molecular dynamics simulations Open
Mycobacterium tuberculosis is a lethal human pathogen, with the key flavoenzyme for catalyzing bacterial cell-wall biosynthesis, decaprenylphosphoryl-D-ribose oxidase (DprE1), considered an Achilles heal for tuberculosis (TB) progression. …
View article: A DFT investigation on the potential of beryllium oxide (Be12O12) as a nanocarrier for nucleobases
A DFT investigation on the potential of beryllium oxide (Be12O12) as a nanocarrier for nucleobases Open
The study of the interactions between biomolecules and nanostructures is quite fascinating. Herein, the adsorption propensity of beryllium oxide (Be 12 O 12 ) nanocarrier toward nucleobases (NBs) was investigated. In terms of DFT calculati…
View article: Immobilization of Silver Nanoparticles with Defensive Gum of Moringa oleifera for Antibacterial Efficacy Against Resistant Bacterial Species from Human Infections
Immobilization of Silver Nanoparticles with Defensive Gum of Moringa oleifera for Antibacterial Efficacy Against Resistant Bacterial Species from Human Infections Open
Background: The worldwide misuse of antibiotics is one of the main factors in microbial resistance that is a serious threat worldwide. Alternative strategies are needed to overcome this issue. Objectives: In this study, a novel strategy wa…
View article: Repurposing of drug candidates against Epstein–Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study
Repurposing of drug candidates against Epstein–Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study Open
Epstein–Barr virus (EBV) was the first tumor virus identified in humans, and it is mostly linked to lymphomas and cancers of epithelial cells. Nevertheless, there is no FDA-licensed drug feasible for this ubiquitous EBV viral contagion. EB…
View article: The dwarf & pale leaf mutation reduces chloroplast numbers, resulting in sugar depletion that inhibits leaf growth of maize seedlings
The dwarf & pale leaf mutation reduces chloroplast numbers, resulting in sugar depletion that inhibits leaf growth of maize seedlings Open
Plant growth is ultimately driven by cell division and expansion, but how these processes are regulated to mediate a wide range of genotypic variation in organ size is still poorly understood. To address this, we screened an EMS maize muta…
View article: On the Versatility of the <i>sp</i>-, <i>sp</i><sup>2</sup>-, and <i>sp</i><sup>3</sup>-Hybridized Chalcogen-Bearing Molecules To Engage in Type I Chalcogen···Chalcogen Interactions: A Quantum Mechanical Investigation of Like···Like and Unlike Complexes
On the Versatility of the <i>sp</i>-, <i>sp</i><sup>2</sup>-, and <i>sp</i><sup>3</sup>-Hybridized Chalcogen-Bearing Molecules To Engage in Type I Chalcogen···Chalcogen Interactions: A Quantum Mechanical Investigation of Like···Like and Unlike Complexes Open
The predilection of sp-, sp 2-, and sp 3-hybridized chalcogen-bearing molecules to engage in type I chalcogen···chalcogen interactions was comparatively unveiled in like···like/unlike CY···YC, YCY…
View article: Antibacterial and anticancer potential of bioactive compounds and secondary metabolites of endophytic fungi isolated from Anethum graveolens
Antibacterial and anticancer potential of bioactive compounds and secondary metabolites of endophytic fungi isolated from Anethum graveolens Open
Fungal endophytes are known to produce bioactive chemicals and secondary metabolites that are often identical to those produced by their host plants. The main objective of the current study was to isolate and identify endophytic fungi asso…
View article: Elucidating the potential of bimetallic mixed metal oxide (FeO/NiO) in fusion with pristine and N- and S-doped graphene oxide for biomedical applications
Elucidating the potential of bimetallic mixed metal oxide (FeO/NiO) in fusion with pristine and N- and S-doped graphene oxide for biomedical applications Open
Antimicrobial resistance is attributed to acquiring new mechanisms by microbes to combat antimicrobial agents, highlighting the necessity to discover new antimicrobial agents to protect human health. Graphene and its derivatives have shown…
View article: Spectral indices with different spatial resolutions in recognizing soybean phenology
Spectral indices with different spatial resolutions in recognizing soybean phenology Open
The aim of the present research was to evaluate the efficiency of different vegetation indices (VI) obtained from satellites with varying spatial resolutions in discriminating the phenological stages of soybean crops. The experiment was ca…
View article: Chemical composition and antimicrobial investigation of the essential oil isolated from <i>Montanoa bipinnatifida</i> (Kunth) K. Koch leaves
Chemical composition and antimicrobial investigation of the essential oil isolated from <i>Montanoa bipinnatifida</i> (Kunth) K. Koch leaves Open
Montanoa bipinnatifida is a perennial shrub belonging to family Asteraceae and geographically distributed in Mexico, Central America and Northern South America. This study aimed to investigate the chemical composition of the essenti…
View article: Comparative Analysis of Dosimetry: IMRT versus 3DCRT in Left-Sided Breast Cancer Patients with Considering Some Organs in Out - of – Field Borders
Comparative Analysis of Dosimetry: IMRT versus 3DCRT in Left-Sided Breast Cancer Patients with Considering Some Organs in Out - of – Field Borders Open
The DVH parameters were subjected to a comparative analysis, focusing on the doses absorbed by both Organs at Risk (OARs) and the Planning Target Volume (PTV). The findings suggest that low doses in IMRT plan might raise the risk of advers…
View article: Antimicrobial characteristics of endophytic Aspergillus terreus and acute oral toxicity analysis
Antimicrobial characteristics of endophytic Aspergillus terreus and acute oral toxicity analysis Open
Background: Endophytic fungi produce biologically robust metabolites suitable for diverse applications, which support the increasing exploration of these fungi. The study aimed to investigate the in vitro antimicrobial properties of the me…
View article: Naturally Occurring Plant‐Based Anticancerous Candidates as Potential ERK2 Inhibitors: <i>In‐Silico</i> Database Mining and Molecular Dynamics Simulations
Naturally Occurring Plant‐Based Anticancerous Candidates as Potential ERK2 Inhibitors: <i>In‐Silico</i> Database Mining and Molecular Dynamics Simulations Open
The evolutionarily conserved extracellular signal‐regulated kinase 2 (ERK2) is involved in regulating cellular signaling in both normal and pathological conditions. ERK2 expression is critical for human development, while hyperactivation i…
View article: Assessing anticancer, antidiabetic, and antioxidant capacities in green-synthesized zinc oxide nanoparticles and solvent-based plant extracts
Assessing anticancer, antidiabetic, and antioxidant capacities in green-synthesized zinc oxide nanoparticles and solvent-based plant extracts Open
Cancer and diabetes represent significant challenges in the field of biomedicine, with major and global impacts on public health. Acacia nilotica, commonly called 'gum arabic tree,' is recognized for its unique biomedical properties…
View article: Influences of Vegetation Rehabilitation on Soil Infiltrability and Root Morphological Characteristics in Coastal Saline Soil
Influences of Vegetation Rehabilitation on Soil Infiltrability and Root Morphological Characteristics in Coastal Saline Soil Open
Soil’s hydraulic properties are an essential characteristic that influences the hydrologic cycle by influencing infiltration and runoff and the transport of soil water and salt in the process of vegetation rehabilitation in coastal saline …
View article: Phytochemicals, Antioxidant, and Antidiabetic Effects of <i>Ranunculus hirtellus</i> Aerial Parts and Roots: Methanol and Aqueous Extracts
Phytochemicals, Antioxidant, and Antidiabetic Effects of <i>Ranunculus hirtellus</i> Aerial Parts and Roots: Methanol and Aqueous Extracts Open
Ranunculus hirtellus, also known as crowfoot (buttercup), has a rich tradition of use in various biological contexts. While antibacterial studies on extracts from this plant have been conducted, the phytochemical composition, antiox…
View article: Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway
Hesperidin - loaded PVA/alginate hydrogel: targeting NFκB/iNOS/COX-2/TNF-α inflammatory signaling pathway Open
Introduction Skin injuries represent a prevalent form of physical trauma, necessitating effective therapeutic strategies to expedite the wound healing process. Hesperidin, a bioflavonoid naturally occurring in citrus fruits, exhibits a ran…
View article: Microenvironment created by Plantago lagopus L. may affect cover and diversity of coexisting species in urban vegetation
Microenvironment created by Plantago lagopus L. may affect cover and diversity of coexisting species in urban vegetation Open
Some plant species may exhibit new microenvironments which lead to significant changes in the cover and diversity of the coexisting species. In this investigation, we evaluated the effects of Plantago lagopus L. on the cover and div…
View article: Targeting the NF-κB p65/Bcl-2 signaling pathway in hepatic cellular carcinoma using radiation assisted synthesis of zinc nanoparticles coated with naturally isolated gallic acid
Targeting the NF-κB p65/Bcl-2 signaling pathway in hepatic cellular carcinoma using radiation assisted synthesis of zinc nanoparticles coated with naturally isolated gallic acid Open
The data imply that Zn-GANPs may prevent and treat DEN-induced liver damage and carcinogenesis.