Marawan A. Elbaset
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View article: Linagliptin Attenuates Kidney Cancer in Rats via AMPK Activation and Suppression of YAP/TAZ/HIF-1α Signaling
Linagliptin Attenuates Kidney Cancer in Rats via AMPK Activation and Suppression of YAP/TAZ/HIF-1α Signaling Open
View article: Dielectric Spectroscopy as a Novel Diagnostic and Therapeutic Monitoring Tool in Apigenin-Mediated Reversal of Obesity-Associated Hepatic Dysfunction
Dielectric Spectroscopy as a Novel Diagnostic and Therapeutic Monitoring Tool in Apigenin-Mediated Reversal of Obesity-Associated Hepatic Dysfunction Open
Background Apigenin (APG), a natural flavonoid, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, and metabolic regulatory effects. This study investigated the therapeutic potential of APG in ameliorati…
View article: Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation
Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation Open
A novel class of antidiabetic drugs known as sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) prevents the renal proximal tubules from reabsorbing glucose. While a recent study showed that SGLT2-Is may be able to slow the proliferation…
View article: Role of rosuvastatin and pitavastatin in alleviating diabetic cardiomyopathy in rats: Targeting of RISK, NF-κB/ NLRP3 inflammasome and TLR4/ NF-κB signaling cascades
Role of rosuvastatin and pitavastatin in alleviating diabetic cardiomyopathy in rats: Targeting of RISK, NF-κB/ NLRP3 inflammasome and TLR4/ NF-κB signaling cascades Open
Diabetic cardiomyopathy (DCM) is a serious outcome of type II diabetes mellitus (T2DM) and a key contributor to high morbidity and death in diabetic individuals. The current research is intended to elucidate and compare the therapeutic ben…
View article: Repositioning gemigliptin for the alleviation of thioacetamide-induced liver fibrosis in rats: Targeting TLR4/MAPK, SIRT1/AMPK/Nrf2, PI3K/AKT/mTOR axis and apoptosis
Repositioning gemigliptin for the alleviation of thioacetamide-induced liver fibrosis in rats: Targeting TLR4/MAPK, SIRT1/AMPK/Nrf2, PI3K/AKT/mTOR axis and apoptosis Open
There are currently few effective treatments for hepatic fibrogenesis, a prominent pathogenic characteristic of chronic liver disorders. Although dipeptidyl peptidase-4 (DPP4) inhibitors are commonly used as antidiabetic medications, which…
View article: Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies
Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies Open
Background Paracetamol overdose causes severe hepatotoxicity. Sonchus oleraceus is traditionally used to treat liver disorders, but its potential against paracetamol-induced liver injury is unexplored. This work aimed to investigate the pr…
View article: Astaxanthin mitigates diabetic cardiomyopathy and nephropathy in HF/HFr/STZ diabetic rats via modulating NOX4, fractalkine, Nrf2, and AP-1 pathways
Astaxanthin mitigates diabetic cardiomyopathy and nephropathy in HF/HFr/STZ diabetic rats via modulating NOX4, fractalkine, Nrf2, and AP-1 pathways Open
View article: Protective role of remogliflozin against experimental liver fibrosis by activating AMPK/SIRT1/Nrf2 and suppressing NF-κB pathways
Protective role of remogliflozin against experimental liver fibrosis by activating AMPK/SIRT1/Nrf2 and suppressing NF-κB pathways Open
Liver fibrosis is considered an epidemic health problem since it can lead to several insults that can be fatal. Remogliflozin (Remo), an inhibitor of the sodium–glucose cotransporter 2 (SGLT2) protein, is one of the most recently developed…
View article: Therapeutic efficacy of canagliflozin against hepatocarcinogenesis induced by CDD/DEN/TAA in a rat model: regulation of AMPK/HIF-1α/YAP-1/TAZ signaling pathways
Therapeutic efficacy of canagliflozin against hepatocarcinogenesis induced by CDD/DEN/TAA in a rat model: regulation of AMPK/HIF-1α/YAP-1/TAZ signaling pathways Open
View article: Unveiling the potency of ZnO and CuO nanocomposites in combating hepatocellular carcinoma by inducing cell death and suppressing migration
Unveiling the potency of ZnO and CuO nanocomposites in combating hepatocellular carcinoma by inducing cell death and suppressing migration Open
Human hepatocellular carcinoma (HCC) is recognized as one of the leading causes of death globally and is resistant to several anticancer drugs. As a result, it is critical to identify more effective druggable therapies. Metal oxide nanopar…
View article: Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats
Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats Open
Olanzapine, an atypical antipsychotic drug, is used to treat psychological diseases. However, it’s use carries common side effects. Those include weight gain, dyslipidemia, elevated glucose levels, and disrupted oxidative balance. We aimed…
View article: Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats
Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats Open
View article: Chrysin mitigates cyclophosphamide-triggered cardiotoxicity in rats: Insights into cardioprotection via Treg expression modulation and iNOS downregulation
Chrysin mitigates cyclophosphamide-triggered cardiotoxicity in rats: Insights into cardioprotection via Treg expression modulation and iNOS downregulation Open
Cyclophosphamide (CP) is a potent chemotherapeutic agent widely used in cancer treatment; however, its clinical efficacy is limited by severe cardiotoxic side effects. This study aimed to evaluate the cardioprotective effects of chrysin, a…
View article: Tephrosia purpurea, with (-)-Pseudosemiglabrin as the Major Constituent, Alleviates Severe Acute Pancreatitis-Mediated Acute Lung Injury by Modulating HMGB1 and IL-22
Tephrosia purpurea, with (-)-Pseudosemiglabrin as the Major Constituent, Alleviates Severe Acute Pancreatitis-Mediated Acute Lung Injury by Modulating HMGB1 and IL-22 Open
Ischemia-reperfusion (IR) injury is a major cause of multiple organ failure. The purpose of this study was to look into the role of Tephrosia purpurea (TEP) and its active constituent pseudosemiglabrin (PS) in alleviating severe acute panc…
View article: Effect of Effervescent Formulation of Silymarin against Experimental Hepatotoxicity in Rats: Involvement of NRF2/HO-1, PI3K/AKT and TLR4/NFκB Pathways
Effect of Effervescent Formulation of Silymarin against Experimental Hepatotoxicity in Rats: Involvement of NRF2/HO-1, PI3K/AKT and TLR4/NFκB Pathways Open
Despite the exploration of pharmaceutical and natural liver-protecting drugs, the number of hepatotoxicity deaths continues to rise. Milk thistle flavonoids, silymarin, have been widely investigated and demonstrated liver disease protectio…
View article: Management of cardiovascular disease by cerium oxide nanoparticles via alleviating oxidative stress and adipokine abnormalities
Management of cardiovascular disease by cerium oxide nanoparticles via alleviating oxidative stress and adipokine abnormalities Open
View article: Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment
Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment Open
Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelator…
View article: Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage
Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage Open
Sepsis, the most common cause of acute kidney injury, remains a major socioeconomic burden. A dysregulated immune response leads to progressive organ dysfunction. Although numerous inflammatory pathways were described, most are still vague…
View article: Tephrosia purpurea and (-)-Pseudosemiglabrin the Major Constituent; Alleviate Severe Acute Pancreatitis-Mediated Acute Lung Injury by Modulating HMGB1 and IL-22
Tephrosia purpurea and (-)-Pseudosemiglabrin the Major Constituent; Alleviate Severe Acute Pancreatitis-Mediated Acute Lung Injury by Modulating HMGB1 and IL-22 Open
Ischemia-reperfusion (IR) injury is a major cause of multiple organ failure. The purpose of this study was to look into the role of Tephrosia purpurea (TEP) and its active constituent pseudosemiglabrin (PS) in allevi-ating severe acute pan…
View article: Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis
Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis Open
This study evaluated the beneficial effects of chrysin against cyclophosphamide (CP)-induced testicular toxicity in rats across several parameters, including hormones, oxidative stress, inflammation, apoptosis, and protein expression. Rats…
View article: Efficacy of goldenberry in improving obesity-induced hemoglobin conformational structure changes in wistar rats: A biophysical perspective
Efficacy of goldenberry in improving obesity-induced hemoglobin conformational structure changes in wistar rats: A biophysical perspective Open
View article: Methylene Blue confers protection against hepatotoxicity induced by Cisplatin; the involvement of the interactions between iron-sensing proteins, NCOA4-mediated ferritinophagy, and oxidative stress
Methylene Blue confers protection against hepatotoxicity induced by Cisplatin; the involvement of the interactions between iron-sensing proteins, NCOA4-mediated ferritinophagy, and oxidative stress Open
Cisplatin (Cisp) is a widely used cancer treatment that is effective and frequently included in treatment plans. Treatment plans that use large doses of Cisp or cumulative dosages, however, may cause liver damage. This study investigated t…
View article: The potency of Thymus vulgaris seed extract in alleviating obesity complications and iron overload in obese rats
The potency of Thymus vulgaris seed extract in alleviating obesity complications and iron overload in obese rats Open
Natural products have long been recognized as valuable sources of bioactive compounds in therapeutic agents. Thymus vulgaris, commonly known as thyme and belonging to the Lamiaceae family, is widely distributed and extensively used in Egyp…
View article: Melatonin and mesenchymal stem cells co-administration alleviates chronic obstructive pulmonary disease via modulation of angiogenesis at the vascular-alveolar unit
Melatonin and mesenchymal stem cells co-administration alleviates chronic obstructive pulmonary disease via modulation of angiogenesis at the vascular-alveolar unit Open
View article: Reno-protective effect of Roflumilast against kidney injury induced by ischemia/reperfusion in rats: Evidence from biochemical and histological investigations
Reno-protective effect of Roflumilast against kidney injury induced by ischemia/reperfusion in rats: Evidence from biochemical and histological investigations Open
View article: Author Correction: Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload
Author Correction: Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload Open
View article: Nefopam exerts anticonvulsant and neuroprotective effects in experimentally-induced status epilepticus
Nefopam exerts anticonvulsant and neuroprotective effects in experimentally-induced status epilepticus Open
Nefopam is a centrally acting, non-opiate analgesic drug used in the prevention of post-operative pain. In this study, the effect of nefopam on epileptic seizures and neuronal brain damage induced in the rat by pentylenetetrazole (PTZ) was…
View article: Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway
Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway Open
This research investigated if pitavastatin (Pita) might protect rats’ kidneys against thioacetamide (TAA). By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost kidney antioxidant capacity and minimize oxidative damage. Statins hav…
View article: Nrf2/<scp>HO</scp>‐1, <scp>NF‐κB</scp> and <scp>PI3K</scp>/Akt signalling pathways decipher the therapeutic mechanism of pitavastatin in early phase liver fibrosis in rats
Nrf2/<span>HO</span>‐1, <span>NF‐κB</span> and <span>PI3K</span>/Akt signalling pathways decipher the therapeutic mechanism of pitavastatin in early phase liver fibrosis in rats Open
Liver fibrosis is a common chronic hepatic disease. This study aimed to investigate the effect of pitavastatin (Pit) against thioacetamide (TAA)‐induced liver fibrosis. Rats were divided into four groups: (1) control group; (2) TAA group (…
View article: Neuroprotective Effects of Trimetazidine against Cisplatin‐Induced Peripheral Neuropathy: Involvement of AMPK‐Mediated PI3K/mTOR, Nrf2, and NF‐<i>κ</i>B Signaling Axes
Neuroprotective Effects of Trimetazidine against Cisplatin‐Induced Peripheral Neuropathy: Involvement of AMPK‐Mediated PI3K/mTOR, Nrf2, and NF‐<i>κ</i>B Signaling Axes Open
Cisplatin‐induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cisplatin chemotherapy used in cancer treatment. This study explored the neuroprotective effects of Trimetazidine (TRI) against CIPN by preserving n…