Mohamed Ahmed Mahmoud Abdel Reheim
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View article: Bioactivity of novel isoxazole-fused heterocycles: comprehensive antimicrobial, antioxidant activities, SwissADME predictions, molecular docking, and DFT analysis
Bioactivity of novel isoxazole-fused heterocycles: comprehensive antimicrobial, antioxidant activities, SwissADME predictions, molecular docking, and DFT analysis Open
Among the foremost goals for organic chemists is to discover novel approaches for the synthesis of a particular heterocyclic and its design. Our approach focused on the vital precursor 4-acetyl-3-phenylisoxazol-5(4 H )-one 3 , as this mole…
View article: Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties
Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties Open
Introduction: Inhibiting cyclooxygenase-2 (COX-2) is a potential strategy in inflammation therapy. Thus, developing COX-2 inhibitors plays a pivotal role in efficient inflammation treatment. This study discloses the synthesis of new hetero…
View article: Novel furo[2,3-<i>d</i>]pyrimidine derivatives as PI3K/AKT dual inhibitors: design, synthesis, biological evaluation, and molecular dynamics simulation
Novel furo[2,3-<i>d</i>]pyrimidine derivatives as PI3K/AKT dual inhibitors: design, synthesis, biological evaluation, and molecular dynamics simulation Open
A series of furo[2,3- d ]pyrimidine derivatives were synthesized and evaluated for their antiproliferative activity. Compound 10b revealed potent anticancer activity with mean GI% above 100, and remarkable anticancer activity.
View article: New 1,3-diphenyl-1H-pyrazol-5-ols as anti-methicillin resistant Staphylococcus aureus agents: Synthesis, antimicrobial evaluation and in silico studies
New 1,3-diphenyl-1H-pyrazol-5-ols as anti-methicillin resistant Staphylococcus aureus agents: Synthesis, antimicrobial evaluation and in silico studies Open
In the present work, two hybrid series of pyrazole-clubbed pyrimidine and pyrazole-clubbed thiazole compounds 3-21 from 4-acetyl-1,3-diphenyl-1H-pyrazole-5(4H)-ole 1 were synthesized as novel antimicrobial agent…
View article: Preparation of new surface coating based on modified oil-based polymers blended with ZnO and CuZnO NPs for steel protection
Preparation of new surface coating based on modified oil-based polymers blended with ZnO and CuZnO NPs for steel protection Open
In our paper, we have synthesized modified PEA and alkyd resin by replacing the new source of polyol (SDEA) which was confirmed by different analyses such as IR, and 1HNMR spectra. A series of conformal, novel, low-cost, and eco-friendly h…
View article: Bis(2-cyanoacetohydrazide) as precursors for synthesis of novel azoles/azines and their biological evaluation
Bis(2-cyanoacetohydrazide) as precursors for synthesis of novel azoles/azines and their biological evaluation Open
The present work deals with the synthesis of 2-cyano- N ′-(3-(2-(2-cyanoacetyl) hydrazinyl) cyclohex-2-en-1-ylidene) acetohydrazide 3 that used as a key precursor in the manufacture of new heterocyclic derivatives, such as pyrazole, pyrane…
View article: Bis (2-Cyanoacetohydrazide) as Precursors for Synthesis of Novel Azoles / Azines and their Biological Evaluation
Bis (2-Cyanoacetohydrazide) as Precursors for Synthesis of Novel Azoles / Azines and their Biological Evaluation Open
The present work deals with the synthesis of 2-cyano-N'-(3-(2-(2-cyanoacetyl) hydrazinyl) cyclohex-2-en-1-ylidene) acetohydrazide 3 that used as a key precursor in the manufacture of new heterocyclic derivatives, such as pyrazole, pyrane, …
View article: Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives
Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives Open
View article: Synthesis and Biological Studies of Some New Pyrazole, Dihydropyridinethione, Pyrimidine, Thiophene and 4H-Pyran Derivatives
Synthesis and Biological Studies of Some New Pyrazole, Dihydropyridinethione, Pyrimidine, Thiophene and 4H-Pyran Derivatives Open
View article: Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives Open
View article: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives Open
View article: Pyrimidinethione as a building block in heterocyclic synthesis: synthesis of pyrano[2,3- <i>d</i> ]pyrimidine, chromeno[2,3- <i>d</i> ]pyrimidine, pyrido[3′,2′:5,6]pyrano[2,3- <i>b</i> ]pyridine, and pyrimido[5′,4′:5,6]pyrano[2,3- <i>d</i> ]pyrimidine derivatives
Pyrimidinethione as a building block in heterocyclic synthesis: synthesis of pyrano[2,3- <i>d</i> ]pyrimidine, chromeno[2,3- <i>d</i> ]pyrimidine, pyrido[3′,2′:5,6]pyrano[2,3- <i>b</i> ]pyridine, and pyrimido[5′,4′:5,6]pyrano[2,3- <i>d</i> ]pyrimidine derivatives Open
New heterocyclic compounds with expected biological activity have been prepared by reactions of 6-phenyl-2-thioxo-2,3-dihydropyrimidine-4(5 H )-one ( 4 ) and 7- amino-5-(4-chlorophenyl)-4-phenyl-2-thioxo-2,5-dihydro-1 H -pyrano[2,3- d ]pyr…
View article: Utility of β-diketones in heterocyclic synthesis: Synthesis of new tetrahydro-pyrimidinethione, pyrazole, thiophene, dihydropyridine, dihydropyrane, pyridazine derivatives and investigation of their antimicrobial activity
Utility of β-diketones in heterocyclic synthesis: Synthesis of new tetrahydro-pyrimidinethione, pyrazole, thiophene, dihydropyridine, dihydropyrane, pyridazine derivatives and investigation of their antimicrobial activity Open
A series of many important diverse number of fused heterocyclic systems were prepared from the reaction of 1-(2-hydroxynaphthalen-1-yl)-3-phenylpropane-1,3-dione with some bifunctional nucleophiles, these reactions mainly proceed via conde…
View article: Synthesis and Spectral Identification of Novel Stable Triazene: As Raw Material for the Synthesis Biocompatible Surfactants-Pyrazole-Isoxazole-Dihydropyrimidine-Tetrahydropyridine Derivatives
Synthesis and Spectral Identification of Novel Stable Triazene: As Raw Material for the Synthesis Biocompatible Surfactants-Pyrazole-Isoxazole-Dihydropyrimidine-Tetrahydropyridine Derivatives Open
The chemical reactivity of novel stable triazene 3 toward some nucleophilic and electrophilic reagents was investigated. Traizene 3 was used as a key precursor for the synthesis of some novel important heterocyclic compounds such as Pyrazo…
View article: A Simple and Convenient Synthesis of Isolated Fused Heterocycles Based on: 6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one and 5-Acetyl-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one
A Simple and Convenient Synthesis of Isolated Fused Heterocycles Based on: 6-Phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one and 5-Acetyl-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one Open
The reaction of 6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one 1 with acetyl chloride in acetic anhydride in the presence of sodium acetate afforded 5-acetyl-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(5H)-one 2 which reacted with bromine, …