Mohamed Amine Benadjaoud
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View article: The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles
The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles Open
DNA integrity and stability are vital for proper cellular activity. Nevertheless, to treat cancer patients, DNA is the main target for inducing tumoral cell death. Nowadays, cancer treatment is improving by the development of new technolog…
View article: Presymptomatic microRNA-based biomarker signatures for the prognosis of localized radiation injury in mice
Presymptomatic microRNA-based biomarker signatures for the prognosis of localized radiation injury in mice Open
The threat of nuclear or radiological events requires early diagnostic tools for radiation induced health effects. Localized radiation injuries (LRI) are severe outcomes of such events, characterized by a latent presymptomatic phase follow…
View article: Differences in the activity intensity distribution over the day between boys and girls aged 3 to 17 years
Differences in the activity intensity distribution over the day between boys and girls aged 3 to 17 years Open
Physical activity (PA) decreases from childhood to adolescence, with girls being less active than boys. The timing of these differences remains unknown. Using accelerometer data from three cross-sectional studies in Norway and Belgium (n =…
View article: Diffusion model uniform manifold filtering for classification of small datasets with underrepresented classes: application to chromosomal aberration microscopy detection
Diffusion model uniform manifold filtering for classification of small datasets with underrepresented classes: application to chromosomal aberration microscopy detection Open
International audience
View article: Metabolomics identifies plasma biomarkers of localized radiation injury
Metabolomics identifies plasma biomarkers of localized radiation injury Open
A radiological accident may result in the development of a local skin radiation injury (LRI) which may evolve, depending on the dose, from dry desquamation to deep ulceration and necrosis through unpredictable inflammatory waves. Therefore…
View article: Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade
Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade Open
View article: Evidence of Alveolar Macrophage Metabolic Shift Following Stereotactic Body Radiation Therapy -Induced Lung Fibrosis in Mice
Evidence of Alveolar Macrophage Metabolic Shift Following Stereotactic Body Radiation Therapy -Induced Lung Fibrosis in Mice Open
Our study brings new possible clues to the understanding of macrophage implications in radiation-induced lung damage, representing an interesting area for exploration in future studies.
View article: Artificial Intelligence and generative data augmentation for automated chromosomal aberration detection in cytogenetic FISH imaging
Artificial Intelligence and generative data augmentation for automated chromosomal aberration detection in cytogenetic FISH imaging Open
International audience
View article: Les micro-ARN comme biomarqueurs des lésions radio-induites
Les micro-ARN comme biomarqueurs des lésions radio-induites Open
En cas d’urgence radiologique ou nucléaire résultant d’un accident ou d’un acte de malveillance, la prise en charge médicale requiert l’identification et le diagnostic des individus exposés à de fortes doses de rayonnements ionisants le pl…
View article: The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles
The DNA damage response in myogenic C2C7 cells depends on the characteristics of ionizing particles Open
DNA integrity and stability are vital for proper cellular activity. Nevertheless, to treat cancer patients, DNA is the main target for inducing tumoral cell death. Nowadays, cancer treatment is improving by the development of new technolog…
View article: Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data
Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data Open
Accelerometers, devices that measure body movements, have become valuable tools for studying the fragmentation of rest-activity patterns, a core circadian rhythm dimension, using metrics such as inter-daily stability (IS), intradaily varia…
View article: MR compatible detectors assessment for a 0.35 T MR-linac commissioning
MR compatible detectors assessment for a 0.35 T MR-linac commissioning Open
Purpose To assess a large panel of MR compatible detectors on the full range of measurements required for a 0.35 T MR-linac commissioning by using a specific statistical method represented as a continuum of comparison with the Monte Carlo …
View article: Comparing cellular response to two radiation treatments based on key features visualization
Comparing cellular response to two radiation treatments based on key features visualization Open
Motivation In modern treatment by radiotherapy, different irradiation modalities can be used, potentially producing different amounts of adverse effects. The differences between these modalities are often studied via two-sample time course…
View article: Bootstrap inference for linear regression between variables that are never jointly observed: application in in vivo experiments
Bootstrap inference for linear regression between variables that are never jointly observed: application in in vivo experiments Open
In modern experimental science, there is a common problem of estimating the coefficients of a linear regression in a context where the variables of interest cannot be observed simultaneously. When there is a categorical variable that is ob…
View article: microRNA blood signature for localized radiation injury
microRNA blood signature for localized radiation injury Open
View article: Joint clustering with alignment for temporal data in a one-point-per-experiment setting
Joint clustering with alignment for temporal data in a one-point-per-experiment setting Open
Temporal data, obtained in the setting where it is only possible to observe one time point per experiment, is widely used in different research fields, yet remains insufficiently addressed from the statistical point of view. Such data ofte…
View article: Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data
Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data Open
Accelerometers, devices that measure body movements, have become valuable tools for studying the fragmentation of rest-activity patterns, a core circadian rhythm dimension, using metrics such as inter-daily stability (IS), intradaily varia…
View article: Ensembling Unets, sparse representation and low dimensional visualization for rare chromosomal aberration detection in light microscopy images
Ensembling Unets, sparse representation and low dimensional visualization for rare chromosomal aberration detection in light microscopy images Open
A bstract In biological dosimetry, a radiation dose is estimated using the average number of chromosomal aberration per peripheral blood lymphocytes. To achieve an adequate precision in the estimation of this average, hundreds of cells mus…
View article: Inflammatory cells dynamics control neovascularization and tissue healing after localized radiation induced injury in mice
Inflammatory cells dynamics control neovascularization and tissue healing after localized radiation induced injury in mice Open
View article: Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy Open
View article: Biodose Tools: an R shiny application for biological dosimetry
Biodose Tools: an R shiny application for biological dosimetry Open
In the event of a radiological accident or incident, the aim of biological dosimetry is to convert the yield of a specific biomarker of exposure to ionizing radiation into an absorbed dose. Since the 1980s, various tools have been used to …
View article: Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis
Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis Open
View article: Biodose Tools: An R shiny Application for Biological Dosimetry
Biodose Tools: An R shiny Application for Biological Dosimetry Open
Introduction In the event of a radiological accident or incident, the aim of biological dosimetry is to convert the yield of a specific biomarker of exposure to ionizing radiation into an absorbed dose. Since the 1980s, various tool…
View article: Biodose Tools: an R shiny application for biological dosimetry
Biodose Tools: an R shiny application for biological dosimetry Open
In the event of a radiological accident or incident, the aim of biological dosimetry is to convert the yield of a specific biomarker of exposure to ionizing radiation into an absorbed dose. Since the 1980s, various tools have been used to …
View article: Identification of physical activity and sedentary behaviour dimensions that predict mortality risk in older adults: development of a machine learning model in the Whitehall II accelerometer sub-study and external validation in the CoLaus study
Identification of physical activity and sedentary behaviour dimensions that predict mortality risk in older adults: development of a machine learning model in the Whitehall II accelerometer sub-study and external validation in the CoLaus study Open
View article: Symptoms of Depression and Anxiety in Adults with High-Grade Glioma: A Literature Review and Findings in a Group of Patients before Chemoradiotherapy and One Year Later
Symptoms of Depression and Anxiety in Adults with High-Grade Glioma: A Literature Review and Findings in a Group of Patients before Chemoradiotherapy and One Year Later Open
High-grade glioma (HGG) is associated with several external and internal stressors that may induce mood alterations at all stages of the disease. Symptoms of depression and anxiety in persons with glioma have multifactorial etiology and re…
View article: Radiation induced cataracts in interventionalists occupationally exposed to ionising radiation
Radiation induced cataracts in interventionalists occupationally exposed to ionising radiation Open
Background: Occupational exposure to ionising radiation may have detrimental health effects. Longer and more complex fluoroscopic procedures have placed interventionalists at increased occupational health risks especially for developing ca…
View article: Molecular Changes In Cardiac Tissue As A New Marker To Predict Cardiac Dysfunction Induced By Radiotherapy
Molecular Changes In Cardiac Tissue As A New Marker To Predict Cardiac Dysfunction Induced By Radiotherapy Open
The contribution of radiotherapy, per se , to late cardiotoxicity remains controversial. To clarify its impact on the development of early cardiac dysfunction, we developed an experimental model in which the hearts of rats were exposed, in…
View article: Circulating microvesicles correlate with radiation proctitis complication after radiotherapy
Circulating microvesicles correlate with radiation proctitis complication after radiotherapy Open
In a large retrospective study, we assessed the putative use of circulating microvesicles (MVs), as innovative biomarkers of radiation toxicity in a cohort of 208 patients with prostate adenocarcinoma overexposed to radiation. The level of…
View article: Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis
Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis Open
Background Cellular therapy seems to be an innovative therapeutic alternative for which mesenchymal stem cells (MSCs) have been shown to be effective for interstitial and hemorrhagic cystitis. However, the action of MSCs on chronic radiati…