Mohamed Boudjelal
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View article: Design of CoM <sub> <i>x</i> </sub> Fe <sub>2-x</sub> O <sub>4</sub> (M = Ag, Ru) Nanoparticles with Magnetic Hyperthermic Capabilities for Cancer Treatment
Design of CoM <sub> <i>x</i> </sub> Fe <sub>2-x</sub> O <sub>4</sub> (M = Ag, Ru) Nanoparticles with Magnetic Hyperthermic Capabilities for Cancer Treatment Open
Nobel metal [silver (Ag) or ruthenium (Ru)] substituted cobalt ferrite CoM x Fe2‑x O4 (M = Ag, Ru; x = 0, 0.2, 0.4) nanoparticles were synthesized by the sol-gel method using Moringa…
View article: Chnoospora minima Polysaccharide-Mediated Green Synthesis of Silver Nanoparticles: Potent Anticancer and Antimicrobial Activities
Chnoospora minima Polysaccharide-Mediated Green Synthesis of Silver Nanoparticles: Potent Anticancer and Antimicrobial Activities Open
Marine algae offer environmentally friendly platforms for green nanoparticle synthesis. This study reports the biosynthesis of silver nanoparticles using polysaccharides isolated from the brown alga Chnoospora minima (PAgNPs) and evaluates…
View article: Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor
Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor Open
View article: First-in-class inhibitors of Nsp15 endoribonuclease of SARS-CoV-2: Modeling, synthesis, and enzymatic assay of thiazolidinedione and rhodanine analogs
First-in-class inhibitors of Nsp15 endoribonuclease of SARS-CoV-2: Modeling, synthesis, and enzymatic assay of thiazolidinedione and rhodanine analogs Open
View article: Correction: Al Subait et al. Discovery of PPAR Alpha Lipid Pathway Modulators That Do Not Bind Directly to the Receptor as Potential Anti-Cancer Compounds. Int. J. Mol. Sci. 2025, 26, 736
Correction: Al Subait et al. Discovery of PPAR Alpha Lipid Pathway Modulators That Do Not Bind Directly to the Receptor as Potential Anti-Cancer Compounds. Int. J. Mol. Sci. 2025, 26, 736 Open
In the published publication [...]
View article: Discovery of PPAR Alpha Lipid Pathway Modulators That Do Not Bind Directly to the Receptor as Potential Anti-Cancer Compounds
Discovery of PPAR Alpha Lipid Pathway Modulators That Do Not Bind Directly to the Receptor as Potential Anti-Cancer Compounds Open
Peroxisome proliferator-activated receptors (PPARs) are considered good drug targets for breast cancer because of their involvement in fatty acid metabolism that induces cell proliferation. In this study, we used the KAIMRC1 breast cancer …
View article: Synthesis of Pyrrolidine Appended Quinolines as Dual Inhibitor (Α-Glucosidase and Α-Amylase): In Silico and in Vitro Evaluation
Synthesis of Pyrrolidine Appended Quinolines as Dual Inhibitor (Α-Glucosidase and Α-Amylase): In Silico and in Vitro Evaluation Open
View article: First Report from Saudi Arabia of Trimethylaminuria Caused by a Premature Stop Codon Mutation in the FMO3 Gene
First Report from Saudi Arabia of Trimethylaminuria Caused by a Premature Stop Codon Mutation in the FMO3 Gene Open
Our findings revealed differential responses in monocytes and endothelial cells stimulated with plasma from the TMAU patient compared to plasma from non-TMAU patients. These distinct responses may be key modulators of endothelial function …
View article: Lasamide Containing Sulfonylpiperazines as Effective Agents for the Management of Glaucoma Associated Symptoms
Lasamide Containing Sulfonylpiperazines as Effective Agents for the Management of Glaucoma Associated Symptoms Open
A series of 2,4‐dichloro‐5‐{[4‐(phenylsulfonyl)piperazin‐1‐yl]carbonyl}benzenesulfonamides were designed and synthesized through amidation of Lasamide 1 with substituted piperazines. The newly obtained compounds demonstrated remarkable inh…
View article: <em>Commiphora myrrha</em> Resin Extract-Modulated Cytochrome P-450 2C9 Enzyme Expression Is Associated with Resin Extract-Derived Metabolites Binding to Pregnane X Receptor<strong> </strong>
<em>Commiphora myrrha</em> Resin Extract-Modulated Cytochrome P-450 2C9 Enzyme Expression Is Associated with Resin Extract-Derived Metabolites Binding to Pregnane X Receptor<strong> </strong> Open
The use of natural health products (NHP) is constantly increasing worldwide. Among the most NHP consumed are the resins of Commiphora myrrha (C. myrrha) tree. Consumption of C. myrrha may result in herb-drug interactions that can lead to s…
View article: Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor
Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor Open
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology. Recently, long-term metabolomics studies have linked high lev…
View article: Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies
Stimulatory effects of Lycium shawii on human melanocyte proliferation, migration, and melanogenesis: In vitro and in silico studies Open
There is no first-line treatment for vitiligo, a skin disease characterized by a lack of melanin produced by the melanocytes, resulting in an urgent demand for new therapeutic drugs capable of stimulating melanocyte functions, including me…
View article: Author Correction: Integration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities
Author Correction: Integration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities Open
View article: Integration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities
Integration of in vitro and in-silico analysis of Caulerpa racemosa against antioxidant, antidiabetic, and anticancer activities Open
View article: The efficacy of Zafirlukast as a SARS-CoV-2 helicase inhibitor in adult patients with moderate COVID-19 Pneumonia (pilot randomized clinical trial)
The efficacy of Zafirlukast as a SARS-CoV-2 helicase inhibitor in adult patients with moderate COVID-19 Pneumonia (pilot randomized clinical trial) Open
View article: New Born Calf Serum Can Induce Spheroid Formation in Breast Cancer KAIMRC1 Cell Line
New Born Calf Serum Can Induce Spheroid Formation in Breast Cancer KAIMRC1 Cell Line Open
Three-dimensional (3D) cell culture systems have become very popular in the field of drug screening and discovery. There is an immense demand for highly efficient and easy methods to produce 3D spheroids in any cell format. We have develop…
View article: Discovery of a novel potentially transforming somatic mutation in <i>CSF2RB</i> gene in breast cancer
Discovery of a novel potentially transforming somatic mutation in <i>CSF2RB</i> gene in breast cancer Open
The colony stimulating factor 2 receptor subunit beta ( CSF2RB ) is the common signaling subunit of the cytokine receptors for IL‐3, IL‐5, and GM‐CSF. Several studies have shown that spontaneous and random mutants of CSF2RB can lead to lig…
View article: A Drug Repositioning Approach Identifies a Combination of Compounds as a Potential Regimen for Chronic Lymphocytic Leukemia Treatment
A Drug Repositioning Approach Identifies a Combination of Compounds as a Potential Regimen for Chronic Lymphocytic Leukemia Treatment Open
Drug repositioning is a promising and powerful innovative strategy in the field of drug discovery. In this study, we screened a compound-library containing 800 Food and Drug Administration approved drugs for their anti-leukemic effect. All…
View article: Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2
Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2 Open
In vitro studies of a disease are key to any in vivo investigation in understanding the disease and developing new therapy regimens. Immortalized cancer cell lines are the best and easiest model for studying cancer in vitro. Here, we repor…
View article: Caring for patients with rare diseases during the COVID-19 pandemic
Caring for patients with rare diseases during the COVID-19 pandemic Open
Rare diseases frequently attack and weaken the immune system, increasing the patient’s vulnerability to develop severe conditions after viral infections, such as COVID-19. Many patients with rare diseases also suffer from mental retardatio…
View article: Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study
Synthesis of new urease enzyme inhibitors as antiulcer drug and computational study Open
In search of potent urease inhibitor indole analogues (1–22) were synthesized and evaluated for their urease inhibitory potential. All analogues (1–22) showed a variable degree of inhibitory interaction potential having IC
View article: Iron Oxide Mesoporous Magnetic Nanostructures with High Surface Area for Enhanced and Selective Drug Delivery to Metastatic Cancer Cells
Iron Oxide Mesoporous Magnetic Nanostructures with High Surface Area for Enhanced and Selective Drug Delivery to Metastatic Cancer Cells Open
This work reports the fabrication of iron oxide mesoporous magnetic nanostructures (IO-MMNs) via the nano-replication method using acid-prepared mesoporous spheres (APMS) as the rigid silica host and iron (III) nitrate as the iron precurso…
View article: COVID-19 vaccines: Global challenges and prospects forum recommendations
COVID-19 vaccines: Global challenges and prospects forum recommendations Open
View article: Using in silico modelling and FRET-based assays in the discovery of novel FDA-approved drugs as inhibitors of MERS-CoV helicase
Using in silico modelling and FRET-based assays in the discovery of novel FDA-approved drugs as inhibitors of MERS-CoV helicase Open
A Förster resonance energy transfer (FRET)-based assay was used to screen the FDA-approved compound library against the MERS-CoV helicase, an essential enzyme for virus replication within the host cell. Five compounds inhibited the helicas…
View article: An easy, fast and inexpensive method of preparing a biological specimen for scanning electron microscopy (SEM)
An easy, fast and inexpensive method of preparing a biological specimen for scanning electron microscopy (SEM) Open
Biological samples usually require cumbersome preparation steps before SEM imaging. Here we propose a simple, fast and inexpensive method to prepare and visualize biological cell culture samples in a few easy steps. We have tested this met…
View article: Proteomics Profiling of KAIMRC1 in Comparison to MDA-MB231 and MCF-7
Proteomics Profiling of KAIMRC1 in Comparison to MDA-MB231 and MCF-7 Open
Proteomics characterization of KAIMRC1 cell line, a naturally immortalized breast cancer cells, is described in comparison to MCF-7 and MDA-MB-231 breast cancer cells. Quantitative proteomics analysis using the tandem mass tag (TMT)-labele…
View article: Why do SARS-COV vaccines not exist? The pharma scientific intelligence and business model must be revisited!
Why do SARS-COV vaccines not exist? The pharma scientific intelligence and business model must be revisited! Open
When the President of United States, Mr. Donald Trump, stated that COVID19 had taken the world by surprise, it was a damnation on the strategy and predictions of all business-driven therapeutic dis...
View article: Novel Strategies to Optimize the Amplification of Single-Stranded DNA
Novel Strategies to Optimize the Amplification of Single-Stranded DNA Open
The generation of single stranded DNA plays a key role in in vitro selection of DNA aptamers and in other molecular techniques such as DNA sequencing and microarrays. Here we describe three novel methodologies for ssDNA production a…
View article: KAIMRC’S Second Therapeutics Discovery Conference
KAIMRC’S Second Therapeutics Discovery Conference Open
Following the success of our first therapeutic discovery conference in 2017 and the selection of King Abdullah International Medical Research Centre (KAIMRC) as the first Phase 1 clinical site in the Kingdom of Saudi Arabia, we organized o…
View article: Therapeutic Efficacy of Nyctanthes arbor-tristis Flowers to Inhibit Proliferation of Acute and Chronic Primary Human Leukemia Cells, with Adipocyte Differentiation and in Silico Analysis of Interactions between Survivin Protein and Selected Secondary Metabolites
Therapeutic Efficacy of Nyctanthes arbor-tristis Flowers to Inhibit Proliferation of Acute and Chronic Primary Human Leukemia Cells, with Adipocyte Differentiation and in Silico Analysis of Interactions between Survivin Protein and Selected Secondary Metabolites Open
Although the antidiabetic efficacy of Nyctanthes arbor-tristis flowers has been reported, antiproliferative and anti-obesity activities are yet to be explored. We examined the anti-obesity and antiproliferative potentials of different frac…