Mohamed Bouhrim
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View article: Identification of stigmasterol derived AChE inhibitors for Alzheimer’s disease using high throughput virtual screening and molecular dynamics simulations
Identification of stigmasterol derived AChE inhibitors for Alzheimer’s disease using high throughput virtual screening and molecular dynamics simulations Open
View article: Elucidating the Isorhamnetin-3-O-glucoside-iNOS Interaction via Molecular Dynamics and Hirshfeld Surface Analyses
Elucidating the Isorhamnetin-3-O-glucoside-iNOS Interaction via Molecular Dynamics and Hirshfeld Surface Analyses Open
Inducible nitric oxide synthase (iNOS) overproduction drives chronic inflammation and oncogenic signaling, yet selective small-molecule modulation remains elusive. We interrogated isorhamnetin-3-O-glucoside (I3OG), a dietary flavonol glyco…
View article: Selection of essential oil extraction methods using the analytic hierarchy process (AHP) and the preference ranking organization method for enrichment evaluations (PROMETHEE) approaches
Selection of essential oil extraction methods using the analytic hierarchy process (AHP) and the preference ranking organization method for enrichment evaluations (PROMETHEE) approaches Open
Essential oils (EOs) play an important role in the pharmaceutical, cosmetic, and food industries for their therapeutic and aromatic properties. Selecting the appropriate extraction method is crucial for optimizing yield, quality, and envir…
View article: Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp ( <scp> <i>Cannabis sativa</i> </scp> L.) Seed Oil
Investigating the Influence of Drying Methods on the Quality and Bioactive Properties of Hemp ( <span> <i>Cannabis sativa</i> </span> L.) Seed Oil Open
This research investigates how oven and microwave drying methods influence mass reduction, oil yield, chemical composition, and bioactivity of Cannabis sativa seed oil, from two C. sativa L. varieties—Beldia and Critical—grown in Ketama an…
View article: Impact of Climate Change on the Composition and Bioactivity of <i>Inula viscosa</i> Essential Oils: In Vitro, <i>In Silico</i> , and <scp>ADME</scp> Analysis
Impact of Climate Change on the Composition and Bioactivity of <i>Inula viscosa</i> Essential Oils: In Vitro, <i>In Silico</i> , and <span>ADME</span> Analysis Open
Medicinal plants, rich in secondary metabolites, play a crucial role in drug development. Climate change, driven by industrialization, affects plant growth and the production of these metabolites. The research explores how climate change i…
View article: Healthy food choices in Morocco: A survey on knowledge, attitudes, and practices
Healthy food choices in Morocco: A survey on knowledge, attitudes, and practices Open
View article: Correlation between semen quality and the seminal biochemical markers: alpha-glucosidase, fructose, and zinc in infertile men compared with a normal population of men
Correlation between semen quality and the seminal biochemical markers: alpha-glucosidase, fructose, and zinc in infertile men compared with a normal population of men Open
Introduction The male reproductive tract's accessory glands produce seminal biochemical markers that can help diagnose reproductive disorders and assess male fertility. This study evaluated the relationship between seminal biochemical comp…
View article: ADMET-Guided Docking and GROMACS Molecular Dynamics of Ziziphus lotus Phytochemicals Uncover Mutation-Agnostic Allosteric Stabilisers of the KRAS Switch-I/II Groove
ADMET-Guided Docking and GROMACS Molecular Dynamics of Ziziphus lotus Phytochemicals Uncover Mutation-Agnostic Allosteric Stabilisers of the KRAS Switch-I/II Groove Open
Background/Objectives: Oncogenic KRAS drives ~30% of solid tumours, yet the only approved G12C-specific drugs benefit ≈ 13% of KRAS-mutant patients, leaving a major clinical gap. We sought mutation-agnostic natural ligands from Ziziphus lo…
View article: Chemical Composition of the Phenolic Profile and Evaluation of Antimicrobial and Cytotoxic Activities of Moroccan Pomegranate (Punica granatum) Peel Extract
Chemical Composition of the Phenolic Profile and Evaluation of Antimicrobial and Cytotoxic Activities of Moroccan Pomegranate (Punica granatum) Peel Extract Open
This study aims to deepen the understanding of the pharmacological properties of the aqueous extract derived from the peel of Punica granatum L., sourced from eastern Morocco. Chemical analysis using ultra-high-performance liquid chromatog…
View article: Molecular characterization, GC-MS analysis, and biological activities of Matricaria chamomilla var. recutita L. essential oils from Taounate, Morocco: In vitro and in silico investigations of antioxidant, antimicrobial, and insecticidal effects
Molecular characterization, GC-MS analysis, and biological activities of Matricaria chamomilla var. recutita L. essential oils from Taounate, Morocco: In vitro and in silico investigations of antioxidant, antimicrobial, and insecticidal effects Open
Chamomile (Matricaria chamomilla L.), a widely recognized medicinal plant, was investigated for its chemical composition, functional properties, and molecular characterization, focusing on samples cultivated in the Taounate region of Moroc…
View article: Evaluation of Food Safety Practices and Microbiological Quality of Street Foods in Marrakech, Morocco
Evaluation of Food Safety Practices and Microbiological Quality of Street Foods in Marrakech, Morocco Open
This study investigates food safety practices and evaluates the microbiological quality of street foods marketed in Marrakech, Morocco. Data collection involved an observational checklist to systematically assess hygiene practices, environ…
View article: Therapeutic Potential of <i>Lavandula stoechas</i> Aqueous Extract in Managing Diabetes and Its Complications: Insights From Biochemical and In Silico Studies
Therapeutic Potential of <i>Lavandula stoechas</i> Aqueous Extract in Managing Diabetes and Its Complications: Insights From Biochemical and In Silico Studies Open
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, commonly associated with dyslipidemia, oxidative stress, and complications affecting multiple organs, including the kidneys and liver. These compl…
View article: Effect of quinoa flour on fermentation, physicochemical and sensory properties of goat milk yogurt
Effect of quinoa flour on fermentation, physicochemical and sensory properties of goat milk yogurt Open
Introduction Goat milk (GM) is highly valued for its rich nutritional content, easy digestibilityand low allergenic potential, making it an excellent alternative in the dairy industry.Quinoa, an Andean pseudo cereal, offers significant nut…
View article: Chemical analysis, antihyperglycemic properties and enzyme inhibition of Opuntia dillenii (Ker Gawl.) Haw.: A detailed analysis of pulp and peel extracts
Chemical analysis, antihyperglycemic properties and enzyme inhibition of Opuntia dillenii (Ker Gawl.) Haw.: A detailed analysis of pulp and peel extracts Open
Opuntia dillenii (Ker Gawl.) Haw., which has long been prized for its therapeutic virtues, has shown promise in treating hyperglycemic conditions. This study investigates the chemical composition and antihyperglycemic capabilities o…
View article: Nutritional value antioxidant strength and antimicrobial efficacy of fig pastes from eastern morocco
Nutritional value antioxidant strength and antimicrobial efficacy of fig pastes from eastern morocco Open
Figs are delectable, beneficial, nutritious, and seasonal; nevertheless, they deteriorate quickly, making processing the optimal method for preservation. Drying figs is the most practical and efficient way to preserve them. Paste is anothe…
View article: Extraction and Analysis of Natural Color From Beetroot ( <scp> <i>Beta vulgaris</i> </scp> L.) Using Different Techniques, and Its Utilization in Ice Cream Manufacturing
Extraction and Analysis of Natural Color From Beetroot ( <span> <i>Beta vulgaris</i> </span> L.) Using Different Techniques, and Its Utilization in Ice Cream Manufacturing Open
A rich source of natural color, beetroot (Beta vulgaris L. subsp. vulgaris) extracts and colorants offer deep red color to the dishes and boost their nutritional and antioxidant value. This research extracted beetroot color using Soxhlet, …
View article: Bibliometric and comparative analysis of research on essential oils and aromatic and medicinal plants in Morocco: Positioning and perspectives in the world
Bibliometric and comparative analysis of research on essential oils and aromatic and medicinal plants in Morocco: Positioning and perspectives in the world Open
Essential oils and aromatic and medicinal plants play a vital role in the pharmaceutical, cosmetic, and food industries due to their therapeutic properties and diverse applications. Morocco’s rich biodiversity offers great potential for th…
View article: Comprehensive assessment of antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves: a potential natural source for managing oxidative stress and diabetes-related complications
Comprehensive assessment of antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves: a potential natural source for managing oxidative stress and diabetes-related complications Open
This study evaluates the phenolic and flavonoid contents, as well as the antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts from Pistacia lentiscus L. leaves. The antioxidant activity was assessed u…
View article: Nutritional composition health benefits and quality of fresh and dried figs from Eastern Morocco
Nutritional composition health benefits and quality of fresh and dried figs from Eastern Morocco Open
View article: Agro-Physiological and Pomological Characterization of Plum Trees in Ex-Situ Collections: Evaluation of Their Genetic Potential in the Saïss Plain
Agro-Physiological and Pomological Characterization of Plum Trees in Ex-Situ Collections: Evaluation of Their Genetic Potential in the Saïss Plain Open
The aim of this research is to assess the genetic potential of plum cultivars in an ex situ collection at the National Institute for Agronomic Research in Meknes, Morocco, under the conditions of the Saïss plain. This is an essential preli…
View article: Isolation and preliminary screening of lactic acid bacteria for antimicrobial potential from raw milk
Isolation and preliminary screening of lactic acid bacteria for antimicrobial potential from raw milk Open
Lactic acid bacteria (LAB) are widely recognized for their role in food preservation and their potential to produce bacteriocins, natural antimicrobial peptides effective against a broad spectrum of foodborne pathogens. This study focuses …
View article: Nutritional, bioactive, and antimicrobial analysis of powders and ethanolic extracts of three important halophyte plants (Anabasis articulata, Lycium shawii, and Zilla spinosa), and their application in bakery product
Nutritional, bioactive, and antimicrobial analysis of powders and ethanolic extracts of three important halophyte plants (Anabasis articulata, Lycium shawii, and Zilla spinosa), and their application in bakery product Open
Introduction New alternate food and pharma sources, halophyte plants have long been displaying exceptional nutritional and functional qualities. Methods Present investigations were carried out to explore three important halophyte herbs; An…
View article: Unveiling the Phenolic Profiling of Moroccan <i>Ferula communis</i> L. Fruits: A Combination of <i>In Silico</i> and <i>In Vivo</i> Protective Effect Against Methotrexate‐Induced Hepato‐Renal Dysfunction
Unveiling the Phenolic Profiling of Moroccan <i>Ferula communis</i> L. Fruits: A Combination of <i>In Silico</i> and <i>In Vivo</i> Protective Effect Against Methotrexate‐Induced Hepato‐Renal Dysfunction Open
Background: Methotrexate (MTX) is associated with several side effects, including hepatic and renal toxicities, which limit its effectiveness as an anticancer medication. These toxicities can lead to hepatotoxicity, nephrotoxicity, and pot…
View article: <i>Ephedra fragilis</i> plant extract: A groundbreaking corrosion inhibitor for mild steel in acidic environments – electrochemical, EDX, DFT, and Monte Carlo studies
<i>Ephedra fragilis</i> plant extract: A groundbreaking corrosion inhibitor for mild steel in acidic environments – electrochemical, EDX, DFT, and Monte Carlo studies Open
The present study introduces an innovative approach to sustainable corrosion inhibition by utilizing the aerial parts of Ephedra fragilis (EF) as a natural inhibitor for steel in hydrochloric acid solutions. Unlike conventional synthetic i…
View article: Phytochemical analysis and antioxidant activity of <i>Azadirachta indica</i> A. Juss from the Republic of Chad: <i>in vitro</i> and <i>in</i> <i>silico</i> studies
Phytochemical analysis and antioxidant activity of <i>Azadirachta indica</i> A. Juss from the Republic of Chad: <i>in vitro</i> and <i>in</i> <i>silico</i> studies Open
Azadirachta indica , commonly known as neem or Mim in Chad, is recognized for its significant biological activities and is used for medicinal purposes. This study quantifies phenolic content, analyzes chemical composition via high-performa…
View article: Integrated Computational Study Reveals Drug-Like Para-Flavonoids as Potent SARS-CoV-2 Mpro Inhibitors
Integrated Computational Study Reveals Drug-Like Para-Flavonoids as Potent SARS-CoV-2 Mpro Inhibitors Open
View article: Seed inoculation with Methylobacterium symbioticum enhances growth of Phaseolus vulgaris under reduced NH4NO3 fertilization
Seed inoculation with Methylobacterium symbioticum enhances growth of Phaseolus vulgaris under reduced NH4NO3 fertilization Open
The healthy growth of Phaseolus vulgaris relies on fertilization of nitrogen with NH4NO3. However, excessive application leads to environmental degradation, including loss of soil fertility and, green gas emissions such as N2O. As an ecolo…
View article: Nutritional value, HPLC-DAD analysis and biological activities of Ceratonia siliqua L. pulp based on in vitro and in silico studies
Nutritional value, HPLC-DAD analysis and biological activities of Ceratonia siliqua L. pulp based on in vitro and in silico studies Open
View article: Theoretical and Electrochemical Evaluation of <i>Cannabis Sativa L</i>. Extracts as Corrosion Inhibitors for Mild Steel in Acidic Medium
Theoretical and Electrochemical Evaluation of <i>Cannabis Sativa L</i>. Extracts as Corrosion Inhibitors for Mild Steel in Acidic Medium Open
The corrosion of metals in acidic environments remains a significant challenge, driving the search for sustainable and eco‐friendly inhibitors derived from natural sources. This study evaluates the corrosion inhibition potential of three e…
View article: Cupidon of the Pahouins: Transition of Musanga cecropioides R.Br. and Alchornea cordifolia Müll.Arg. from Traditional Use to a Rational Anti-Infective Phytodrug. Preclinical and Clinical Efficacy in Treating Microbial and Fungal Infections
Cupidon of the Pahouins: Transition of Musanga cecropioides R.Br. and Alchornea cordifolia Müll.Arg. from Traditional Use to a Rational Anti-Infective Phytodrug. Preclinical and Clinical Efficacy in Treating Microbial and Fungal Infections Open
Background: The traditional recipe of Cupidon of Pahouins (CP) is an age-old secret kept by the female healers of the Fang people in Central Africa for feminine intimate care. The most widely used formulation is composed of four plant extr…