Mohamed El‐Tabbal
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View article: Scn2a insufficiency alters spontaneous neuronal Ca2+ activity in somatosensory cortex during wakefulness
Scn2a insufficiency alters spontaneous neuronal Ca2+ activity in somatosensory cortex during wakefulness Open
SCN2A protein-truncating variants (PTV) can result in neurological disorders such as autism spectrum disorder and intellectual disability, but they are less likely to cause epilepsy in comparison to missense variants. While in vitro…
View article: Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments
Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments Open
Dysregulated cortical expression of the neural cell adhesion molecule (NCAM) and deficits of its associated polysialic acid (polySia) have been found in Alzheimer's disease and schizophrenia. However, the functional role of polySia in cort…
View article: TOB is an effector of the hippocampus-mediated acute stress response
TOB is an effector of the hippocampus-mediated acute stress response Open
View article: TOB is an effector of the hippocampus-mediated acute stress response
TOB is an effector of the hippocampus-mediated acute stress response Open
Stress affects behavior and involves critical dynamic changes at multiple levels ranging from molecular pathways to neural circuits and behavior. Abnormalities at any of these levels lead to decreased stress resilience and pathological beh…
View article: The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex
The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex Open
View article: Removal of the extracellular matrix biases auditory cortical layer dynamics towards supragranular frequency integration
Removal of the extracellular matrix biases auditory cortical layer dynamics towards supragranular frequency integration Open
In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. However, the underlying impact of local removal of the ECM on cor…