Mohamed Eltoukhi
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View article: Antibacterial Activity of Clindamycin/BPO in Combination With Adapalene
Antibacterial Activity of Clindamycin/BPO in Combination With Adapalene Open
Introduction: Acne guidelines recommend the addition of benzoyl peroxide (BPO) to antibiotics to reduce resistance in Cutibacterium acnes (C. acnes). Pairing the antibiotic/BPO combination with a retinoid, such as adapalene, may further in…
View article: Supplementary Figure 2 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 2 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 2: Patient Recruitment Flow Chart Flowchart illustrating the step-by-step recruitment process of bladder cancer patients, detailing inclusion and exclusion criteria and subsequent enrollment stages
View article: FIGURE 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Analysis of SCFA concentrations in relation to chemotherapy response. Top: Mean SCFA concentrations in plasma and stool of patients with bladder cancer categorized by NAC response status (CR vs. NR), showing no significant differences. Bot…
View article: Supplementary Figure 7 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 7 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 7: Gut Microbiome Changes in Partners of Bladder Cancer PatientsA: Stacked bar chart representing the relative abundances of key bacterial genera before, during, and after the chemotherapy periods in partners of patien…
View article: Supplementary Figure 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 6: Gut Microbiome Dynamics During Neoadjuvant ChemotherapyA: Relative abundance of major bacterial genera before, during, and after chemotherapy. Each color represents a different genus, with patient-specific changes h…
View article: FIGURE 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Analysis of SCFA concentrations in relation to chemotherapy response. Top: Mean SCFA concentrations in plasma and stool of patients with bladder cancer categorized by NAC response status (CR vs. NR), showing no significant differences. Bot…
View article: Supplementary Figure 7 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 7 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 7: Gut Microbiome Changes in Partners of Bladder Cancer PatientsA: Stacked bar chart representing the relative abundances of key bacterial genera before, during, and after the chemotherapy periods in partners of patien…
View article: FIGURE 3 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 3 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Microbial composition variance in relation to chemotherapy response in patients with bladder cancer. A, Proportional representation of the GM's phylogenetic composition in patients showing CR versus NR to NAC (Also depicted in C). B, Alpha…
View article: Supplementary Figure 8 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 8 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 8: Microbial Composition Differences in Mice Exposed to BBN Versus WaterWater Group:A: Alpha diversity indices (ACE, Chao1, Shannon) plotted over multiple time points (0, 6, 12, 16-22 weeks), showing variations in micr…
View article: Supplementary Figure 1 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 1 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 1: Overview of Sample Collection and Experimental Setup Diagram outlining the protocols for human fecal sample collection across various time points during chemotherapy in bladder cancer patients, accompanied by the se…
View article: FIGURE 5 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 5 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Predictive efficacy of microbial biomarkers on NAC response. A, Graphical representation of model performance metrics (out of bag score, sensitivity, NPV, specificity, PPV, AUC score) across iterations, evaluating the robustness of microbi…
View article: FIGURE 5 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 5 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Predictive efficacy of microbial biomarkers on NAC response. A, Graphical representation of model performance metrics (out of bag score, sensitivity, NPV, specificity, PPV, AUC score) across iterations, evaluating the robustness of microbi…
View article: Supplementary Figure 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 4: Sex-Specific Microbiome Diversity in Bladder Cancer and Control GroupsA: Stacked bar plot showing the phylogenetic composition of bacterial taxa at the genus level in male and female cohorts of bladder cancer patien…
View article: Supplementary Figure 9 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 9 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 9: Microbial Composition Variability by Sex in BBN-Exposed MiceBBN Gender Female:A: Alpha diversity indices (ACE, Chao1, Shannon) across different time points (0, 6, 12, 16-22 weeks), showing variations in microbial di…
View article: Supplementary Figure 3 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 3 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 3: Imaging of Murine Urothelial Cancer CT urography and ultrasound images displaying bladder tumors induced by BBN in mice, shown in both axial and coronal views, with tumors highlighted by arrows.
View article: Supplementary Figure 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 6: Gut Microbiome Dynamics During Neoadjuvant ChemotherapyA: Relative abundance of major bacterial genera before, during, and after chemotherapy. Each color represents a different genus, with patient-specific changes h…
View article: FIGURE 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 6 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Longitudinal microbiota analysis in a murine model exposed to BBN versus water. A, Shannon diversity index measures across different timepoints (0, 6, 12, 16–22 weeks) showing changes in alpha diversity in mice treated with BBN compared wi…
View article: Supplementary Figure Legends from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure Legends from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure Legends
View article: FIGURE 2 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 2 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Correlations between participant demographics, clinical characteristics, and microbial taxa. A, Plots illustrating the impact of smoking status and age on specific microbial taxa, annotated with statistical significance and effect sizes. B…
View article: Supplementary Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplemental Data
View article: Supplementary Figure 5 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 5 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 5: Community Grouping Based on Gut Microbiome Response StatusA: Hierarchical clustering identifying two distinct microbial community groups among bladder cancer patients (CR and NR).B and C: Alpha and beta diversity an…
View article: Supplementary Figure 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 4 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 4: Sex-Specific Microbiome Diversity in Bladder Cancer and Control GroupsA: Stacked bar plot showing the phylogenetic composition of bacterial taxa at the genus level in male and female cohorts of bladder cancer patien…
View article: Supplementary Figure Legends from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure Legends from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure Legends
View article: Supplementary Table 1 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Table 1 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Patient Characteristics
View article: FIGURE 1 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
FIGURE 1 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Bladder cancer versus controls microbiome diversity and differences. A, Stacked bar plot displaying the relative abundances of predominant bacterial genera identified in patients with bladder cancer (n = 142) and control individuals (n = 4…
View article: Supplementary Figure 8 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 8 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 8: Microbial Composition Differences in Mice Exposed to BBN Versus WaterWater Group:A: Alpha diversity indices (ACE, Chao1, Shannon) plotted over multiple time points (0, 6, 12, 16-22 weeks), showing variations in micr…
View article: Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Neoadjuvant chemotherapy (NAC) is linked with clinical advantages in urothelial carcinoma for patients with muscle-invasive bladder cancer (MIBC). Despite comprehensive research into the influence of tumor mutation expression profiles and …
View article: Supplementary Figure 3 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Figure 3 from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplementary Figure 3: Imaging of Murine Urothelial Cancer CT urography and ultrasound images displaying bladder tumors induced by BBN in mice, shown in both axial and coronal views, with tumors highlighted by arrows.
View article: Supplementary Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Supplementary Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Supplemental Data
View article: Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation
Data from Role of Gut Microbiome in Neoadjuvant Chemotherapy Response in Urothelial Carcinoma: A Multi-institutional Prospective Cohort Evaluation Open
Neoadjuvant chemotherapy (NAC) is linked with clinical advantages in urothelial carcinoma for patients with muscle-invasive bladder cancer (MIBC). Despite comprehensive research into the influence of tumor mutation expression profiles and …