Mohamed Ghait
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View article: Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48
Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48 Open
Please see Acknowledgements.
View article: The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI‐α and Controls Myogenic Differentiation
The Novel MuRF2 Target SNX5 Regulates PKA Activity Through Stabilization of RI‐α and Controls Myogenic Differentiation Open
Background Muscle RING finger (MuRF) proteins are striated muscle‐specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabili…
View article: Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection
Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection Open
View article: The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated during immunosuppression-associated organ damage Open
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections to carry out pyroptosis. Inadequate act…
View article: AB0275 SERUM LEVELS OF HOMOCYSTEINE, LEPTIN AND NEOPTERIN AS MARKERS OF DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS
AB0275 SERUM LEVELS OF HOMOCYSTEINE, LEPTIN AND NEOPTERIN AS MARKERS OF DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS Open
View article: The TLR‐chaperone CNPY3 is a critical regulator of NLRP3‐inflammasome activation
The TLR‐chaperone CNPY3 is a critical regulator of NLRP3‐inflammasome activation Open
TLRs mediate the recognition of microbial and endogenous insults to orchestrate the inflammatory response. TLRs localize to the plasma membrane or endomembranes, depending on the member, and rely critically on ER‐resident chaperones to mat…
View article: Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release
Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release Open
Molecular mechanisms through which Gram-positive bacteria induce the canonical inflammasome are poorly understood. Here, we studied the effects of Group B streptococci (GBS) and Staphylococcus aureus (SA) on inflammasome activation in huma…
View article: RIPK3 promoter hypermethylation in hepatocytes protects from bile acid induced inflammation and necroptosis
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid induced inflammation and necroptosis Open
Background & Aims Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a major role in various liver diseases, albeit the cell type-specific regulation of necroptosis in th…
View article: Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis
Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis Open
View article: Induction of innate immune memory via microRNA targeting of chromatin remodelling factors
Induction of innate immune memory via microRNA targeting of chromatin remodelling factors Open