Explanipedia

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria Open

Jérémie Rosain, Anna‐Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen , et al. · 2025

Ibpa a Mutual Prodrug of Ibuprofen and Acetaminophen Alleviates Inflammation, Immune Dysregulation and Fibrosis in Preclinical Models of Systemic Sclerosis Open

Anderson Rodrigues de Almeida, Francisco Jaime Bezerra Mendonça, Andréa Tavares Dantas, Maria Eduarda de Oliveira Gonçalves, Charlotte Chêne , et al. · 2024

Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD Open

Deepika Raman, Charlotte Chêne, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu , et al. · 2023

Graft-versus-host disease (GVHD) is a life-threatening systemic complication of allogeneic hematopoietic stem cell transplantation (HSCT) characterized by dysregulation of T and B cell activation and function, scleroderma-like features, an…

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria Open

Jérémie Rosain, Anna‐Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen , et al. · 2023

A Fenton-like cation can improve arsenic trioxide treatment of sclerodermatous chronic Graft-versus-Host Disease in mice Open

Charlotte Chêne, Mohamed Jeljeli, Dominique Rongvaux-Gaïda, Marine Thomas, François Rieger , et al. · 2022

Graft-versus Host Disease (GvHD) is a major complication of hematopoietic stem cell transplant. GvHD is characterized by the chronic activation of immune cells leading to the development of systemic inflammation, autoimmunity, fibrosis and…

P-372 The role of the immune system in the physiopathology of infertility in case of adenomyosis: a mouse model study Open

Alexander Maget, Mathilde Bourdon, Piétro Santulli, Mohamed Jeljeli, Louis Marcellin , et al. · 2022

Study question Are there any fertility disorders and related local and/or systemic immune changes during the early implantation period in a mouse model of adenomyosis? Summary answer An increase in fertility disorders was observed in adeno…

LPSlow-Macrophages Alleviate the Outcome of Graft-Versus-Host Disease Without Aggravating Lymphoma Growth in Mice Open

Mohamed Jeljeli, Charlotte Chêne, Sandrine Chouzenoux, Marine Thomas, Benjamin Segain , et al. · 2021

Despite significant therapeutic advances, graft- versus -host disease (GvHD) remains the main life-threatening complication following allogeneic hematopoietic stem cell transplantation. The pathogenesis of GvHD is dominated by a dysregulat…

Corrigendum: The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma Open

Niloufar Kavian, S. Mehlal, Mohamed Jeljeli, Nathaniel Edward Bennett Saidu, Carole Nicco , et al. · 2021

CORRECTION article Front. Immunol., 27 July 2021Sec. Immunological Tolerance and Regulation Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.737303

TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis Open

Paôline Laurent, Benoît Allard, Pauline Manicki, Valérie Jolivel, Émeline Levionnois , et al. · 2021

Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy Open

Vivien Béziat, Franck Rapaport, Jiafen Hu, Matthias Titeux, Mathilde Bonnet des Claustres , et al. · 2021

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine Open

Paul Bastard, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Marwa Chbihi, Tom Le Voyer , et al. · 2021

Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported i…

A new strategy against endometriosis: Oral probiotic treatments Open

Sandrine Chouzenoux, Mohamed Jeljeli, Mathilde Bourdon, Ludivine Doridot, Mary Kathleen Thomas , et al. · 2021

Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria Open

Rui Yang, Federico Mele, Lisa Worley, David Langlais, Jérémie Rosain , et al. · 2020

Macrophage Immune Memory Controls Endometriosis in Mice and Humans Open

Mohamed Jeljeli, Luiza Gama Coelho Riccio, Sandrine Chouzenoux, Fabiana Moresi, Laurie Toullec , et al. · 2020

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria Open

Rui Yang, Federico Mele, Lisa Worley, David Langlais, Jérémie Rosain , et al. · 2020

Summary Inborn errors of human IFN-γ immunity underlie mycobacterial disease. We report a patient with mycobacterial disease due to an inherited deficiency of the transcription factor T-bet. This deficiency abolishes the expression of T-be…

Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial Open

Matthieu Mahévas, Imane Azzaoui, Étienne Crickx, Florence Canouï‐Poitrine, Delphine Gobert , et al. · 2020

B-cell activating factor may be involved in the failure of B-cell depleting therapy with rituximab in immune thrombocytopenia (ITP) by promoting the emergence of splenic long-lived plasma cells. From results obtained in mouse models, we hy…

Immunological changes associated with adenomyosis: a systematic review Open

Mathilde Bourdon, Piétro Santulli, Mohamed Jeljeli, Silvia Vannuccini, Louis Marcellin , et al. · 2020

BACKGROUND Adenomyosis is a benign gynecological disorder associated with subfertility, pelvic pain and abnormal uterine bleeding that have significant consequences for the health and quality of life of women. Histologically, it is defined…

Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease Open

Alain Lescoat, M Lelong, Mohamed Jeljeli, Claire Piquet‐Pellorce, Claudie Morzadec , et al. · 2020

Immune Defect in Adults With Down Syndrome: Insights Into a Complex Issue Open

Yannick Dieudonné, B. Uring‐Lambert, Mohamed Jeljeli, Vincent Gies, Yves Alembik , et al. · 2020

Children with Down syndrome (DS) suffer from recurrent respiratory infections, which represent the leading cause of mortality during childhood. This susceptibility to infections is usually considered multifactorial and related to both impa…

Trained immunity modulates inflammation-induced fibrosis Open

Mohamed Jeljeli, Luiza Gama Coelho Riccio, Ludivine Doridot, Charlotte Chêne, Carole Nicco , et al. · 2019

Role of thyroid dysimmunity and thyroid hormones in endometriosis Open

Marine Peyneau, Niloufar Kavian, Sandrine Chouzenoux, Carole Nicco, Mohamed Jeljeli , et al. · 2019

Significance Endometriosis is a common gynecological disorder whose physiopathology is still unclear. Thyroid autoimmunity has long been associated with endometriosis, without a mechanistic explanation to link the two pathologies. First, w…

Ontogeny of cytokine responses to PHA from birth to adulthood Open

Mohamed Jeljeli, Valérie Guérin‐El Khourouj, Béatrice Pédron, Pierre Gressèns, Olivier Sibony , et al. · 2019

Implication of oxidative stress in the pathogenesis of systemic sclerosis via inflammation, autoimmunity and fibrosis Open

Ludivine Doridot, Mohamed Jeljeli, Charlotte Chêne, Frédéric Batteux · 2019

The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma Open

Niloufar Kavian, S. Mehlal, Mohamed Jeljeli, Nathaniel Edward Bennett Saidu, Carole Nicco , et al. · 2018

Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and internal organs and vascular alterations. Dysregulations in the oxidant/antioxidant balance are known to be a major factor in the pathogenesis of the disease. …

Altered vaccine‐induced immunity in children with Dravet syndrome Open

Stéphane Auvin, Mohamed Jeljeli, Béatrice Desnous, Nadia Soussi‐Yanicostas, Pascal Dournaud , et al. · 2018

Summary Dravet syndrome ( DS ) is a refractory epileptic syndrome. Vaccination is the trigger of the first seizure in about 50% of cases. Fever remains a trigger of seizures during the course of the disease. We compared ex vivo cytokine re…

Cytokine/chemokine secretion for detecting tuberculosis in quantiferon supernatants from HIV + and HIV − children Open

Mohamed Jeljeli, Valérie Guérin‐El Khourouj, Virginie Pommelet, Myriam Hormi, Pierre Gressèns , et al. · 2017

The QuantiFERON-Gold In Tube assay (QFT) relies on the detection of IFN-gamma secreted by immune T-cells after whole blood stimulation with ESAT-6, CFP-10 and TB7-7 mycobacterium tuberculosis (M.tb) antigens (Ag). Although QFT has proved m…

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