Mohamed Eddouks
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View article: The acute toxicity, antioxidant and antihyperlipidemic activity of flavonoid glycosides from Ruta montana in female rats with hyperlipidemia induced by Triton WR-1339
The acute toxicity, antioxidant and antihyperlipidemic activity of flavonoid glycosides from Ruta montana in female rats with hyperlipidemia induced by Triton WR-1339 Open
This work aimed to evaluate the antihyperlipidemic activity of the aerial part of Ruta montana flavonoid- glycosides enriched extract (RMFEE) in Triton WR1339-induced hyperlipidemia in female rats, along with its antioxidant properties and…
View article: Antihypertensive, vasorelaxant and antidyslipidemic effects of Santolina africana in rats
Antihypertensive, vasorelaxant and antidyslipidemic effects of Santolina africana in rats Open
Hypertension and dyslipidemia are major causes of cardiovascular disease. Medicinal plants continue to be widely used as therapeutic options for the management of cardiovascular diseases. Santolina africana is a medicinal and aromatic plan…
View article: Antihypertensive and Vasorelaxant Effects of Cistanche phelypaea Leaves through Inhibition of Receptor-Operated Calcium Channels in Rats
Antihypertensive and Vasorelaxant Effects of Cistanche phelypaea Leaves through Inhibition of Receptor-Operated Calcium Channels in Rats Open
Cistanche phelypaea (family: Orobanchaceae) is a medicinal plant traditionally used for its vasorelaxant, diuretic, and sedative properties, highlighting its potential relevance in the management of hypertension. The present study aimed to…
View article: Antihyperglycemic and antidyslipidemic effects of the aqueous extract of Withania adpressa in rats
Antihyperglycemic and antidyslipidemic effects of the aqueous extract of Withania adpressa in rats Open
The current study was conducted to evaluate the antihyperglycemic and antidyslipidemic effects of Withania adpressa aqueous extract (WAAE) in 2 experimental animal models. In streptozotocin-induced diabetic rats, daily oral administration …
View article: Scorzonera undulata: Traditional Applications, Phytochemical Analysis, and Biological and Pharmacological Attributes
Scorzonera undulata: Traditional Applications, Phytochemical Analysis, and Biological and Pharmacological Attributes Open
Scorzonera undulata (S. undulata) is a medicinal plant that is traditionally used to treat various health conditions, including diabetes, constipation, diarrhea, and other digestive issues. However, comprehensive analysis of its traditiona…
View article: Antioxidant and antimicrobial potentials of Matricaria pubescens from the southeastern Morocco
Antioxidant and antimicrobial potentials of Matricaria pubescens from the southeastern Morocco Open
This study explores the antioxidant and antimicrobial properties of Matricaria pubescens (Desf) Schultz, an aromatic plant traditionally used in Moroccan medicine. Collected from Errachidia, extracts were prepared using water, methanol and…
View article: Antihypertensive and vasorelaxant effects of Salvia tingitana in rats
Antihypertensive and vasorelaxant effects of Salvia tingitana in rats Open
Salvia tingitana (S. tingitana) is a medicinal and aromatic plant that belongs to the Lamiaceae family with several medicinal properties. Secondary metabolites, including flavonoids, polyphenols and tannins, were identified through phytoch…
View article: Synthesis and characterization of surfactants derived from phenolphthalein: <i>In vivo</i> and <i>in silico</i> studies of their antihyperlipidemic effect
Synthesis and characterization of surfactants derived from phenolphthalein: <i>In vivo</i> and <i>in silico</i> studies of their antihyperlipidemic effect Open
New phenolphthalein-based surfactants were synthesized, and their antihyperlipidemic activity was evaluated through both in vivo and in silico investigations. The target compounds were synthesized using the O-alkylation reaction between ph…
View article: Anti-hyperlipidemic effect and phytochemical analysis of essential oil from <i>Achillea ageratum</i> L.
Anti-hyperlipidemic effect and phytochemical analysis of essential oil from <i>Achillea ageratum</i> L. Open
The objective of this study was to assess the impact of Achillea ageratum L. (A. ageratum) essential oil (EO) administered at a dosage of 50 mg/kg on triton WR-1339-induced hyperlipidemia in Wistar rats. The phytochemical com…
View article: An overview on pharmacological, ethnomedicinal, and phytochemical investigations of Zygophyllum gaetulum Emb. & Maire - an endemic species of southeast of Morocco
An overview on pharmacological, ethnomedicinal, and phytochemical investigations of Zygophyllum gaetulum Emb. & Maire - an endemic species of southeast of Morocco Open
Zygophyllum gaetulum Emb. Maire (Zygophyllaceae), commonly known as "El Aggaya" or "El Berraya", is a medicinal plant Indigenous to the Moroccan Sahara. It exhibits endemic characteristics and is notably prevalent in the Drâa-Tafilalet reg…
View article: Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer
Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer Open
Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties and adapt to environmental conditions, suc…
View article: Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from <i>Laurus nobilis</i> essential oil in rat
Antihyperlipidemic effect and GC-MS analysis of phytoconstituents from <i>Laurus nobilis</i> essential oil in rat Open
This study aimed to evaluate the effect of Laurus nobilis (L. nobilis) essential oil (EOs) (80 mg/kg) on Triton WR-1339-induced dyslipidemia in Wistar rats. The effect of L. nobilis essential oil (80 mg/kg) on lipid an…
View article: Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein
Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein Open
Cervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages …
View article: Assessment of Hematological, and Biochemical Effects of Acute and Subacute Toxicity of the Aqueous Extract from Retama Sphaerocarpa Leaves in Wistar Rats, and In-Silico Investigation of Phenolic Compounds as Potential Inhibitors Against Hpv16 E6 Oncoprotein
Assessment of Hematological, and Biochemical Effects of Acute and Subacute Toxicity of the Aqueous Extract from Retama Sphaerocarpa Leaves in Wistar Rats, and In-Silico Investigation of Phenolic Compounds as Potential Inhibitors Against Hpv16 E6 Oncoprotein Open
View article: <i>Salvia aucheri</i> Exhibits Antihypertensive Activity in Hypertensive Rats
<i>Salvia aucheri</i> Exhibits Antihypertensive Activity in Hypertensive Rats Open
Aims: The present work aimed to assess the antihypertensive activity of Salvia aucheri. Background: Salvia aucheri (S. aucheri) is an aromatic and medicinal herb belonging to the Lamiaceae family. In Morocco, this plant is locally used for…
View article: Origin, Early History, Cultivation, and Characteristics of the Traditional Varieties of Moroccan <i>Cannabis sativa</i> L.
Origin, Early History, Cultivation, and Characteristics of the Traditional Varieties of Moroccan <i>Cannabis sativa</i> L. Open
Background: Cannabis has been cultivated and used for centuries in the north Moroccan Rif (local name is kif). However, its history is poorly known and the date of its first introduction and dispersal in Morocco is sti…
View article: Editorial: Mechanisms of Traditional Medicinal Plants Used to Control Type 2 Diabetes or Metabolic Syndrome
Editorial: Mechanisms of Traditional Medicinal Plants Used to Control Type 2 Diabetes or Metabolic Syndrome Open
EDITORIAL article Front. Pharmacol., 14 January 2021 | https://doi.org/10.3389/fphar.2020.617018
View article: Adherence to the Mediterranean diet of school-age children in Moroccan oases, Draa-Tafilalet Region
Adherence to the Mediterranean diet of school-age children in Moroccan oases, Draa-Tafilalet Region Open
Most of the study population had medium to good adherence to MedDiet, but low KIDMED index was observed. Interventions and strategies should be devised for preserving and promoting healthy eating habits in this target population.
View article: Meet Our Regional Editor
Meet Our Regional Editor Open
View article: Aqueous Extract of Matricaria pubescens Exhibits Antihypertensive Activity in L-NAME-induced Hypertensive Rats through its Vasorelaxant Effect
Aqueous Extract of Matricaria pubescens Exhibits Antihypertensive Activity in L-NAME-induced Hypertensive Rats through its Vasorelaxant Effect Open
Background: Matricaria pubescens is a medicinal plant from North Africa. This plant is widely used in alternative medicine as a remedy against rheumatism, inflammation, diabetes and hypertension. Aim: The aim of the study was to evaluate t…
View article: Effect of Terebinthus atlanticus on Glucose Metabolism in Diabetic Rats
Effect of Terebinthus atlanticus on Glucose Metabolism in Diabetic Rats Open
Background: Terebinthus atlanticus (Anacardiaceae) is an important source of essential oil and phenolic compounds justifying its use in traditional medicine. Objective: The present work aimed to evaluate the antidiabetic and the antioxidan…
View article: Leaf Aqueous Extract of Argania spiniosa Exhibits Antihyperglycemic Effect in Diabetic Rats
Leaf Aqueous Extract of Argania spiniosa Exhibits Antihyperglycemic Effect in Diabetic Rats Open
Introduction: Argania Spinosa L. (Sapotaceae) is an endemic species from south-western Morocco. This plant has many traditional uses including its use in the treatment of diabetes. Objective: The objective of the study was to evaluate the …
View article: Hypolipidemic and Antioxidant Activities of Corrigiola telephiifolia in Diabetic Rats
Hypolipidemic and Antioxidant Activities of Corrigiola telephiifolia in Diabetic Rats Open
Objective: The evaluation of the hypolipidemic and antioxidant activities of the aerial parts aqueous extract of Corrigiola telephiifolia (APAE of C. telephiifolia) in normal and streptozotocin (STZ)-induced diabetic rats. Methods: The eff…
View article: Glucose Lowering Activity of Aqueous Ammodaucus leucotrichus Extract in Diabetic Rats
Glucose Lowering Activity of Aqueous Ammodaucus leucotrichus Extract in Diabetic Rats Open
Background: Ammodaucus leucotrichus (Apiaceae) is a medicinal plant widely used by the Moroccan population to treat various diseases including diabetes. Aims: The aim of this study was to evaluate the antidiabetic effect of the aqueous ext…
View article: Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats
Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats Open
Background and Objective: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia…
View article: Ethnobotanic, Ethnopharmacologic Aspects and New Phytochemical Insights into Moroccan Argan Fruits
Ethnobotanic, Ethnopharmacologic Aspects and New Phytochemical Insights into Moroccan Argan Fruits Open
This review summarizes available data on argan fruit botany, geographical distribution, traditional uses, environmental interest, socioeconomic role, phytochemistry, as well as health beneficial effects and examination of future prospects.…
View article: Contribution to the study of medicinal plants used in the treatment of diabetes, obesity and hypertension in Tafilalet region (Morocco)
Contribution to the study of medicinal plants used in the treatment of diabetes, obesity and hypertension in Tafilalet region (Morocco) Open
The aims of the current review were to give an overview of the contribution of our research team to the study of antidiabetic, antihypertensive and anti-obesity medicinal plants in the southeastern region of Morocco (Tafilalet). A systemat…
View article: <i>Capparis spinosa L.</i> aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice.
<i>Capparis spinosa L.</i> aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice. Open
We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.
View article: Pharmacological Properties of Capparis spinosa Linn
Pharmacological Properties of Capparis spinosa Linn Open
Capparis spinosa Linn. (Capparaceae) was traditionally used for pharmacological purposes and has potential for use in modern cosmetics. This review aims to assess the current available knowledge of Capparis spinosa and its constituents for…
View article: Pathophysiologic Aspects of Hypertension
Pathophysiologic Aspects of Hypertension Open
Hypertension is defined as a sustained increase in blood pressure. Historically, the level of blood pressure designating hypertension has been a systolic blood pressure of 140 mm Hg or more and/or a diastolic blood pressure of 90 mm Hg or …