Shahid Aziz
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View article: Screening of novel therapeutic targets and chimeric vaccine construction against antibiotic-resistant Yersinia Enterocolitica
Screening of novel therapeutic targets and chimeric vaccine construction against antibiotic-resistant Yersinia Enterocolitica Open
Yersinia enterocolitica is known to cause a variety of infections, including mild gastroenteritis and severe systemic disease. This bacterium has developed resistance to several antibiotics, including cephalosporins, penicillins, and fluor…
View article: Kocher’s Diacondylar Fracture of the Distal Humerus: A Case Report and Literature Review
Kocher’s Diacondylar Fracture of the Distal Humerus: A Case Report and Literature Review Open
Kocher’s diacondylar fracture is a rare form of coronal shear fracture involving both the capitellum and trochlea as a single osseous fragment. Due to its rarity and the limitations of standard radiographic imaging, diagnosis is often dela…
View article: KNEE PIGMENTED VILLONODULAR SYNOVITIS WITH AN ATYPICAL MULTI-SYSTEM SYNDROME : CASE REPORT
KNEE PIGMENTED VILLONODULAR SYNOVITIS WITH AN ATYPICAL MULTI-SYSTEM SYNDROME : CASE REPORT Open
Pigmented villonodular synovitis is still of an unknown etiology. This article presents a case with knee pigmented villonodular synovitis associated with an new atypical multi-systemic syndrome. It also presents the peculiarities of clinic…
View article: A Rare Combined Fracture of the Ankle, Talar Neck Fracture-Dislocation and Jones Fracture: Case Report and Management
A Rare Combined Fracture of the Ankle, Talar Neck Fracture-Dislocation and Jones Fracture: Case Report and Management Open
Highlights • This article aims to present a rare fracture combination of ankle and foot fractures and dislocations. Which will allow professionals a rapid recognition and adequate management of this type of trauma. • It also presents the p…
View article: Tissue- and Condition-Specific Biosynthesis of Ascorbic Acid in Glycine max L.: Insights from Genome-Wide Analyses of Pathway-Encoding Genes, Expression Profiling, and Mass Fraction Determination
Tissue- and Condition-Specific Biosynthesis of Ascorbic Acid in Glycine max L.: Insights from Genome-Wide Analyses of Pathway-Encoding Genes, Expression Profiling, and Mass Fraction Determination Open
Ascorbic acid (AsA) is an essential plant metabolite that acts primarily as an antioxidant, regulates cell division and elongation, and enhances stress tolerance. Despite its crucial physiological role, the biosynthesis of AsA in G. max, a…
View article: Risk Factors Evaluation and Antiviral Eradication Therapies Among HCV Infected Family Members of Northern Regions, Pakistan
Risk Factors Evaluation and Antiviral Eradication Therapies Among HCV Infected Family Members of Northern Regions, Pakistan Open
Hepatitis C virus (HCV) poses a global health threat, often transmitted intra-familial. This study aims to assess HCV transmission within Pakistani households and identify associated risk factors. To analyze 125 household subjects for HCV …
View article: Prevalence of HBV Infection and Associated Risk Factors in the General Population of District Peshawar, Pakistan
Prevalence of HBV Infection and Associated Risk Factors in the General Population of District Peshawar, Pakistan Open
Objective: This study aimed to assess the prevalence of hepatitis B virus (HBV) infection and its associated risk factors in the general population of Peshawar, Khyber Pakhtunkhwa (KPK), Pakistan. Methodology: This cross-sectional study wa…
View article: Evaluation of fundus first laparoscopic cholecystectomy in an obscured calot triangle: outcomes
Evaluation of fundus first laparoscopic cholecystectomy in an obscured calot triangle: outcomes Open
Background: A fundus first laparoscopic cholecystectomy when performed by an experienced surgeon, provides the same level of safety and durability as an open cholecystectomy. When Calot's triangle cannot be safely dissected during laparosc…
View article: Evaluation of fundus first laparoscopic cholecystectomy in an obscured calot triangle: outcomes
Evaluation of fundus first laparoscopic cholecystectomy in an obscured calot triangle: outcomes Open
Background: A fundus first laparoscopic cholecystectomy when performed by an experienced surgeon, provides the same level of safety and durability as an open cholecystectomy. When Calot's triangle cannot be safely dissected during laparosc…
View article: Genome-level therapeutic targets identification and chimeric Vaccine designing against the Blastomyces dermatitidis
Genome-level therapeutic targets identification and chimeric Vaccine designing against the Blastomyces dermatitidis Open
View article: Transcriptome Analyses in Adult Olive Trees Indicate Acetaldehyde Release and Cyanide-Mediated Respiration Traits as Critical for Tolerance against Xylella fastidiosa and Suggest AOX Gene Family as Marker for Multiple-Resilience
Transcriptome Analyses in Adult Olive Trees Indicate Acetaldehyde Release and Cyanide-Mediated Respiration Traits as Critical for Tolerance against Xylella fastidiosa and Suggest AOX Gene Family as Marker for Multiple-Resilience Open
Xylella fastidiosa (Xf) is a global bacterial threat for a diversity of plants, including olive trees. However, current understanding of host responses upon Xf-infection is limited to allow early disease prediction, diagnosis, and sustaina…
View article: The value of neutrophil, platelet-to-lymphocyte ratio and lymphocyte to monocyte ratio with disease activity in rheumatoid arthritis
The value of neutrophil, platelet-to-lymphocyte ratio and lymphocyte to monocyte ratio with disease activity in rheumatoid arthritis Open
View article: Indocyanine Green as an Alternative to Intraoperative Cholangiogram to Delineate Extrahepatic Biliary Tract in Laparoscopic Cholecystectomy
Indocyanine Green as an Alternative to Intraoperative Cholangiogram to Delineate Extrahepatic Biliary Tract in Laparoscopic Cholecystectomy Open
View article: Transcriptome Analyses in a Selected Gene Set Indicate Alternative Oxidase (AOX) and Early Enhanced Fermentation as Critical for Salinity Tolerance in Rice
Transcriptome Analyses in a Selected Gene Set Indicate Alternative Oxidase (AOX) and Early Enhanced Fermentation as Critical for Salinity Tolerance in Rice Open
Plants subjected to stress need to respond rapidly and efficiently to acclimatize and survive. In this paper, we investigated a selected gene set potentially involved in early cell reprogramming in two rice genotypes with contrasting salin…
View article: Allelic gene polymorphisms suspected to diversify the individual early metabolic response upon influenza H3N2 and SARS-CoV-2 infections
Allelic gene polymorphisms suspected to diversify the individual early metabolic response upon influenza H3N2 and SARS-CoV-2 infections Open
In this brief report, we point to virus infection time-dependent transcript levels of polymorphic ASMTL genes in human nasal epithelial cells from seven cell origins. Our observations encourage focused top-down and hypothesis-driven studie…
View article: Cross-continental admixture in the Kho population from northwest Pakistan
Cross-continental admixture in the Kho population from northwest Pakistan Open
View article: Diversity Control in Early Transcribed ROS/RNS-balancing Genes: A Common Mechanism for Healthy Resilience?
Diversity Control in Early Transcribed ROS/RNS-balancing Genes: A Common Mechanism for Healthy Resilience? Open
Recently, we highlighted adaptive reactive oxygen species (ROS)/reactive nitrogen species (RNS) equilibration in severe acute respiratory syndrome coronavirus 2– (SARS-CoV-2-) and influenza H3N2–infected human nasal epithelial cells (NECs)…
View article: Allelic Gene Polymorphisms Suspected to Diversify the Individual Early Metabolic Response Upon Influenza H3N2 and SARS-CoV-2 Infections
Allelic Gene Polymorphisms Suspected to Diversify the Individual Early Metabolic Response Upon Influenza H3N2 and SARS-CoV-2 Infections Open
Recently, we identified early reactive oxygen species (ROS) and reactive nitrogen species (RNS) rebalancing as part of a major complex trait, named CoV-MAC-TED, that characterized host cell response on SARS-CoV-2 infections from two geneti…
View article: Efficient Rebalancing of ROS Levels in Plants Links to Temporarily Enhanced Aerobic Fermentation, Distinct Cell Restructuration, and Resilience in Field
Efficient Rebalancing of ROS Levels in Plants Links to Temporarily Enhanced Aerobic Fermentation, Distinct Cell Restructuration, and Resilience in Field Open
Recently we identified a major complex trait for early de novo programming (CoV-MAC-TED) in virus-infected human cells by using an interdisciplinary approach that integrates research in plant and human cell systems.[1,2] CoV-MAC-TED includ…
View article: Major Complex Trait for Early De Novo Programming ‘CoV-MAC-TED’ Detected in Human Nasal Epithelial Cells Infected by Two SARS-CoV-2 Variants Is Promising to Help in Designing Therapeutic Strategies
Major Complex Trait for Early De Novo Programming ‘CoV-MAC-TED’ Detected in Human Nasal Epithelial Cells Infected by Two SARS-CoV-2 Variants Is Promising to Help in Designing Therapeutic Strategies Open
Background: Early metabolic reorganization was only recently recognized as an essentially integrated part of immunology. In this context, unbalanced ROS/RNS levels connected to increased aerobic fermentation, which is linked to alpha-tubul…
View article: Transcriptome data from human nasal epithelial cells infected by H3N2 influenza virus indicate early unbalanced ROS/RNA levels, temporarily increased aerobic fermentation linked to enhanced α-tubulin and rapid energy-dependent IRF9-marked immunization
Transcriptome data from human nasal epithelial cells infected by H3N2 influenza virus indicate early unbalanced ROS/RNA levels, temporarily increased aerobic fermentation linked to enhanced α-tubulin and rapid energy-dependent IRF9-marked immunization Open
Background Transcriptome studies of a selected gene set ( ReprogVirus ) had identified unbalanced ROS/RNS levels, which connected to increased aerobic fermentation that linked to alpha-tubulin-based cell restructuration and cell cycle cont…
View article: Major complex trait for early de novo programming ‘CoV-MAC-TED’ detected in human nasal epithelial cells infected by two SARS-CoV-2 variants is promising for designing therapeutic strategies
Major complex trait for early de novo programming ‘CoV-MAC-TED’ detected in human nasal epithelial cells infected by two SARS-CoV-2 variants is promising for designing therapeutic strategies Open
Background Early metabolic reorganization was only recently recognized as essentially integrated part of immunology. In this context, unbalanced ROS/RNS levels that connected to increased aerobic fermentation, which linked to alpha-tubulin…
View article: ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control – a Complex Early Trait (‘CoV-MAC-TED’) for Combating SARS-CoV-2-Induced Cell Reprogramming
ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control – a Complex Early Trait (‘CoV-MAC-TED’) for Combating SARS-CoV-2-Induced Cell Reprogramming Open
In a perspective entitled ‘From plant survival under severe stress to anti-viral human defense’ we raised and justified the hypothesis that transcript level profiles of justified target genes established from in vitro somatic embryogenesis…
View article: From Plant Survival Under Severe Stress to Anti-Viral Human Defense – A Perspective That Calls for Common Efforts
From Plant Survival Under Severe Stress to Anti-Viral Human Defense – A Perspective That Calls for Common Efforts Open
Reprogramming of primary virus-infected cells is the critical step that turns viral attacks harmful to humans by initiating super-spreading at cell, organism and population levels. To develop early anti-viral therapies and proactive admini…
View article: ROS/RNS balancing, aerobic fermentation regulation and cell cycle control – a complex early trait (‘CoV-MAC-TED’) for combating SARS-CoV-2-induced cell reprogramming
ROS/RNS balancing, aerobic fermentation regulation and cell cycle control – a complex early trait (‘CoV-MAC-TED’) for combating SARS-CoV-2-induced cell reprogramming Open
In a perspective entitled ‘From plant survival under severe stress to anti-viral human defense’ we raised and justified the hypothesis that transcript level profiles of justified target genes established from in vitro somatic embryogenesis…
View article: A Comparison of Transverse Palatal Width in Adult Untreated Cleft Palate Patients with Normal Adult Palates: A Pilot Study
A Comparison of Transverse Palatal Width in Adult Untreated Cleft Palate Patients with Normal Adult Palates: A Pilot Study Open
Objective: The purpose of this pilot study is to compare the transverse palatal widths in untreated adult cleft palate patients with normal adult patients. Methods and Materials: The study was conducted in Bangladesh recruiting 10 patients…
View article: Anticancer Activity of Hispidulin from Saussurea simpsoniana and Lupeol from Vincetoxicum arnottianum
Anticancer Activity of Hispidulin from Saussurea simpsoniana and Lupeol from Vincetoxicum arnottianum Open
View article: The genetic composition of Shina population from Gilgit-Baltistan, Pakistan based on mtDNA analyses
The genetic composition of Shina population from Gilgit-Baltistan, Pakistan based on mtDNA analyses Open
The present study aimed to gain insight into the genetic origin of the Shina population from Gilgit-Baltistan, Pakistan. We partially performed the mitochondrial DNA (mtDNA) control region of healthy unrelated individuals of Shina tribe re…