Mohammad Ahmadvand
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View article: Incidence and risk factors of hypothyroidism in patients with hematological malignancies compared to healthy population: a systematic review and meta-analysis
Incidence and risk factors of hypothyroidism in patients with hematological malignancies compared to healthy population: a systematic review and meta-analysis Open
View article: Gamma Delta T Cells in the Tumour Microenvironment: A Double‐Edged Sword
Gamma Delta T Cells in the Tumour Microenvironment: A Double‐Edged Sword Open
Gamma delta (γδ) T cells represent a distinct group of lymphocytes capable of functioning in both pro‐tumorigenic and anti‐tumorigenic capacities inside the tumour microenvironment (TME). Their unique ability for MHC‐independent recognitio…
View article: Allogeneic CART progress: platforms, current progress and limitations
Allogeneic CART progress: platforms, current progress and limitations Open
Allogenic chimeric antigen receptor T (CAR-T) cells have advantages compared to autologous T cell therapies such as availability cells for production, a suitable HLA-matched donor (if graft-vs-host-disease and rejection effects are to be a…
View article: Reduced Cish expression by siRNA knockdown in Natural Killer cells promotes anti-tumor effects against gastric cancer cell lines
Reduced Cish expression by siRNA knockdown in Natural Killer cells promotes anti-tumor effects against gastric cancer cell lines Open
Improving immune cell functions in tumors remains a main challenge in cancer immunotherapy. NK are main innate effector cells with anti-tumor activity against various tumors. Consequently, NK cells are proper candidates for cancer immunoth…
View article: Cytogenetic Abnormalities and Their Impact on Acute Myeloid Leukemia Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation: A Single‐Center Retrospective Study
Cytogenetic Abnormalities and Their Impact on Acute Myeloid Leukemia Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation: A Single‐Center Retrospective Study Open
Background and Aims Cytogenetic abnormalities at diagnosis are detected in over half of adult patients with acute myeloid leukemia (AML). This study aimed to evaluate the impact of these abnormalities on the outcomes of AML patients underg…
View article: Evaluating the safety and feasibility of allogeneic NK cell infusion in high-risk lymphoma patients post-autologous stem cell transplantation
Evaluating the safety and feasibility of allogeneic NK cell infusion in high-risk lymphoma patients post-autologous stem cell transplantation Open
Lymphoma, a cancer with poor prognosis is a growing global health challenge that encompasses two primary types, Hodgkin (HL) and non-Hodgkin lymphoma (NHL), each further divided into various subtypes with distinct biological behaviors. Con…
View article: Immune checkpoints and ncRNAs: pioneering immunotherapy approaches for hematological malignancies
Immune checkpoints and ncRNAs: pioneering immunotherapy approaches for hematological malignancies Open
View article: Cell therapy using anti-NKG2A pretreated natural killer cells in patients with hepatocellular carcinoma
Cell therapy using anti-NKG2A pretreated natural killer cells in patients with hepatocellular carcinoma Open
Background: The activities and functions of natural killer (NK) cells are controlled by a limited repertoire of activating and inhibitory NK receptors. Therefore, blocking inhibitory receptors such as NKG2A using monoclonal antibodies (mAb…
View article: CAR-NK Cells as Promising Immune Therapeutics: Platforms and Current Progress
CAR-NK Cells as Promising Immune Therapeutics: Platforms and Current Progress Open
Context: Adoptive T-cell therapy with chimeric antigen receptor (CAR) has shown tremendous progress in hematological cancers. However, some obstacles, such as high price tag, cytokine release syndrome, inability to penetrate solid tumors, …
View article: Upregulation of lnc-FOXD2-AS1, CDC45, and CDK1 in patients with primary non-M3 AML is associated with a worse prognosis
Upregulation of lnc-FOXD2-AS1, CDC45, and CDK1 in patients with primary non-M3 AML is associated with a worse prognosis Open
View article: Cytokine-Treated Natural Killer Cells Derived from Cord Blood Haematopoietic Stem Cells Exhibit Potential Cytotoxicity Against Cancer Cells
Cytokine-Treated Natural Killer Cells Derived from Cord Blood Haematopoietic Stem Cells Exhibit Potential Cytotoxicity Against Cancer Cells Open
Background: Despite substantial efforts to leverage natural killer (NK) cells in cancer immunotherapy, challenges associated with limited cell numbers and sources persist. In this study, our objective is to differentiate NK cells from cord…
View article: Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients
Phase I non-randomized clinical trial of allogeneic natural killer cells infusion in acute myeloid leukemia patients Open
View article: Abnormal Promoter Methylation of Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) Gene in the Pathogenesis of Crohn’s Disease
Abnormal Promoter Methylation of Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) Gene in the Pathogenesis of Crohn’s Disease Open
Changes in the expression of nucleotide-binding oligomerization domain containing 2 (NOD2) play an important role in the pathogenesis of several autoimmune diseases, such as inflammatory bowel diseases (IBD), including Crohn’s disease (CD)…
View article: Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML)
Investigation of KIR/HLA relationship and other clinical variables after T-cell-replete haploidentical bone marrow transplantation in patients with acute myeloid leukemia (AML) Open
View article: The long-term outcome and efficacy of PR1/BCR-ABL multipeptides vaccination in chronic myeloid leukemia: results of a 7-year longitudinal investigation
The long-term outcome and efficacy of PR1/BCR-ABL multipeptides vaccination in chronic myeloid leukemia: results of a 7-year longitudinal investigation Open
The long-term outcome and efficacy of PR1/BCR-ABL multipeptides vaccination in chronic myeloid leukemia: results of a 7-year longitudinal investigation
View article: Use of expanded carrier screening for retrospective diagnosis of two deceased siblings with Van Maldergem syndrome 2: case report
Use of expanded carrier screening for retrospective diagnosis of two deceased siblings with Van Maldergem syndrome 2: case report Open
Van Maldergem syndrome (VMLDS) is a recessive disease which affects multiple organs including the face, ear, and limb extremities. It can be caused by pathogenic variants in either the gene DCHS1 or FAT4. Diagnosis of VMLDS is complicated,…
View article: Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model
Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model Open
Introduction: Gastric cancer is one of the most commonly known malignancies and is the fifth cancer-related death globally. Whereas natural killer (NK) cells play a critical role in tumor elimination; therefore, adoptive NK cell therapy ha…
View article: A Comparative Study of the Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells (MSCs) Efficiency on Generating MSC-Educated Macrophages (MEMs)
A Comparative Study of the Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells (MSCs) Efficiency on Generating MSC-Educated Macrophages (MEMs) Open
To the best of our knowledge, this study shows for the first time that the co-culture of MQs with UC-derived MSCs efficiently contributes to the generation of MEMs even greater than BM-MSCs; shedding light on the promising potential of UC …
View article: In Vitro Generation of BK polyomavirus-specific T cells for adoptive cell therapy in refractory cystitis hemorrhagic patients after hematopoietic stem cell transplantation
In Vitro Generation of BK polyomavirus-specific T cells for adoptive cell therapy in refractory cystitis hemorrhagic patients after hematopoietic stem cell transplantation Open
Introduction BKPyV associated hemorrhagic cystitis (BKPyV-HC) is a major and prevalent outcome of hematopoietic stem cell transplantation (HSCT) with no standard treatment option. Adoptive T cell therapy (ACT) against transplant-associated…
View article: Association of Aberrant Promoter Methylation Changes in the Suppressor of Cytokine Signaling 3 (SOCS3) Gene with Susceptibility to Crohn's Disease
Association of Aberrant Promoter Methylation Changes in the Suppressor of Cytokine Signaling 3 (SOCS3) Gene with Susceptibility to Crohn's Disease Open
Background: Growing evidence supports that changes in the methylation state of Inflammatory Bowel Disease (IBD)-associated genes could significantly alter levels of gene expression, potentially contributing to disease onset and progression…
View article: Adaptive NK Cell Therapy Modulated by Anti-PD-1 Antibody in Gastric Cancer Model
Adaptive NK Cell Therapy Modulated by Anti-PD-1 Antibody in Gastric Cancer Model Open
Recently, adaptive NK cell therapy has become a promising treatment but has limited efficacy as a monotherapy. The identification of immune checkpoint inhibitor (ICI) molecules has opened a new horizon of immunotherapy. Herein, we aimed to…
View article: High Expression of Long Noncoding RNA NORAD is Associated With Poor Clinical Outcomes in Non-M3 Acute Myeloid Leukemia Patients
High Expression of Long Noncoding RNA NORAD is Associated With Poor Clinical Outcomes in Non-M3 Acute Myeloid Leukemia Patients Open
Objective/Background: Dysregulation of long noncoding RNA NORAD has been identified in human solid tumors. However, the expression profile of NORAD and its clinical implications in acute myeloid leukemia (AML) is unclear. The current study…
View article: FAS-670A＞G gene polymorphism and the risk of allograft rejection after organ transplantation: a systematic review and meta-analysis
FAS-670A＞G gene polymorphism and the risk of allograft rejection after organ transplantation: a systematic review and meta-analysis Open
The association between the risk of allograft rejection after organ transplantation and FAS gene polymorphism has been evaluated previously. However, inconsistent results have been reported. Hence, we conducted the most up-to-date meta-ana…
View article: Influence of Follicular Fluid and Seminal Plasma on The Expression of Endometrial Receptivity Genes in Endometrial Cells.
Influence of Follicular Fluid and Seminal Plasma on The Expression of Endometrial Receptivity Genes in Endometrial Cells. Open
Human SP and FF may modulate the endometrial receptivity and improve the implantation rate in assisted reproduction cycles through the up-regulation of endometrial receptivity genes.
View article: Treatment protocols for BK virus associated hemorrhagic cystitis after hematopoietic stem cell transplantation.
Treatment protocols for BK virus associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Open
Hematopoietic stem cell transplantation (HSCT) represents a vital curative choice for many disease. However its outcome can be hampered by a variety of transplant associated complications. Hemorrhagic cystitis (HC) considered as one of the…
View article: MicroRNAs as Potential Diagnostic, Prognostic, and Predictive Biomarkers for Acute Graft-versus-Host Disease
MicroRNAs as Potential Diagnostic, Prognostic, and Predictive Biomarkers for Acute Graft-versus-Host Disease Open
Successful treatment of various hematologic diseases with allogeneic hematopoietic stem cell transplantation is often limited due to the occurrence of acute graft-versus-host disease (aGVHD). So far, there are no approved molecular biomark…
View article: Clinical significance of cell-free DNA as a prognostic biomarker in patients with diffuse large B-cell lymphoma
Clinical significance of cell-free DNA as a prognostic biomarker in patients with diffuse large B-cell lymphoma Open
Quantification of cfDNA with qPCR at the time of diagnosis may allow identification of patients with high cfDNA concentration, which correlates with aggressive clinical outcomes and adverse prognosis.
View article: Performance Evaluation of ORBIT Algorithm to Some Effective Parameters
Performance Evaluation of ORBIT Algorithm to Some Effective Parameters Open
ORBIT is a derivative-free trust-region framework that employs a radial basis function (RBF) interpolation to solve the computationally expensive optimization problems. The accuracy and stability of RBF interpolation depend on a so-call…
View article: Designing Human Health Risk Management Model for Dam Construction Projects
Designing Human Health Risk Management Model for Dam Construction Projects Open
Identifying the risks of dam construction projects due to their high importance in terms of utilization, the amount of investment they invest in, the location of the region, the nature of the complexity of the project, and the presence of …
View article: A novel 8-bp duplication in ADAT3 causes mild intellectual disability
A novel 8-bp duplication in ADAT3 causes mild intellectual disability Open