Mohammad Ali Abdullah Almoyad
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View article: Advances in magnesium spinel ferrites for photocatalytic degradation of methylene blue: Challenges and future prospectives
Advances in magnesium spinel ferrites for photocatalytic degradation of methylene blue: Challenges and future prospectives Open
View article: Exploring drug repurposing for PAK2 inhibition: a systematic virtual screening of FDA-approved drugs against cancer
Exploring drug repurposing for PAK2 inhibition: a systematic virtual screening of FDA-approved drugs against cancer Open
The p21-activated kinase 2 (PAK2), a serine/threonine kinase, directly participates in the regulation of various cellular signaling pathways and plays a critical role in cell motility, survival, and proliferation. Due to its crucial role i…
View article: A region-of-interest embedded graph neural architecture for gallbladder cancer detection
A region-of-interest embedded graph neural architecture for gallbladder cancer detection Open
Gallbladder cancer (GBC) is a reasonably competitive disorder, accounting for almost 50% of biliary tract cancers. Diagnosing GBC is challenging because of its asymptomatic nature in early stages and the similarity in imaging capabilities …
View article: Development and in-vitro Assessment of Topical Gel of Celecoxib-Loaded Nanosponges for the Rheumatoid Arthritis
Development and in-vitro Assessment of Topical Gel of Celecoxib-Loaded Nanosponges for the Rheumatoid Arthritis Open
Background Osteoarthritis is characterised by degenerative changes, while rheumatoid arthritis is an inflammatory disorder characterised by swelling and inflammation in the synovial membranes of the joints, which leads to bone erosion and …
View article: A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis
A Hybrid Transfer Learning Framework for Brain Tumor Diagnosis Open
Brain tumors are among the most severe health challenges, necessitating early and precise diagnosis for effective treatment planning. This study introduces an optimized hybrid transfer learning (TL) framework for brain tumor classification…
View article: Exploring gene regulatory interaction networks and predicting therapeutic molecules for hypopharyngeal cancer and <scp>EGFR</scp> ‐mutated lung adenocarcinoma
Exploring gene regulatory interaction networks and predicting therapeutic molecules for hypopharyngeal cancer and <span>EGFR</span> ‐mutated lung adenocarcinoma Open
Hypopharyngeal cancer is a disease that is associated with EGFR‐mutated lung adenocarcinoma. Here we utilized a bioinformatics approach to identify genetic commonalities between these two diseases. To this end, we examined microarray datas…
View article: Repurposing Drugs to Modulate Sortilin: Structure-Guided Strategies Against Atherogenesis, Coronary Artery Disease, and Neurological Disorders
Repurposing Drugs to Modulate Sortilin: Structure-Guided Strategies Against Atherogenesis, Coronary Artery Disease, and Neurological Disorders Open
Sortilin (SORT1) is a multifunctional protein intricately involved in atherogenesis, coronary artery disease (CAD), and various neurological disorders. It has materialized as a potential pharmacological target for therapeutic development d…
View article: The effectiveness of botulinum toxin for temporomandibular disorders: A systematic review and meta-analysis
The effectiveness of botulinum toxin for temporomandibular disorders: A systematic review and meta-analysis Open
Objective The current body of research on utilizing botulinum toxin (BTX) to manage temporomandibular disorders (TMDs) has not yet yielded definitive conclusions. The primary objective of this study was to determine the effectiveness of BT…
View article: Exploring Gene Regulatory Interaction Networks and predicting therapeutic molecules for Hypopharyngeal Cancer and EGFR-mutated lung adenocarcinoma
Exploring Gene Regulatory Interaction Networks and predicting therapeutic molecules for Hypopharyngeal Cancer and EGFR-mutated lung adenocarcinoma Open
With the advent of Information technology, the Bioinformatics research field is becoming increasingly attractive to researchers and academicians. The recent development of various Bioinformatics toolkits has facilitated the rapid processin…
View article: Examining the Prevalence of Congenital Anomalies in Newborns: A Cross-Sectional Study at a Tertiary Care Maternity Hospital in Saudi Arabia
Examining the Prevalence of Congenital Anomalies in Newborns: A Cross-Sectional Study at a Tertiary Care Maternity Hospital in Saudi Arabia Open
Background: Congenital anomalies, representing structural or functional abnormalities present at birth, pose a substantial global health challenge, affecting 8 million newborns annually. With 3.3 million succumbing before age five and 3.2 …
View article: Identification of ZINC08101049 as a potential IL1β inhibitor through molecular docking and MD simulations for cancer therapeutics
Identification of ZINC08101049 as a potential IL1β inhibitor through molecular docking and MD simulations for cancer therapeutics Open
Cancer is a significant global health concern that has a major impact on morbidity and mortality worldwide. Research has demonstrated the involvement of Interleukin-1 beta (IL1β) in various aspects of cancer development and progression, in…
View article: Robust clinical applicable CNN and U-Net based algorithm for MRI classification and segmentation for brain tumor
Robust clinical applicable CNN and U-Net based algorithm for MRI classification and segmentation for brain tumor Open
Early diagnosis of brain tumors is critical for enhancing patient prognosis and treatment options, while accurate classification and segmentation of brain tumors are vital for developing personalized treatment strategies. Despite the wides…
View article: Optimization of chromatographic conditions via Box‒Behnken design in RP-HPLC-PDA method development for the estimation of folic acid and methotrexate in bulk and tablets
Optimization of chromatographic conditions via Box‒Behnken design in RP-HPLC-PDA method development for the estimation of folic acid and methotrexate in bulk and tablets Open
Simultaneous estimation of folic acid and methotrexate in bulk and tablet dosage form by RP-HPLC-PDA was conducted via Box‒Behnken design application. Three-factor numerical values were finalized from the graphical and numerical optimizati…
View article: Cancer Classification Utilizing Voting Classifier with Ensemble Feature Selection Method and Transcriptomic Data
Cancer Classification Utilizing Voting Classifier with Ensemble Feature Selection Method and Transcriptomic Data Open
Biomarker-based cancer identification and classification tools are widely used in bioinformatics and machine learning fields. However, the high dimensionality of microarray gene expression data poses a challenge for identifying important g…
View article: [Bis(quinoline)palladium (II) Chloride] as an Anticancer Drug Demonstrates Promising Activity on Its Own and in the Presence of 6-Shogaol
[Bis(quinoline)palladium (II) Chloride] as an Anticancer Drug Demonstrates Promising Activity on Its Own and in the Presence of 6-Shogaol Open
Synthesis and antitumour activity of a palladium compound, [Bis (quinoline) palladium (II) chloride] (coded as NH1) alone and in combination along with its proposed mechanism of action has been described in the present study. Antitumour ac…
View article: Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer
Exploring the mTOR Signalling Pathway and Its Inhibitory Scope in Cancer Open
Mechanistic target of rapamycin (mTOR) is a protein kinase that regulates cellular growth, development, survival, and metabolism through integration of diverse extracellular and intracellular stimuli. Additionally, mTOR is involved in inte…
View article: An Insight into the Global Problem of Gastrointestinal Helminth Infections amongst Livestock: Does Nanotechnology Provide an Alternative?
An Insight into the Global Problem of Gastrointestinal Helminth Infections amongst Livestock: Does Nanotechnology Provide an Alternative? Open
Helminth parasitic infections are a considerable constraint to the livestock industries worldwide. Nematode parasites cause the major proportion of harm to livestock. The infections caused are accountable for severe economic losses in catt…
View article: An efficient deep learning model to categorize brain tumor using reconstruction and fine-tuning
An efficient deep learning model to categorize brain tumor using reconstruction and fine-tuning Open
Brain tumors are among the most fatal and devastating diseases, often resulting in significantly reduced life expectancy. An accurate diagnosis of brain tumors is crucial to devise treatment plans that can extend the lives of affected indi…
View article: Correction to: Development and evaluation of sunscreen cream containing solid lipid nanoparticles of Spinacia oleraceae
Correction to: Development and evaluation of sunscreen cream containing solid lipid nanoparticles of Spinacia oleraceae Open
View article: Exploring natural compound, Panicutine as leucine-rich repeat kinase 2 inhibitor against Parkinson’s disease: a structure-guided approach
Exploring natural compound, Panicutine as leucine-rich repeat kinase 2 inhibitor against Parkinson’s disease: a structure-guided approach Open
Leucine-rich repeat kinase 2 (LRRK2) is a promising drug target for the therapeutic management of Parkinson’s disease (PD) and other neurodegenerative disorders. LRRK2 inhibitors have the potential to modulate neuroinflammation, reduce alp…
View article: <i>In silico</i> identification of potential protein kinase C alpha inhibitors from phytochemicals from IMPPAT database for anticancer therapeutics: a virtual screening approach
<i>In silico</i> identification of potential protein kinase C alpha inhibitors from phytochemicals from IMPPAT database for anticancer therapeutics: a virtual screening approach Open
Protein Kinase C alpha (PKCα) is a critical signaling molecule that plays a crucial role in various physiological processes, including cell growth, differentiation, and survival. Over the years, there has been a growing interest in targeti…
View article: Synergism from combination of targeted therapy and phytochemicals in colorectal cancer
Synergism from combination of targeted therapy and phytochemicals in colorectal cancer Open
Colorectal cancer is the second most common cancer in women and third in men, accounting for 9.7 % of all cancers incidence. Oxaliplatin is a platinum-based anticancer drug used typically in combination with folinic acid and 5-fluorouracil…
View article: Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action
Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action Open
Polyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most majo…