Mohammad Ayman Salkini
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View article: Effect of Drying on the Quantity and Composition of Artemisia monosperma Essential Oil and Exploring the Bronchodilator Effect Using Guinea Pig Tracheal Muscles
Effect of Drying on the Quantity and Composition of Artemisia monosperma Essential Oil and Exploring the Bronchodilator Effect Using Guinea Pig Tracheal Muscles Open
Artemisia monosperma is a plant with many traditional uses including some affecting smooth muscles.The A. momosperma essential oil (AMEO) prepared by hydrodistillation from fresh and dry aerial parts was compared qualitatively and quantita…
View article: Bio-guided isolation and bioinformatic studies of cytotoxic phytosterols from <i>Acanthospermum hispidum</i> DC against breast (MCF7) and colorectal (HT29) cancer cells
Bio-guided isolation and bioinformatic studies of cytotoxic phytosterols from <i>Acanthospermum hispidum</i> DC against breast (MCF7) and colorectal (HT29) cancer cells Open
Acanthospermum hispidum DC (Asteraceae), a traditional medicinal plant, plays a role as an alternative remedy for various diseases, such as bacterial and viral infections, jaundice, malaria, fever, gastrointestinal disorders, headache, con…
View article: Thymol and carvacrol derivatives as anticancer agents; synthesis, <i>in vitro</i> activity, and computational analysis of biological targets
Thymol and carvacrol derivatives as anticancer agents; synthesis, <i>in vitro</i> activity, and computational analysis of biological targets Open
Thymol and carvacrol derivatives synthesized and examined for anticancer activity, network pharmacology properties, and molecular docking.
View article: Effects of Tiliroside and Lisuride Co-Treatment on the PI3K/Akt Signal Pathway: Modulating Neuroinflammation and Apoptosis in Parkinson’s Disease
Effects of Tiliroside and Lisuride Co-Treatment on the PI3K/Akt Signal Pathway: Modulating Neuroinflammation and Apoptosis in Parkinson’s Disease Open
Researchers are actively exploring potential bioactive compounds to enhance the effectiveness of Lisuride (Lis) in treating Parkinson’s disease (PD) over the long term, aiming to mitigate the serious side effects associated with its extend…
View article: Nanogel-Based Delivery System for Lemongrass Essential Oil: A Promising Approach to Overcome Antibiotic Resistance in Pseudomonas aeruginosa Infections
Nanogel-Based Delivery System for Lemongrass Essential Oil: A Promising Approach to Overcome Antibiotic Resistance in Pseudomonas aeruginosa Infections Open
The emergence of antibiotic-resistant strains of Pseudomonas aeruginosa (P. aeruginosa) presents a substantial obstacle in medical environments. To effectively tackle this problem, we suggest an innovative approach: employing a delivery sy…
View article: Synergistic Combination of Letrozole and Berberine in Ascorbic Acid-Stabilized AuNPs: A Promising Solution for Breast Cancer
Synergistic Combination of Letrozole and Berberine in Ascorbic Acid-Stabilized AuNPs: A Promising Solution for Breast Cancer Open
Breast cancer is a deadly disease that affects countless women worldwide. The most conventional treatments for breast cancer, such as the administration of anticancer medications such as letrozole (LTZ), pose significant barriers due to th…
View article: Gallic-Acid-Loaded PLGA Nanoparticles: A Promising Transdermal Drug Delivery System with Antioxidant and Antimicrobial Agents
Gallic-Acid-Loaded PLGA Nanoparticles: A Promising Transdermal Drug Delivery System with Antioxidant and Antimicrobial Agents Open
The objective of this study was to develop an innovative gallic-acid (GA) drug delivery system that could be administered transdermally, resulting in enhanced therapeutic benefits and minimal negative consequences. The method employed invo…
View article: Comparative GC Analysis, Bronchodilator Effect and the Detailed Mechanism of Their Main Component—Cinnamaldehyde of Three Cinnamon Species
Comparative GC Analysis, Bronchodilator Effect and the Detailed Mechanism of Their Main Component—Cinnamaldehyde of Three Cinnamon Species Open
Cinnamon is one of the most commonly used spices worldwide. In some Arab countries, cinnamon is used with other ingredients to relieve bronchospasm and treatment of airways-related disorders. In the current study, GC, GC-MS and tracheal re…
View article: Caraway Nanoemulsion Gel: A Potential Antibacterial Treatment against Escherichia coli and Staphylococcus aureus
Caraway Nanoemulsion Gel: A Potential Antibacterial Treatment against Escherichia coli and Staphylococcus aureus Open
Novel antibiotics are needed due to the rise of antibiotic-resistant pathogens. Traditional antibiotics are ineffective due to antibiotic-resistant microorganisms, and finding alternative therapies is expensive. Hence, plant-derived carawa…
View article: Antioxidant, Antibacterial, and Anticancer Activity of Ultrasonic Nanoemulsion of Cinnamomum Cassia L. Essential Oil
Antioxidant, Antibacterial, and Anticancer Activity of Ultrasonic Nanoemulsion of Cinnamomum Cassia L. Essential Oil Open
Cinnamomum cassia (C. assia) has long been used in traditional holistic medicine for its medicinal properties. It is used as an antioxidant, antibacterial, anti-inflammatory and anticancer agent. Cinnamon, in particular, the essential oil …
View article: Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation
Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer’s disease in rats: Mechanistic approach to prevent inflammation Open
The most common form of dementia, Alzheimer’s disease (AD), is characterized by gradual declines in cognitive abilities and behavior. It is caused by a combination of factors, including amyloid-β (Aβ) accumulation, acetylcholine (ACh) loss…
View article: Protective Effects of a Polyphenolic Phytochemical Quercetin against Oxidative Dysfunctions in Rats
Protective Effects of a Polyphenolic Phytochemical Quercetin against Oxidative Dysfunctions in Rats Open
Background . Quercetin hastraditionally been used in various oxidative and urinary tract dysfunctions. Thecurrent project is consequently set to evaluate the defensive efficacy ofQuercetin against potassium bromate (KBrO3) induced testicul…
View article: Babchi Oil-Based Nanoemulsion Hydrogel for the Management of Psoriasis: A Novel Energy Economic Approach Employing Biosurfactants
Babchi Oil-Based Nanoemulsion Hydrogel for the Management of Psoriasis: A Novel Energy Economic Approach Employing Biosurfactants Open
The current research aimed to assess the Babchi oil nanoemulsion-based hydrogel prepared using biosurfactants through a low-energy emulsification process for the topical management of psoriasis. The emulsification capacity and solubilities…
View article: Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators Open
This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats. Quercetin was administered orally for 1 week, and behavioral parameters a…
View article: Herbal Fennel Essential Oil Nanogel: Formulation, Characterization and Antibacterial Activity against Staphylococcus aureus
Herbal Fennel Essential Oil Nanogel: Formulation, Characterization and Antibacterial Activity against Staphylococcus aureus Open
Antimicrobial resistance (AMR) is one of the greatest threats to humanity in the world. Antibiotic-resistant bacteria spread easily in communities and hospitals. Staphylococcus aureus (S. aureus) is a serious human infectious agent with th…
View article: Achillea fragrantissima Essential Oil: Composition and Detailed Pharmacodynamics Study of the Bronchodilator Activity
Achillea fragrantissima Essential Oil: Composition and Detailed Pharmacodynamics Study of the Bronchodilator Activity Open
The bronchodilator effect of the Achillea fragrantissima essential oil (AFO) was studied in guinea pigs’ tracheas and the influence of drying on the quantity and composition of AFO was studied using GC-MS and GC analyses. AFO produced a co…
View article: Rutin Improves Anxiety and Reserpine-Induced Depression in Rats
Rutin Improves Anxiety and Reserpine-Induced Depression in Rats Open
Mental disorders have a poor clinical prognosis and account for approximately 8% of the global burden of disease. Some examples of mental disorders are anxiety and depression. Conventional antidepressants have limited efficacy in patients …
View article: Site-Specific Evaluation of Bioactive Coumarin-Loaded Dendrimer G4 Nanoparticles against Methicillin Resistant <i>Staphylococcus aureus</i>
Site-Specific Evaluation of Bioactive Coumarin-Loaded Dendrimer G4 Nanoparticles against Methicillin Resistant <i>Staphylococcus aureus</i> Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a foremost treatment challenge in today's clinical practice. Natural coumarins contain a variety of bioactivities and have the ability to alter resistance in several ways. In developing…
View article: Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus
Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus Open
Bacterial infections caused by antibiotic-resistant pathogens are a significant public health problem. This is because the transmission of infectious diseases is shifting, and new antibiotic-resistant strains of bacteria are emerging. The …
View article: Wound Healing Potential of Calligonum Comosum in the Rat Model: Morphological and Histopathological Evidences
Wound Healing Potential of Calligonum Comosum in the Rat Model: Morphological and Histopathological Evidences Open
Calligonum comosum Family Polygonaceae is a perennial shrub that grows in the desert areas in Saudi Arabia.The plant is extensively used for economic purposes and in Saudi traditional medicine.The plant is used for tanning hides and for wo…
View article: Wound Healing Potential of Commiphora gileadensis Stems Essential Oil and Chloroform Extract
Wound Healing Potential of Commiphora gileadensis Stems Essential Oil and Chloroform Extract Open
Essential oils (EOs) prepared from the fresh and dried stems of Commiphora gileadensis were compared qualitatively and quantitatively. Although the components were closely similar, the amount of oil decreased from 2.23 to 1.77% upon drying…
View article: Potential Active Constituents from Opophytum forsskalii (Hochst. ex Boiss.) N.E.Br against Experimental Gastric Lesions in Rats
Potential Active Constituents from Opophytum forsskalii (Hochst. ex Boiss.) N.E.Br against Experimental Gastric Lesions in Rats Open
Opophytum forsskalii (O. forsskalii) is a desert plant that belongs to the Aizoaceae family. Although it is a natural food source for Bedouin tribes in northern Saudi Arabia, there is little information on its active metabolites. Therefore…
View article: Ecofriendly Validated RP-HPTLC Method for Simultaneous Determination of the Bioactive Sesquiterpene Coumarins Feselol and Samarcandin in Five Ferula Species Using Green Solvents
Ecofriendly Validated RP-HPTLC Method for Simultaneous Determination of the Bioactive Sesquiterpene Coumarins Feselol and Samarcandin in Five Ferula Species Using Green Solvents Open
An environmentally friendly unreported rapid and simple reverse-phase high-performance thin-layer chromatography (RP-HPTLC) has been designed for the simultaneous determination of bioactive sesquiterpene coumarins feselol and samarcandin i…
View article: Development of Gum-Acacia-Stabilized Silver Nanoparticles Gel of Rutin against Candida albicans
Development of Gum-Acacia-Stabilized Silver Nanoparticles Gel of Rutin against Candida albicans Open
Candida spp. is one of the most causative pathogens responsible for fungal infections. It is often a hospital-acquired form of sepsis with a very high number of deaths. Currently, the most effective anti-fungal agents are based on polyenes…
View article: Simultaneous Estimation of Rhein and Aloe-Emodin in Traditional and Ultrasound-Based Extracts of Rheum palmatum L. (Rhubarb) Using Sustainable Reverse-Phase and Conventional Normal-Phase HPTLC Methods
Simultaneous Estimation of Rhein and Aloe-Emodin in Traditional and Ultrasound-Based Extracts of Rheum palmatum L. (Rhubarb) Using Sustainable Reverse-Phase and Conventional Normal-Phase HPTLC Methods Open
The greenness indices of literature analytical procedures for the simultaneous measurement of rhein and aloe-emodin have not been determined. As a consequence, the first goal of this study was to design and validate a sensitive and sustain…
View article: Terpenes from the Fresh Stems of Commiphora gileadensis with Antimicrobial Activity
Terpenes from the Fresh Stems of Commiphora gileadensis with Antimicrobial Activity Open
Phytochemical study directed by antimicrobial activity of the fresh Commiphora gileadensis stems CHCl3 extract resulted in the isolation of compounds 1-9.The structures of the isolated compounds were elucidated utilizing various spectrosco…
View article: A Simple, Cost-Effective, and Green HPTLC Method for the Estimation of Ascorbic Acid in Solvent and Ultrasound-Assisted Extracts of Phyllanthus emblica, Capsicum annuum, and Psidium guajava
A Simple, Cost-Effective, and Green HPTLC Method for the Estimation of Ascorbic Acid in Solvent and Ultrasound-Assisted Extracts of Phyllanthus emblica, Capsicum annuum, and Psidium guajava Open
Greener analytical methodologies for the estimation of ascorbic acid (AA) are poorly reported in the literature. Furthermore, the green indexes of the literature’s analytical assays of AA estimation have not been assessed. As a consequence…