Mohammad E. Kabir
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View article: Acute interstitial nephritis after COVID-19 vaccination
Acute interstitial nephritis after COVID-19 vaccination Open
A woman in her 70s presented to the hospital being generally unwell 8 days following the first dose of the AstraZeneca COVID-19 vaccination. She was in stage III acute kidney injury (AKI) with hyperkalaemia and metabolic acidosis. Urinalys…
View article: Enamelin Is Critical for Ameloblast Integrity and Enamel Ultrastructure Formation
Enamelin Is Critical for Ameloblast Integrity and Enamel Ultrastructure Formation Open
Mutations in the human enamelin gene cause autosomal dominant hypoplastic amelogenesis imperfecta in which the affected enamel is thin or absent. Study of enamelin knockout NLS-lacZ knockin mice revealed that mineralization along the dista…
View article: Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection
Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection Open
Preclinical mouse models that recapitulate some characteristics of coronavirus disease (COVID-19) will facilitate focused study of pathogenesis and virus-host responses. Human agniotensin-converting enzyme 2 (hACE2) serves as an entry rece…
View article: Deuterium incorporation for peptic fragments derived from MM1 rPrP<sup>Sc</sup> (red) and MM2 rPrP<sup>Sc</sup>(blue).
Deuterium incorporation for peptic fragments derived from MM1 rPrP<sup>Sc</sup> (red) and MM2 rPrP<sup>Sc</sup>(blue). Open
(a) 5 min incubation in D2O. (b) 240 h incubation in D2O. Error bars indicate standard deviation (3 independent experiments). *, P<0.05; **, P<0.02.
View article: Schematic representation of PK-resistant fragments in rPrP<sup>Sc</sup> corresponding to Type 1 (MM1) and Type 2 (MM2) sCJD prions and molecular characteristics of purified human rPrPSc used in structural studies.
Schematic representation of PK-resistant fragments in rPrP<sup>Sc</sup> corresponding to Type 1 (MM1) and Type 2 (MM2) sCJD prions and molecular characteristics of purified human rPrPSc used in structural studies. Open
(a) Outline of classification of Type 1 and Type 2 human prions based on proteolytic fragmentation of PrPSc [5,52]. Major cleavage sites by PK are indicated by arrows; GLP—glycolipid; CHO- complex N-glycosylation chains. The cod…
View article: Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions.
Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions. Open
Source, biophysical characteristics, and replication rate of Type 1 and Type 2 sCJD prions.
View article: G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion
G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion Open
Three types of estrogen receptors (ER) exist in the heart, Esr1, Esr2 and the G protein-coupled estrogen receptor 1, Gper1. However, their relative importance in mediating estrogen protective action is unknown. We found that, in the male m…
View article: Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions
Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions Open
The infectious pathogen responsible for prion diseases is the misfolded, aggregated form of the prion protein, PrPSc. In contrast to recent progress in studies of laboratory rodent-adapted prions, current understanding of the molecular bas…
View article: ERs transcripts
ERs transcripts Open
Gper1 mRNAs are the most abundant ER transcripts in male mouse ventricle.
View article: Heart Function
Heart Function Open
Gper1-but not Esr1 nor Esr2- activation is essential for acute E2-mediated heart protection from ischemic/reperfusion (I/R) injury.
View article: ER Western Analysis
ER Western Analysis Open
E2 triggers ERK1/2 and Akt parallel pathways but only ERK1/2 pathway converges on GSK-3β.
View article: Table 1. Heart recovery parameters by E2 in WT, Esr1-/-, Esr2-/- and Gper1-/-
Table 1. Heart recovery parameters by E2 in WT, Esr1-/-, Esr2-/- and Gper1-/- Open
Cardiac functional parameters, left ventricular systolic pressure (LVSP); left ventricular end-diastolic pressure (LVEDP); left ventricular developed pressure (LVDP) and heart rate (HR) before ischemia (Basal) and at different times of rep…
View article: ERs-Western Blot Analysis
ERs-Western Blot Analysis Open
Signaling mechanisms involved in E2-mediated Gper1 activation: role of Akt, ERK1/2and GSK-3β phosphorylation.
View article: Myocardial Infaction analysis
Myocardial Infaction analysis Open
We also examined whether Gper1 expression is required for acute E2-induced improvement of heart viability by determining the myocardial infarct size in sham or hearts subjected to I/R. 3A. Hearts were sectioned and analyzed at the end of t…
View article: Table 2. Heart functional recovery parameters by E2 and in presence of MEK1/2, PKC translocation and PI-3K inhibitors in WT mice.
Table 2. Heart functional recovery parameters by E2 and in presence of MEK1/2, PKC translocation and PI-3K inhibitors in WT mice. Open
Cardiac functional parameters in WT male mice. Left ventricular systolic pressure (LVSP); left ventricular end-diastolic pressure (LVEDP); left ventricular developed pressure (LVDP) and heart rate (HR) before ischemia (Basal) and at differ…
View article: Mitochondrial Calcium Retention Capacity
Mitochondrial Calcium Retention Capacity Open
Gper1 activation is required for E2-mediated increase in mitochondrial Ca2+ retention capacity.