Mohammad Hassan Khadem Ansari
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View article: Boswellia Serrata-Infused Transdermal Patches: A Promising Therapy for Arthritis
Boswellia Serrata-Infused Transdermal Patches: A Promising Therapy for Arthritis Open
Chronic joint inflammatory conditions like osteoarthritis and rheumatoid arthritis share common features, including increased inflammation and oxidative stress, which lead to ongoing tissue damage and debilitating symptoms. In conventional…
View article: Hepatoprotective potential of vanillic acid against isoniazid-rifampicin-induced liver toxicity
Hepatoprotective potential of vanillic acid against isoniazid-rifampicin-induced liver toxicity Open
Liver toxicity induced by antitubercular drugs, such as isoniazid and rifampicin, poses a significant clinical challenge due to oxidative stress and hepatocellular damage. This study evaluated the hepatoprotective potential of vanillic aci…
View article: Dietary silymarin supplementation enhances chemotherapy efficacy of capecitabine and irinotecan and mitigates hepatotoxicity in a mouse model of colon cancer
Dietary silymarin supplementation enhances chemotherapy efficacy of capecitabine and irinotecan and mitigates hepatotoxicity in a mouse model of colon cancer Open
Background and purpose: The flavonoid silymarin (SMN) has shown promise due to its antioxidant, anti-inflammatory, and anticancer properties. SMN has been widely used in preclinical and clinical studies to treat various types of cancer, al…
View article: C1 lateral mass reconstruction using a titanium cage following total resection of the aneurysmal bone cyst: illustrative cases and literature insights
C1 lateral mass reconstruction using a titanium cage following total resection of the aneurysmal bone cyst: illustrative cases and literature insights Open
Introduction: There are limited reports of C1 lateral mass reconstruction using a titanium mesh cage following the surgical removal of an aneurysmal bone cyst (ABC). We describe two uncommon and challenging cases of C1 ABC, highlighting th…
View article: The Effect of Amyloid‐Beta on Empathy‐like Behavior in Rats
The Effect of Amyloid‐Beta on Empathy‐like Behavior in Rats Open
Background Empathy is a complex behavior enabling individuals to recognize and sense the emotional situation of others. Empathy requires cognitive, emotional, and learning abilities to understand and react to the suffering of others. The c…
View article: Sellar hemangiopericytoma masquerading as pituitary adenoma: an overlooked intriguing case study unveiling a rare surgical conundrum
Sellar hemangiopericytoma masquerading as pituitary adenoma: an overlooked intriguing case study unveiling a rare surgical conundrum Open
Hemangiopericytoma (HPC) constitutes less than 1% of all primary central nervous system tumors. It is a vascular neoplasm with potential malignancy that, in rare instances, manifests as a primary lesion within the brain. Typically, it orig…
View article: An 11-month-old boy with tuberculous meningitis presenting as progressive limb weakness, fever, developmental retardation, and loss of consciousness: a case report
An 11-month-old boy with tuberculous meningitis presenting as progressive limb weakness, fever, developmental retardation, and loss of consciousness: a case report Open
View article: Chemotherapeutic Activity of Dietary Supplementation of Silymarin Combined with Capecitabine and Irinotecan in 1,2 Dimethylhydrazine-Induced Mouse Colon Carcinogenesis
Chemotherapeutic Activity of Dietary Supplementation of Silymarin Combined with Capecitabine and Irinotecan in 1,2 Dimethylhydrazine-Induced Mouse Colon Carcinogenesis Open
The flavonoid silymarin (SMN) has been widely used in preclinical and clinical studies to treat various types of cancer, either alone or in combination with chemotherapy agents. Herein, we investigated the therapeutic efficacy of SMN and i…
View article: Association of Helicobacter Pylori Infection with Endothelial Dysfunction in Metabolic Syndrome
Association of Helicobacter Pylori Infection with Endothelial Dysfunction in Metabolic Syndrome Open
Background: Metabolic risk factors play a critical role in metabolic syndrome (MetS), and endothelial dysfunction is important in its development. On the other hand, Helicobacter pylori (H. pylori) infection has an essential role in MetS. …
View article: A rare case of aneurysmal bone cyst of the frontal bone, and an overlook of literature
A rare case of aneurysmal bone cyst of the frontal bone, and an overlook of literature Open
The skull's aneurysmal bone cyst (ABC) represents a rare benign non-neoplastic lesion that usually occurs before the 3rd decade of life. ABC frequently occurs in the long tubular bones. However, skull bone involvement remains rare and limi…
View article: Multiple and recurrent intracranial pseudolymphoma mimicking multiple skull base meningioma, a case report
Multiple and recurrent intracranial pseudolymphoma mimicking multiple skull base meningioma, a case report Open
View article: Serum Levels of Interleukin-1β and Disease Progression in Multiple Myeloma Patients: A Case and Control Study
Serum Levels of Interleukin-1β and Disease Progression in Multiple Myeloma Patients: A Case and Control Study Open
The results of the study indicate the possible involvement of IL-1β at stage-I MM and it can indicate the role of chemokines in the disease process, especially in the early stages. Changes in the chemical profiles mentioned can help in the…
View article: Cooperative Treatment of Gastric Cancer Using B7-H7 siRNA and Docetaxel; How Could They Modify Their Effectiveness?
Cooperative Treatment of Gastric Cancer Using B7-H7 siRNA and Docetaxel; How Could They Modify Their Effectiveness? Open
Purpose: Despite the high prevalence of gastric cancer (GC), drug resistance is a major problem for effective chemotherapy. B7-H7 is a novel member of the B7 superfamily and is expressed in most common cancers. However, the role of B7-H7 o…
View article: Evaluation of Serum Levels of MicroRNA-200C and ACE2 Gene Expression in Severe and Mild Phases of Patients with COVID-19
Evaluation of Serum Levels of MicroRNA-200C and ACE2 Gene Expression in Severe and Mild Phases of Patients with COVID-19 Open
The role of microRNA (miR)200c-3p in regulating ACE2 gene expression in viral and bacterial respiratory diseases has been established. Since ACE2 reduces the acute inflammatory effects in lung diseases and acts as a coronavirus receptor to…
View article: The role of microRNAs in COVID-19 with a focus on miR-200c
The role of microRNAs in COVID-19 with a focus on miR-200c Open
Objective: Epigenetics is a quickly spreading scientific field, and the study of epigenetic regulation in various diseases such as infectious diseases is emerging. The microribonucleic acids (miRNAs) as one of the types of epigenetic proce…
View article: Lupeol synergizes with doxorubicin to induce anti-proliferative and apoptotic effects on breast cancer cells
Lupeol synergizes with doxorubicin to induce anti-proliferative and apoptotic effects on breast cancer cells Open
View article: B7-H7 Suppression Increases the Expression of CTLA-4 and VISTA Genes in Gastric Cancer Cell Line
B7-H7 Suppression Increases the Expression of CTLA-4 and VISTA Genes in Gastric Cancer Cell Line Open
Gastric cancer (GC) is a multifactorial genetic malignancy that tumor metastasis is one of the principal characteristics of this disease. The B7 family immune checkpoints have important functions in maintaining the immune system's equilibr…
View article: Comparative assessment of immunochromatography and ELISA diagnostic tests for HBsAg detection in PCR-confirmed HBV infection
Comparative assessment of immunochromatography and ELISA diagnostic tests for HBsAg detection in PCR-confirmed HBV infection Open
According to our results, the immunochromatographic test was accurate for diagnosing HBs-Ag in blood and the ELISA test had acceptable sensitivity and specificity, compared with PCR testing.
View article: Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy
Comparison of CEA and CA15-3 Markers with Serotonin, Ceruloplasmin and Copper in Breast Cancer Recurrence after Chemotherapy Open
Background: The serotonin, copper, and ceruloplasmin markers are altered in various cancers, including breast cancer. It has been reported that these markers have the potential to be used in the study of cancer recurrence. The purpose of t…
View article: Evaluación comparativa de las pruebas de diagnóstico ELISA e inmunocromatografía para detección de HBsAg en infección por VHB confirmada por PCR
Evaluación comparativa de las pruebas de diagnóstico ELISA e inmunocromatografía para detección de HBsAg en infección por VHB confirmada por PCR Open
Resumen: Introducción y objetivos: La hepatitis viral aparece más frecuentemente al nacer o durante la infancia y es una enfermedad cuyas vías de transmisión incluyen lágrimas, bilis, fluidos sexuales, sudor, leche, orina, heces y saliva. …
View article: A comprehensive review of anticancer mechanisms of action of Alantolactone
A comprehensive review of anticancer mechanisms of action of Alantolactone Open
Cancer is considered as the main challenge of human communities, and it annually imposes a significant economic burden on society. Natural products have been used for treatment of many diseases including inflammation, infections, neurologi…
View article: Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma
Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma Open
The present study indicates the possible role of XO and NOX 1 in the etiology of MM. Although we found no correlation between uric acid and XO, further studies will help clarify the function of uric acid in the pathogenesis of MM..
View article: The effect of a multimodality cardiac imaging elective on pre-clinical medical students
The effect of a multimodality cardiac imaging elective on pre-clinical medical students Open
The Texas Tech University Health Sciences Center School of Medicine has developed an immersive Cardiac Imaging and Innovation week for medical students during their preclinical year. A pre- and post-survey administered to participants show…
View article: The Effects of Nano-curcumin Supplementation on Serum Level of hs-CRP, Adhesion Molecules, and Lipid Profiles in Hemodialysis Patients, A Randomized Controlled Clinical Trial.
The Effects of Nano-curcumin Supplementation on Serum Level of hs-CRP, Adhesion Molecules, and Lipid Profiles in Hemodialysis Patients, A Randomized Controlled Clinical Trial. Open
The current study indicates that nano-curcumin may show beneficial effects in lowering inflammation and hs-CRP levels, as well as adhesion molecules (ICAM-1, VCAM-1), in hemodialysis patients. However, the evidence is still insufficient.
View article: Serum Levels of Interleukin-8 and Soluble Interleukin-6 Receptor in Patients with Stage-I Multiple Myeloma: A Case-Control Study
Serum Levels of Interleukin-8 and Soluble Interleukin-6 Receptor in Patients with Stage-I Multiple Myeloma: A Case-Control Study Open
The results of study suggest the possible involvement of IL-8 and the sIL-6R at stage-I MM and can better characterize the role of chemokines and their receptors in the disease process, especially in the early stages.
View article: Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells through STAT3 signaling pathway
Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells through STAT3 signaling pathway Open
ALT combated the stemness of cancer cells and metastasis by antagonizing of STAT3 signaling pathway. In addition, ALT exhibited anti-metastatic properties and may have potential as a new chemotherapy agent for the reduction of PCa metastas…
View article: Serum levels of bone sialoprotein, osteopontin, and β2-microglobulin in stage I of multiple myeloma
Serum levels of bone sialoprotein, osteopontin, and β2-microglobulin in stage I of multiple myeloma Open
The results suggested that myeloma cells may affect the production of BSP and OPN, which possibly contributes to osteoclastic bone resorption in MM-I patients. Their levels may be a useful biomarker for assessing bone destruction in MM-I p…
View article: The Effect of Curcumin on Functional and Structural Alterations of the Liver in Rats after MDMA Consumption
The Effect of Curcumin on Functional and Structural Alterations of the Liver in Rats after MDMA Consumption Open
Background: Nowadays, one of the problems of human beings is drug addiction, which causes individual, economic and social damages. One of the most commonly used substances in parties is ecstasy pills or 3, 4-methylenedioxymethamphetamine (…
View article: Dihydropyrimidine Dehydrogenase Levels in Colorectal Cancer Cells Treated with a Combination of Heat Shock Protein 90 Inhibitor and Oxaliplatin or Capecitabine
Dihydropyrimidine Dehydrogenase Levels in Colorectal Cancer Cells Treated with a Combination of Heat Shock Protein 90 Inhibitor and Oxaliplatin or Capecitabine Open
Purpose: Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme in the catabolism of fluoropyrimidine drugs including capecitabine. A recent report has suggested that oxaliplatin chemotherapy is associated with elevated DPD levels a…
View article: Protective effect of lutein on spinal cord ischemia-reperfusion injury in rats.
Protective effect of lutein on spinal cord ischemia-reperfusion injury in rats. Open
Findings of the present study demonstrate that lutein may support spinal cord neurons from I-R damage.