Mohammad M. Sajadi
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View article: Sports massage or active exercise for DOMS relief? A systematic review and meta-analysis among healthy population
Sports massage or active exercise for DOMS relief? A systematic review and meta-analysis among healthy population Open
Background: Delayed-onset muscle soreness (DOMS) commonly appears 24–72 hours following eccentric exercise and can impair performance, recovery, and functional capacity. Sports massage therapy (SMT) and active exercise therapy (AET) are fr…
View article: Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation
Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation Open
Broadly neutralizing antibodies (bnAbs) against HIV hold promise as therapeutic and prophylactic agents, but realizing this potential requires antibodies that function across the antigenic heterogeneity of the HIV envelope glycoprotein (En…
View article: Genomic diversity and surveillance of SARS-CoV-2 in Nigeria
Genomic diversity and surveillance of SARS-CoV-2 in Nigeria Open
View article: Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies
Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies Open
CDC Emerging Infectious Disease Research Core Funds, funding for reagent, CDC personal, travel. Defence Threat Reduction Agency (HDTRA12210007): E.K. salary. Oak Ridge Institute for Science and Education (ORISE): E.K. salary and travel. Na…
View article: A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV Open
View article: Effect of Online Mindfulness-Based Cognitive Therapy on Pain Severity and Life Quality in Women Receiving Treatment for Breast Cancer
Effect of Online Mindfulness-Based Cognitive Therapy on Pain Severity and Life Quality in Women Receiving Treatment for Breast Cancer Open
View article: Craft: a machine learning approach to dengue subtyping
Craft: a machine learning approach to dengue subtyping Open
Motivation The dengue virus poses a major global health threat, with nearly 390 million infections annually. A recently proposed hierarchical dengue nomenclature system enhances spatial resolution by defining major and minor lineages withi…
View article: Review of open-source software for developing heterogeneous data management systems for bioinformatics applications
Review of open-source software for developing heterogeneous data management systems for bioinformatics applications Open
Summary In a world where data drive effective decision-making, bioinformatics and health science researchers often encounter difficulties managing data efficiently. In these fields, data are typically diverse in format and subject. Consequ…
View article: A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV Open
Anti-HIV envelope broadly neutralizing antibodies (bnAbs) are alternatives to conventional antiretrovirals with the potential to prevent and treat infection, reduce latent reservoirs, and/or mediate a functional cure. Clinical trials with …
View article: To prescribe or not: a two-center retrospective observational study of antibiotics usage and outcomes of COVID-19 in Turkey
To prescribe or not: a two-center retrospective observational study of antibiotics usage and outcomes of COVID-19 in Turkey Open
View article: Investigating the Interaction between Excipients and Monoclonal Antibodies PGT121 and N49P9.6-FR-LS: A Comprehensive Analysis
Investigating the Interaction between Excipients and Monoclonal Antibodies PGT121 and N49P9.6-FR-LS: A Comprehensive Analysis Open
N49P9.6-FR-LS and PGT121 are promising antibodies with significant therapeutic potential against HIV infection, but they are prone to precipitation at high concentrations. This study evaluates the influence of six excipients—L-arginine, L-…
View article: Review 4: "The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination"
Review 4: "The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination" Open
Reviewers suggest caution in interpreting the data, particularly regarding the classification of long-lived plasma cells as well as the researchers' definitive conclusions due to methodological limitations and sample heterogeneity.
View article: 450 Developing Methods for High-Resolution Characterization of Plasma Cells
450 Developing Methods for High-Resolution Characterization of Plasma Cells Open
OBJECTIVES/GOALS: Antibodies play an important role in the pathogenesis of a wide range of diseases, including cancer, autoimmune diseases, and infections. There are currently no reliable methods to isolate and study specific plasma cell s…
View article: Early elevated IFNα is a key mediator of HIV pathogenesis
Early elevated IFNα is a key mediator of HIV pathogenesis Open
Background A complete understanding of the different steps of HIV replication and an effective drug combination have led to modern antiretroviral regimens that block HIV replication for decades, but these therapies are not curative and mus…
View article: IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
IFNα induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation Open
Background Among people living with HIV, elite controllers (ECs) maintain an undetectable viral load, even without receiving anti-HIV therapy. In non-EC patients, this therapy leads to marked improvement, including in immune parameters, bu…
View article: Discordant Antigenic Properties of Soluble and Virion SARS-CoV-2 Spike Proteins
Discordant Antigenic Properties of Soluble and Virion SARS-CoV-2 Spike Proteins Open
Efforts to develop vaccine and immunotherapeutic countermeasures against the COVID-19 pandemic focus on targeting the trimeric spike (S) proteins of SARS-CoV-2. Vaccines and therapeutic design strategies must impart the characteristics of …
View article: Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Deficient Generation of Spike-Specific Long-Lived Plasma Cells in the Bone Marrow After Severe Acute Respiratory Syndrome Coronavirus 2 Infection Open
Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized t…
View article: Understanding Antibody Magnitude and Durability Following Vaccination Against Sars-Cov-2
Understanding Antibody Magnitude and Durability Following Vaccination Against Sars-Cov-2 Open
View article: Rapid, Sensitive, and Species-Independent Detection of Crimean Congo Hemorrhagic Fever Virus Nucleoprotein and GP38 Antibodies
Rapid, Sensitive, and Species-Independent Detection of Crimean Congo Hemorrhagic Fever Virus Nucleoprotein and GP38 Antibodies Open
View article: Unveiling the multifaceted landscape of N-glycosylation in antibody variable domains: Insights and implications
Unveiling the multifaceted landscape of N-glycosylation in antibody variable domains: Insights and implications Open
View article: Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology
Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology Open
View article: Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG
Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG Open
Antibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from …
View article: The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11
The molecular basis of the neutralization breadth of the RBD-specific antibody CoV11 Open
SARS-CoV-2, the virus behind the COVID-19 pandemic, has changed over time to the extent that the current virus is substantially different from what originally led to the pandemic in 2019–2020. Viral variants have modified the severity and …
View article: Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers
Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers Open
View article: IFNα induces CCR5 in CD4+ T-cells, causing its anti- HIV inefficiency and its subsequent pathogenic elevation, partially controlled by anti-HIV therapy
IFNα induces CCR5 in CD4+ T-cells, causing its anti- HIV inefficiency and its subsequent pathogenic elevation, partially controlled by anti-HIV therapy Open
Like EC, we find that ART-treated patients control serum IFNα concentration and show few immune cell alterations enabling a healthy but fragile medical status. However, treatment interruption leads to elevated IFNα reflecting virus product…
View article: Replacement of Antiretroviral Therapy with HIV Broadly Neutralizing Antibodies to Maximize the Effectiveness of Chemotherapy in HIV Patients with Lung Cancer
Replacement of Antiretroviral Therapy with HIV Broadly Neutralizing Antibodies to Maximize the Effectiveness of Chemotherapy in HIV Patients with Lung Cancer Open
Non-small cell lung cancer (NSCLC) is the most fatal non-AIDS defining cancer in people living with HIV (PWH) on antiretroviral therapy (ART). Treatment of malignancies in PWH requires concomitant cancer therapy and ART, which can lead to …
View article: Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breast milk feeding
Maternal transfer of IgA and IgG SARS-CoV-2 specific antibodies transplacentally and via breast milk feeding Open
Background Although there have been many studies on antibody responses to SARS-CoV-2 in breast milk, very few have looked at the fate of these in the infant, and whether they are delivered to immunologically relevant sites in infants. Meth…
View article: Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies
Histopathology and SARS-CoV-2 Cellular Localization in Eye Tissues of COVID-19 Autopsies Open
View article: Referee report. For: Diagnostic accuracy for a plasma SARS-CoV-2 Nucleocapsid Protein method [version 2; peer review: 1 approved]
Referee report. For: Diagnostic accuracy for a plasma SARS-CoV-2 Nucleocapsid Protein method [version 2; peer review: 1 approved] Open
View article: Characterization of Quantiferon Sars-Cov-2 and Anti-Sars-Cov-2 Nucleocapsid and S1 Spike Protein Antibodies in Vaccinated and Unvaccinated Covid-19 Patients
Characterization of Quantiferon Sars-Cov-2 and Anti-Sars-Cov-2 Nucleocapsid and S1 Spike Protein Antibodies in Vaccinated and Unvaccinated Covid-19 Patients Open