Mohammad M. Zarshenas
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View article: Single-cell RNA sequencing of cerebrospinal fluid reveals the expansion of innate lymphoid cells with upregulated transposable elements in multiple sclerosis
Single-cell RNA sequencing of cerebrospinal fluid reveals the expansion of innate lymphoid cells with upregulated transposable elements in multiple sclerosis Open
Background Multiple sclerosis (MS) is a chronic and often immune-mediated demyelinating disease with no definitive treatment. Transposable elements (TEs) are receiving increasing attention as potential contributors to neurodegenerative dis…
View article: Design and Pharmaceutical Evaluation of <i>Piper nigrum</i> Oil Nanoemulsion by Phase Diagram for Topical Analgesic Applications
Design and Pharmaceutical Evaluation of <i>Piper nigrum</i> Oil Nanoemulsion by Phase Diagram for Topical Analgesic Applications Open
Background: Plant-based pain-relieving formulations have garnered attention in drug discovery, particularly those with a traditional background, often considered essential remedies for communities that rely on plant-based therapies for pai…
View article: A gas chromatographic and spectrophotometric-based assessment of an oral preparation from a traditional exhilarating formulation; linking Persian medicine to the modern phytopharmaceuticals
A gas chromatographic and spectrophotometric-based assessment of an oral preparation from a traditional exhilarating formulation; linking Persian medicine to the modern phytopharmaceuticals Open
Aim: Depression is one of the most important mental diseases. Different pharmacological and non-pharmacological methods are used to treat depression. Traditional and complementary medicine also have a special role in the treatment of depre…
View article: The effectiveness of Melissa officinalis L. essential oil inhalation on anxiety and symptom burden of hemodialysis patients: a randomized trial study
The effectiveness of Melissa officinalis L. essential oil inhalation on anxiety and symptom burden of hemodialysis patients: a randomized trial study Open
View article: Comparison of the Antibacterial Effect of the Essence and Hydroalcoholic Extract of Celery (<i>Apium graveolens</i>) Against <i>Streptococcus mutans</i> in Vitro
Comparison of the Antibacterial Effect of the Essence and Hydroalcoholic Extract of Celery (<i>Apium graveolens</i>) Against <i>Streptococcus mutans</i> in Vitro Open
Background: Streptococcus mutans is the microorganism associated with dental caries, a process involving the demineralization of teeth. Apium graveolens Linn. (celery), belonging to the family Apiaceae, is recognized as a medicinal plant. …
View article: Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review
Exploring the Phytochemistry, Signaling Pathways, and Mechanisms of Action of Tanacetum parthenium (L.) Sch.Bip.: A Comprehensive Literature Review Open
The traditional use of Tanacetum parthenium (L.) Sch.Bip., commonly known as feverfew, extends across various medical conditions, notably those associated with pain and inflammation. In alignment with the growing trend towards developing m…
View article: The Efficacy of a Traditional Herbal Medicine Compound for Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Trial
The Efficacy of a Traditional Herbal Medicine Compound for Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Trial Open
Background: Herbal medicines have recently been incorporated into the treatment algorithm for functional dyspepsia (FD). Persian-FACT, a traditional herbal medicine compound, has been used for centuries in Persian medicine to alleviate dys…
View article: Evaluation of the Effects of <i>Punica granatum</i> Flower Tablets on Pain and Healing of Minor Recurrent Aphthous Stomatitis: A Randomized Clinical Trial
Evaluation of the Effects of <i>Punica granatum</i> Flower Tablets on Pain and Healing of Minor Recurrent Aphthous Stomatitis: A Randomized Clinical Trial Open
Objectives The purpose of this study was to determine the therapeutic effect of the Punica granatum (PG) flower on recurrent aphthous stomatitis in comparison with corticosteroid therapy. Materials and Methods This cross‐over randomized cl…
View article: The Impact of Tadbir as a Pre-Application Treatment of Medicinal Plants on Their Chemical Profiles and Biological Activities in Traditional Persian Pharmacy
The Impact of Tadbir as a Pre-Application Treatment of Medicinal Plants on Their Chemical Profiles and Biological Activities in Traditional Persian Pharmacy Open
Based on basic traditional medicine practice, many plants undergo primary treatments to improve their pharmacological characteristics or to attenuate unwanted or unfavorable features of drugs before incorporating them into drug formulation…
View article: The Effects of Aloe Vera Cream on the Alar Scar in Rhinoplasty, A Randomized Double-Blind Controlled Trial.
The Effects of Aloe Vera Cream on the Alar Scar in Rhinoplasty, A Randomized Double-Blind Controlled Trial. Open
Although both interventions had a significant effect on PSAQ and VSS, compared to Face Duox, the topical use of Aloe Vera cream significantly reduced scar formation after alar resection, both statistically and clinically.
View article: Safety and efficacy of a polyherbal formulation from traditional Persian medicine in patients with calcium kidney stones: A randomized, double-blinded clinical trial
Safety and efficacy of a polyherbal formulation from traditional Persian medicine in patients with calcium kidney stones: A randomized, double-blinded clinical trial Open
Background: 10%–15% of the world’s population suffers from kidney stones. Nearly 50% increase was observed in diagnosing and treating nephrolithiasis in the last decades. Effective medical treatment for the disease is not yet well establis…
View article: Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial
Evaluation of the Effect of Cichorium intybus L. on the Liver Enzymes in Burn Patients: A Randomized Double-Blind Clinical Trial Open
Burn injuries are considered an important public health problem in the world. Burns are considered the fourth most common kind of trauma in the world, after traffic accidents, falls, and interpersonal violence. Various biochemical agents a…
View article: Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial
Efficacy of castor oil cream in treating infraorbital hyperpigmentation: An exploratory single‐arm clinical trial Open
Introduction Infraorbital hyperpigmentation represents one of the most prevalent conditions in cosmetic dermatology. To treat this condition, many patients prefer natural remedies. This study explored the efficacy of topical castor oil cre…
View article: The Added-on of <i>Ziziphus jujube</i> Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H<sub>1</sub> Antihistamine: A Double-Blind Randomized Clinical Trial.
The Added-on of <i>Ziziphus jujube</i> Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H<sub>1</sub> Antihistamine: A Double-Blind Randomized Clinical Trial. Open
Ziziphus jujube syrup could be an effective adjuvant treatment for CSU.Trial Registration Number: IRCT20190304042916N1.
View article: Topical Licorice for Aphthous: A Systematic Review of Clinical Trials.
Topical Licorice for Aphthous: A Systematic Review of Clinical Trials. Open
Licorice extract has been used in different dosage forms, including paste, patch, and mouthwash with concentrations of 1% or 5%. The healing time after licorice therapy is expected to be within 4-8 days. Licorice did not show any adverse e…
View article: Linking traditional medicine to modern phytotherapy: Chemical characterization and assessment of antioxidant and anticholinesterase effects in vitro of a natural Persian remedy for dementia
Linking traditional medicine to modern phytotherapy: Chemical characterization and assessment of antioxidant and anticholinesterase effects in vitro of a natural Persian remedy for dementia Open
View article: Single-cell RNA sequencing of cerebrospinal fluid reveals the expansion of innate lymphoid cells with upregulated transposable elements in multiple sclerosis
Single-cell RNA sequencing of cerebrospinal fluid reveals the expansion of innate lymphoid cells with upregulated transposable elements in multiple sclerosis Open
Background: Multiple sclerosis (MS) is a chronic and often immune-mediated demyelinating disease with no absolute treatment. Transposable elements (TEs) are getting more attention as a possible culprit in neurodegenerative disease. However…
View article: The efficacy of <i>Allium ampeloprasum</i> L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial.
The efficacy of <i>Allium ampeloprasum</i> L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial. Open
A fresh, lyophilized extract from deciduous leaves of A. ampeloprasum L. can effectively shorten the ANC recovery time leading to an earlier release from the hospital. The trial was registered in the Iranian Registry of Clinical Tri…
View article: Antiseizure Effects of <i>Peganum harmala</i> L. and <i>Lavandula angustifolia</i>
Antiseizure Effects of <i>Peganum harmala</i> L. and <i>Lavandula angustifolia</i> Open
Peganum harmala L. and Lavandula angustifolia are two traditional herbs with probable antiseizure effects. This study evaluated the effects of these two herbal extracts on pentylenetetrazol‐ (PTZ‐) induced seizures in mice. We prepared hyd…
View article: A critical overview of Scrophularia striata Boiss.: Phytochemical and pharmacological investigations
A critical overview of Scrophularia striata Boiss.: Phytochemical and pharmacological investigations Open
Ethnopharmacological relevance, Scrophularia striata Boiss belongs to Scrophulariaceae family and grows in western parts of Iran. S. striata phytochemical and pharmacological data were compiled in this review. Scopus database searched for …
View article: Evaluation of metabolites in Iranian Licorice accessions under salinity stress and Azotobacter sp. inoculation
Evaluation of metabolites in Iranian Licorice accessions under salinity stress and Azotobacter sp. inoculation Open
View article: A clinical trial on preventive effects of licorice on propranolol-related dizziness, a side-effect in patients with migraine headache
A clinical trial on preventive effects of licorice on propranolol-related dizziness, a side-effect in patients with migraine headache Open
Background/Aims: This trial aimed to evaluate Licorice preventive effects on dizziness, a side effect of propranolol in patients with migraine headaches (systolic blood pressure < 120 mmHg). Methods: Forty patients (systolic blood pressure…
View article: Herbal Medications to Manage Insomnia: An Overview of Clinical Trials Using Herbal Treatment for Insomnia
Herbal Medications to Manage Insomnia: An Overview of Clinical Trials Using Herbal Treatment for Insomnia Open
Insomnia is one of the most prevalent sleep disorders worldwide which significantly affects the quality of life. Pharmacological and non-pharmacological approaches have been applied in managing insomnia. The risk of tolerance and dependenc…
View article: Startup-Based Learning as an Innovative Method for Pharmacy Education: Medicinal Plants Course Model.
Startup-Based Learning as an Innovative Method for Pharmacy Education: Medicinal Plants Course Model. Open
We found this model effective in boosting students' satisfaction, creativity, and entrepreneurial spirit. Lecturers also play a facilitator role in addition to specialized training. Therefore, in this model, both lecturers and students can…
View article: Design, reformulation, and standardization of a traditional-based memory enhancer herbal preparation originated from Persian medicine
Design, reformulation, and standardization of a traditional-based memory enhancer herbal preparation originated from Persian medicine Open
Design, reformulation, and standardization of a traditional-based memory enhancer herbal preparation originated from Persian medicine
View article: Assessment of Authenticity of Market Samples of Hypericum using Phytochemical Fingerprinting Tools
Assessment of Authenticity of Market Samples of Hypericum using Phytochemical Fingerprinting Tools Open
Aims: Hypericum perforatum L., known as “Hofarighun” is a widely used herbal drug in Traditional Persian Medicine (TPM). Detection of non-relevant plants, instead of this species, in the herbal market encourages the need for the establishm…
View article: Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial Open
Primary hypothyroidism is a common disease. Some patients have persistent symptoms despite normal serum thyroid-stimulating hormone (TSH) levels. Ginger is reported to be beneficial in relieving similar symptoms. Our aim was to evaluate th…
View article: Cardiovascular implications of the COVID-19
Cardiovascular implications of the COVID-19 Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has rapidly spread worldwide and has been infected more than 219 million individuals with 4.55 million deaths worldwide as of September 2021, c…
View article: Volatile composition analysis and quantitative determination of specific markers in a traditional preparation, Jawārish-e-Komooni
Volatile composition analysis and quantitative determination of specific markers in a traditional preparation, Jawārish-e-Komooni Open
The control and standardization process of herbal products is a critical point in traditional medicine. Many drugs that are being used today are not standardized and also there is no noticeable control over them. Out of all the different p…
View article: Author Correction: A systems pharmacology approach to identify the autophagy‑inducing effects of Traditional Persian medicinal plants
Author Correction: A systems pharmacology approach to identify the autophagy‑inducing effects of Traditional Persian medicinal plants Open