Explanipedia

Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression Open

Abdullah Hamadi, Rashid Mir, Osama M. Al‐Amer, Mohammed Alasseiri, Gasim Dobie , et al. · 2025

Background Ischemic stroke poses a notable global public health challenge, with the Kingdom of Saudi Arabia (KSA) being no exception. This multifaceted condition is affected by a combination of factors, including hypertension, diabetes, an…

Impact of Surgical Timing on Outcome in Papillary Thyroid Cancer Patients in Saudi Arabia Open

Omar Zaki A. Alaidaroos, Talal Banan Alanazi, Mohammad Alanazi, Khalid Ayidh Alqahtani, Mohammed Alessa · 2025

Background/Objectives: To evaluate whether the interval between diagnosis and surgery is associated with aggressive histopathological features in papillary thyroid carcinoma (PTC) among patients treated at a tertiary hospitals in Saudi Ara…

Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients Open

Abdullah Hamadi, Rashid Mir, Osama M. Al‐Amer, Mohammed Alasseiri, Imadeldin Elfaki , et al. · 2025

Military Pharmacists and the Management of Chemical, Biological, Radiological, and Nuclear (CBRN) Threats Open

ADEL KHALID HALANAZI, Mohammad Alanazi, NADER THEIFALLAH F AlEINZI, Abdullah D. Alanazi, THEYAB ALI N. ALATAWI , et al. · 2025

Insights from Metabolomics Profiling of MSUD in Pediatrics Toward Disease Progression Open

Abeer Z. Alotaibi, Reem H. AlMalki, Rajaa Sebaa, Maha Al Mogren, Mohammad Alanazi , et al. · 2025

Background: Maple syrup urine disease (MSUD) is a genetic disorder caused by mutations in the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, leading to toxic buildup of branched-chain amino acids (BCAAs) and their ketoacid deriva…

RadGame: An AI-Powered Platform for Radiology Education Open

Mohammed Baharoon, Sasan R. Raissi, Jae‐Bum Jun, Thibault Heintz, Mahmoud Alabbad , et al. · 2025

We introduce RadGame, an AI-powered gamified platform for radiology education that targets two core skills: localizing findings and generating reports. Traditional radiology training is based on passive exposure to cases or active practice…

Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes Open

Rashid Mir, Mohammad Fahad Ullah, Imadeldin Elfaki, Mohammad Alanazi, Naseh A. Algehainy , et al. · 2025

The global impact of COVID-19 was staggering, with millions of cases and related mortality reported worldwide. Genetic variations play a significant role in determining an individual’s susceptibility to SARS-CoV-2 infection and progress to…

Genetic variations in BCL3, MDM4, KLF14, and miR-146a and their associations with the predisposition and progression of myeloproliferative disorder and chronic myeloid leukemia patients Open

Osama M. Al‐Amer, Mohammed Alasseiri, Faris J. Tayeb, Mohammed M. Alanazi, Abdullah Hamadi , et al. · 2025

Introduction: Prior research on the genotype and allele variations of immunometabolism genes and their correlations with the risk of myeloproliferative neoplasms (MPNs) and chronic myeloid leukemia (CML) is inconsistent. Aim: This study ai…

Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies Open

Alshymaa Abdel-Rahman Gomaa, Hesham A. Abou‐Zied, Sara Mahmoud Farhan, Ruqaiah I. Bedaiwi, Mohammad Alanazi , et al. · 2025

Metabolic predictors and risk stratification of post-thyroidectomy hypocalcemia: A retrospective analysis and predictive machinery model Open

Abdullah AlSohaim, Omar Ibrahim Alanazi, Raed Aldahash, Mohammad A Alghamdi, Mohammed Bukhaytan , et al. · 2025

Introduction Post-thyroidectomy hypocalcemia remains a significant surgical complication with varying reported incidence rates. While traditional focus has centered on surgical factors, the role of metabolic predictors in calcium homeostas…

Calendula Arvensis L. Extracts: GC-MS And HPLC-DAD Quantification Of The Main Phenolic Components And Their Pharmacological Potential Open

Ines Sekhara, Wassila Benabderrahmane, Imad Mennai, Chawki Bensouıcı, Giangiacomo Beretta , et al. · 2025

The aim of the current research was to examine and quantify the chemical composition of the chloroform extract of Calendula arvensis, as well as investigate the pharmacologicala ctivities of two different extracts using enzymatic, chemical…

University service utilization patterns in students with specific learning disabilities: An institutional cross-sectional study. Open

Syed Mohammed Basheeruddin Asdaq, Mamdouh Saleh Alharbi, Mohanad Abdullah Alansari, Saleh Alshuqayr, Mohammad Alanazi , et al. · 2025

This study reveals significant underutilization of university services among students with specific learning disabilities (SLDs), despite high prevalence rates. Engagement patterns were strongly influenced by SLD type, academic progression…

On trees with a given number of segments and their maximum general $ Z $-type index Open

Hicham Saber, Zahid Raza, Mohammad Alanazi, Adel A. Attiya, Akbar Ali · 2025

The general $ Z $-type index is a molecular descriptor, introduced recently by Chen and Lin [Discrete Optim., 50 (2023), 100808], which generalizes several well-known molecular descriptors, including the (general) sum-connectivity index an…

The Role of Systemic Inflammation in the Progression of Chronic Diseases A Review Open

Mohammad Alanazi · 2024

Chronic diseases, such as Cardiovascular Diseases CVD, diabetes, Rheumatoid Arthritis RA, and Chronic Kidney Disease CKD, are among the most pressing global health challenges of the 21st century 1.

Empowering Recovery: Evidence-Based Social Work Interventions for Mental Health Patients in Saudi Arabia Open

Mubarak Fehaid S Alkahtani, Abdulrahman Nuwaish Saud Alotaibi, Mohammed Saeed Abdullah Almurayri, Waflah Nasser Alhalf, Ali Alghamdi , et al. · 2024

Mental health disorders remain a significant public health challenge in Saudi Arabia, where cultural stigma and limited resources often complicate the provision of mental health services. This paper explores the role of evidence-based soci…

Health Risk Assessments of Traffic EmissionsImpact on the Environment Open

H. Uguru, Moses O. Akwenuke, Rufus O Akpomrere, O. I. Akpokodje, Hamsa Jameel Banjer , et al. · 2024

On Bond Incident Degree Indices of Fixed-Size Bicyclic Graphs with Given Matching Number Open

Akbar Ali, Abeer M. Albalahi, Mohammad Alanazi, Akhlaq Ahmad Bhatti, Tariq Alraqad , et al. · 2024

A connected graph with p vertices and q edges satisfying q=p+1 is referred to as a bicyclic graph. This paper is concerned with an optimal study of the BID (bond incident degree) indices of fixed-size bicyclic graphs with a given matching …

Chronic Pain Management: Biochemical Pathways, Psychological Impacts, and Nursing Care Approaches Open

Fatimah Mutairan Almutairi, Thekra Bandar Khalid Albahuth, Mousa Yahya Hassan Sahli, Mohammad Alanazi, Mohammad Ali Hamad Al-Qaisi , et al. · 2024

On Unicyclic Graphs with a Given Number of Pendent Vertices or Matching Number and Their Graphical Edge-Weight-Function Indices Open

Akbar Ali, Mohammad Alanazi, Taher S. Hassan, Yilun Shang · 2024

Consider a unicyclic graph G with edge set E(G). Let f be a real-valued symmetric function defined on the Cartesian square of the set of all distinct elements of G’s degree sequence. A graphical edge-weight-function index of G is defined a…

Awareness and Knowledge of Common ENT-Related Issues Among the Population in the Qassim Region: A Cross-Sectional Study Open

Mazyad Alenezi, Faisal A Al-Harbi, Razan Alharbi, Abdullah S Alayed, Emad K. Al-Oadah , et al. · 2024

Background ENT disorders are common, leading many people to seek medical advice. A common misconception among the population is that upper respiratory tract viral infections can be treated with antibiotics, despite their ineffectiveness ag…

Unveiling Lobophytum sp. the neuroprotective potential of Parkinson's disease through multifaceted mechanisms, supported by metabolomic analysis and network pharmacology Open

Hussain T. Bakhsh, Dalia H. Abu‐Baih, Rania H. Abu-baih, Entesar Ali Saber, Faisal H. Altemani , et al. · 2024

Differential expression and regulation of ADAD1, DMRTC2, PRSS54, SYCE1, SYCP1, TEX101, TEX48, and TMPRSS12 gene profiles in colon cancer tissues and their in vitro response to epigenetic drugs Open

Mikhlid H. Almutairi, Turki Mayudh Alrubie, Alaa T. Alshareeda, Nada Albarakati, Alhomidi Almotiri , et al. · 2024

Colon cancer (CC) is a significant cause of death worldwide, particularly in Saudi Arabia. To increase the accuracy of diagnosis and treatment, it is important to discover new specific biomarkers for CC. The main objectives of this researc…

Exploratory Untargeted Metabolomics of Dried Blood Spot Samples from Newborns with Maple Syrup Urine Disease Open

Abeer Z. Alotaibi, Reem H. AlMalki, Maha Al Mogren, Rajaa Sebaa, Mohammad Alanazi , et al. · 2024

Currently, tandem mass spectrometry-based newborn screening (NBS), which examines targeted biomarkers, is the first approach used for the early detection of maple syrup urine disease (MSUD) in newborns, followed by confirmatory genetic mut…

Cytosolic DNA sensor AIM2 promotes KRAS‐driven lung cancer independent of inflammasomes Open

Mohammad Alanazi, Teresa Weng, Louise McLeod, Linden J. Gearing, Julian A. Smith , et al. · 2024

Constitutively active KRAS mutations are among the major drivers of lung cancer, yet the identity of molecular co‐operators of oncogenic KRAS in the lung remains ill‐defined. The innate immune cytosolic DNA sensor and pattern recognition r…

(133) Non-Occupational SCC of the Scrotum; Case Presentation and Management Open

Magdy S. El‐Bahnasawy, Mohammad Alanazi, G Talahmeh, A Abolhasan, Ahmed Kamal · 2024

Introduction Although the incidence of scrotal malignancies is extremely low Squamous cell carcinoma (SCC) is the most common scrotal malignancy. Its overall annual incidence is approximately 1.5 per 1,000,000 persons in Western countries.…

(245) Epididymo-Orchitis as the First Presentation of Brucellosis in an Endemic Area Open

Magdy S. El‐Bahnasawy, Talal Alzahrani, Mohammad Alanazi, Alanoud Mansour Ayed Albalawi · 2024

Introduction Brucellosis, which is also called Mediterranean or Malta fever, is an endemic enzootic disease and can involve various organ systems. It is commonly endemic in the Mediterranean countries and the Middle East. Epididymo-orchiti…

Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease Open

Amar Alomair, Abdullah Alamri, Jilani Shaik, Salman A. Aljafari, Mohammed Ba Abdullah , et al. · 2024

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and multiple single‑nucleotide polymorphisms of DNA repair genes have been found to be associated with CVD. The aim of the present study was to assess the ef…

Extracellular vesicles as tools and targets in therapy for diseases Open

Mudasir A. Kumar, Sadaf Khursheed Baba, Hana Q. Sadida, Sara Al Marzooqi, Jayakumar Jerobin , et al. · 2024

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and surface markers and are ubiquitously released from cells under normal and pathological cond…

The role of artificial intelligence in predicting disease outbreaks: A multidisciplinary approach Open

Abrar Abdullah Ibrahim Alfardan, Rashed Faisai Rashed Alharbi, Wael Hassan Ali Alrammaal, Fahad Alharbi, Mohammed Salem Almotairi , et al. · 2024

This transdisciplinary research examines the use of Artificial Intelligence (AI) in forecasting disease epidemics. The rising frequency and complexity of epidemics need proactive solutions, and AI provides robust capabilities for evaluatin…

Submandibular basal cell adenoma – A rare presentation Open

Fahad Al Qooz, Mohammad Alanazi, Mohammad S. Al Olaimat, Tasneem Malahmeh, Zaid R. Alzoubi · 2024

A basal cell adenoma is a rare salivary gland tumor that usually occurs in the parotid gland, upper lip, palate, or sometimes the nasal septum. It rarely involves the submandibular gland. To the best of our knowledge, only 6 cases involvin…

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