Mahmoud Hamdan
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View article: The Search for Predictive Biomarkers in Response to Immune Checkpoint Inhibitors and Associated Adverse Events
The Search for Predictive Biomarkers in Response to Immune Checkpoint Inhibitors and Associated Adverse Events Open
The introduction of immune checkpoint inhibitors (ICIs) as a part of immunotherapy represented a therapeutic breakthrough in the landscape of cancer treatment. The action of these inhibitors consists of blocking certain inhibitory receptor…
View article: Allelic Homolog Harmonize Theory Explain Hybrid Vigor : A Review
Allelic Homolog Harmonize Theory Explain Hybrid Vigor : A Review Open
Most studies of Hybrid Vigor (H.V) did not advance to the nature of the presence of homologous alleles controlling, as an effective force during hybridization and Heterosis. Current study indicated that the vigor and type of homologous all…
View article: Isoforms of Phosphorylated Tau as Potential Biomarkers for Alzheimer’s Disease: The Contribution of Mass Spectrometry-Based Proteomics
Isoforms of Phosphorylated Tau as Potential Biomarkers for Alzheimer’s Disease: The Contribution of Mass Spectrometry-Based Proteomics Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, heterogeneous at the molecular level and characterized by diverse and complex pathological features. Such features are known to accumulate silently in the brain over yea…
View article: Programmed Cell Death Ligand as a Biomarker for Response to Immunotherapy: Contribution of Mass Spectrometry-Based Analysis
Programmed Cell Death Ligand as a Biomarker for Response to Immunotherapy: Contribution of Mass Spectrometry-Based Analysis Open
Immune checkpoint inhibition is a major component in today’s cancer immunotherapy. In recent years, the FDA has approved a number of immune checkpoint inhibitors (ICIs) for the treatment of melanoma, non-small-cell lung, breast and gastroi…
View article: Proteomic Investigation of Immune Checkpoints and Some of Their Inhibitors
Proteomic Investigation of Immune Checkpoints and Some of Their Inhibitors Open
Immune checkpoints are crucial molecules for the maintenance of antitumor immune responses. The activation or inhibition of these molecules is dependent on the interactions between receptors and ligands; such interactions can provide inhib…
View article: Will Liquid Biopsy Deliver the Expected Breakthrough in Clinical Oncology? Contribution of Mass Spectrometry-Based Proteomics
Will Liquid Biopsy Deliver the Expected Breakthrough in Clinical Oncology? Contribution of Mass Spectrometry-Based Proteomics Open
Analysis of liquid biopsy samples can reveal a wealth of molecular as well as cellular entities circulating in various body fluids. These entities include circulating tumor cells, circulating cell-free and tumor DNA, RNA, and proteins. Det…
View article: Mass Spectrometry Investigation of Some ATP-Binding Cassette (ABC) Proteins
Mass Spectrometry Investigation of Some ATP-Binding Cassette (ABC) Proteins Open
Drug resistance remains one of the main causes of poor outcome in cancer therapy. It is also becoming evident that drug resistance to both chemotherapy and to antibiotics is driven by more than one mechanism. So far, there are at least eig…
View article: Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers
Mass Spectrometry-Based Proteomics: Analyses Related to Drug-Resistance and Disease Biomarkers Open
Mass spectrometry-based proteomics is a key player in research efforts to characterize aberrant epigenetic alterations, including histone post-translational modifications and DNA methylation. Data generated by this approach complements and…
View article: Mass Spectrometry Contribution to Pediatric Cancers Research
Mass Spectrometry Contribution to Pediatric Cancers Research Open
For over four decades, mass spectrometry-based methods have provided a wealth of information relevant to various challenges in the field of cancers research. These challenges included identification and validation of novel biomarkers for v…