Amr Ahmed
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View article: Targeting the feminized nature of prostate cancer exploring estrogen-driven metabolic reprogramming and its therapeutic intervention: а narrative review
Targeting the feminized nature of prostate cancer exploring estrogen-driven metabolic reprogramming and its therapeutic intervention: а narrative review Open
Prostate cancer (PCa) has long been classified as an androgen-driven malignancy; however, mounting evidence underscores the pivotal role of estrogen in its initiation, progression, and therapeutic resistance. This review establishes that P…
View article: Disruption of the transsulfuration pathway as a sulfur-driven etiology of insulin resistance: proinsulin misfolding, disulfide bond deformation, and PDI dysregulation
Disruption of the transsulfuration pathway as a sulfur-driven etiology of insulin resistance: proinsulin misfolding, disulfide bond deformation, and PDI dysregulation Open
Type 2 diabetes mellitus (T2DM), expected to exceed 700 million cases by 2045, is usually attributed to obesity and peripheral resistance but neglects insulin’s structural integrity. This review introduces the Sulfur-Insulin Deformation Hy…
View article: Pharmacological inhibition of type 5 adenylyl cyclase, a model for healthful aging, enhanced exercise capacity and glucose tolerance
Pharmacological inhibition of type 5 adenylyl cyclase, a model for healthful aging, enhanced exercise capacity and glucose tolerance Open
Adenylyl cyclase 5 knockout (AC5 KO) is a healthful longevity model; not only do the AC5 KO mice live a third longer than wild-type (WT) mice, but they are also protected against obesity, diabetes, heart failure, and exercise intolerance, …
View article: Pharmacologic Inhibition of Interleukin-6 by Tocilizumab as a Potential Therapy for Prediabetes Redirecting Fat Distribution from Visceral to Subcutaneous Adiposity and Metabolic Restoration
Pharmacologic Inhibition of Interleukin-6 by Tocilizumab as a Potential Therapy for Prediabetes Redirecting Fat Distribution from Visceral to Subcutaneous Adiposity and Metabolic Restoration Open
Interleukin-6 (IL-6), a pleiotropic cytokine pivotal to adipose homeostasis, has emerged as a key mediator in prediabetes pathogenesis. Within senescent visceral adipose tissue (VAT) adipocytes, hypoxia-inducible factor-1α (HIF-1α)-driven …
View article: SULT1A1/SULT1E1-Mediated Adipokine Hypersulfation and Insulin Trapping: Defining a Sulfur Flux Subtype in the Pathogenesis of Pre-Diabetes
SULT1A1/SULT1E1-Mediated Adipokine Hypersulfation and Insulin Trapping: Defining a Sulfur Flux Subtype in the Pathogenesis of Pre-Diabetes Open
Pre-diabetes, a critical phase within the obesity/adiposity-based chronic disease (ABCD) framework, is characterized by hyperinsulinemia and impaired glucose tolerance without classical insulin resistance. This review proposes a novel hypo…
View article: SULT-Mediated Lipid Sulfation and the LXR/SREBP-1c Axis: Defining a Sulfur Flux Subtype of Treatment-Resistant Obesity/Adiposity-Based Chronic Disease (ABCD)
SULT-Mediated Lipid Sulfation and the LXR/SREBP-1c Axis: Defining a Sulfur Flux Subtype of Treatment-Resistant Obesity/Adiposity-Based Chronic Disease (ABCD) Open
Treatment-resistant obesity/adiposity-based chronic disease (ABCD), affecting approximately 20-30% of cases, poses a significant challenge beyond traditional insulin resistance, often manifesting with preserved insulin sensitivity in early…
View article: Glutathione-CRP Inflammatory Index: A Novel Biomarker Differentiating Acute Versus Chronic Inflammation Depth and Clinical Implications via Redox-Immune Pathway Integration
Glutathione-CRP Inflammatory Index: A Novel Biomarker Differentiating Acute Versus Chronic Inflammation Depth and Clinical Implications via Redox-Immune Pathway Integration Open
Background: Chronic inflammation drives pathologies such as prediabetes, type 2 diabetes, colorectal cancer (CRC), severe community-acquired pneumonia (CAP), and liver cirrhosis, yet biomarkers like high-sensitivity C-reactive protein (hsC…
View article: Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD
Failure of Hepatic Insulin Clearance via CEACAM1-Mediated Endocytosis: The Missing Physiological Link Between Proinsulin Misfolding, Hyperinsulinemia, and Metabolic Complications in Type 2 Diabetes, Obesity, and NAFLD Open
Type 2 diabetes mellitus (T2DM), projected to affect 700 million individuals by 2045, may be driven by a hypothesized physiological axis where impaired hepatic insulin clearance, mediated by CEACAM1 endocytosis, links proinsulin misfolding…
View article: Exploring glutamate-gated chloride channels in cancer cells: A narrative review on a hypothetical mechanism underpinning the anticancer effects of antiparasitic drugs
Exploring glutamate-gated chloride channels in cancer cells: A narrative review on a hypothetical mechanism underpinning the anticancer effects of antiparasitic drugs Open
Chloride channels play a fundamental role in cellular homeostasis, influencing ion balance, pH regulation, and apoptotic signaling. While glutamate-gated chloride channels (GluCl) are traditionally restricted to invertebrates, recent evide…
View article: Localized Semaglutide Injection for Hyperinsulinemia-Induced Lymphatic Dysfunction: A Narrative Review Proposing a Promising Metabolic Perspective for Lymphedema Therapy
Localized Semaglutide Injection for Hyperinsulinemia-Induced Lymphatic Dysfunction: A Narrative Review Proposing a Promising Metabolic Perspective for Lymphedema Therapy Open
Lymphedema, traditionally viewed as a mechanical consequence of lymphatic obstruction, is increasingly recognized as a complex disorder rooted in metabolic dysfunction, particularly insulin resistance and chronic hyperinsulinemia. This par…
View article: Metformin as a Metabolic Adjuvant to Amoxicillin: A Hypothesis on Synergistic Antibacterial Action
Metformin as a Metabolic Adjuvant to Amoxicillin: A Hypothesis on Synergistic Antibacterial Action Open
View article: The Sulfur Insulin Deformation Hypothesis: Disulfide Bond Disruption (A6–A11, A7–B7, A20–B19) and PDI Dysregulation as an Etiology of Insulin Resistance
The Sulfur Insulin Deformation Hypothesis: Disulfide Bond Disruption (A6–A11, A7–B7, A20–B19) and PDI Dysregulation as an Etiology of Insulin Resistance Open
Type 2 diabetes mellitus (T2DM), projected to affect over 700 million by 2045, requires a new etiological framework. The Sulfur Insulin Deformation Hypothesis redefines T2DM as a sulfur metabolism disorder, driven by mitochondrial suffocat…
View article: The Sulfur Insulin Deformation Hypothesis: Disulfide Bond Disruption (A6–A11, A7–B7, A20–B19) and PDI Dysregulation as an Etiology of Insulin Resistance
The Sulfur Insulin Deformation Hypothesis: Disulfide Bond Disruption (A6–A11, A7–B7, A20–B19) and PDI Dysregulation as an Etiology of Insulin Resistance Open
Type 2 diabetes mellitus (T2DM), projected to afflict over 700 million individuals by 2045, demands a revolutionary etiological paradigm. The Sulfur Insulin Deformation Hypothesis redefines T2DM as a sulfur metabolism disorder driven by in…
View article: Sulfur-Dependent Disulfide Bond Disruption in Insulin Resistance: A Hypothesis
Sulfur-Dependent Disulfide Bond Disruption in Insulin Resistance: A Hypothesis Open
View article: 521. L655,708 A NEGATIVE ALLOSTERIC MODULATOR AT OF GABAA RECEPTOR INCREASED DOPAMINE NEURONAL ACTIVITY UP TO 1 WEEK AFTER A SINGLE INJECTION
521. L655,708 A NEGATIVE ALLOSTERIC MODULATOR AT OF GABAA RECEPTOR INCREASED DOPAMINE NEURONAL ACTIVITY UP TO 1 WEEK AFTER A SINGLE INJECTION Open
Background Negative allosteric modulators of gamma-aminobutyric acid A receptors (GABAA-NAMs) bind with high affinity at the α5 subunit located primarily on glutamatergic pyramidal neurons in the prefrontal cortex (PFC) and hippocamps, the…
View article: Sulfur-Dependent Misfolding of Insulin as a Root Cause of Type 2 Diabetes: A Hypothesis Centered on Disulfide Bond Disruption at A6–A11, A7–B7, and A20–B19 in the Etiology of Insulin Resistance
Sulfur-Dependent Misfolding of Insulin as a Root Cause of Type 2 Diabetes: A Hypothesis Centered on Disulfide Bond Disruption at A6–A11, A7–B7, and A20–B19 in the Etiology of Insulin Resistance Open
Type 2 diabetes mellitus (T2DM), projected to affect over 700 million people by 2045, necessitates a transformative etiological perspective. The Sulfur Insulin Deformation Hypothesis redefines T2DM as a sulfur metabolism disorder driven by…
View article: Integrating carboxytherapy and hypochlorous acid: a novel molecular approach harnessing the Bohr effect for diabetic foot ulcer treatment
Integrating carboxytherapy and hypochlorous acid: a novel molecular approach harnessing the Bohr effect for diabetic foot ulcer treatment Open
View article: From tumor-resistant cardiac fatty acid oxidation to whole-body metabolic reprogramming: Anti-Warburg effect of the high-fat AMRD diet for cancer therapy
From tumor-resistant cardiac fatty acid oxidation to whole-body metabolic reprogramming: Anti-Warburg effect of the high-fat AMRD diet for cancer therapy Open
Cancer cells primarily rely on anaerobic glycolysis for energy, a phenomenon known as the Warburg effect, which drives rapid growth, immunosuppression, and tumor microenvironment acidification. In stark contrast, the heart, a tissue remark…
View article: Performance characteristics of the SARS-CoV-2 Isothermal Molecular Assay for point-of-care molecular diagnosis of SARS-CoV-2
Performance characteristics of the SARS-CoV-2 Isothermal Molecular Assay for point-of-care molecular diagnosis of SARS-CoV-2 Open
Background Access to diagnostics was a significant challenge during the early stages of the COVID-19 pandemic, as laboratory reagents, supplies, and consumables were in short supply and high demand. Central laboratories, equipped with adva…
View article: Tumor Cytobiology of IGF-1R in Breast Tumor Activation and Propagation; And the Role of Celecoxib in its Inhibition
Tumor Cytobiology of IGF-1R in Breast Tumor Activation and Propagation; And the Role of Celecoxib in its Inhibition Open
The Insulin-like Growth Factor 1 Receptor (IGF-1R) stands as a central orchestrator in cellular signaling, governing pivotal processes encompassing growth, proliferation, and differentiation. Its aberrant activation is intricately intertwi…
View article: Localized Injection of Semaglutide, a GLP-1 Agonist, for Hyperinsulinemia-Induced Lymphatic Dysfunction A Novel Therapeutic Strategy for Lymphedema Treatment
Localized Injection of Semaglutide, a GLP-1 Agonist, for Hyperinsulinemia-Induced Lymphatic Dysfunction A Novel Therapeutic Strategy for Lymphedema Treatment Open
Lymphedema, traditionally considered a secondary complication of lymphatic damage, may have a deeper, metabolic etiology tied to chronic hyperinsulinemia and insulin resistance. This emerging hypothesis posits that prolonged hyperinsulinem…
View article: Unraveling the Sulfur Insulin Deformation Hypothesis: A Novel Therapeutic Avenue for Type 2 Diabetes
Unraveling the Sulfur Insulin Deformation Hypothesis: A Novel Therapeutic Avenue for Type 2 Diabetes Open
This manuscript presents the “Sulfur Insulin Deformation Hypothesis,” proposing that organic sulfur deficiency contributes to the improper formation of insulin’s disulfide bonds, leading to insulin structural deformation and functional imp…
View article: Biological Therapies in Oncology: Balancing Efficacy and Safety in the Context of Latent Tuberculosis.
Biological Therapies in Oncology: Balancing Efficacy and Safety in the Context of Latent Tuberculosis. Open
View article: Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential
Flavonoids as modulators of miRNA expression in pancreatic cancer: Pathways, Mechanisms, And Therapeutic Potential Open
Pancreatic cancer (PC) is a complex malignancy, distinguished by its aggressive characteristics and unfavorable prognosis. Recent developments in understanding the molecular foundations of this disease have brought attention to the notewor…
View article: Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology
Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology Open
Type 1 Diabetes Mellitus (T1DM) has traditionally been understood through the lens of autoimmune destruction of pancreatic beta cells. However, emerging evidence suggests that defects in the peritoneal membrane, particularly in the pancrea…
View article: Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology
Exploring the Autoimmune Hypothesis of Type 1 Diabetes: Investigating the Potential Role of Peritoneal Membrane Defects in the Pancreatic Tail and Revisiting Alternative Theories of Disease Etiology Open
Type 1 Diabetes Mellitus (T1DM) has traditionally been understood through the lens of autoimmune destruction of pancreatic beta cells. However, emerging evidence suggests that defects in the peritoneal membrane, particularly in the pancrea…
View article: Heat Stroke and Hyperosmolar Hyperglycemia State: Two Faces of the Same Coin (Dehydration) in the Hajj Journey - How to Reduce Deaths Among Pilgrims
Heat Stroke and Hyperosmolar Hyperglycemia State: Two Faces of the Same Coin (Dehydration) in the Hajj Journey - How to Reduce Deaths Among Pilgrims Open
Heat stroke (HS) and hyperosmolar hyperglycemic state (HHS) are critical conditions frequently affecting pilgrims during the Hajj, especially with temperatures exceeding 50°C (122°F). This brief commentary examines the interconnected risks…
View article: Lymphocytic Variant of Triple-Negative Breast Cancer Carcinoma Erysipeloides: A Rare Case of Carcinoma Erysipeloides Following TNBC Mastectomy
Lymphocytic Variant of Triple-Negative Breast Cancer Carcinoma Erysipeloides: A Rare Case of Carcinoma Erysipeloides Following TNBC Mastectomy Open
Background: Carcinoma erysipeloides (CE) is a rare but significant cutaneous manifestation of metastatic breast cancer, often misdiagnosed due to its rarity and nonspecific presentation. This is particularly true in patients with triple-ne…
View article: Cytobiological Alterations Induced by Celecoxib as an Anticancer Agent for Breast and Metastatic Breast Cancer
Cytobiological Alterations Induced by Celecoxib as an Anticancer Agent for Breast and Metastatic Breast Cancer Open
Breast cancer remains a formidable public health challenge worldwide, characterized by its initiation within the breast’s diverse tissues, particularly the ducts and lobules. This malignancy is predominantly categorized into three subtypes…
View article: Exploring the Interplay between the Warburg Effect and Glucolipotoxicity in Cancer Development: A Novel Perspective on Cancer Etiology
Exploring the Interplay between the Warburg Effect and Glucolipotoxicity in Cancer Development: A Novel Perspective on Cancer Etiology Open
The Warburg effect, first observed by Otto Warburg in the 1920s, delineates a metabolic phenomenon in which cancer cells exhibit heightened glucose uptake and lactate production, even under normoxic conditions. This metabolic shift towards…