Mohammad Rehan Ajmal
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View article: Glycation-mediated binding defect in human serum albumin transport oferdosteine: implications in diabetes
Glycation-mediated binding defect in human serum albumin transport oferdosteine: implications in diabetes Open
Human serum albumin (HSA) is a protein in human blood primarily responsible for transporting ligands. Erdosteine is an important drug used in the treatment of acute and chronic respiratory diseases. This study employed molecular docking an…
View article: Baicalein inhibits amyloid beta42 aggregation through disruption of the Asp23-Lys28 salt bridge
Baicalein inhibits amyloid beta42 aggregation through disruption of the Asp23-Lys28 salt bridge Open
The aggregation of amyloid beta-42 (Aβ42) into β-sheet-rich fibrillar structures is a critical pathogenic feature of Alzheimer's disease (AD). Baicalein (BCN), a natural flavonoid, has been shown to inhibit aggregation in amyloidogenic pro…
View article: Prediction of 28-day compressive strength of high-slag concrete by establishing accelerated oven curing regimes for rapid quality control
Prediction of 28-day compressive strength of high-slag concrete by establishing accelerated oven curing regimes for rapid quality control Open
High slag concrete (HSC) offers substantial benefits in terms of durability and reduced carbon footprint, but its late strength gains delayaccurate 28-day strength prediction from early strength. This study aims to develop accelerated oven…
View article: Experimental Evaluation of a Portable Oxygen Concentrator Based on Pressure Swing Adsorption
Experimental Evaluation of a Portable Oxygen Concentrator Based on Pressure Swing Adsorption Open
View article: Computational prediction of the pathogenic variants of arachidonate 5-lipoxygenase activating protein using Molecular Dynamics simulation
Computational prediction of the pathogenic variants of arachidonate 5-lipoxygenase activating protein using Molecular Dynamics simulation Open
The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates leukotrienes (LTs) synthesis. LTs are involved in inflammation which is implicated in cardiovascular diseases (CVDs) and stroke. Variations in ALOX5AP gene are associat…
View article: Drug Repurposing Revealed Abemaciclib and Palbociclib as Inhibitor of Phosphodiesterase-5 (PDE5) in Cancer-Associated Fibroblasts Paving the Way for the Treatment of Breast Cancer
Drug Repurposing Revealed Abemaciclib and Palbociclib as Inhibitor of Phosphodiesterase-5 (PDE5) in Cancer-Associated Fibroblasts Paving the Way for the Treatment of Breast Cancer Open
View article: Efficient hydrogen peroxide reduction in glutathione peroxidase cycle using cost-effective FeSe2 nanospheres
Efficient hydrogen peroxide reduction in glutathione peroxidase cycle using cost-effective FeSe2 nanospheres Open
Introduction Hydrogen peroxide plays a crucial role in melanogenesis by regulating tyrosinase activity, the key melanin-forming enzyme responsible for the browning of fruits, vegetables, and seafood. The need for effective solutions to mit…
View article: Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus
Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus Open
Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease. In addition to the very bad socioeconomic impacts, it influen…
View article: Cytotoxic and anti-metastatic action mediates the anti-proliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in chemopreventive mechanism
Cytotoxic and anti-metastatic action mediates the anti-proliferative activity of Rhazya stricta Decne inducing apoptotic cell death in human cancer cells: Implication in chemopreventive mechanism Open
Cancer is associated with a high rate of pre-mature mortality worldwide and serves as a significant impediment to extended life expectancy, leading to undesirable long-term effects on the quality of life of the patients. Bioactive chemical…
View article: Binding of Novobiocin Paves the Way for Inhibition of DEAH-box Helicase 8
Binding of Novobiocin Paves the Way for Inhibition of DEAH-box Helicase 8 Open
Introduction: DEAH-box helicase 8 (DHX8) is a crucial DEAH-box RNA helicase involved in splicing and required for the release of mature mRNA from the splice. Here, we report the interaction study of human DHX8 and four test compounds namel…
View article: Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response
Protein Misfolding and Aggregation in Proteinopathies: Causes, Mechanism and Cellular Response Open
Proteins are central to life functions. Alterations in the structure of proteins are reflected in their function. Misfolded proteins and their aggregates present a significant risk to the cell. Cells have a diverse but integrated network o…
View article: Glutaredoxin proteins from E. coli isoforms were compared in terms of energy frustration
Glutaredoxin proteins from E. coli isoforms were compared in terms of energy frustration Open
Glutaredoxin (GRXs) protein plays a vital role inside the cell, including redox control of transcription to the cell's antioxidant defense, apoptosis, and cellular differentiation regulation. In this study, we have investigated the energy …
View article: Phytochemical Analysis and Binding Interaction of Cotton Seed Cake Derived Compounds with Target Protein of Meloidogyne incognita for Nematicidal Evaluation
Phytochemical Analysis and Binding Interaction of Cotton Seed Cake Derived Compounds with Target Protein of Meloidogyne incognita for Nematicidal Evaluation Open
The root-knot nematode Meloidogyne incognita is one of the most damaging plant-parasitic nematodes and is responsible for significant crop losses worldwide. Rising human health and environmental concerns have led to the withdrawal of commo…
View article: Stroke Characteristics as Predictors of New-onset Seizure in Patients with Acute Ischemic Stroke
Stroke Characteristics as Predictors of New-onset Seizure in Patients with Acute Ischemic Stroke Open
Introduction: The current guidelines on diagnosis and management of new-onset seizures in stroke are not well defined, especially in the Indian setting. Our study aims at providing insight into the hospital prevalence risk of new-onset sei…
View article: Protective Effect of Catharanthus roseus Extract on Cadmium-Induced Toxicity in Albino Rats: A Putative Mechanism of Detoxification
Protective Effect of Catharanthus roseus Extract on Cadmium-Induced Toxicity in Albino Rats: A Putative Mechanism of Detoxification Open
Globally, people are highly affected by Cadmium (Cd), the most hazardous heavy metal. It has been implicated in various pathogeneses. Oxidative stress may be one the main reasons for Cd-induced disorders in the body. This article investiga…
View article: Studies on Some Less Familiar Ferrocyanogen Complex. Part XV. Composition of the Reaction Products of Chromous Chloride and Potassium Ferricyanide
Studies on Some Less Familiar Ferrocyanogen Complex. Part XV. Composition of the Reaction Products of Chromous Chloride and Potassium Ferricyanide Open
Studies on Some Less Familiar Ferrocyanogen Complex. Part XV. Composition of the Reaction Products of Chromous Chloride and Potassium Ferricyanide
View article: Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells Open
Cancer progression is linked to abnormal epigenetic alterations such as DNA methylation and histone modifications. Since epigenetic alterations, unlike genetic changes, are heritable and reversible, they have been considered as interesting…
View article: The inhibitory and anticancer properties of Annona squamosa L. seed extracts
The inhibitory and anticancer properties of Annona squamosa L. seed extracts Open
Although Annona squamosa Linn. (Annonaceae) has been used in traditional medicine and is known to have several pharmacological properties, its impact on EGFR kinase has not been fully investigated. An assay (biochemical) was used to govern…
View article: Correction: The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis
Correction: The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis Open
In “The Impact of COVID-19 Management Policies Tailored
\nto Airborne SARS-CoV-2 Transmission: Policy Analysis”
\n(JMIR Public Health Surveill 2021;7(4):e20699), the authors
\nnoted one error.
\nThe academic degree of author Archisman Roy …
View article: Correction: The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis (Preprint)
Correction: The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis (Preprint) Open
UNSTRUCTURED Daily new COVID-19 cases from January to April 2020 demonstrate varying patterns of SARS-CoV-2 transmission across different geographical regions. Constant infection rates were observed in some countries, whereas China and So…
View article: Characterization of three phase solid state VAR compensation scheme in three phase pulse width modulation voltage source inverter
Characterization of three phase solid state VAR compensation scheme in three phase pulse width modulation voltage source inverter Open
The principle of a three phase solid state VAR compensation (SSVC) system that uses a three-phase pulse width-modulated (PWM) Voltage-Source Inverter (VSI) is presented and analyzed. The proposed SSVC system can compensate for leading and …
View article: COVID-19 and Immune Function – “A Significant” Zinc
COVID-19 and Immune Function – “A Significant” Zinc Open
The pandemic COVID-19 is the most terrible calamity of the present human history also it has led to the worldwide issue of public health as a primary health safety problem. It was assumed that the infection of COVID -19 has two-phases, the…
View article: The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis
The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis Open
Background Daily new COVID-19 cases from January to April 2020 demonstrate varying patterns of SARS-CoV-2 transmission across different geographical regions. Constant infection rates were observed in some countries, whereas China and South…
View article: Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach
Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach Open
In the present study, we employ fluorescence spectroscopy, dynamic light scattering, and molecular docking methods. Binding of anticancer drug anastrozole with human lysozyme (HL) is studied. Binding of anastrozole to HL is moderate but sp…
View article: INOCULATION OF BRASSICA NAPUS L. GENOTYPES WITH ENDOPHYTIC BACTERIA PROMOTE GROWTH AND ALLEVIATE CADMIUM TOXICITY
INOCULATION OF BRASSICA NAPUS L. GENOTYPES WITH ENDOPHYTIC BACTERIA PROMOTE GROWTH AND ALLEVIATE CADMIUM TOXICITY Open
Cadmium is a non-essential heavy metal that is highly toxic for most of the plants, even at low concentrations.Cadmium tolerant endophytic bacteria isolated from different sources have been effectively used for mitigating cadmium toxicity …
View article: The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis (Preprint)
The Impact of COVID-19 Management Policies Tailored to Airborne SARS-CoV-2 Transmission: Policy Analysis (Preprint) Open
BACKGROUND Daily new COVID-19 cases from January to April 2020 demonstrate varying patterns of SARS-CoV-2 transmission across different geographical regions. Constant infection rates were observed in some countries, whereas China and Sout…
View article: Comparison of protective effects of carvedilol and α-tocopherol on doxorubicin-induced cardiotoxocity
Comparison of protective effects of carvedilol and α-tocopherol on doxorubicin-induced cardiotoxocity Open
Background: Doxorubicin, an effective anticancer drug used to treat multiple solid tumours and childhood malignancies since many decades but its cardiac adverse effects limits its use in full therapeutic dose. The mechanism involved in car…
View article: Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals
Bio-mediated synthesis of 5-FU based nanoparticles employing orange fruit juice: a novel drug delivery system to treat skin fibrosarcoma in model animals Open
View article: Systematic Biophysical Insights into the Interaction of Anti MERS-CoV Drug Ribavirin with Major Transport Protein in Human Serum: In-Vitro Studies and Implications in Diabetes and Uremia
Systematic Biophysical Insights into the Interaction of Anti MERS-CoV Drug Ribavirin with Major Transport Protein in Human Serum: In-Vitro Studies and Implications in Diabetes and Uremia Open
View article: Effects of carbon and nitrogen sources on production of proteases by Bacillus subtilis IC-5
Effects of carbon and nitrogen sources on production of proteases by Bacillus subtilis IC-5 Open
The effects of various carbon and nitrogen sources were evaluated on production of proteases by Bacillus subtilis IC-5. Both type and concentration of carbon and nitrogen sources influenced the production of proteases. Among the carbon sou…